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The map label for this gene is siaT [H]

Identifier: 110633144

GI number: 110633144

Start: 865471

End: 866748

Strand: Reverse

Name: siaT [H]

Synonym: Meso_0787

Alternate gene names: 110633144

Gene position: 866748-865471 (Counterclockwise)

Preceding gene: 110633145

Following gene: 110633143

Centisome position: 19.64

GC content: 62.36

Gene sequence:

>1278_bases
ATGATCCTGACCTTATTCCTGGTCTTCTTCGCCTGCCTGCTGATCGGTGTTCCGATCGGCTTCGGCATGGGTTTCGCTTC
TATGGTCGCGATCGCCCTTCATGGCAGTTTCCCCATGGAGGTCATTCCCCATAAGATGGCGAATGCCGTCAATTCCTTTC
CGCTGGTGGCGTTGCCGCTGTTCATTCTCGCAGGCGCGCTGGCAGGGGAAACGAGCATCGCGGGTCGGCTCGTCCGCTTC
GCCGATGCCCTGTTCGGGCATATCCGCGGCGGCCTCGGCCACGTGAACGTCGCCTCGTCGATGTTCTTCGGTGGCATTTC
GGGTTCGGCGGTCGCCGACACGGCCGCAATCGGCAGCCTCATGATCCCGGCCATGGAAAAGCAGGGCTACAAACGCGCCG
ATGCGGGCGCGATTACCATCTGCTCTTCCGTCATCGGCGTGCTGATCCCGCCGAGCATTCCCATGGTTCTCTACGGCGTG
ACAGTCGGCACCTCTATCGGGTCGCTGTTCCTTGCCGGAATCGTGCCCGGCGTACTGGTCGGCGTTTTCCTGATGGCGGC
CGTGTTCTTCATGTCGAAAAAGAAGGGCTGGCCGCGGCGGGAACACCGCGCGCCCGCAGGTGAGCTCTGGTCAGCGTTCA
AGCAGGCGATCCTGCCGCTGCTGCTGCCGGTCTTCCTGCTCGGAGCGATCGTTTCCGGCCTCACCACCGCCACCGAGGCA
GGCGTTATCGGCGTGGTTTATGCGCTGATCCTCGGCGGCTTCGTCTACCGCGATCATACGCTGCCGGACCTCTTCCGCAT
CGCGGTCGACGCGGCAATCAGCACTGCGATTCCGGTCTTCGTCCTGGCCACCACCTCGGTTGCGGCCTGGATCATCGCCA
TCGAGCAATTCCCGGCGGCGCTGGCTGGCTTCTTCTCGGAGATGGCTTTCGGCAAGATAATCGTCCTCCTCGTCATCAAC
TTGTTCCTGATGCTGGTTGGCATGGTGATGGATCTGGTTCCCGCCCTGATCCTGTTCGCACCGATCCTGCTGCCGGTGGC
GCAGGAGGCTGGCATGGATGCGATCCAGTTCGGCGTGTTGATGGTGGTGAACCTCGGCGTCGGACTGGTGACACCGCCGG
TGGGCAACTGCCTCTATCTCGGGGCGGTGGTCGCCCGTGTCGATCTCTCCTCCCTGATCCGCGCGAGCCTGCCCTTCCTG
ATGGTCAACTTATTCGTGCTGCTGCTGGTCACCTATGTGCCGCAGCTCAGCACCTTCCTCCCATCCCTCTTCTACTGA

Upstream 100 bases:

>100_bases
ACGTCTACGCCTGCCTGCCGCTTTCGGCCACGCTGATGACCATCAGTGCGCTTGGCAAAGCCTGGGAAGCCGTCCTTCGA
CTGACCGGAAAGGTATCTCC

Downstream 100 bases:

>100_bases
CGGGCCGGCCACCGGCTTTCCCGCAAGGAGTTTGAAATGACTGGTCTTCTGGGGCGCGGAGCCCTCGTCAACTGGGGCGG
CGTCATTGCCTCCGGCGAAC

Product: TRAP dicarboxylate transporter, DctM subunit

Products: NA

Alternate protein names: N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MILTLFLVFFACLLIGVPIGFGMGFASMVAIALHGSFPMEVIPHKMANAVNSFPLVALPLFILAGALAGETSIAGRLVRF
ADALFGHIRGGLGHVNVASSMFFGGISGSAVADTAAIGSLMIPAMEKQGYKRADAGAITICSSVIGVLIPPSIPMVLYGV
TVGTSIGSLFLAGIVPGVLVGVFLMAAVFFMSKKKGWPRREHRAPAGELWSAFKQAILPLLLPVFLLGAIVSGLTTATEA
GVIGVVYALILGGFVYRDHTLPDLFRIAVDAAISTAIPVFVLATTSVAAWIIAIEQFPAALAGFFSEMAFGKIIVLLVIN
LFLMLVGMVMDLVPALILFAPILLPVAQEAGMDAIQFGVLMVVNLGVGLVTPPVGNCLYLGAVVARVDLSSLIRASLPFL
MVNLFVLLLVTYVPQLSTFLPSLFY

Sequences:

>Translated_425_residues
MILTLFLVFFACLLIGVPIGFGMGFASMVAIALHGSFPMEVIPHKMANAVNSFPLVALPLFILAGALAGETSIAGRLVRF
ADALFGHIRGGLGHVNVASSMFFGGISGSAVADTAAIGSLMIPAMEKQGYKRADAGAITICSSVIGVLIPPSIPMVLYGV
TVGTSIGSLFLAGIVPGVLVGVFLMAAVFFMSKKKGWPRREHRAPAGELWSAFKQAILPLLLPVFLLGAIVSGLTTATEA
GVIGVVYALILGGFVYRDHTLPDLFRIAVDAAISTAIPVFVLATTSVAAWIIAIEQFPAALAGFFSEMAFGKIIVLLVIN
LFLMLVGMVMDLVPALILFAPILLPVAQEAGMDAIQFGVLMVVNLGVGLVTPPVGNCLYLGAVVARVDLSSLIRASLPFL
MVNLFVLLLVTYVPQLSTFLPSLFY
>Mature_425_residues
MILTLFLVFFACLLIGVPIGFGMGFASMVAIALHGSFPMEVIPHKMANAVNSFPLVALPLFILAGALAGETSIAGRLVRF
ADALFGHIRGGLGHVNVASSMFFGGISGSAVADTAAIGSLMIPAMEKQGYKRADAGAITICSSVIGVLIPPSIPMVLYGV
TVGTSIGSLFLAGIVPGVLVGVFLMAAVFFMSKKKGWPRREHRAPAGELWSAFKQAILPLLLPVFLLGAIVSGLTTATEA
GVIGVVYALILGGFVYRDHTLPDLFRIAVDAAISTAIPVFVLATTSVAAWIIAIEQFPAALAGFFSEMAFGKIIVLLVIN
LFLMLVGMVMDLVPALILFAPILLPVAQEAGMDAIQFGVLMVVNLGVGLVTPPVGNCLYLGAVVARVDLSSLIRASLPFL
MVNLFVLLLVTYVPQLSTFLPSLFY

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid [H]

COG id: COG1593

COG function: function code G; TRAP-type C4-dicarboxylate transport system, large permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the TRAP transporter large permease family [H]

Homologues:

Organism=Escherichia coli, GI48994950, Length=414, Percent_Identity=35.2657004830918, Blast_Score=233, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010656
- InterPro:   IPR007387
- InterPro:   IPR004681 [H]

Pfam domain/function: PF06808 DctM; PF04290 DctQ [H]

EC number: NA

Molecular weight: Translated: 44538; Mature: 44538

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILTLFLVFFACLLIGVPIGFGMGFASMVAIALHGSFPMEVIPHKMANAVNSFPLVALPL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHH
FILAGALAGETSIAGRLVRFADALFGHIRGGLGHVNVASSMFFGGISGSAVADTAAIGSL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
MIPAMEKQGYKRADAGAITICSSVIGVLIPPSIPMVLYGVTVGTSIGSLFLAGIVPGVLV
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GVFLMAAVFFMSKKKGWPRREHRAPAGELWSAFKQAILPLLLPVFLLGAIVSGLTTATEA
HHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVIGVVYALILGGFVYRDHTLPDLFRIAVDAAISTAIPVFVLATTSVAAWIIAIEQFPAA
HHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAGFFSEMAFGKIIVLLVINLFLMLVGMVMDLVPALILFAPILLPVAQEAGMDAIQFGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
MVVNLGVGLVTPPVGNCLYLGAVVARVDLSSLIRASLPFLMVNLFVLLLVTYVPQLSTFL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PSLFY
HHHCC
>Mature Secondary Structure
MILTLFLVFFACLLIGVPIGFGMGFASMVAIALHGSFPMEVIPHKMANAVNSFPLVALPL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHH
FILAGALAGETSIAGRLVRFADALFGHIRGGLGHVNVASSMFFGGISGSAVADTAAIGSL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
MIPAMEKQGYKRADAGAITICSSVIGVLIPPSIPMVLYGVTVGTSIGSLFLAGIVPGVLV
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GVFLMAAVFFMSKKKGWPRREHRAPAGELWSAFKQAILPLLLPVFLLGAIVSGLTTATEA
HHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVIGVVYALILGGFVYRDHTLPDLFRIAVDAAISTAIPVFVLATTSVAAWIIAIEQFPAA
HHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAGFFSEMAFGKIIVLLVINLFLMLVGMVMDLVPALILFAPILLPVAQEAGMDAIQFGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
MVVNLGVGLVTPPVGNCLYLGAVVARVDLSSLIRASLPFLMVNLFVLLLVTYVPQLSTFL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PSLFY
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]