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The map label for this gene is moaB [H]

Identifier: 110633062

GI number: 110633062

Start: 779467

End: 780009

Strand: Reverse

Name: moaB [H]

Synonym: Meso_0705

Alternate gene names: 110633062

Gene position: 780009-779467 (Counterclockwise)

Preceding gene: 110633063

Following gene: 110633061

Centisome position: 17.68

GC content: 62.8

Gene sequence:

>543_bases
ATGTCTGAACGGCAGTTCATTCCCGTGCGATTCGCGGTGCTCACCATTTCCGACACGCGCACCATGGAGAACGACAAGTC
CGGCCAGACCTTGGCTGATCGCATAGAGCAAGCCGGCCATGAGCTGGCCGGCCGCGCCATCGCGCCGGATGAGGCTGGGG
TAATCAGCCGCCAGGTGCTCTCCTGGTGCGCGGATCCGCATATCGACGCCGTAATCACCACGGGCGGAACCGGCTTTACG
GGGCGCGATGTGACGCCGGAGGCGCTGGAGCCGCTCTTCGAAAAGCGCATGGACGGCTTTTCACAGGTTTTCCACAGGGT
TTCTTTCGAGAAGATCGGCACCTCCACCATCCAGTCCCGAGCCACCGCGGGGCTCATCAACCAGACGTTCGTCTTCATCC
TTCCGGGCTCTCCGGGCGCCTGCCGCGACGCCTGGGATCTCATCCTGAAGGATCAGTTCGACTACCGGCACATGCCCTGC
AACTTCGTGGAAATCATGCCGCGCCTGGACGAGCATCTGAAACGCGGCGCCAGCTCCGCCTGA

Upstream 100 bases:

>100_bases
GCGAGCAAAGCCCGGCAGGCGGGCGAGATGATCTCCCGGAGACATCCCGGCTGGTTTGTCCGCGCGACCCAGACGAGGGC
CTCCATGCCGGAGTTGAGTC

Downstream 100 bases:

>100_bases
TCTTGTTATCCACAGCTTTTCCTCCCTCCCATCTCCCGCCCGTTCCGATCTGATCGCGAAAAGTTCTTGATTTGTTCCAT
ATCAGAAGATAGGAATAGAT

Product: molybdenum cofactor biosynthesis protein B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MSERQFIPVRFAVLTISDTRTMENDKSGQTLADRIEQAGHELAGRAIAPDEAGVISRQVLSWCADPHIDAVITTGGTGFT
GRDVTPEALEPLFEKRMDGFSQVFHRVSFEKIGTSTIQSRATAGLINQTFVFILPGSPGACRDAWDLILKDQFDYRHMPC
NFVEIMPRLDEHLKRGASSA

Sequences:

>Translated_180_residues
MSERQFIPVRFAVLTISDTRTMENDKSGQTLADRIEQAGHELAGRAIAPDEAGVISRQVLSWCADPHIDAVITTGGTGFT
GRDVTPEALEPLFEKRMDGFSQVFHRVSFEKIGTSTIQSRATAGLINQTFVFILPGSPGACRDAWDLILKDQFDYRHMPC
NFVEIMPRLDEHLKRGASSA
>Mature_179_residues
SERQFIPVRFAVLTISDTRTMENDKSGQTLADRIEQAGHELAGRAIAPDEAGVISRQVLSWCADPHIDAVITTGGTGFTG
RDVTPEALEPLFEKRMDGFSQVFHRVSFEKIGTSTIQSRATAGLINQTFVFILPGSPGACRDAWDLILKDQFDYRHMPCN
FVEIMPRLDEHLKRGASSA

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=146, Percent_Identity=32.1917808219178, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI10880983, Length=146, Percent_Identity=32.1917808219178, Blast_Score=84, Evalue=9e-17,
Organism=Escherichia coli, GI1787000, Length=158, Percent_Identity=48.7341772151899, Blast_Score=164, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17564954, Length=147, Percent_Identity=31.2925170068027, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136978, Length=144, Percent_Identity=35.4166666666667, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24638841, Length=144, Percent_Identity=35.4166666666667, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 19925; Mature: 19794

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERQFIPVRFAVLTISDTRTMENDKSGQTLADRIEQAGHELAGRAIAPDEAGVISRQVL
CCCCCEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SWCADPHIDAVITTGGTGFTGRDVTPEALEPLFEKRMDGFSQVFHRVSFEKIGTSTIQSR
HHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATAGLINQTFVFILPGSPGACRDAWDLILKDQFDYRHMPCNFVEIMPRLDEHLKRGASSA
HHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SERQFIPVRFAVLTISDTRTMENDKSGQTLADRIEQAGHELAGRAIAPDEAGVISRQVL
CCCCEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SWCADPHIDAVITTGGTGFTGRDVTPEALEPLFEKRMDGFSQVFHRVSFEKIGTSTIQSR
HHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATAGLINQTFVFILPGSPGACRDAWDLILKDQFDYRHMPCNFVEIMPRLDEHLKRGASSA
HHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]