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The map label for this gene is trpF

Identifier: 110633024

GI number: 110633024

Start: 745519

End: 746175

Strand: Reverse

Name: trpF

Synonym: Meso_0667

Alternate gene names: 110633024

Gene position: 746175-745519 (Counterclockwise)

Preceding gene: 110633025

Following gene: 110633023

Centisome position: 16.91

GC content: 65.3

Gene sequence:

>657_bases
ATGCAACTCGACATTAAAATCTGCGGGCTGAAGACCGAGGACGCCATTGCCGCCGCGCTCGACGGCGGGGCGAGCCATGT
CGGCTTCATCTTCTTTCCAAAAAGCCCGCGGAACGTGGATATCGAGACGGCCGCCCGGCTGCGGCATCTGGCGAGCGGGC
GCGCGCAGGCCGTGGCGGTGACGGTGGATGCCGACGACGAAATGCTTGATCGCATCGTCGAGGGCATGCGGCCGGATGTG
TTGCAACTCCATGGGCATGAGCGTCCGGTGCGCGTGGAAGCACTGAAGAAGCGCTATCATCTGCCGGTGATGAAGGCGGT
TTCGGTTCGCGAGGCAAGCGACCTGGAGGTGCTGCCCGCCTATCGCGGCGTGGCCGACCGCTTCCTTCTCGACGCCAAGC
CGCCCGCAGGCGCCGAGCTTCCCGGCGGCAACGGCATCCCCTTCGACTGGTCGCTTCTAGCTTCCCTTGACGGGAAAGTG
GATTACATGCTTTCGGGTGGTCTGAGCGCGGTCAATATCGGCGAGGCGCTGAGCATCGCCCGGCCGCGCGGCATCGACAT
TTCCTCCGGCGTGGAACGCGCGCCGGGCGAAAAGGACCCGGATTTGATACGCGCCTTCTTCAGCGCCGTGCGGGCCGCAC
GGGGCAAGCGCGAGTAA

Upstream 100 bases:

>100_bases
AATAGCGAATAGCGAGTAGCAAGCGGCAATTATTCGCTACTCGCTATTCCCTATTCGCTCACTATCGACTCCGCCCTCAT
TTCATGCCACTTCCACGCCC

Downstream 100 bases:

>100_bases
CGGAGGCGGCATGAACAAGCCGGTTGAACCAAACTCCTTCCGCACCGGACCCGACGAGCAGGGCATGTTCGGCATCTTCG
GCGGCCGCTTCGTGGCGGAA

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MQLDIKICGLKTEDAIAAALDGGASHVGFIFFPKSPRNVDIETAARLRHLASGRAQAVAVTVDADDEMLDRIVEGMRPDV
LQLHGHERPVRVEALKKRYHLPVMKAVSVREASDLEVLPAYRGVADRFLLDAKPPAGAELPGGNGIPFDWSLLASLDGKV
DYMLSGGLSAVNIGEALSIARPRGIDISSGVERAPGEKDPDLIRAFFSAVRAARGKRE

Sequences:

>Translated_218_residues
MQLDIKICGLKTEDAIAAALDGGASHVGFIFFPKSPRNVDIETAARLRHLASGRAQAVAVTVDADDEMLDRIVEGMRPDV
LQLHGHERPVRVEALKKRYHLPVMKAVSVREASDLEVLPAYRGVADRFLLDAKPPAGAELPGGNGIPFDWSLLASLDGKV
DYMLSGGLSAVNIGEALSIARPRGIDISSGVERAPGEKDPDLIRAFFSAVRAARGKRE
>Mature_218_residues
MQLDIKICGLKTEDAIAAALDGGASHVGFIFFPKSPRNVDIETAARLRHLASGRAQAVAVTVDADDEMLDRIVEGMRPDV
LQLHGHERPVRVEALKKRYHLPVMKAVSVREASDLEVLPAYRGVADRFLLDAKPPAGAELPGGNGIPFDWSLLASLDGKV
DYMLSGGLSAVNIGEALSIARPRGIDISSGVERAPGEKDPDLIRAFFSAVRAARGKRE

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=214, Percent_Identity=34.5794392523364, Blast_Score=89, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320210, Length=215, Percent_Identity=27.906976744186, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_MESSB (Q11KK8)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673232.1
- ProteinModelPortal:   Q11KK8
- SMR:   Q11KK8
- STRING:   Q11KK8
- GeneID:   4180691
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0667
- NMPDR:   fig|266779.1.peg.2803
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- PhylomeDB:   Q11KK8
- ProtClustDB:   PRK01222
- BioCyc:   MSP266779:MESO_0667-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 23427; Mature: 23427

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLDIKICGLKTEDAIAAALDGGASHVGFIFFPKSPRNVDIETAARLRHLASGRAQAVAV
CEEEEEEECCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEE
TVDADDEMLDRIVEGMRPDVLQLHGHERPVRVEALKKRYHLPVMKAVSVREASDLEVLPA
EECCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCEEHHH
YRGVADRFLLDAKPPAGAELPGGNGIPFDWSLLASLDGKVDYMLSGGLSAVNIGEALSIA
HHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCEEECCHHHHCC
RPRGIDISSGVERAPGEKDPDLIRAFFSAVRAARGKRE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQLDIKICGLKTEDAIAAALDGGASHVGFIFFPKSPRNVDIETAARLRHLASGRAQAVAV
CEEEEEEECCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEE
TVDADDEMLDRIVEGMRPDVLQLHGHERPVRVEALKKRYHLPVMKAVSVREASDLEVLPA
EECCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCEEHHH
YRGVADRFLLDAKPPAGAELPGGNGIPFDWSLLASLDGKVDYMLSGGLSAVNIGEALSIA
HHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCEEECCHHHHCC
RPRGIDISSGVERAPGEKDPDLIRAFFSAVRAARGKRE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA