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The map label for this gene is phoR [H]

Identifier: 110632374

GI number: 110632374

Start: 11239

End: 12513

Strand: Reverse

Name: phoR [H]

Synonym: Meso_0012

Alternate gene names: 110632374

Gene position: 12513-11239 (Counterclockwise)

Preceding gene: 110632376

Following gene: 110632373

Centisome position: 0.28

GC content: 61.1

Gene sequence:

>1275_bases
ATGACGGACACCAAAACAAGGCCTTTGCGGAACCTGCTGCTGGCGGCGCGCGAGCGGCTTGCTCGCCACGGCACGGTGCT
TGCCGTCTCCGCGGCTGCCTGCCTTGTGCTCGACCTTTCCTTAGGCGGCAGCGGACTGGGCGCGGCGATTGCGATTGCGA
TTATTGTACCGATAGCTCTTTTTCTTCCCCAAAAAACGCAGGGGATACAACCTGAAGAGCGTCGAGAGGGCGGCGGGCGC
CGAATGGAGACGCTGCTTGCCCTTGACTTGGCAGCAGCCGTTCACGACCCCCTGATCTTCTGCGACGCGAATGGCGATGT
CGTGCACGCCAATGAAGCAGCGTCACTCGCTTTCGGCTCGCTTGCGCCCGGAATGCCCCTGCAACTGAAATTCCGCGCGC
CGGAAATGCAAAACTTCATCCTCCGCATAATGGAAGGGGGAGCGGGCCCCTTTGGCATAGACTATATCGAGCGCGTCCCT
GTCGAGCGCGCCTATCGGGTATCGGCAACGCGGATCAGTGACGGCTCTGGACTTTTCGTGCTGCTGTTCAAGGACCAAAG
CGAAGCTCGGCGCATCGACCGGATGAGGGCCGACTTTATCGCCAATGCGAGCCATGAGCTGCGCACACCGCTTGCCTCAA
TCGCCGGATTCATAGAGACGCTGCGCGGGCCGGCACGCGATGACGCCAAGGCACGTGACAGCTTTTTGCAGATCATGCAG
GATCAAACCTCGCGCATGGCCCGATTGATCGACGATTTGCTTTCGCTGTCTCGCCTGGAGGTCAAGCCCTACGGGAAGCC
CACCGAAAAGATAGACCTGCGCCCGGTTATCGGCGGGGTGCGGGATGCGCTTGCGACCCTCGCCAAAGATTCCGGCGTCA
CCATCGAGCTCGACATGCCTGACGAGCCCCTTGAGGTACTCGGCCACCAGGACGAGCTTGTGCAAGTGTTCGAGAACCTG
CTCGAAAACGCCTGCAAATATGGCAGCCCCGGAGGGCGTGTTATCGTCTCGGCCGGCAAGCCTGTCGAAGGGCTGGAGAG
GACGGTCACCGTTACCGATTTCGGGCCGGGAATTCCGGAAGAGCATATTCCCAGGATTACGGAGCGTTTCTACCGCGTCA
CTGTCGAAAAGGGGCGTGCCCCGAAGGGGACCGGCCTCGGCCTTGCGATTGTCAAGCACATCCTGACGCGCCACGACGCG
CGGCTCTCGATCCGCTCCAAGATTGGGGAGGGATCGTCCTTCACGATCCATTTCCCCGCTCCCAATCACGCCTGA

Upstream 100 bases:

>100_bases
TTTATCCAAAGGCTTATTCATAAACTTTATCCTTTGCGACAGTAGGTTTGATGCTAGCCGTCACGATCAAGGCGGTCTAG
TAGCAGGTCGGGGGCAGGAG

Downstream 100 bases:

>100_bases
TGGGGAGTGAACACAGCCTCTACCTGGCTGAAAATCTTCTCCTGGAGCCTATTTCTTTTTTCCGTCATGTAGCTAGCCTA
CGTCATGACAGGGGTGATTT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTDTKTRPLRNLLLAARERLARHGTVLAVSAAACLVLDLSLGGSGLGAAIAIAIIVPIALFLPQKTQGIQPEERREGGGR
RMETLLALDLAAAVHDPLIFCDANGDVVHANEAASLAFGSLAPGMPLQLKFRAPEMQNFILRIMEGGAGPFGIDYIERVP
VERAYRVSATRISDGSGLFVLLFKDQSEARRIDRMRADFIANASHELRTPLASIAGFIETLRGPARDDAKARDSFLQIMQ
DQTSRMARLIDDLLSLSRLEVKPYGKPTEKIDLRPVIGGVRDALATLAKDSGVTIELDMPDEPLEVLGHQDELVQVFENL
LENACKYGSPGGRVIVSAGKPVEGLERTVTVTDFGPGIPEEHIPRITERFYRVTVEKGRAPKGTGLGLAIVKHILTRHDA
RLSIRSKIGEGSSFTIHFPAPNHA

Sequences:

>Translated_424_residues
MTDTKTRPLRNLLLAARERLARHGTVLAVSAAACLVLDLSLGGSGLGAAIAIAIIVPIALFLPQKTQGIQPEERREGGGR
RMETLLALDLAAAVHDPLIFCDANGDVVHANEAASLAFGSLAPGMPLQLKFRAPEMQNFILRIMEGGAGPFGIDYIERVP
VERAYRVSATRISDGSGLFVLLFKDQSEARRIDRMRADFIANASHELRTPLASIAGFIETLRGPARDDAKARDSFLQIMQ
DQTSRMARLIDDLLSLSRLEVKPYGKPTEKIDLRPVIGGVRDALATLAKDSGVTIELDMPDEPLEVLGHQDELVQVFENL
LENACKYGSPGGRVIVSAGKPVEGLERTVTVTDFGPGIPEEHIPRITERFYRVTVEKGRAPKGTGLGLAIVKHILTRHDA
RLSIRSKIGEGSSFTIHFPAPNHA
>Mature_423_residues
TDTKTRPLRNLLLAARERLARHGTVLAVSAAACLVLDLSLGGSGLGAAIAIAIIVPIALFLPQKTQGIQPEERREGGGRR
METLLALDLAAAVHDPLIFCDANGDVVHANEAASLAFGSLAPGMPLQLKFRAPEMQNFILRIMEGGAGPFGIDYIERVPV
ERAYRVSATRISDGSGLFVLLFKDQSEARRIDRMRADFIANASHELRTPLASIAGFIETLRGPARDDAKARDSFLQIMQD
QTSRMARLIDDLLSLSRLEVKPYGKPTEKIDLRPVIGGVRDALATLAKDSGVTIELDMPDEPLEVLGHQDELVQVFENLL
ENACKYGSPGGRVIVSAGKPVEGLERTVTVTDFGPGIPEEHIPRITERFYRVTVEKGRAPKGTGLGLAIVKHILTRHDAR
LSIRSKIGEGSSFTIHFPAPNHA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=242, Percent_Identity=37.603305785124, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=33.0543933054393, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786783, Length=225, Percent_Identity=32.4444444444444, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=31.1965811965812, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=29.4117647058824, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789149, Length=240, Percent_Identity=28.75, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI48994928, Length=242, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788713, Length=259, Percent_Identity=25.0965250965251, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790346, Length=200, Percent_Identity=30.5, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788549, Length=352, Percent_Identity=23.5795454545455, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=27.8481012658228, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=29.3859649122807, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789403, Length=201, Percent_Identity=32.3383084577114, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790861, Length=223, Percent_Identity=30.0448430493274, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787374, Length=226, Percent_Identity=29.646017699115, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=241, Percent_Identity=27.8008298755187, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789808, Length=228, Percent_Identity=29.3859649122807, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45989; Mature: 45858

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTKTRPLRNLLLAARERLARHGTVLAVSAAACLVLDLSLGGSGLGAAIAIAIIVPIAL
CCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHEEEEEEECCCCCCHHHHHHHHHHHHHHH
FLPQKTQGIQPEERREGGGRRMETLLALDLAAAVHDPLIFCDANGDVVHANEAASLAFGS
HCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEECCCHHHHHHCC
LAPGMPLQLKFRAPEMQNFILRIMEGGAGPFGIDYIERVPVERAYRVSATRISDGSGLFV
CCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHEEEEEEECCCCCEEE
LLFKDQSEARRIDRMRADFIANASHELRTPLASIAGFIETLRGPARDDAKARDSFLQIMQ
EEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
DQTSRMARLIDDLLSLSRLEVKPYGKPTEKIDLRPVIGGVRDALATLAKDSGVTIELDMP
HHHHHHHHHHHHHHHHHHEEECCCCCCCCCEECHHHHHHHHHHHHHHHCCCCCEEEECCC
DEPLEVLGHQDELVQVFENLLENACKYGSPGGRVIVSAGKPVEGLERTVTVTDFGPGIPE
CCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCH
EHIPRITERFYRVTVEKGRAPKGTGLGLAIVKHILTRHDARLSIRSKIGEGSSFTIHFPA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEECCC
PNHA
CCCC
>Mature Secondary Structure 
TDTKTRPLRNLLLAARERLARHGTVLAVSAAACLVLDLSLGGSGLGAAIAIAIIVPIAL
CCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHEEEEEEECCCCCCHHHHHHHHHHHHHHH
FLPQKTQGIQPEERREGGGRRMETLLALDLAAAVHDPLIFCDANGDVVHANEAASLAFGS
HCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEECCCHHHHHHCC
LAPGMPLQLKFRAPEMQNFILRIMEGGAGPFGIDYIERVPVERAYRVSATRISDGSGLFV
CCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHEEEEEEECCCCCEEE
LLFKDQSEARRIDRMRADFIANASHELRTPLASIAGFIETLRGPARDDAKARDSFLQIMQ
EEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
DQTSRMARLIDDLLSLSRLEVKPYGKPTEKIDLRPVIGGVRDALATLAKDSGVTIELDMP
HHHHHHHHHHHHHHHHHHEEECCCCCCCCCEECHHHHHHHHHHHHHHHCCCCCEEEECCC
DEPLEVLGHQDELVQVFENLLENACKYGSPGGRVIVSAGKPVEGLERTVTVTDFGPGIPE
CCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCH
EHIPRITERFYRVTVEKGRAPKGTGLGLAIVKHILTRHDARLSIRSKIGEGSSFTIHFPA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEECCC
PNHA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]