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The map label for this gene is dcp [H]

Identifier: 110632489

GI number: 110632489

Start: 155173

End: 157218

Strand: Reverse

Name: dcp [H]

Synonym: Meso_0127

Alternate gene names: 110632489

Gene position: 157218-155173 (Counterclockwise)

Preceding gene: 110632495

Following gene: 110632488

Centisome position: 3.56

GC content: 61.97

Gene sequence:

>2046_bases
ATGGCTTCCATCGATCTTTCCACACATCCGCTCACTGCCTGGAACGGCCCGTTGGGGCTCCCGGAATTTGATGGCATCGA
GGAATCCGCTTTCGCGCCGGTTTTCGAATCTGCCTTTGCCGCGCATGAAGCGGAGATCGCGGCCATTGCGGATAGCGGCG
AGGCGCCGACTGTCGAGAACACGCTTGCCGCGCTTGAGCTTTCCGGCGACCCGCTGTCGCGCGTGTCGGCCATCTTCTGG
TGCCGGGCGGGTGCTCATACCAATGAGGTTATCCAGAAGCTGGAACGCGAAATCTCGCCGCGCATGGCCCGGCATTATTC
GCGTCTCTTTATGAACGAGGCGCTCTTCAGGCGCATCGACACGCTCTATGGCGCGCGAACCACCCTCGGGCTGGACAAGG
AGACCGCGCGCGTTCTGGAAAAGACCTGGAAGCATTTCGTGCGTGGTGGCGCCAAGCTTGATGCCGAGGGCAAGGCACGG
CTAGCGAAGATCAATGAGGAACTGGCAGAGCTCGGAGCGCGGTTCGGCCAGAATGTGCTCGCCGACGAAAGCAAGTGGGC
GCTCTTCCTGGAAGAGACCGATCTGGCGGGTCTGCCGTCCTCGCTTAGGAGCGCAATGGCCGAGGCGGCGCAATCGCGTG
GACAGCCCGGACGCTACGCCGTCACGCTCTCCCGCTCGATTGCGGAACCCTTCCTTTCTTTCTCTTCGCGCCGCGACCTG
CGCGAAGCGGTGCTGGAAGCCTTCACTCGTCGGGGCGCCAATGACGGAGAGGCAAACAATGCCGGGATCGTTCAGAAGAC
ATTGAAGCTGCGCGCCGAGAAGGCACGCCTTCTCGGCTATGAGAACTATGCCGCCTACAAGCTCGACGACACCATGGCGA
AGACGCCCGACGCCGTGATGACGCTGCTCGAGCCTGTTTGGGAAAAGGCGCGGGAAAAAGCCGCGGCCGACGAGAAGGAG
CTACAGCGCCTCGCCGCCGCCGAAGGCTACAATCACCCAATCGCCGCGTGGGACTGGCGCTACTATGCCGAGAAGCTCAG
GGCTGAACGCTTTACCTTCGACGAGGGCGCGCTTGAACCCTATCTGGCGCTGGAAAATGTCATCGCGGCTGCCTTCGACG
TGGCTCACCGCCTGTTTGGCCTCACCTTCGAGGAACAGAAGAGCGTTCCGGCCTGGCATGAGGATGTTCGTGTCTTCACA
GTCAAAAATCGGGACGGCAGCGAGCGCGGCGTGTTCCTGGCCGATTACTTCAACCGGCCATCAAAGCGCTCCGGCGCGTG
GATGAGCGGGTTGCAGTCTGGTTACAAGCTAGGCCACGGCGAGAGCCCCATCATCTATAACATCATGAATTTCGCCAAGC
CGCCAAAAGGCAAGCCGGCGCTTCTTTCGGTCGACGACGCGCGCACGCTCTTCCACGAGTTCGGCCATGCGCTGCACGGC
CTCCTCTCCGACGTCACCTGGCCCTCGATCGCCGGCACCTCGGTTGCGCGGGATTTCGTCGAGCTTCCATCGCAGCTCTT
TGAACACTGGTTCAGCACGCCCCAAGTGCTCTCGAAGCACGCGCGCCATGTCGAGACCGGCGAATCCATACCGGCGGAGC
TGCTGGAGAAAATGCGCGCGGCGCGCAATTTCAACGCCGGTTTCGCCACGGTTGAATTCACGGCCTCCGCACTGGTCGAC
ATGGCCTATCACGCACGCCCCGATGCTCCCGAAGACCCTCTCGCCTTTGAAGCCGAGGTGCTTGAGAAGCTTGCGAAGCC
CGCGGCAGTTCCCATGCGGCATGCCACGCCGCATTTTCTCCATGTGTTCTCGGGCGAAGGCTATTCGGCGGGCTACTATT
CCTATCTCTGGTCGGAGGTGCTGGACGCGGACGCCTTCCGCGCCTTCGAGGAAGCCGGCGATCCTTTCGATCAGGGCACT
GCCGAAAAGCTGCGCCGCTACATCTATTCCGCAGGCGGTTCAGCGGATCCCGAGGAGCTTTACAAGACCTTCCGCGGGCG
ATTGCCGAGCCCCGATGCTATGATGGAGAAGAAGGGGCTCGCTTGA

Upstream 100 bases:

>100_bases
CGGTGACGAGGAGAGCGCGCGCGCCCCTGAGGAGGAGTGGTTGCGCGCCGAGGCGGCCGGGCTTACATCGGAATAGAGAT
CTTCCTGCCCGCGAGGTTCC

Downstream 100 bases:

>100_bases
CCACAATAGATCCCCTCTCGCATGGGCTGTGGGAGAAGACGGCACCACCCGCGCCGCTGACCGAACATCTTTCGGGCGAA
AAACGCGCCGACGTGGCAGT

Product: peptidyl-dipeptidase Dcp

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 681; Mature: 680

Protein sequence:

>681_residues
MASIDLSTHPLTAWNGPLGLPEFDGIEESAFAPVFESAFAAHEAEIAAIADSGEAPTVENTLAALELSGDPLSRVSAIFW
CRAGAHTNEVIQKLEREISPRMARHYSRLFMNEALFRRIDTLYGARTTLGLDKETARVLEKTWKHFVRGGAKLDAEGKAR
LAKINEELAELGARFGQNVLADESKWALFLEETDLAGLPSSLRSAMAEAAQSRGQPGRYAVTLSRSIAEPFLSFSSRRDL
REAVLEAFTRRGANDGEANNAGIVQKTLKLRAEKARLLGYENYAAYKLDDTMAKTPDAVMTLLEPVWEKAREKAAADEKE
LQRLAAAEGYNHPIAAWDWRYYAEKLRAERFTFDEGALEPYLALENVIAAAFDVAHRLFGLTFEEQKSVPAWHEDVRVFT
VKNRDGSERGVFLADYFNRPSKRSGAWMSGLQSGYKLGHGESPIIYNIMNFAKPPKGKPALLSVDDARTLFHEFGHALHG
LLSDVTWPSIAGTSVARDFVELPSQLFEHWFSTPQVLSKHARHVETGESIPAELLEKMRAARNFNAGFATVEFTASALVD
MAYHARPDAPEDPLAFEAEVLEKLAKPAAVPMRHATPHFLHVFSGEGYSAGYYSYLWSEVLDADAFRAFEEAGDPFDQGT
AEKLRRYIYSAGGSADPEELYKTFRGRLPSPDAMMEKKGLA

Sequences:

>Translated_681_residues
MASIDLSTHPLTAWNGPLGLPEFDGIEESAFAPVFESAFAAHEAEIAAIADSGEAPTVENTLAALELSGDPLSRVSAIFW
CRAGAHTNEVIQKLEREISPRMARHYSRLFMNEALFRRIDTLYGARTTLGLDKETARVLEKTWKHFVRGGAKLDAEGKAR
LAKINEELAELGARFGQNVLADESKWALFLEETDLAGLPSSLRSAMAEAAQSRGQPGRYAVTLSRSIAEPFLSFSSRRDL
REAVLEAFTRRGANDGEANNAGIVQKTLKLRAEKARLLGYENYAAYKLDDTMAKTPDAVMTLLEPVWEKAREKAAADEKE
LQRLAAAEGYNHPIAAWDWRYYAEKLRAERFTFDEGALEPYLALENVIAAAFDVAHRLFGLTFEEQKSVPAWHEDVRVFT
VKNRDGSERGVFLADYFNRPSKRSGAWMSGLQSGYKLGHGESPIIYNIMNFAKPPKGKPALLSVDDARTLFHEFGHALHG
LLSDVTWPSIAGTSVARDFVELPSQLFEHWFSTPQVLSKHARHVETGESIPAELLEKMRAARNFNAGFATVEFTASALVD
MAYHARPDAPEDPLAFEAEVLEKLAKPAAVPMRHATPHFLHVFSGEGYSAGYYSYLWSEVLDADAFRAFEEAGDPFDQGT
AEKLRRYIYSAGGSADPEELYKTFRGRLPSPDAMMEKKGLA
>Mature_680_residues
ASIDLSTHPLTAWNGPLGLPEFDGIEESAFAPVFESAFAAHEAEIAAIADSGEAPTVENTLAALELSGDPLSRVSAIFWC
RAGAHTNEVIQKLEREISPRMARHYSRLFMNEALFRRIDTLYGARTTLGLDKETARVLEKTWKHFVRGGAKLDAEGKARL
AKINEELAELGARFGQNVLADESKWALFLEETDLAGLPSSLRSAMAEAAQSRGQPGRYAVTLSRSIAEPFLSFSSRRDLR
EAVLEAFTRRGANDGEANNAGIVQKTLKLRAEKARLLGYENYAAYKLDDTMAKTPDAVMTLLEPVWEKAREKAAADEKEL
QRLAAAEGYNHPIAAWDWRYYAEKLRAERFTFDEGALEPYLALENVIAAAFDVAHRLFGLTFEEQKSVPAWHEDVRVFTV
KNRDGSERGVFLADYFNRPSKRSGAWMSGLQSGYKLGHGESPIIYNIMNFAKPPKGKPALLSVDDARTLFHEFGHALHGL
LSDVTWPSIAGTSVARDFVELPSQLFEHWFSTPQVLSKHARHVETGESIPAELLEKMRAARNFNAGFATVEFTASALVDM
AYHARPDAPEDPLAFEAEVLEKLAKPAAVPMRHATPHFLHVFSGEGYSAGYYSYLWSEVLDADAFRAFEEAGDPFDQGTA
EKLRRYIYSAGGSADPEELYKTFRGRLPSPDAMMEKKGLA

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=580, Percent_Identity=32.9310344827586, Blast_Score=280, Evalue=4e-75,
Organism=Homo sapiens, GI14149738, Length=595, Percent_Identity=28.4033613445378, Blast_Score=225, Evalue=9e-59,
Organism=Homo sapiens, GI156105687, Length=667, Percent_Identity=25.3373313343328, Blast_Score=181, Evalue=2e-45,
Organism=Escherichia coli, GI1787819, Length=673, Percent_Identity=37.890044576523, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1789913, Length=685, Percent_Identity=33.8686131386861, Blast_Score=352, Evalue=5e-98,
Organism=Caenorhabditis elegans, GI32565901, Length=632, Percent_Identity=21.993670886076, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71999758, Length=596, Percent_Identity=21.4765100671141, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319793, Length=577, Percent_Identity=29.2894280762565, Blast_Score=214, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6322715, Length=459, Percent_Identity=26.797385620915, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21356111, Length=702, Percent_Identity=26.0683760683761, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI20129717, Length=409, Percent_Identity=27.3838630806846, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 75537; Mature: 75405

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASIDLSTHPLTAWNGPLGLPEFDGIEESAFAPVFESAFAAHEAEIAAIADSGEAPTVEN
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHH
TLAALELSGDPLSRVSAIFWCRAGAHTNEVIQKLEREISPRMARHYSRLFMNEALFRRID
HHHHEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
TLYGARTTLGLDKETARVLEKTWKHFVRGGAKLDAEGKARLAKINEELAELGARFGQNVL
HHHCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHH
ADESKWALFLEETDLAGLPSSLRSAMAEAAQSRGQPGRYAVTLSRSIAEPFLSFSSRRDL
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHH
REAVLEAFTRRGANDGEANNAGIVQKTLKLRAEKARLLGYENYAAYKLDDTMAKTPDAVM
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHH
TLLEPVWEKAREKAAADEKELQRLAAAEGYNHPIAAWDWRYYAEKLRAERFTFDEGALEP
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCH
YLALENVIAAAFDVAHRLFGLTFEEQKSVPAWHEDVRVFTVKNRDGSERGVFLADYFNRP
HHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEECCCCCCCCEEEHHHHCCC
SKRSGAWMSGLQSGYKLGHGESPIIYNIMNFAKPPKGKPALLSVDDARTLFHEFGHALHG
CCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHH
LLSDVTWPSIAGTSVARDFVELPSQLFEHWFSTPQVLSKHARHVETGESIPAELLEKMRA
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
ARNFNAGFATVEFTASALVDMAYHARPDAPEDPLAFEAEVLEKLAKPAAVPMRHATPHFL
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEE
HVFSGEGYSAGYYSYLWSEVLDADAFRAFEEAGDPFDQGTAEKLRRYIYSAGGSADPEEL
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHH
YKTFRGRLPSPDAMMEKKGLA
HHHHHCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
ASIDLSTHPLTAWNGPLGLPEFDGIEESAFAPVFESAFAAHEAEIAAIADSGEAPTVEN
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHH
TLAALELSGDPLSRVSAIFWCRAGAHTNEVIQKLEREISPRMARHYSRLFMNEALFRRID
HHHHEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
TLYGARTTLGLDKETARVLEKTWKHFVRGGAKLDAEGKARLAKINEELAELGARFGQNVL
HHHCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHH
ADESKWALFLEETDLAGLPSSLRSAMAEAAQSRGQPGRYAVTLSRSIAEPFLSFSSRRDL
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHH
REAVLEAFTRRGANDGEANNAGIVQKTLKLRAEKARLLGYENYAAYKLDDTMAKTPDAVM
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHH
TLLEPVWEKAREKAAADEKELQRLAAAEGYNHPIAAWDWRYYAEKLRAERFTFDEGALEP
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCH
YLALENVIAAAFDVAHRLFGLTFEEQKSVPAWHEDVRVFTVKNRDGSERGVFLADYFNRP
HHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEECCCCCCCCEEEHHHHCCC
SKRSGAWMSGLQSGYKLGHGESPIIYNIMNFAKPPKGKPALLSVDDARTLFHEFGHALHG
CCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHH
LLSDVTWPSIAGTSVARDFVELPSQLFEHWFSTPQVLSKHARHVETGESIPAELLEKMRA
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
ARNFNAGFATVEFTASALVDMAYHARPDAPEDPLAFEAEVLEKLAKPAAVPMRHATPHFL
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEE
HVFSGEGYSAGYYSYLWSEVLDADAFRAFEEAGDPFDQGTAEKLRRYIYSAGGSADPEEL
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHH
YKTFRGRLPSPDAMMEKKGLA
HHHHHCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1537804; 11677609 [H]