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The map label for this gene is irlS [H]

Identifier: 110633257

GI number: 110633257

Start: 993661

End: 995067

Strand: Direct

Name: irlS [H]

Synonym: Meso_0903

Alternate gene names: 110633257

Gene position: 993661-995067 (Clockwise)

Preceding gene: 110633256

Following gene: 110633258

Centisome position: 22.52

GC content: 60.7

Gene sequence:

>1407_bases
ATGGCCACGCTGTCGGCCGTCATGAAGACAACCGCTGCACGGCTTTCGGCACTTTATCTTGTGCTGTTCGCCGCTTGCGC
GGTGATGCTCGTCATCTATGTAAGCTCACTTTCCACTCGCATACTGGTTGGGCAGACCCAGGAGGCAATCTCGGAGGAGG
TTGCCGGGCTAGGCCGTGCCTATCAACGCGGCGGACTGATCGGACTCGTCCGGCTCGTCGAAATCCGGGCCAGGCAGCCG
GGCGCCAATCTCTACCTTATTACGGATCCGAATGGCCGCATCCTCTCCGGAAACGTGGAGAGCATACAGCCAGGCGTGCT
CGACTCACCGGGCTGGACGGAAAACGCTTTCTTTTATCGCCGCTTCGGCGAGCCGGGGCCTGAGGGTGGCGAGAACGGCC
ATGCGGCGGTGGCCCAGATCATTCGTCTTCCCAATCGGATGATCCTGCTGGTCGGCCGGGATCTGAGCGAGCCTGACAAG
TTCGGACGCGTGATGCGCCGCGCGCTCGCCGCCTCTCTGGCGATGATGGGGCTCGGCGCGTTCCTGATTTGGTATTTCGT
AGGCAGACGGGCGCTGCGCCGTATCGATAGCGTGACTGAAGCCAGCCGCCAGATCATGGGCGGGGATCTGGCGAGGCGGC
TGCCCGTTTCCGGGGCGGGTGATGAATTCGACCGGCTTTCGGAAAACCTGAATGCGATGCTCGATCGAATTGCCGGTTTG
AACGAGGGGCTGAAACAGGTTTCCGCGAATATCGCTCACGATCTGAAAACGCCCTTGACGCGCCTGCGCAACCGAGCCGA
GGCGGCGCTGAACAGCAGTGGCGGCCCCGATGCAGCGAAGGAAGCGCTGGAGCAAACAATTGCTGAGTCCGATCAACTCA
TCCGCACCTTCAATGCGATATTGATGATCTCGCGGCTGGAAGCCGGGTATTCAGCGGAAAGCACGACCAAGCTGGATCTT
GCAGCGATCCTGTCCGATGTCGTCGAGCTTTATGAGCCAGCGGCGGAAGAACAGGGCGTGGACCTCAAAGCCGAGACTGT
TGAAAGTGTTCAGATCGATGGCAACCGTGAACTTATCGGCCAGGCGCTTTCCAACATCGTCGATAACGCCATCAAATATT
CCGCGGGCTTTGGCCAGAAGCCGTCTGTTTCCCTGTCCCTCCGGAAGGAGAAACACGCAATCCGCTTGGCCGTGAACGAC
ACCGGCCCGGGCATTCCGGAAAAGGATCGCGAACGCGCAACAGAGCGCTTTGTACGCCTAGAGCCAAGCCGGAGCCGGCC
GGGATCAGGGCTGGGTCTCAGCCTGGCCAAGGCGGTGATGACCTTTCACGGCGGGCGTCTTGAGCTTTCGGGGACAAGCG
GCGGGTTCACAGTTGCCATGATCTTCCCCGCGGGCAAGAATGGGTGA

Upstream 100 bases:

>100_bases
GCATGTCTCGCGCCTCAGAGGCAAGATCGAGAGGGGCTTCGACAAGCCCATTCTGCACACGGTGCGCGGGGCGGGTTATA
TGATCCGGGCGGACTGACCG

Downstream 100 bases:

>100_bases
TATTGCTGCCTCTTGCCAACCCCTCTCTGGCCCGCCCGCCAGAGGGCTATAAGGGAAATGCCAGGAAGAAATATGTCCGA
ACCGTCACCGCAGCATCCGG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MATLSAVMKTTAARLSALYLVLFAACAVMLVIYVSSLSTRILVGQTQEAISEEVAGLGRAYQRGGLIGLVRLVEIRARQP
GANLYLITDPNGRILSGNVESIQPGVLDSPGWTENAFFYRRFGEPGPEGGENGHAAVAQIIRLPNRMILLVGRDLSEPDK
FGRVMRRALAASLAMMGLGAFLIWYFVGRRALRRIDSVTEASRQIMGGDLARRLPVSGAGDEFDRLSENLNAMLDRIAGL
NEGLKQVSANIAHDLKTPLTRLRNRAEAALNSSGGPDAAKEALEQTIAESDQLIRTFNAILMISRLEAGYSAESTTKLDL
AAILSDVVELYEPAAEEQGVDLKAETVESVQIDGNRELIGQALSNIVDNAIKYSAGFGQKPSVSLSLRKEKHAIRLAVND
TGPGIPEKDRERATERFVRLEPSRSRPGSGLGLSLAKAVMTFHGGRLELSGTSGGFTVAMIFPAGKNG

Sequences:

>Translated_468_residues
MATLSAVMKTTAARLSALYLVLFAACAVMLVIYVSSLSTRILVGQTQEAISEEVAGLGRAYQRGGLIGLVRLVEIRARQP
GANLYLITDPNGRILSGNVESIQPGVLDSPGWTENAFFYRRFGEPGPEGGENGHAAVAQIIRLPNRMILLVGRDLSEPDK
FGRVMRRALAASLAMMGLGAFLIWYFVGRRALRRIDSVTEASRQIMGGDLARRLPVSGAGDEFDRLSENLNAMLDRIAGL
NEGLKQVSANIAHDLKTPLTRLRNRAEAALNSSGGPDAAKEALEQTIAESDQLIRTFNAILMISRLEAGYSAESTTKLDL
AAILSDVVELYEPAAEEQGVDLKAETVESVQIDGNRELIGQALSNIVDNAIKYSAGFGQKPSVSLSLRKEKHAIRLAVND
TGPGIPEKDRERATERFVRLEPSRSRPGSGLGLSLAKAVMTFHGGRLELSGTSGGFTVAMIFPAGKNG
>Mature_467_residues
ATLSAVMKTTAARLSALYLVLFAACAVMLVIYVSSLSTRILVGQTQEAISEEVAGLGRAYQRGGLIGLVRLVEIRARQPG
ANLYLITDPNGRILSGNVESIQPGVLDSPGWTENAFFYRRFGEPGPEGGENGHAAVAQIIRLPNRMILLVGRDLSEPDKF
GRVMRRALAASLAMMGLGAFLIWYFVGRRALRRIDSVTEASRQIMGGDLARRLPVSGAGDEFDRLSENLNAMLDRIAGLN
EGLKQVSANIAHDLKTPLTRLRNRAEAALNSSGGPDAAKEALEQTIAESDQLIRTFNAILMISRLEAGYSAESTTKLDLA
AILSDVVELYEPAAEEQGVDLKAETVESVQIDGNRELIGQALSNIVDNAIKYSAGFGQKPSVSLSLRKEKHAIRLAVNDT
GPGIPEKDRERATERFVRLEPSRSRPGSGLGLSLAKAVMTFHGGRLELSGTSGGFTVAMIFPAGKNG

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance. Probably activates irlR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=272, Percent_Identity=26.8382352941176, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787894, Length=308, Percent_Identity=29.5454545454545, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=29.6803652968037, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789403, Length=251, Percent_Identity=29.4820717131474, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=24.2647058823529, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790861, Length=305, Percent_Identity=27.8688524590164, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1789808, Length=325, Percent_Identity=28.6153846153846, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1788279, Length=258, Percent_Identity=26.7441860465116, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=27.6018099547511, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1790551, Length=304, Percent_Identity=27.3026315789474, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=27.037037037037, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789149, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788713, Length=223, Percent_Identity=22.8699551569507, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787374, Length=405, Percent_Identity=22.7160493827161, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788549, Length=239, Percent_Identity=25.1046025104602, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082128, Length=244, Percent_Identity=28.2786885245902, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50272; Mature: 50141

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLSAVMKTTAARLSALYLVLFAACAVMLVIYVSSLSTRILVGQTQEAISEEVAGLGRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCHHHHHHHHHHHHHHH
YQRGGLIGLVRLVEIRARQPGANLYLITDPNGRILSGNVESIQPGVLDSPGWTENAFFYR
HHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCHHHCCCCCCCCCCCCCCCHHHH
RFGEPGPEGGENGHAAVAQIIRLPNRMILLVGRDLSEPDKFGRVMRRALAASLAMMGLGA
CCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FLIWYFVGRRALRRIDSVTEASRQIMGGDLARRLPVSGAGDEFDRLSENLNAMLDRIAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
NEGLKQVSANIAHDLKTPLTRLRNRAEAALNSSGGPDAAKEALEQTIAESDQLIRTFNAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMISRLEAGYSAESTTKLDLAAILSDVVELYEPAAEEQGVDLKAETVESVQIDGNRELIG
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHEEECCCHHHHH
QALSNIVDNAIKYSAGFGQKPSVSLSLRKEKHAIRLAVNDTGPGIPEKDRERATERFVRL
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCC
EPSRSRPGSGLGLSLAKAVMTFHGGRLELSGTSGGFTVAMIFPAGKNG
CCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
ATLSAVMKTTAARLSALYLVLFAACAVMLVIYVSSLSTRILVGQTQEAISEEVAGLGRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCHHHHHHHHHHHHHHH
YQRGGLIGLVRLVEIRARQPGANLYLITDPNGRILSGNVESIQPGVLDSPGWTENAFFYR
HHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCHHHCCCCCCCCCCCCCCCHHHH
RFGEPGPEGGENGHAAVAQIIRLPNRMILLVGRDLSEPDKFGRVMRRALAASLAMMGLGA
CCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FLIWYFVGRRALRRIDSVTEASRQIMGGDLARRLPVSGAGDEFDRLSENLNAMLDRIAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
NEGLKQVSANIAHDLKTPLTRLRNRAEAALNSSGGPDAAKEALEQTIAESDQLIRTFNAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMISRLEAGYSAESTTKLDLAAILSDVVELYEPAAEEQGVDLKAETVESVQIDGNRELIG
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHEEECCCHHHHH
QALSNIVDNAIKYSAGFGQKPSVSLSLRKEKHAIRLAVNDTGPGIPEKDRERATERFVRL
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCC
EPSRSRPGSGLGLSLAKAVMTFHGGRLELSGTSGGFTVAMIFPAGKNG
CCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]