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The map label for this gene is sdcS [H]

Identifier: 109947997

GI number: 109947997

Start: 1306480

End: 1308141

Strand: Reverse

Name: sdcS [H]

Synonym: Hac_1505

Alternate gene names: 109947997

Gene position: 1308141-1306480 (Counterclockwise)

Preceding gene: 109948000

Following gene: 109947996

Centisome position: 84.18

GC content: 43.32

Gene sequence:

>1662_bases
ATGGAAGATTATTCACACACTAATGCATGCACTGATGCAAACACTGATGATAGAAGCACCAAGATCGTGCGCTTATTGGG
GTTAGTAGGGGGGGTATTGATCGCGTTTATTGTTTATTACGCCTTAAACGCTCAAATGCCCCATGCAATAGAAGAAATCC
CCAAACTTAGCGCTTTAAATTATAAAGCAATGCCTGTTGTGGCGGGGGTGGCTATTTTAATGGGGATATGGTGGATGACA
GAAGCCGTTGACTTGCCCGCAACCGCGCTTTTACCTTTGGTGATTTTTAGTGTTTTTAGCGTGGATCAATTCGCCAGCGT
TAGCTCTTCTTACGCATCGCCGATTATTTTTCTTTTTATGGGAGGGTTTATTTTGGCTTTAAGCATGCAAAAATGGAATT
TGCACACACGCATCGCTTTAAGCATCATTTTATTGGTAGGCACAAGCCCTAGAAGGTTGATTTTAGGTTTTATGATCGCC
ACAGGCTTTTTGTCCATGTGGGTGAGCAATACTGCAACGGCGGTGATGATGCTCCCTGTTGGCATGAGCGTGTTGCAACT
AGTCGCTAAACTTGTGGGTAAAGAAAACGCCCCCAATTCATGGTATCAAAAAGAAGAAATCACCAAAGTGCATGGGGGTA
TTATGGGCAATATCGTGCATAAGGGTAAGGATATTGCAAATGTGATCCAAGAAAAGACCACTATTTATCGCACGAATTTT
AGTATTTGCTTGATGCTTGGTATCGCTTATGCCGCTTCCATTGGTTCTTTAGGCACTCTCATTGGCACGCCGCCTAACGC
TTTATTGGCCGGCTATATGAAAACCGCTTTCAACATTGAAATTGATTTCGCTCAATGGATGGTGTTTGGGACGCCGTTAG
CCTTTATCATGCTCATTTTAGCGTGGCTCTTGCTCACTTATGTGATTTTCCCTTTAAAGATCAAAGAAATCCCAGGGGGT
AAGGAAGTCATCAGATTAGAGTTGAAAAAATTAGGCCGTTTGAGTCAAGCGGAAATCTCTGTGGGGATTCTTTTTGTTTT
AGCGTCTTTAGGGTGGATTTTTTTAGGCGCGATCTTAAAATCTTGGGGCATTAAGATAGATAAAATTGATTCAGTGATCG
CTATGGGGGTTTCTGCACTTCTATTCATTTTGCCCGCTAACAATAAGGGTGAAAGGCTGATTGAATGGGACACTGCTAAA
AAACTCCCTTGGGATGTGTTGCTCTTATTTGGCGGAGGGTTAGCTTTGAGCGCGCAATTTTCTAAAACTGGGTTGAGTTT
GTGGATTGGGCATTTGGTCTCTGGCTTTTCGCATTTACCGATTTTACTCATTATTGTTTTGGTAACTTTAATGGTCATTT
TCTTAACCGAAATCACTTCTAACACCGCCACCGCTGCGGCGTTTTTACCGGTGATTGGGGGGGTTGCAGTAGGCATGGGC
TATGGGAATAGCGAAAGCTTGTTATTGACCATTCCTGTGGCCTTGAGCGCGACTTGCGCGTTCATGCTCCCTGTGGCCAC
CCCACCAAATGCGATAGCTTATGGCTCTGGGTATGTTAAAATAACAGATATGATTAAGGCCGGTTTGTGGCTCAATCTGG
TAGGGGTTGTTTTAATCAGTGCGTTTAGCTATTGTTTGGTCTCACTGATATTCATTCATTAA

Upstream 100 bases:

>100_bases
ACCACTTTTTTTCCTATTTTAATATTATTTTTTTAAAGTCCTATTTTTAAATGAGTTTTATTGTAGCATGTAAGTCAATA
ACTTTAAAGGGCAAAACATA

Downstream 100 bases:

>100_bases
GGAACAATGTGGAAGAAAAGTTATTTAAAGAAAAGTCTCGCTATATCACAGGGATTATTTTAATCATTGCGTCAGGCTTG
ATTTTGTATGCGGACAATTT

Product: sodium-dependent transporter

Products: tartrate [Cytoplasm]; succinate [Periplasm] [C]

Alternate protein names: Na(+)/dicarboxylate symporter [H]

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MEDYSHTNACTDANTDDRSTKIVRLLGLVGGVLIAFIVYYALNAQMPHAIEEIPKLSALNYKAMPVVAGVAILMGIWWMT
EAVDLPATALLPLVIFSVFSVDQFASVSSSYASPIIFLFMGGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIA
TGFLSMWVSNTATAVMMLPVGMSVLQLVAKLVGKENAPNSWYQKEEITKVHGGIMGNIVHKGKDIANVIQEKTTIYRTNF
SICLMLGIAYAASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLILAWLLLTYVIFPLKIKEIPGG
KEVIRLELKKLGRLSQAEISVGILFVLASLGWIFLGAILKSWGIKIDKIDSVIAMGVSALLFILPANNKGERLIEWDTAK
KLPWDVLLLFGGGLALSAQFSKTGLSLWIGHLVSGFSHLPILLIIVLVTLMVIFLTEITSNTATAAAFLPVIGGVAVGMG
YGNSESLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLISAFSYCLVSLIFIH

Sequences:

>Translated_553_residues
MEDYSHTNACTDANTDDRSTKIVRLLGLVGGVLIAFIVYYALNAQMPHAIEEIPKLSALNYKAMPVVAGVAILMGIWWMT
EAVDLPATALLPLVIFSVFSVDQFASVSSSYASPIIFLFMGGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIA
TGFLSMWVSNTATAVMMLPVGMSVLQLVAKLVGKENAPNSWYQKEEITKVHGGIMGNIVHKGKDIANVIQEKTTIYRTNF
SICLMLGIAYAASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLILAWLLLTYVIFPLKIKEIPGG
KEVIRLELKKLGRLSQAEISVGILFVLASLGWIFLGAILKSWGIKIDKIDSVIAMGVSALLFILPANNKGERLIEWDTAK
KLPWDVLLLFGGGLALSAQFSKTGLSLWIGHLVSGFSHLPILLIIVLVTLMVIFLTEITSNTATAAAFLPVIGGVAVGMG
YGNSESLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLISAFSYCLVSLIFIH
>Mature_553_residues
MEDYSHTNACTDANTDDRSTKIVRLLGLVGGVLIAFIVYYALNAQMPHAIEEIPKLSALNYKAMPVVAGVAILMGIWWMT
EAVDLPATALLPLVIFSVFSVDQFASVSSSYASPIIFLFMGGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIA
TGFLSMWVSNTATAVMMLPVGMSVLQLVAKLVGKENAPNSWYQKEEITKVHGGIMGNIVHKGKDIANVIQEKTTIYRTNF
SICLMLGIAYAASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLILAWLLLTYVIFPLKIKEIPGG
KEVIRLELKKLGRLSQAEISVGILFVLASLGWIFLGAILKSWGIKIDKIDSVIAMGVSALLFILPANNKGERLIEWDTAK
KLPWDVLLLFGGGLALSAQFSKTGLSLWIGHLVSGFSHLPILLIIVLVTLMVIFLTEITSNTATAAAFLPVIGGVAVGMG
YGNSESLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLISAFSYCLVSLIFIH

Specific function: Mediates the transport of dicarboxylates across the cytoplasmic membrane via a Na(+)-electrochemical gradient [H]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily [H]

Homologues:

Organism=Homo sapiens, GI31377715, Length=525, Percent_Identity=34.4761904761905, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI58761541, Length=521, Percent_Identity=34.3570057581574, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI29171306, Length=513, Percent_Identity=36.0623781676413, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI301069349, Length=507, Percent_Identity=32.9388560157791, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI19923838, Length=529, Percent_Identity=34.0264650283554, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI4506979, Length=522, Percent_Identity=34.4827586206897, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI301069353, Length=470, Percent_Identity=33.8297872340426, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI31795546, Length=564, Percent_Identity=29.6099290780142, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI225637549, Length=571, Percent_Identity=32.0490367775832, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI301069346, Length=506, Percent_Identity=33.201581027668, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI225637552, Length=489, Percent_Identity=33.5378323108384, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI219802232, Length=449, Percent_Identity=34.9665924276169, Blast_Score=216, Evalue=4e-56,
Organism=Escherichia coli, GI1789444, Length=449, Percent_Identity=25.1670378619154, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1786829, Length=442, Percent_Identity=25.7918552036199, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71989118, Length=492, Percent_Identity=32.520325203252, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI71988385, Length=483, Percent_Identity=32.5051759834368, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI32565804, Length=471, Percent_Identity=32.9087048832272, Blast_Score=229, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17551790, Length=511, Percent_Identity=27.2015655577299, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI32564681, Length=500, Percent_Identity=28.4, Blast_Score=184, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324340, Length=500, Percent_Identity=22.8, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI281366409, Length=500, Percent_Identity=32.2, Blast_Score=209, Evalue=6e-54,
Organism=Drosophila melanogaster, GI17737623, Length=500, Percent_Identity=32.2, Blast_Score=209, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24666468, Length=500, Percent_Identity=32.2, Blast_Score=209, Evalue=6e-54,
Organism=Drosophila melanogaster, GI45551633, Length=500, Percent_Identity=32.2, Blast_Score=208, Evalue=7e-54,
Organism=Drosophila melanogaster, GI281362116, Length=520, Percent_Identity=30.7692307692308, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI281362114, Length=520, Percent_Identity=30.5769230769231, Blast_Score=180, Evalue=3e-45,
Organism=Drosophila melanogaster, GI281362112, Length=520, Percent_Identity=30.5769230769231, Blast_Score=180, Evalue=3e-45,
Organism=Drosophila melanogaster, GI78706796, Length=505, Percent_Identity=28.7128712871287, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI78706798, Length=505, Percent_Identity=28.7128712871287, Blast_Score=129, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 59691; Mature: 59691

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDYSHTNACTDANTDDRSTKIVRLLGLVGGVLIAFIVYYALNAQMPHAIEEIPKLSALN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHCCC
YKAMPVVAGVAILMGIWWMTEAVDLPATALLPLVIFSVFSVDQFASVSSSYASPIIFLFM
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIATGFLSMWVSNTATAVMMLPV
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHEEHHHHC
GMSVLQLVAKLVGKENAPNSWYQKEEITKVHGGIMGNIVHKGKDIANVIQEKTTIYRTNF
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHEEECCH
SICLMLGIAYAASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLIL
HHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHEEEEEEHHHHHHHCCHHHHHHHHH
AWLLLTYVIFPLKIKEIPGGKEVIRLELKKLGRLSQAEISVGILFVLASLGWIFLGAILK
HHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SWGIKIDKIDSVIAMGVSALLFILPANNKGERLIEWDTAKKLPWDVLLLFGGGLALSAQF
HHCCCHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCHHHHEEECCCEEEEEHH
SKTGLSLWIGHLVSGFSHLPILLIIVLVTLMVIFLTEITSNTATAAAFLPVIGGVAVGMG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
YGNSESLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLIS
CCCCCCEEEEECHHHHHHHHHEEECCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHH
AFSYCLVSLIFIH
HHHHHHHHHHHCC
>Mature Secondary Structure
MEDYSHTNACTDANTDDRSTKIVRLLGLVGGVLIAFIVYYALNAQMPHAIEEIPKLSALN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHCCC
YKAMPVVAGVAILMGIWWMTEAVDLPATALLPLVIFSVFSVDQFASVSSSYASPIIFLFM
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGFILALSMQKWNLHTRIALSIILLVGTSPRRLILGFMIATGFLSMWVSNTATAVMMLPV
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHEEHHHHC
GMSVLQLVAKLVGKENAPNSWYQKEEITKVHGGIMGNIVHKGKDIANVIQEKTTIYRTNF
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHEEECCH
SICLMLGIAYAASIGSLGTLIGTPPNALLAGYMKTAFNIEIDFAQWMVFGTPLAFIMLIL
HHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHEEEEEEHHHHHHHCCHHHHHHHHH
AWLLLTYVIFPLKIKEIPGGKEVIRLELKKLGRLSQAEISVGILFVLASLGWIFLGAILK
HHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SWGIKIDKIDSVIAMGVSALLFILPANNKGERLIEWDTAKKLPWDVLLLFGGGLALSAQF
HHCCCHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCHHHHEEECCCEEEEEHH
SKTGLSLWIGHLVSGFSHLPILLIIVLVTLMVIFLTEITSNTATAAAFLPVIGGVAVGMG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
YGNSESLLLTIPVALSATCAFMLPVATPPNAIAYGSGYVKITDMIKAGLWLNLVGVVLIS
CCCCCCEEEEECHHHHHHHHHEEECCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHH
AFSYCLVSLIFIH
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: tartrate [Periplasm]; succinate [Cytoplasm] [C]

Specific reaction: tartrate [Periplasm] + succinate [Cytoplasm] = tartrate [Cytoplasm] + succinate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA