Click here to switch to the map view.

The map label for this gene is guaB [H]

Identifier: 110632828

GI number: 110632828

Start: 514736

End: 516238

Strand: Reverse

Name: guaB [H]

Synonym: Meso_0467

Alternate gene names: 110632828

Gene position: 516238-514736 (Counterclockwise)

Preceding gene: 110632829

Following gene: 110632825

Centisome position: 11.7

GC content: 61.81

Gene sequence:

>1503_bases
ATGGCAAAAATTATCCAGACTCCCACCGGCGCGGAAGCGCTTACTTTTGATGACGTGCTTCTCCAGCCCGGTCATTCAGA
GGTCATGCCTGGCCAGACGGATGTGAGCACGCGGATCGCCGGCGACATCGAGCTCAATATTCCCATCCTTTCAGCCGCCA
TGGACACGGTGACGGAGGCGCGGCTTGCAATTGCCATGGCGCAGGCGGGCGGCATCGGCGTGATTCACCGCAATCTCACG
CCTGCGGAGCAGGCGGAAGAGGTGCGCCAGGTAAAGAAGTTCGAATCCGGCATGGTAGTGAACCCGGTCACCATCGGCCC
CGACGCCACGCTTGCCGATGCTCATGCCCTGATGGGCGCTCATCGCATATCGGGGATCCCGGTTGTGGAGAATGGCGGGC
TAGGTGGTCATACGGTCGGCAAATTGGTGGGTATCCTCACCAATCGCGATGTACGCTTCGCCTCGAACCCGGCGCAGCCC
GTGCGCGAGTTGATGACGCATGACCGGCTGATCACCGTGAAGGAAAGCGTGAGCCAGGAGGAGGCAAAGCGCCTCCTACA
TCAAAACCGTATCGAAAAGCTGCTGGTTGTCGATGATGCCGGCAATTGCGTTGGTTTGATCACCGTTAAAGATATAGAGA
AATCCCAACTCAACCCACATGCAAGCAAGGACGCGCAAGGCCGGTTGCGCGTGGCCGCAGCCACCAGCGTGGGCGATGAC
GGATTTGAACGGGCCGAGCGGCTTATCGATGCCGGAGTGGACCTGCTCGTGATCGATACGGCCCACGGCCACTCGCAACG
CGTGCTGGATGCCGTGAAGCGGGCAAAAATGTTGTCGAACGCGGTGCGGATCATAGCCGGCAACGTCGCCACAGCGGACG
GCACAAAGGCTTTGATCGATGCGGGCGCAGATGGCGTGAAGGTGGGAATCGGCCCCGGCTCGATCTGTACCACCCGCGTT
GTAGCGGGCGTGGGTGTGCCGCAACTCGCCGCAATAATGTCCGCCGTGGAGGCAGGGCAGAAGCTGGGCATTTCCATCAT
TGCCGATGGCGGCATCAAATTTTCAGGCGACCTTGCCAAGGCGCTCGCCGCCGGCGCAAACGCGGCGATGATCGGCTCGC
TTCTGGCCGGTACGGATGAGAGCCCTGGCGAGGTGTTCCTTTATCAGGGCCGATCCTTCAAGGCATATCGGGGCATGGGG
TCGGTCGGCGCGATGGCGCGCGGCTCGGCAGATCGCTACTTCCAGGCGGAAGTGCGTGATACGCTGAAGCTCGTTCCGGA
GGGGATCGAGGGGCAAGTCCCCTATAAGGGCCCCGCGGCCGGCGTCCTGCATCAGCTCACCGGCGGGTTGCGGGCAGCGA
TGGGTTACGTGGGGGCACACAATCTGAGAGAATTGCAGGAGAAGGCCACCTTCGTGCGCATCTCCGGCGCCGGTCTTCGT
GAAAGCCACCCACACGACGTGACCATCACGCGCGAAAGCCCGAACTATCCGGGCGCGTCATGA

Upstream 100 bases:

>100_bases
GTGTTACCAGCCCTTGCCAATCCGCAAAGGGTTAAAAGAGTCGGGCGCGGTCTTGTTGAAACAACGGCCAGCGCCTGTCG
TATATTTTCAGGATTGGGCA

Downstream 100 bases:

>100_bases
GACAATAGAACCCTGGAAGGTAAGACAAAAAACGCCCGGCAAGCCGGGCGTTTTTATTTCTGGATATTTGCTAGATCAGG
CCTTTGCCTTCTTCAAAAGG

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MAKIIQTPTGAEALTFDDVLLQPGHSEVMPGQTDVSTRIAGDIELNIPILSAAMDTVTEARLAIAMAQAGGIGVIHRNLT
PAEQAEEVRQVKKFESGMVVNPVTIGPDATLADAHALMGAHRISGIPVVENGGLGGHTVGKLVGILTNRDVRFASNPAQP
VRELMTHDRLITVKESVSQEEAKRLLHQNRIEKLLVVDDAGNCVGLITVKDIEKSQLNPHASKDAQGRLRVAAATSVGDD
GFERAERLIDAGVDLLVIDTAHGHSQRVLDAVKRAKMLSNAVRIIAGNVATADGTKALIDAGADGVKVGIGPGSICTTRV
VAGVGVPQLAAIMSAVEAGQKLGISIIADGGIKFSGDLAKALAAGANAAMIGSLLAGTDESPGEVFLYQGRSFKAYRGMG
SVGAMARGSADRYFQAEVRDTLKLVPEGIEGQVPYKGPAAGVLHQLTGGLRAAMGYVGAHNLRELQEKATFVRISGAGLR
ESHPHDVTITRESPNYPGAS

Sequences:

>Translated_500_residues
MAKIIQTPTGAEALTFDDVLLQPGHSEVMPGQTDVSTRIAGDIELNIPILSAAMDTVTEARLAIAMAQAGGIGVIHRNLT
PAEQAEEVRQVKKFESGMVVNPVTIGPDATLADAHALMGAHRISGIPVVENGGLGGHTVGKLVGILTNRDVRFASNPAQP
VRELMTHDRLITVKESVSQEEAKRLLHQNRIEKLLVVDDAGNCVGLITVKDIEKSQLNPHASKDAQGRLRVAAATSVGDD
GFERAERLIDAGVDLLVIDTAHGHSQRVLDAVKRAKMLSNAVRIIAGNVATADGTKALIDAGADGVKVGIGPGSICTTRV
VAGVGVPQLAAIMSAVEAGQKLGISIIADGGIKFSGDLAKALAAGANAAMIGSLLAGTDESPGEVFLYQGRSFKAYRGMG
SVGAMARGSADRYFQAEVRDTLKLVPEGIEGQVPYKGPAAGVLHQLTGGLRAAMGYVGAHNLRELQEKATFVRISGAGLR
ESHPHDVTITRESPNYPGAS
>Mature_499_residues
AKIIQTPTGAEALTFDDVLLQPGHSEVMPGQTDVSTRIAGDIELNIPILSAAMDTVTEARLAIAMAQAGGIGVIHRNLTP
AEQAEEVRQVKKFESGMVVNPVTIGPDATLADAHALMGAHRISGIPVVENGGLGGHTVGKLVGILTNRDVRFASNPAQPV
RELMTHDRLITVKESVSQEEAKRLLHQNRIEKLLVVDDAGNCVGLITVKDIEKSQLNPHASKDAQGRLRVAAATSVGDDG
FERAERLIDAGVDLLVIDTAHGHSQRVLDAVKRAKMLSNAVRIIAGNVATADGTKALIDAGADGVKVGIGPGSICTTRVV
AGVGVPQLAAIMSAVEAGQKLGISIIADGGIKFSGDLAKALAAGANAAMIGSLLAGTDESPGEVFLYQGRSFKAYRGMGS
VGAMARGSADRYFQAEVRDTLKLVPEGIEGQVPYKGPAAGVLHQLTGGLRAAMGYVGAHNLRELQEKATFVRISGAGLRE
SHPHDVTITRESPNYPGAS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=466, Percent_Identity=39.9141630901288, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI34328928, Length=461, Percent_Identity=40.1301518438178, Blast_Score=315, Evalue=6e-86,
Organism=Homo sapiens, GI34328930, Length=461, Percent_Identity=40.1301518438178, Blast_Score=315, Evalue=7e-86,
Organism=Homo sapiens, GI156616279, Length=466, Percent_Identity=39.9141630901288, Blast_Score=315, Evalue=8e-86,
Organism=Homo sapiens, GI217035152, Length=454, Percent_Identity=40.0881057268723, Blast_Score=308, Evalue=9e-84,
Organism=Homo sapiens, GI66933016, Length=466, Percent_Identity=38.1974248927039, Blast_Score=308, Evalue=1e-83,
Organism=Homo sapiens, GI217035148, Length=466, Percent_Identity=39.0557939914163, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI217035150, Length=466, Percent_Identity=36.480686695279, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI50541956, Length=262, Percent_Identity=38.1679389312977, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI50541954, Length=262, Percent_Identity=38.1679389312977, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI50541952, Length=262, Percent_Identity=38.1679389312977, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI50541948, Length=262, Percent_Identity=38.1679389312977, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI156104880, Length=249, Percent_Identity=39.7590361445783, Blast_Score=169, Evalue=5e-42,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=57.5819672131148, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI1786293, Length=248, Percent_Identity=40.3225806451613, Blast_Score=172, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71994385, Length=477, Percent_Identity=35.8490566037736, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=37.0023419203747, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17560440, Length=284, Percent_Identity=36.6197183098592, Blast_Score=173, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323585, Length=461, Percent_Identity=39.0455531453362, Blast_Score=316, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6322012, Length=461, Percent_Identity=37.3101952277657, Blast_Score=307, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6323464, Length=462, Percent_Identity=39.1774891774892, Blast_Score=306, Evalue=7e-84,
Organism=Saccharomyces cerevisiae, GI6319352, Length=341, Percent_Identity=36.3636363636364, Blast_Score=231, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6319353, Length=117, Percent_Identity=41.8803418803419, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641071, Length=462, Percent_Identity=38.7445887445887, Blast_Score=315, Evalue=6e-86,
Organism=Drosophila melanogaster, GI24641073, Length=462, Percent_Identity=38.7445887445887, Blast_Score=315, Evalue=6e-86,
Organism=Drosophila melanogaster, GI28571163, Length=420, Percent_Identity=39.7619047619048, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52099; Mature: 51968

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIIQTPTGAEALTFDDVLLQPGHSEVMPGQTDVSTRIAGDIELNIPILSAAMDTVTEA
CCCEECCCCCCCEEEEHHHHCCCCCCCCCCCCCCCCEEEECEEEECCHHHHHHHHHHHHH
RLAIAMAQAGGIGVIHRNLTPAEQAEEVRQVKKFESGMVVNPVTIGPDATLADAHALMGA
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEEECCCCCHHHHHHHHHH
HRISGIPVVENGGLGGHTVGKLVGILTNRDVRFASNPAQPVRELMTHDRLITVKESVSQE
HHHCCCCEEECCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCCEEEEHHHCCHH
EAKRLLHQNRIEKLLVVDDAGNCVGLITVKDIEKSQLNPHASKDAQGRLRVAAATSVGDD
HHHHHHHHHCCCEEEEEECCCCEEEEEEEECCHHHCCCCCCCCCCCCEEEEEEECCCCCH
GFERAERLIDAGVDLLVIDTAHGHSQRVLDAVKRAKMLSNAVRIIAGNVATADGTKALID
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEECCEECCCCCHHHHH
AGADGVKVGIGPGSICTTRVVAGVGVPQLAAIMSAVEAGQKLGISIIADGGIKFSGDLAK
CCCCCEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCHHCCEEEEECCCEEECHHHHH
ALAAGANAAMIGSLLAGTDESPGEVFLYQGRSFKAYRGMGSVGAMARGSADRYFQAEVRD
HHHCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCHHHCCCCCCEEHHHHHH
TLKLVPEGIEGQVPYKGPAAGVLHQLTGGLRAAMGYVGAHNLRELQEKATFVRISGAGLR
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCEEEEECCCCC
ESHPHDVTITRESPNYPGAS
CCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
AKIIQTPTGAEALTFDDVLLQPGHSEVMPGQTDVSTRIAGDIELNIPILSAAMDTVTEA
CCEECCCCCCCEEEEHHHHCCCCCCCCCCCCCCCCEEEECEEEECCHHHHHHHHHHHHH
RLAIAMAQAGGIGVIHRNLTPAEQAEEVRQVKKFESGMVVNPVTIGPDATLADAHALMGA
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEECCEEECCCCCHHHHHHHHHH
HRISGIPVVENGGLGGHTVGKLVGILTNRDVRFASNPAQPVRELMTHDRLITVKESVSQE
HHHCCCCEEECCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCCEEEEHHHCCHH
EAKRLLHQNRIEKLLVVDDAGNCVGLITVKDIEKSQLNPHASKDAQGRLRVAAATSVGDD
HHHHHHHHHCCCEEEEEECCCCEEEEEEEECCHHHCCCCCCCCCCCCEEEEEEECCCCCH
GFERAERLIDAGVDLLVIDTAHGHSQRVLDAVKRAKMLSNAVRIIAGNVATADGTKALID
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEECCEECCCCCHHHHH
AGADGVKVGIGPGSICTTRVVAGVGVPQLAAIMSAVEAGQKLGISIIADGGIKFSGDLAK
CCCCCEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCHHCCEEEEECCCEEECHHHHH
ALAAGANAAMIGSLLAGTDESPGEVFLYQGRSFKAYRGMGSVGAMARGSADRYFQAEVRD
HHHCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCHHHCCCCCCEEHHHHHH
TLKLVPEGIEGQVPYKGPAAGVLHQLTGGLRAAMGYVGAHNLRELQEKATFVRISGAGLR
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCEEEEECCCCC
ESHPHDVTITRESPNYPGAS
CCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA