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The map label for this gene is dxr fragment 2 [H]

Identifier: 109947994

GI number: 109947994

Start: 1304578

End: 1305318

Strand: Reverse

Name: dxr fragment 2 [H]

Synonym: Hac_1502

Alternate gene names: 109947994

Gene position: 1305318-1304578 (Counterclockwise)

Preceding gene: 109947995

Following gene: 109947993

Centisome position: 84.0

GC content: 41.03

Gene sequence:

>741_bases
GTGAGCGCAGGGCATTTATTAGACATTTCACAAATCACACCCGTTGATAGCGAGCATTTTGGCTTGTGGGCGTTGTTGCA
AAACAAGGCTTTGAAACCCAAATCTTTAATCATTAGCGCTAGTGGGGGGGCTTTTAGGGACACGCCTTTAGAATTAATCC
CTATTCAAGGCGTTCAAAACGCACTCAAACACCCTAATTGGAGCATGGGATCTAAAATCACTATTGATTCAGCGAGCATG
GTCAATAAGCTTTTTGAAGTTTTAGAAACCTATTGGCTTTTTGGCGCGTCTTTAAAGATTGATGCACTCATTGAAAGGAA
TTCTGTCGTGCATGCTTTAGTGGAGTTTGAAGACAATTCTATGATCGCGCATTTAGCGAGTGCAGACATGAAATTACCCA
TAAGTTATGCTATTAACCCCAAGTTAGCCTCTTTGAGTGCTTCTGTCAAGCCATTAGATCTATACGCTTTAGGTGCAATT
AAGTTTGAGCCAATTGATTTAGAGCGCTACACTTTGTGGCGTTATAAAGATTTGTTGTTAGAAAACCCAAAGCTTGGCGT
GGTGCTGAATGCGAGCAATGAAGTGGCGATAAAGAAGTTTTTGAATCAAGAAATCGCCTTTGGAGGCCTTATCAAAATTA
TCTCTCAAGCCTTGGAATTGTATGCCAAAACGCCTTTCAAGCTCTCTTTTTTAGACGAAGTGCTAGAGTTAGACAAAGAA
GTTAGGGAGCGTTTGGATTGA

Upstream 100 bases:

>100_bases
TTAGTCCTTAACGCTATTGTGGGCGTGGCTGGATTGAGAGCGAGCTTTAAAAGCTTACAAAGGAATAAAAAACTAGCCCT
AGCGAATAAAGAAAGTTTTA

Downstream 100 bases:

>100_bases
AGTGCAGTAGAGGTGTAGTGCAATTAAACAATTAAAGTTTTGCTTGTCATAGCGTTTTATTTTATTAGGGGTTTTTATGG
GATTAAAAAATAAAAATACA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MSAGHLLDISQITPVDSEHFGLWALLQNKALKPKSLIISASGGAFRDTPLELIPIQGVQNALKHPNWSMGSKITIDSASM
VNKLFEVLETYWLFGASLKIDALIERNSVVHALVEFEDNSMIAHLASADMKLPISYAINPKLASLSASVKPLDLYALGAI
KFEPIDLERYTLWRYKDLLLENPKLGVVLNASNEVAIKKFLNQEIAFGGLIKIISQALELYAKTPFKLSFLDEVLELDKE
VRERLD

Sequences:

>Translated_246_residues
MSAGHLLDISQITPVDSEHFGLWALLQNKALKPKSLIISASGGAFRDTPLELIPIQGVQNALKHPNWSMGSKITIDSASM
VNKLFEVLETYWLFGASLKIDALIERNSVVHALVEFEDNSMIAHLASADMKLPISYAINPKLASLSASVKPLDLYALGAI
KFEPIDLERYTLWRYKDLLLENPKLGVVLNASNEVAIKKFLNQEIAFGGLIKIISQALELYAKTPFKLSFLDEVLELDKE
VRERLD
>Mature_245_residues
SAGHLLDISQITPVDSEHFGLWALLQNKALKPKSLIISASGGAFRDTPLELIPIQGVQNALKHPNWSMGSKITIDSASMV
NKLFEVLETYWLFGASLKIDALIERNSVVHALVEFEDNSMIAHLASADMKLPISYAINPKLASLSASVKPLDLYALGAIK
FEPIDLERYTLWRYKDLLLENPKLGVVLNASNEVAIKKFLNQEIAFGGLIKIISQALELYAKTPFKLSFLDEVLELDKEV
RERLD

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=252, Percent_Identity=34.9206349206349, Blast_Score=137, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 27374; Mature: 27243

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGHLLDISQITPVDSEHFGLWALLQNKALKPKSLIISASGGAFRDTPLELIPIQGVQN
CCCCCEEEHHHCCCCCCCCCHHHEEHHCCCCCCCEEEEECCCCCCCCCCEEEEECHHHHH
ALKHPNWSMGSKITIDSASMVNKLFEVLETYWLFGASLKIDALIERNSVVHALVEFEDNS
HHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEECCCC
MIAHLASADMKLPISYAINPKLASLSASVKPLDLYALGAIKFEPIDLERYTLWRYKDLLL
EEEEECCCCCCCEEEEECCCCHHHCCCCCCCEEEEEECCEEECCCCCCHHHHHHHHHHHH
ENPKLGVVLNASNEVAIKKFLNQEIAFGGLIKIISQALELYAKTPFKLSFLDEVLELDKE
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VRERLD
HHHHCC
>Mature Secondary Structure 
SAGHLLDISQITPVDSEHFGLWALLQNKALKPKSLIISASGGAFRDTPLELIPIQGVQN
CCCCEEEHHHCCCCCCCCCHHHEEHHCCCCCCCEEEEECCCCCCCCCCEEEEECHHHHH
ALKHPNWSMGSKITIDSASMVNKLFEVLETYWLFGASLKIDALIERNSVVHALVEFEDNS
HHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEECCCC
MIAHLASADMKLPISYAINPKLASLSASVKPLDLYALGAIKFEPIDLERYTLWRYKDLLL
EEEEECCCCCCCEEEEECCCCHHHCCCCCCCEEEEEECCEEECCCCCCHHHHHHHHHHHH
ENPKLGVVLNASNEVAIKKFLNQEIAFGGLIKIISQALELYAKTPFKLSFLDEVLELDKE
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VRERLD
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA