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The map label for this gene is trpB

Identifier: 110633023

GI number: 110633023

Start: 744288

End: 745508

Strand: Reverse

Name: trpB

Synonym: Meso_0666

Alternate gene names: 110633023

Gene position: 745508-744288 (Counterclockwise)

Preceding gene: 110633024

Following gene: 110633022

Centisome position: 16.9

GC content: 63.55

Gene sequence:

>1221_bases
ATGAACAAGCCGGTTGAACCAAACTCCTTCCGCACCGGACCCGACGAGCAGGGCATGTTCGGCATCTTCGGCGGCCGCTT
CGTGGCGGAAACGCTGATGCCGCTGATATTGGAACTCGAAGAGCACTGGAACGCGGCAAAGAACGATCCCGCCTTCAAGG
CAGAGCTCCAGCAACTGGGCGCGCACTATACCGGGCGCCCATCGCCCCTCTATTTCGCCGAGCGCCTGACGGAGCATCTC
GGCGGCGCCAAGGTCTATTTCAAGCGCGAGGAATTGAACCACACCGGCAGCCACAAGGTGAACAATTGCCTGGGCCAGAT
CCTGCTCGCCAAGCGGATGGGCAAGACGCGCATTATTGCCGAGACAGGCGCCGGCCAGCACGGCGTGGCTTCGGCTACCG
TGGCGGCGCGTTTCGGACTGCCCTGCGTGGTCTATATGGGCGCGACCGACGTGGAACGGCAGGCGCCGAACGTCTTCCGC
ATGCGGCTGCTCGGCGCTGAAGTGAAGCCCGTGACTTCCGGCCATGGTACGCTCAAGGATGCCATGAACGAGGCGCTTCG
CGACTGGGTGACCAATGTCGAGGACACCTATTACTTGATCGGCACCGCTGCCGGCCCGCACCCTTATCCCGAGCTGGTGC
GCGACTTCCAGTCCGTCATCGGACAGGAGACGAAGGAGCAGATCCTTGCGGCCGAGGGCCGCCTGCCGGACATGCTGGTG
GCCGCCGTCGGCGGCGGCTCCAACGCCATTGGCCTTTTCCATCCCTTCCTCGATGACAAGGGCGTGGCGATGGTGGGCGT
GGAGGCCGGAGGGAAGGGGCTTGAGGGCGATGAGCATTGCGCAAGCCTCACCGCCGGCAGTCCCGGCGTGCTGCACGGCA
ACCGCACCTATCTGCTCCAGGATTCAGACGGACAGATCAAGGAAGGCCACTCGATCTCGGCCGGCCTCGACTATCCGGGC
ATCGGGCCGGAGCACTCCTGGCTCAAGGAGGCGGGCCGCGTCGAATATGTGCCGATCATGGATCACGAGGCGCTCGAAGC
CTTCCAGCTCCTGACGCGGCTCGAAGGCATCATTCCGGCTCTGGAGCCTTCCCATGCGCTGGCCGAGGTGATCAAGCGCG
CGCCGAAGATGGGCAAGGATCAGATCATCGTCATGAACCTTTCCGGCCGTGGCGACAAGGACATCTTCGCCGTGGCGAAG
CATCTGAAGATGGATGTTTGA

Upstream 100 bases:

>100_bases
GGCGTGGAACGCGCGCCGGGCGAAAAGGACCCGGATTTGATACGCGCCTTCTTCAGCGCCGTGCGGGCCGCACGGGGCAA
GCGCGAGTAACGGAGGCGGC

Downstream 100 bases:

>100_bases
GCATGACGCTCGCCTTCATCGACATATGGGTGAACTGCCCCGACCGGGAGACGGCGGAAAAGATCGCCGATGCCTGCATC
GGCGCGAAGCTTGCCGCCTG

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNKPVEPNSFRTGPDEQGMFGIFGGRFVAETLMPLILELEEHWNAAKNDPAFKAELQQLGAHYTGRPSPLYFAERLTEHL
GGAKVYFKREELNHTGSHKVNNCLGQILLAKRMGKTRIIAETGAGQHGVASATVAARFGLPCVVYMGATDVERQAPNVFR
MRLLGAEVKPVTSGHGTLKDAMNEALRDWVTNVEDTYYLIGTAAGPHPYPELVRDFQSVIGQETKEQILAAEGRLPDMLV
AAVGGGSNAIGLFHPFLDDKGVAMVGVEAGGKGLEGDEHCASLTAGSPGVLHGNRTYLLQDSDGQIKEGHSISAGLDYPG
IGPEHSWLKEAGRVEYVPIMDHEALEAFQLLTRLEGIIPALEPSHALAEVIKRAPKMGKDQIIVMNLSGRGDKDIFAVAK
HLKMDV

Sequences:

>Translated_406_residues
MNKPVEPNSFRTGPDEQGMFGIFGGRFVAETLMPLILELEEHWNAAKNDPAFKAELQQLGAHYTGRPSPLYFAERLTEHL
GGAKVYFKREELNHTGSHKVNNCLGQILLAKRMGKTRIIAETGAGQHGVASATVAARFGLPCVVYMGATDVERQAPNVFR
MRLLGAEVKPVTSGHGTLKDAMNEALRDWVTNVEDTYYLIGTAAGPHPYPELVRDFQSVIGQETKEQILAAEGRLPDMLV
AAVGGGSNAIGLFHPFLDDKGVAMVGVEAGGKGLEGDEHCASLTAGSPGVLHGNRTYLLQDSDGQIKEGHSISAGLDYPG
IGPEHSWLKEAGRVEYVPIMDHEALEAFQLLTRLEGIIPALEPSHALAEVIKRAPKMGKDQIIVMNLSGRGDKDIFAVAK
HLKMDV
>Mature_406_residues
MNKPVEPNSFRTGPDEQGMFGIFGGRFVAETLMPLILELEEHWNAAKNDPAFKAELQQLGAHYTGRPSPLYFAERLTEHL
GGAKVYFKREELNHTGSHKVNNCLGQILLAKRMGKTRIIAETGAGQHGVASATVAARFGLPCVVYMGATDVERQAPNVFR
MRLLGAEVKPVTSGHGTLKDAMNEALRDWVTNVEDTYYLIGTAAGPHPYPELVRDFQSVIGQETKEQILAAEGRLPDMLV
AAVGGGSNAIGLFHPFLDDKGVAMVGVEAGGKGLEGDEHCASLTAGSPGVLHGNRTYLLQDSDGQIKEGHSISAGLDYPG
IGPEHSWLKEAGRVEYVPIMDHEALEAFQLLTRLEGIIPALEPSHALAEVIKRAPKMGKDQIIVMNLSGRGDKDIFAVAK
HLKMDV

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=385, Percent_Identity=57.4025974025974, Blast_Score=441, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6321412, Length=384, Percent_Identity=58.8541666666667, Blast_Score=463, Evalue=1e-131,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB_MESSB (Q11KK9)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673231.1
- ProteinModelPortal:   Q11KK9
- SMR:   Q11KK9
- STRING:   Q11KK9
- GeneID:   4180690
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0666
- NMPDR:   fig|266779.1.peg.2802
- eggNOG:   COG0133
- HOGENOM:   HBG303148
- OMA:   LKREDLC
- PhylomeDB:   Q11KK9
- ProtClustDB:   PRK04346
- BioCyc:   MSP266779:MESO_0666-MONOMER
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 43916; Mature: 43916

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPVEPNSFRTGPDEQGMFGIFGGRFVAETLMPLILELEEHWNAAKNDPAFKAELQQLG
CCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
AHYTGRPSPLYFAERLTEHLGGAKVYFKREELNHTGSHKVNNCLGQILLAKRMGKTRIIA
CCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEE
ETGAGQHGVASATVAARFGLPCVVYMGATDVERQAPNVFRMRLLGAEVKPVTSGHGTLKD
ECCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHHHHCCCCCCCCCCCCHHHH
AMNEALRDWVTNVEDTYYLIGTAAGPHPYPELVRDFQSVIGQETKEQILAAEGRLPDMLV
HHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEE
AAVGGGSNAIGLFHPFLDDKGVAMVGVEAGGKGLEGDEHCASLTAGSPGVLHGNRTYLLQ
EEECCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCEEECCEEEEEE
DSDGQIKEGHSISAGLDYPGIGPEHSWLKEAGRVEYVPIMDHEALEAFQLLTRLEGIIPA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCC
LEPSHALAEVIKRAPKMGKDQIIVMNLSGRGDKDIFAVAKHLKMDV
CCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKPVEPNSFRTGPDEQGMFGIFGGRFVAETLMPLILELEEHWNAAKNDPAFKAELQQLG
CCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
AHYTGRPSPLYFAERLTEHLGGAKVYFKREELNHTGSHKVNNCLGQILLAKRMGKTRIIA
CCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEE
ETGAGQHGVASATVAARFGLPCVVYMGATDVERQAPNVFRMRLLGAEVKPVTSGHGTLKD
ECCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHHHHCCCCCCCCCCCCHHHH
AMNEALRDWVTNVEDTYYLIGTAAGPHPYPELVRDFQSVIGQETKEQILAAEGRLPDMLV
HHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEE
AAVGGGSNAIGLFHPFLDDKGVAMVGVEAGGKGLEGDEHCASLTAGSPGVLHGNRTYLLQ
EEECCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCEEECCEEEEEE
DSDGQIKEGHSISAGLDYPGIGPEHSWLKEAGRVEYVPIMDHEALEAFQLLTRLEGIIPA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCC
LEPSHALAEVIKRAPKMGKDQIIVMNLSGRGDKDIFAVAKHLKMDV
CCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA