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The map label for this gene is ftsI, pbpB [H]

Identifier: 109948138

GI number: 109948138

Start: 1447806

End: 1449647

Strand: Reverse

Name: ftsI, pbpB [H]

Synonym: Hac_1663

Alternate gene names: 109948138

Gene position: 1449647-1447806 (Counterclockwise)

Preceding gene: 109948139

Following gene: 109948135

Centisome position: 93.29

GC content: 38.65

Gene sequence:

>1842_bases
ATGGATAATAAAGATATTGATTCTCACTTCAACCTAGAGCAATTTTTACAAACCCAAAGATACAAGTGTGCTTCTACTGG
TTTAGTTTTTTTATTGCTTTTTTTGTTTTTTTTGATAGTGGCGTTTTTCAAGGCTTTTTCTCCGCGATCCAACATGCCCA
CTCTGATGGCAAGCAAGCAAGACATTGCTACTAGGGGGGCTATTTATAGTCAAGATAACTACAGCCTAGCCACTTCACAA
ACCCTTTTCAAACTGGGCTTTGACACGAGGTTTTTAAACCCAAATAAAGAAGATTTTTTCATTGATTTCCTTTCTATTTA
TAGCAATATCCCTAAAAAATCCTTAAAAGATGCGATCAACACGAAAGGCTACACGATTCTAGCTTATGATCTCACGCCCA
ACACGGCTGCCAATCTTAAAGACTTGAACAGGAAATTTTTAGCCTTTGGGGTTTTTCAAAATTTCAAAGACGCGCACGAT
AAAGTATGGCAAAAGCAAGGGTTAAATATTGAAGTGAGTGGCGTTTCTAGGTATTATCCTTATCAAAATAGCTTAGAGCC
TATCATTGGCTATGTGCAAAAAAAAGAAGAAGACAAACTCACTCTCACTACCGGTAAAAAAGGCGTTGAAAAATCTCAAA
ACCACTTGCTTAAAGCCCAACAAAATGGCGTAAGGACAGGCAAAAGAGATGTGGGTTTTAATTTCATTCAAAACCACTCT
TACACCGAATTAGAGCGCCTTGATGGCTATGAAGTGTATTTAAGCATTCCTTTAAAGCTTCAAAGAGAAATTGAAACCTT
GCTAGACAAAACCAAAGACAAACTCAAGGCTAAAGAAATCCTAGTGGGTATTATCAACCCTAAAAGTGGGGAAATTTTAT
CTTTAGCTTCAAGCAATCGTTTTGATCCGAATGCGATTAAAGCCAGCGATTATGAAAACTTGAATTTGAGCGTTGCTGAA
AAGGTTTTTGAGCCAGGCAGCACCATCAAACCCATTGTTTATTCCTTGCTACTAGATAAAAAATTGATCAACCCCAAAGA
GCGCATTGATTTGAATCGTGGTTATCACCAACTAGGAAAATACACCATTAAAGACGATTTTATCCCTAGTAAAAAAGCCC
TTGTTGAAGATGTTTTGATCCAATCTAGTAATGTAGGCATGATAAAAATCAGCAAAAATCTCAACCCAGAGGATTTCTAT
AATGGGCTTTTAGGCTATGGATTTTCTCAAAAAACTGGTATCGACTTATCTTTAGAAGCCACAGGAAAGATCCCTCCTTT
GTCCGCTTTCAAGCGCGAAGTGTTAAAAGGCAGCGTCTCTTATGGCTATGGGTTGAATGCGACTTTTTTGCAGCTTTTAA
GGGCTTATGCGGTGTTTTCTAATGAAGGTAAATTAACCACCCCCTATTTAGTGCAACGAGAAACCGCCCCTAATGGCGAT
ATTTACATCCCTAGCCCCAAACCAACTTTTCAAGTCATTAGCCCAAAAAGCGCTAGAAAAATGAAAGAAACCTTAATTAA
AGTGGTGCGTTATGGCACAGGCAAAAACGCTCAATTTGAAGGGCTATACATAGGGGGTAAAACAGGCACCGCTAGGGTGG
CAAAAAACGGGAGTTATAGCACGGAGTCCTACAACAGCTCTTTTTTTGGGTTTGCTGAAGATGAAAAGCAAGCTTTTACC
ATTGGCGTGGTTATCTTAGGCTCGCATGGCAAGGAAGAATATTATGCCAGCAAGATTGCAGCCCCTATTTTTAAAGAAAT
CACCGAAATTTTAGTGCGTTACAATTATCTCTCTCCCTCTGTTGCAATTCAAAATGCTTTGGAAAAGAATCGTTTGAAGT
AA

Upstream 100 bases:

>100_bases
CTTTTTTTGCTACACCCAATTTTAATGGATCTTGTCATCAAAATTCACACTCCCATGCGTTGTGAAACTCCAACGCCACG
CCATTTCTAAGTAAGCACTC

Downstream 100 bases:

>100_bases
GGCTAGAATTTAGAGTAAAATGCATGAAAGATTTTATAAAAAATTAAGCCCGCTAAAGATAAAAATAATACCCAATAAAT
TGCCATGCTTTTGATCGAGA

Product: cell division protein FtsI/penicillin-binding protein

Products: NA

Alternate protein names: PBP-2B; Penicillin-binding protein B [H]

Number of amino acids: Translated: 613; Mature: 613

Protein sequence:

>613_residues
MDNKDIDSHFNLEQFLQTQRYKCASTGLVFLLLFLFFLIVAFFKAFSPRSNMPTLMASKQDIATRGAIYSQDNYSLATSQ
TLFKLGFDTRFLNPNKEDFFIDFLSIYSNIPKKSLKDAINTKGYTILAYDLTPNTAANLKDLNRKFLAFGVFQNFKDAHD
KVWQKQGLNIEVSGVSRYYPYQNSLEPIIGYVQKKEEDKLTLTTGKKGVEKSQNHLLKAQQNGVRTGKRDVGFNFIQNHS
YTELERLDGYEVYLSIPLKLQREIETLLDKTKDKLKAKEILVGIINPKSGEILSLASSNRFDPNAIKASDYENLNLSVAE
KVFEPGSTIKPIVYSLLLDKKLINPKERIDLNRGYHQLGKYTIKDDFIPSKKALVEDVLIQSSNVGMIKISKNLNPEDFY
NGLLGYGFSQKTGIDLSLEATGKIPPLSAFKREVLKGSVSYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
IYIPSPKPTFQVISPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYSTESYNSSFFGFAEDEKQAFT
IGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPSVAIQNALEKNRLK

Sequences:

>Translated_613_residues
MDNKDIDSHFNLEQFLQTQRYKCASTGLVFLLLFLFFLIVAFFKAFSPRSNMPTLMASKQDIATRGAIYSQDNYSLATSQ
TLFKLGFDTRFLNPNKEDFFIDFLSIYSNIPKKSLKDAINTKGYTILAYDLTPNTAANLKDLNRKFLAFGVFQNFKDAHD
KVWQKQGLNIEVSGVSRYYPYQNSLEPIIGYVQKKEEDKLTLTTGKKGVEKSQNHLLKAQQNGVRTGKRDVGFNFIQNHS
YTELERLDGYEVYLSIPLKLQREIETLLDKTKDKLKAKEILVGIINPKSGEILSLASSNRFDPNAIKASDYENLNLSVAE
KVFEPGSTIKPIVYSLLLDKKLINPKERIDLNRGYHQLGKYTIKDDFIPSKKALVEDVLIQSSNVGMIKISKNLNPEDFY
NGLLGYGFSQKTGIDLSLEATGKIPPLSAFKREVLKGSVSYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
IYIPSPKPTFQVISPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYSTESYNSSFFGFAEDEKQAFT
IGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPSVAIQNALEKNRLK
>Mature_613_residues
MDNKDIDSHFNLEQFLQTQRYKCASTGLVFLLLFLFFLIVAFFKAFSPRSNMPTLMASKQDIATRGAIYSQDNYSLATSQ
TLFKLGFDTRFLNPNKEDFFIDFLSIYSNIPKKSLKDAINTKGYTILAYDLTPNTAANLKDLNRKFLAFGVFQNFKDAHD
KVWQKQGLNIEVSGVSRYYPYQNSLEPIIGYVQKKEEDKLTLTTGKKGVEKSQNHLLKAQQNGVRTGKRDVGFNFIQNHS
YTELERLDGYEVYLSIPLKLQREIETLLDKTKDKLKAKEILVGIINPKSGEILSLASSNRFDPNAIKASDYENLNLSVAE
KVFEPGSTIKPIVYSLLLDKKLINPKERIDLNRGYHQLGKYTIKDDFIPSKKALVEDVLIQSSNVGMIKISKNLNPEDFY
NGLLGYGFSQKTGIDLSLEATGKIPPLSAFKREVLKGSVSYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
IYIPSPKPTFQVISPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYSTESYNSSFFGFAEDEKQAFT
IGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPSVAIQNALEKNRLK

Specific function: Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. PBP-2B is required for vegetative cell division and sporulation septation. Beta-lactamase inactivates the PBPs by acylating an essential serine residue in the active sit

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PASTA domains [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=587, Percent_Identity=25.3833049403748, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1786854, Length=593, Percent_Identity=24.9578414839798, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005543
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03793 PASTA; PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 69021; Mature: 69021

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNKDIDSHFNLEQFLQTQRYKCASTGLVFLLLFLFFLIVAFFKAFSPRSNMPTLMASKQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCH
DIATRGAIYSQDNYSLATSQTLFKLGFDTRFLNPNKEDFFIDFLSIYSNIPKKSLKDAIN
HHHHCCCEEECCCCCCHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHCCCCHHHHHHHHC
TKGYTILAYDLTPNTAANLKDLNRKFLAFGVFQNFKDAHDKVWQKQGLNIEVSGVSRYYP
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEECC
YQNSLEPIIGYVQKKEEDKLTLTTGKKGVEKSQNHLLKAQQNGVRTGKRDVGFNFIQNHS
CCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHCCCHHHCCCC
YTELERLDGYEVYLSIPLKLQREIETLLDKTKDKLKAKEILVGIINPKSGEILSLASSNR
CHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEECCCCC
FDPNAIKASDYENLNLSVAEKVFEPGSTIKPIVYSLLLDKKLINPKERIDLNRGYHQLGK
CCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHCC
YTIKDDFIPSKKALVEDVLIQSSNVGMIKISKNLNPEDFYNGLLGYGFSQKTGIDLSLEA
EEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEC
TGKIPPLSAFKREVLKGSVSYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCC
IYIPSPKPTFQVISPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYS
EECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCCC
TESYNSSFFGFAEDEKQAFTIGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPS
CCCCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VAIQNALEKNRLK
HHHHHHHHHCCCC
>Mature Secondary Structure
MDNKDIDSHFNLEQFLQTQRYKCASTGLVFLLLFLFFLIVAFFKAFSPRSNMPTLMASKQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCH
DIATRGAIYSQDNYSLATSQTLFKLGFDTRFLNPNKEDFFIDFLSIYSNIPKKSLKDAIN
HHHHCCCEEECCCCCCHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHCCCCHHHHHHHHC
TKGYTILAYDLTPNTAANLKDLNRKFLAFGVFQNFKDAHDKVWQKQGLNIEVSGVSRYYP
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEECC
YQNSLEPIIGYVQKKEEDKLTLTTGKKGVEKSQNHLLKAQQNGVRTGKRDVGFNFIQNHS
CCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHCCCHHHCCCC
YTELERLDGYEVYLSIPLKLQREIETLLDKTKDKLKAKEILVGIINPKSGEILSLASSNR
CHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEECCCCC
FDPNAIKASDYENLNLSVAEKVFEPGSTIKPIVYSLLLDKKLINPKERIDLNRGYHQLGK
CCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHCC
YTIKDDFIPSKKALVEDVLIQSSNVGMIKISKNLNPEDFYNGLLGYGFSQKTGIDLSLEA
EEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEC
TGKIPPLSAFKREVLKGSVSYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGD
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCC
IYIPSPKPTFQVISPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYS
EECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCCC
TESYNSSFFGFAEDEKQAFTIGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPS
CCCCCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VAIQNALEKNRLK
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8244929; 9384377; 8289242 [H]