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The map label for this gene is pyrD

Identifier: 110632456

GI number: 110632456

Start: 123827

End: 124918

Strand: Direct

Name: pyrD

Synonym: Meso_0094

Alternate gene names: 110632456

Gene position: 123827-124918 (Clockwise)

Preceding gene: 110632455

Following gene: 110632458

Centisome position: 2.81

GC content: 58.79

Gene sequence:

>1092_bases
ATGATGCATATTATCGACCGGCTGACGCGGCCCGTTCTCTTCGCATTCGATCCGGAGCGTGCGCATGAGCTTTCCATTGC
CGCGCTTAAAACTGGCATCCCGTTTTGTAGTGGCGGGGTCCAGAATTCAAAGCTGGCGGTTTCCGTCGCGGGCCTGAACT
TTCCAAATCCCATCGGCATGGCGGCAGGCTATGACAAGAACGCGGAAATACCGGATGCGCTGCTCAATCTCGGCTTTGGC
TTCGCCGAATGCGGCACGGTTACACCGAAGCCCCAGGAGGGAAATCCGCGGCCACGCATTTTCCGGCTGACGCGTGATCG
TGCCGTCATCAATCGGCTCGGCTTCAACAATGAAGGTCATGCGCAAGCGCTGGCCCGGCTTTCATTACGCAAGGGAAAAA
GCGGGATCGTCGGTGTCAATATTGGCGCCAACCGCGACAGTTCCGATCGGATGGCAGACTATGAGGAGGGGGTGCGGACC
TTCGCAGCCGTTGCCTCATATCTGACGATCAATATTTCTTCACCCAACACCACCGGCCTCCGGGGGCTGCAGGATCGGGA
AAATCTCTCCGAATTGCTTCAGCGTGTCATGCGGGTGCGCAACGAGCAGGCTGCGCTGATCAAGCGAAAAGTACCGGTTT
TCCTGAAAATCGCACCGGATCTTTCCGAAGAAGCCTTGGCGGATATTGCCCAGGAGGTGCTTGAAAAGGGTTTGGACGGC
CTCATCGTTTCCAACACCACCCTTTCGCGCGAAGGGGTCAGTGCGCCCGCGGCAAGCGAGACCGGCGGCCTTTCCGGGGA
ACCGCTTTTCGAACGTTCAACTATCGTGCTCGCCAAAATGCGCAGGTTGGTCGGACCCGCCCTCCCCATCATCGGGGTGG
GCGGCGTCCATTCCGCCGAAACGGCGCTTGAAAAAATGCGGGCGGGCGCTGACCTGGTTCAGCTCTACACCGGTATGGTT
TTTGCCGGACCGGGACTTCCTGCTCGGATTGTAAGCAGGCTAGCAGCTTATGCCGAGGCCAACGGGTTGAATTCCATCGC
TGAGATCAGGGACAGCAACATCAAGCCTTGGGCGGACCGGCCGCTCGCGTGA

Upstream 100 bases:

>100_bases
TCCCGCATCTCTATGGCCGGCTTCCGCTAGCTGCCGTGCGCTGGGTCAAGCCCCTGCCGCTCGGCACCGGCGGCCGGCAT
GTTTTTCCGGTGCTGGACGC

Downstream 100 bases:

>100_bases
GCCCGTCAGGCGAACCTCTGGCGCTTGCGGCAGGATATTGGTTGAACAATGTCAATCAACTCGCCCGGCGGCATCGCCGG
CCGTGTGATCAGCGCCTGAG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MMHIIDRLTRPVLFAFDPERAHELSIAALKTGIPFCSGGVQNSKLAVSVAGLNFPNPIGMAAGYDKNAEIPDALLNLGFG
FAECGTVTPKPQEGNPRPRIFRLTRDRAVINRLGFNNEGHAQALARLSLRKGKSGIVGVNIGANRDSSDRMADYEEGVRT
FAAVASYLTINISSPNTTGLRGLQDRENLSELLQRVMRVRNEQAALIKRKVPVFLKIAPDLSEEALADIAQEVLEKGLDG
LIVSNTTLSREGVSAPAASETGGLSGEPLFERSTIVLAKMRRLVGPALPIIGVGGVHSAETALEKMRAGADLVQLYTGMV
FAGPGLPARIVSRLAAYAEANGLNSIAEIRDSNIKPWADRPLA

Sequences:

>Translated_363_residues
MMHIIDRLTRPVLFAFDPERAHELSIAALKTGIPFCSGGVQNSKLAVSVAGLNFPNPIGMAAGYDKNAEIPDALLNLGFG
FAECGTVTPKPQEGNPRPRIFRLTRDRAVINRLGFNNEGHAQALARLSLRKGKSGIVGVNIGANRDSSDRMADYEEGVRT
FAAVASYLTINISSPNTTGLRGLQDRENLSELLQRVMRVRNEQAALIKRKVPVFLKIAPDLSEEALADIAQEVLEKGLDG
LIVSNTTLSREGVSAPAASETGGLSGEPLFERSTIVLAKMRRLVGPALPIIGVGGVHSAETALEKMRAGADLVQLYTGMV
FAGPGLPARIVSRLAAYAEANGLNSIAEIRDSNIKPWADRPLA
>Mature_363_residues
MMHIIDRLTRPVLFAFDPERAHELSIAALKTGIPFCSGGVQNSKLAVSVAGLNFPNPIGMAAGYDKNAEIPDALLNLGFG
FAECGTVTPKPQEGNPRPRIFRLTRDRAVINRLGFNNEGHAQALARLSLRKGKSGIVGVNIGANRDSSDRMADYEEGVRT
FAAVASYLTINISSPNTTGLRGLQDRENLSELLQRVMRVRNEQAALIKRKVPVFLKIAPDLSEEALADIAQEVLEKGLDG
LIVSNTTLSREGVSAPAASETGGLSGEPLFERSTIVLAKMRRLVGPALPIIGVGGVHSAETALEKMRAGADLVQLYTGMV
FAGPGLPARIVSRLAAYAEANGLNSIAEIRDSNIKPWADRPLA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=342, Percent_Identity=46.7836257309941, Blast_Score=283, Evalue=1e-76,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=44.4444444444444, Blast_Score=257, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI17509475, Length=350, Percent_Identity=42, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI281361352, Length=363, Percent_Identity=47.1074380165289, Blast_Score=303, Evalue=8e-83,
Organism=Drosophila melanogaster, GI17137316, Length=363, Percent_Identity=47.1074380165289, Blast_Score=303, Evalue=8e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_MESSB (Q11M76)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_672664.1
- ProteinModelPortal:   Q11M76
- SMR:   Q11M76
- STRING:   Q11M76
- GeneID:   4179557
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0094
- NMPDR:   fig|266779.1.peg.3254
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- PhylomeDB:   Q11M76
- ProtClustDB:   PRK05286
- BioCyc:   MSP266779:MESO_0094-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 38810; Mature: 38810

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMHIIDRLTRPVLFAFDPERAHELSIAALKTGIPFCSGGVQNSKLAVSVAGLNFPNPIGM
CCHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCC
AAGYDKNAEIPDALLNLGFGFAECGTVTPKPQEGNPRPRIFRLTRDRAVINRLGFNNEGH
CCCCCCCCCCHHHHHHCCCCHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCHH
AQALARLSLRKGKSGIVGVNIGANRDSSDRMADYEEGVRTFAAVASYLTINISSPNTTGL
HHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
RGLQDRENLSELLQRVMRVRNEQAALIKRKVPVFLKIAPDLSEEALADIAQEVLEKGLDG
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCC
LIVSNTTLSREGVSAPAASETGGLSGEPLFERSTIVLAKMRRLVGPALPIIGVGGVHSAE
EEEECCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHH
TALEKMRAGADLVQLYTGMVFAGPGLPARIVSRLAAYAEANGLNSIAEIRDSNIKPWADR
HHHHHHHCCHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCC
PLA
CCC
>Mature Secondary Structure
MMHIIDRLTRPVLFAFDPERAHELSIAALKTGIPFCSGGVQNSKLAVSVAGLNFPNPIGM
CCHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCC
AAGYDKNAEIPDALLNLGFGFAECGTVTPKPQEGNPRPRIFRLTRDRAVINRLGFNNEGH
CCCCCCCCCCHHHHHHCCCCHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCHH
AQALARLSLRKGKSGIVGVNIGANRDSSDRMADYEEGVRTFAAVASYLTINISSPNTTGL
HHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
RGLQDRENLSELLQRVMRVRNEQAALIKRKVPVFLKIAPDLSEEALADIAQEVLEKGLDG
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCC
LIVSNTTLSREGVSAPAASETGGLSGEPLFERSTIVLAKMRRLVGPALPIIGVGGVHSAE
EEEECCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHH
TALEKMRAGADLVQLYTGMVFAGPGLPARIVSRLAAYAEANGLNSIAEIRDSNIKPWADR
HHHHHHHCCHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCC
PLA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA