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The map label for this gene is neuC [H]

Identifier: 109947791

GI number: 109947791

Start: 1092686

End: 1093927

Strand: Reverse

Name: neuC [H]

Synonym: Hac_1270

Alternate gene names: 109947791

Gene position: 1093927-1092686 (Counterclockwise)

Preceding gene: 109947792

Following gene: 109947790

Centisome position: 70.4

GC content: 39.94

Gene sequence:

>1242_bases
ATGGCTTCAAATAAAACTCTTCCATTTTTCGGAGGGGGGGGCGATTTAGAAAGCCCCAAAAAATCCACAAACAACAAAAA
TAAGAAAAAAATCGTTTTTGTCACCAACAGCCGGGCGGATTATGGCAAGCTCAAGCCTTTGATGAAAGCCCTTAAGGATT
TAAGCCCCAAACACCCCTTATACAATCGGATCGCTTATCGTATTTTTGTGTGTGGCATGCATTTGCTAGAAAAATACGGC
AACACTTACATTGAAATTTTAAAAGATGGTTTTGAGCATGTTTTTTTAAGTAAGCCCTATGAAAACGAAATTCCTATGGA
CTTTGCTTTAGCCAACACGATCACGCAATTTTCTTCTTTCATTGTGCAAGAAAAACCCGACCTAATTATTGTGCATGGCG
ATAGGATAGAGAGCTTGGCATGTGCGATTGTAGCGAGTTTCAATAACATTTTATGCGCGCATATTGAAGGCGGGGAAGTT
TCAGGCACGCTGGATGAGAGTATCCGCCATAGCGTGTCAAAACTTGCGCACCTCCATTATGTTTGCAACCAACAAGCGGA
GCGAAATTTGATCCAAATGGGCGAAAAAATGGAGTGCATTTTTAATATTGGTTCGAGCGATATTGATGCAATGCTAGGCG
ATTTGCCTGACTTTGAAGAAGTGGAGCGCTATTATTATCAAATCAAGCGTTTTAATAGAAATTATGCGATTTTGATCTAC
CATCCTGTGGTGAGTGAAACGATTGACTTGCCCAAACATGTTTTTGAAGTGCTAGAGGGGGTTAAGGCGAGTTTAAAAAA
CTTTGTCGTGATCTATCCTAATAACGATTTAGGATCAAACATTATCCTAAAGGCTTTAGAGGGTTTAAAGGGGCATGATC
GTTTTATCGCTTTCCCTAGCATGCGTTTTGAGTATTTTTTAACGCTCTTGAAAAACGCGCAATTTATCATTGGAAATTCA
AGCTGCGGTATTAGAGAAGCAGGGGTGTATGGCGTGCCTTGCATCAATTGCGGCACCAGGCAGCACAACAGAAGCGATGC
AAAACACATTATCAATGTCAAAGAAAATAAAGATGAGATTTATCTCGCTATAAAAAAGGTCCATCAATTAAAAAGCATTT
TAAAAAAGAGCTCTCATTTTGGTCAAGGCGATAGCGCTAAGCGGTTTTTAGCGAGTTTGAATTTAGAATTGTTTGACACG
CCTACGCAAAAAAGCTTTGTGATAAGGGAGGTGAAAGGATGA

Upstream 100 bases:

>100_bases
GGATTATGAAAAGACTTTGGGTAGAGTGGCTAAAATAGATATTGGCATAGACGAACACATTTGCGATGAAATGCTAGAAA
ATAAGGAATAAAAGATACTA

Downstream 100 bases:

>100_bases
AAATTTTAGCCTACATTCCTGCCAGAAGCGGTTCTAAAGGGGTGAAAGATAAGAATATTAAACCCTTTAAAGGCTTGCCT
TTGATGGCGCACACAATCCT

Product: hypothetical protein

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MASNKTLPFFGGGGDLESPKKSTNNKNKKKIVFVTNSRADYGKLKPLMKALKDLSPKHPLYNRIAYRIFVCGMHLLEKYG
NTYIEILKDGFEHVFLSKPYENEIPMDFALANTITQFSSFIVQEKPDLIIVHGDRIESLACAIVASFNNILCAHIEGGEV
SGTLDESIRHSVSKLAHLHYVCNQQAERNLIQMGEKMECIFNIGSSDIDAMLGDLPDFEEVERYYYQIKRFNRNYAILIY
HPVVSETIDLPKHVFEVLEGVKASLKNFVVIYPNNDLGSNIILKALEGLKGHDRFIAFPSMRFEYFLTLLKNAQFIIGNS
SCGIREAGVYGVPCINCGTRQHNRSDAKHIINVKENKDEIYLAIKKVHQLKSILKKSSHFGQGDSAKRFLASLNLELFDT
PTQKSFVIREVKG

Sequences:

>Translated_413_residues
MASNKTLPFFGGGGDLESPKKSTNNKNKKKIVFVTNSRADYGKLKPLMKALKDLSPKHPLYNRIAYRIFVCGMHLLEKYG
NTYIEILKDGFEHVFLSKPYENEIPMDFALANTITQFSSFIVQEKPDLIIVHGDRIESLACAIVASFNNILCAHIEGGEV
SGTLDESIRHSVSKLAHLHYVCNQQAERNLIQMGEKMECIFNIGSSDIDAMLGDLPDFEEVERYYYQIKRFNRNYAILIY
HPVVSETIDLPKHVFEVLEGVKASLKNFVVIYPNNDLGSNIILKALEGLKGHDRFIAFPSMRFEYFLTLLKNAQFIIGNS
SCGIREAGVYGVPCINCGTRQHNRSDAKHIINVKENKDEIYLAIKKVHQLKSILKKSSHFGQGDSAKRFLASLNLELFDT
PTQKSFVIREVKG
>Mature_412_residues
ASNKTLPFFGGGGDLESPKKSTNNKNKKKIVFVTNSRADYGKLKPLMKALKDLSPKHPLYNRIAYRIFVCGMHLLEKYGN
TYIEILKDGFEHVFLSKPYENEIPMDFALANTITQFSSFIVQEKPDLIIVHGDRIESLACAIVASFNNILCAHIEGGEVS
GTLDESIRHSVSKLAHLHYVCNQQAERNLIQMGEKMECIFNIGSSDIDAMLGDLPDFEEVERYYYQIKRFNRNYAILIYH
PVVSETIDLPKHVFEVLEGVKASLKNFVVIYPNNDLGSNIILKALEGLKGHDRFIAFPSMRFEYFLTLLKNAQFIIGNSS
CGIREAGVYGVPCINCGTRQHNRSDAKHIINVKENKDEIYLAIKKVHQLKSILKKSSHFGQGDSAKRFLASLNLELFDTP
TQKSFVIREVKG

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885285, Length=410, Percent_Identity=34.1463414634146, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI190014632, Length=410, Percent_Identity=34.1463414634146, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI298566312, Length=410, Percent_Identity=34.1463414634146, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI298566325, Length=363, Percent_Identity=33.6088154269972, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI298566315, Length=317, Percent_Identity=32.1766561514196, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 46720; Mature: 46588

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASNKTLPFFGGGGDLESPKKSTNNKNKKKIVFVTNSRADYGKLKPLMKALKDLSPKHPL
CCCCCCCCEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHH
YNRIAYRIFVCGMHLLEKYGNTYIEILKDGFEHVFLSKPYENEIPMDFALANTITQFSSF
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHH
IVQEKPDLIIVHGDRIESLACAIVASFNNILCAHIEGGEVSGTLDESIRHSVSKLAHLHY
HHCCCCCEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
VCNQQAERNLIQMGEKMECIFNIGSSDIDAMLGDLPDFEEVERYYYQIKRFNRNYAILIY
HHCCHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEE
HPVVSETIDLPKHVFEVLEGVKASLKNFVVIYPNNDLGSNIILKALEGLKGHDRFIAFPS
CCHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEECCC
MRFEYFLTLLKNAQFIIGNSSCGIREAGVYGVPCINCGTRQHNRSDAKHIINVKENKDEI
HHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCHH
YLAIKKVHQLKSILKKSSHFGQGDSAKRFLASLNLELFDTPTQKSFVIREVKG
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEECCCCCCCEEEEECCC
>Mature Secondary Structure 
ASNKTLPFFGGGGDLESPKKSTNNKNKKKIVFVTNSRADYGKLKPLMKALKDLSPKHPL
CCCCCCCEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHH
YNRIAYRIFVCGMHLLEKYGNTYIEILKDGFEHVFLSKPYENEIPMDFALANTITQFSSF
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHH
IVQEKPDLIIVHGDRIESLACAIVASFNNILCAHIEGGEVSGTLDESIRHSVSKLAHLHY
HHCCCCCEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
VCNQQAERNLIQMGEKMECIFNIGSSDIDAMLGDLPDFEEVERYYYQIKRFNRNYAILIY
HHCCHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEE
HPVVSETIDLPKHVFEVLEGVKASLKNFVVIYPNNDLGSNIILKALEGLKGHDRFIAFPS
CCHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEECCC
MRFEYFLTLLKNAQFIIGNSSCGIREAGVYGVPCINCGTRQHNRSDAKHIINVKENKDEI
HHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCHH
YLAIKKVHQLKSILKKSSHFGQGDSAKRFLASLNLELFDTPTQKSFVIREVKG
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEECCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]