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The map label for this gene is hemA [H]

Identifier: 110632450

GI number: 110632450

Start: 116662

End: 117939

Strand: Direct

Name: hemA [H]

Synonym: Meso_0088

Alternate gene names: 110632450

Gene position: 116662-117939 (Clockwise)

Preceding gene: 110632449

Following gene: 110632452

Centisome position: 2.64

GC content: 60.95

Gene sequence:

>1278_bases
ATGGACTATCAGCGGTTCTTCTCCGAGGCTATCGACCAACTTCACGCGGAGCGGCGCTACAGGGTTTTTGCGGATCTCGA
GCGGATCGCAGGAGCCTTTCCGCGCGCCATCTGGCGCGCCGATGGAAAGGCACGTGAGATCACTGTCTGGTGCTCGAATG
ACTATCTGGGCATGGGCCAGCATCCGGATGTGATCGCCGCCATGCAGGAGGCTGTCGGCCGGATCGGCGTGGGCGCTGGC
GGCACTCGCAATATTTCCGGCACAAACCACCCGCTGGTGGAACTCGAGGCGGAACTGGCCGACTTGCATGGGAAAGAAGC
CGCCCTCGTTTTCACCTCCGGTTTCGTTTCCAACGAGGCTTCGATCTCGACCATCGCGCGCCTCCTGCCCAATTGCCTGG
TCCTTTCAGACGAACTCAACCATGCCTCCATGATCGAAGGCGTGCGCCGTTCCGGGGCAGAGAAGAAGATTTTCCGCCAC
AACGACCTGGAGCATTTGGAAAGCCTGCTGAGGGCCGCAGAGCCCCGCCGGGCAAAGCTCATCGTGTTCGAGTCGGTATA
TTCGATGGATGGCGACATCGCGCCGATCGCGGAGATTGCCGACCTTGCCGACCGCTATAATGCGATGACCTATATCGATG
AGGTGCATGCTGTCGGCATGTATGGTGCACATGGCGGCGGGATCACCGAGCGGGAAGGCCTCGCACACCGCATTGATGTG
ATCGAGGGCACGCTGGCAAAGGCGTTTGGCGTCATCGGCGGCTATATCGCAGGGTCGGCATCGCTCGTCGACGCAGTACG
CTCCTACGCGCCCGGATTCATCTTTACGACTGCGCTGCCGCCTGCCATCGCAGCGGCTGCCACCGCATCGATCCGGCATC
TGAAGAAATCGAACGCGGAGCGCGAGGCGCAGCAAAGGCAGGCGCGACGGACAACGGAGGTTTTGCGTGCGGCCGGCCTT
CATGTCATGCCGTCCGAAACGCATATCGTGCCGGTCCTGGTCGGCGACCCCGAGCTTTGCAAGAAAGCGAGCGACCGGCT
TTTGGAAAAACACAGCATCTACATTCAGCCGATCAACTATCCCACTGTTCCGCGCGGAACAGAGCGCCTGCGCATAACAC
CCACGCCCTTCCACTCGGACGACCTTGTCGAGAAGCTGAGGGACGCACTGCTTGAGACCTGGCAGGCTCTCGGCATCAGC
TTCAACGAAGCGAATCCTACGTCGGCCGCGCGGACAGATCGCATCATCCCGCTGGTGGTCTCGAAATCAGGCGGATAG

Upstream 100 bases:

>100_bases
GCGGAATCACGGCTGCGGACGTGGCATTTTGCCCACGATTCCGGTAATGGACGCCCGCGTGGCGGGCGTCTATGATCCGC
TGGCAACCTAGGACGGCAGC

Downstream 100 bases:

>100_bases
AACGGGATTGGTGAGGCGGATCAGGTGCCGCCTCACTGCCTGCCTTCTTTTCTCTCCATGGCGGCTGTGGCCGCCTTTCG
CTTATCTTCTTGCCAGCAGA

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MDYQRFFSEAIDQLHAERRYRVFADLERIAGAFPRAIWRADGKAREITVWCSNDYLGMGQHPDVIAAMQEAVGRIGVGAG
GTRNISGTNHPLVELEAELADLHGKEAALVFTSGFVSNEASISTIARLLPNCLVLSDELNHASMIEGVRRSGAEKKIFRH
NDLEHLESLLRAAEPRRAKLIVFESVYSMDGDIAPIAEIADLADRYNAMTYIDEVHAVGMYGAHGGGITEREGLAHRIDV
IEGTLAKAFGVIGGYIAGSASLVDAVRSYAPGFIFTTALPPAIAAAATASIRHLKKSNAEREAQQRQARRTTEVLRAAGL
HVMPSETHIVPVLVGDPELCKKASDRLLEKHSIYIQPINYPTVPRGTERLRITPTPFHSDDLVEKLRDALLETWQALGIS
FNEANPTSAARTDRIIPLVVSKSGG

Sequences:

>Translated_425_residues
MDYQRFFSEAIDQLHAERRYRVFADLERIAGAFPRAIWRADGKAREITVWCSNDYLGMGQHPDVIAAMQEAVGRIGVGAG
GTRNISGTNHPLVELEAELADLHGKEAALVFTSGFVSNEASISTIARLLPNCLVLSDELNHASMIEGVRRSGAEKKIFRH
NDLEHLESLLRAAEPRRAKLIVFESVYSMDGDIAPIAEIADLADRYNAMTYIDEVHAVGMYGAHGGGITEREGLAHRIDV
IEGTLAKAFGVIGGYIAGSASLVDAVRSYAPGFIFTTALPPAIAAAATASIRHLKKSNAEREAQQRQARRTTEVLRAAGL
HVMPSETHIVPVLVGDPELCKKASDRLLEKHSIYIQPINYPTVPRGTERLRITPTPFHSDDLVEKLRDALLETWQALGIS
FNEANPTSAARTDRIIPLVVSKSGG
>Mature_425_residues
MDYQRFFSEAIDQLHAERRYRVFADLERIAGAFPRAIWRADGKAREITVWCSNDYLGMGQHPDVIAAMQEAVGRIGVGAG
GTRNISGTNHPLVELEAELADLHGKEAALVFTSGFVSNEASISTIARLLPNCLVLSDELNHASMIEGVRRSGAEKKIFRH
NDLEHLESLLRAAEPRRAKLIVFESVYSMDGDIAPIAEIADLADRYNAMTYIDEVHAVGMYGAHGGGITEREGLAHRIDV
IEGTLAKAFGVIGGYIAGSASLVDAVRSYAPGFIFTTALPPAIAAAATASIRHLKKSNAEREAQQRQARRTTEVLRAAGL
HVMPSETHIVPVLVGDPELCKKASDRLLEKHSIYIQPINYPTVPRGTERLRITPTPFHSDDLVEKLRDALLETWQALGIS
FNEANPTSAARTDRIIPLVVSKSGG

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=409, Percent_Identity=49.8777506112469, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI83977440, Length=409, Percent_Identity=49.8777506112469, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI83977444, Length=409, Percent_Identity=49.8777506112469, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI4502025, Length=417, Percent_Identity=48.2014388489209, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI40316939, Length=417, Percent_Identity=48.2014388489209, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI7657118, Length=356, Percent_Identity=36.2359550561798, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=36.2068965517241, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI119220554, Length=400, Percent_Identity=31.25, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4758668, Length=389, Percent_Identity=29.8200514138817, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI5454084, Length=248, Percent_Identity=30.6451612903226, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1790046, Length=397, Percent_Identity=33.7531486146096, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1786993, Length=352, Percent_Identity=33.2386363636364, Blast_Score=168, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=376, Percent_Identity=35.1063829787234, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17560914, Length=365, Percent_Identity=31.2328767123288, Blast_Score=168, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17560912, Length=365, Percent_Identity=31.2328767123288, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI32566772, Length=379, Percent_Identity=29.287598944591, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71982617, Length=234, Percent_Identity=30.3418803418803, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71982625, Length=234, Percent_Identity=30.3418803418803, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320438, Length=421, Percent_Identity=46.5558194774347, Blast_Score=402, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6320267, Length=414, Percent_Identity=27.536231884058, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6323954, Length=271, Percent_Identity=23.6162361623616, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137420, Length=404, Percent_Identity=48.2673267326733, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24662918, Length=374, Percent_Identity=34.2245989304813, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI17136286, Length=375, Percent_Identity=31.4666666666667, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24653280, Length=275, Percent_Identity=28.7272727272727, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653276, Length=275, Percent_Identity=28.7272727272727, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653278, Length=275, Percent_Identity=28.7272727272727, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 46373; Mature: 46373

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYQRFFSEAIDQLHAERRYRVFADLERIAGAFPRAIWRADGKAREITVWCSNDYLGMGQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
HPDVIAAMQEAVGRIGVGAGGTRNISGTNHPLVELEAELADLHGKEAALVFTSGFVSNEA
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHCCCCCEEEEEECCCCCCCH
SISTIARLLPNCLVLSDELNHASMIEGVRRSGAEKKIFRHNDLEHLESLLRAAEPRRAKL
HHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCCCCEEE
IVFESVYSMDGDIAPIAEIADLADRYNAMTYIDEVHAVGMYGAHGGGITEREGLAHRIDV
EEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
IEGTLAKAFGVIGGYIAGSASLVDAVRSYAPGFIFTTALPPAIAAAATASIRHLKKSNAE
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCHH
REAQQRQARRTTEVLRAAGLHVMPSETHIVPVLVGDPELCKKASDRLLEKHSIYIQPINY
HHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEECCC
PTVPRGTERLRITPTPFHSDDLVEKLRDALLETWQALGISFNEANPTSAARTDRIIPLVV
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEEE
SKSGG
ECCCC
>Mature Secondary Structure
MDYQRFFSEAIDQLHAERRYRVFADLERIAGAFPRAIWRADGKAREITVWCSNDYLGMGQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
HPDVIAAMQEAVGRIGVGAGGTRNISGTNHPLVELEAELADLHGKEAALVFTSGFVSNEA
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHCCCCCEEEEEECCCCCCCH
SISTIARLLPNCLVLSDELNHASMIEGVRRSGAEKKIFRHNDLEHLESLLRAAEPRRAKL
HHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCCCCEEE
IVFESVYSMDGDIAPIAEIADLADRYNAMTYIDEVHAVGMYGAHGGGITEREGLAHRIDV
EEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
IEGTLAKAFGVIGGYIAGSASLVDAVRSYAPGFIFTTALPPAIAAAATASIRHLKKSNAE
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCHH
REAQQRQARRTTEVLRAAGLHVMPSETHIVPVLVGDPELCKKASDRLLEKHSIYIQPINY
HHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEECCC
PTVPRGTERLRITPTPFHSDDLVEKLRDALLETWQALGISFNEANPTSAARTDRIIPLVV
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEEE
SKSGG
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]