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The map label for this gene is ruvC

Identifier: 109947765

GI number: 109947765

Start: 1075957

End: 1076430

Strand: Reverse

Name: ruvC

Synonym: Hac_1242

Alternate gene names: 109947765

Gene position: 1076430-1075957 (Counterclockwise)

Preceding gene: 109947771

Following gene: 109947763

Centisome position: 69.27

GC content: 40.08

Gene sequence:

>474_bases
ATGCATATTTTAGGAATAGATCCAGGCAGTAGGAAATGTGGGTATGCTATCATTTCTTATGCTTCTAACAAGCTTTCTTT
AATCACGGCTGGGTTTATCAATATTACCACGACGCACTTGCAAGAACAAATCTTGGATTTGATAGAAGCCCTAGATTGTT
TATTGGATCGTTATGAAGTGCATGAAGTGGCGATTGAAGATATTTTCTTTGGGTATAACCCAAAAAGCGTGATCAAACTC
GCGCAATTTAGGGGAGCGTTGTCCTTAAAGATTTTAGAAAGGGTTGGTAATTTTAGTGAATACACGCCCTTGCAAGTTAA
AAAAGCTCTCACCGGTAACGGCAAAGCCGCTAAAGAGCAAGTAGCCTTTATGGTCAAACGGCTACTTCATATCACAAGCG
AGATCAAGCCTTTGGATATTAGCGATGCGATAGCCGTTGCCATCATGCATGCACAACGATTAAAACTTTATTGA

Upstream 100 bases:

>100_bases
TTAAAAGCTCTCAATATAATCTTGTATTTTACACCCACAAGAAACATGGATATAATAATAGCGTTTTTTAAACCTTGAGA
TAAATAATAGGAATGACTGC

Downstream 100 bases:

>100_bases
TTGAATGCAAAACGCTGCAATAAAAAGCTTTGTTTTTAAAAAGTGGGGTTTTAATTACTTTATTTAAAACTCATTCCCTT
AAGGGGATAGGGGGTATTTT

Product: Holliday junction resolvase

Products: NA

Alternate protein names: Holliday junction nuclease ruvC; Holliday junction resolvase ruvC

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MHILGIDPGSRKCGYAIISYASNKLSLITAGFINITTTHLQEQILDLIEALDCLLDRYEVHEVAIEDIFFGYNPKSVIKL
AQFRGALSLKILERVGNFSEYTPLQVKKALTGNGKAAKEQVAFMVKRLLHITSEIKPLDISDAIAVAIMHAQRLKLY

Sequences:

>Translated_157_residues
MHILGIDPGSRKCGYAIISYASNKLSLITAGFINITTTHLQEQILDLIEALDCLLDRYEVHEVAIEDIFFGYNPKSVIKL
AQFRGALSLKILERVGNFSEYTPLQVKKALTGNGKAAKEQVAFMVKRLLHITSEIKPLDISDAIAVAIMHAQRLKLY
>Mature_157_residues
MHILGIDPGSRKCGYAIISYASNKLSLITAGFINITTTHLQEQILDLIEALDCLLDRYEVHEVAIEDIFFGYNPKSVIKL
AQFRGALSLKILERVGNFSEYTPLQVKKALTGNGKAAKEQVAFMVKRLLHITSEIKPLDISDAIAVAIMHAQRLKLY

Specific function: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leav

COG id: COG0817

COG function: function code L; Holliday junction resolvasome, endonuclease subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvC family

Homologues:

Organism=Escherichia coli, GI1788170, Length=131, Percent_Identity=32.824427480916, Blast_Score=74, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVC_HELAH (Q17WI2)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664993.1
- ProteinModelPortal:   Q17WI2
- SMR:   Q17WI2
- STRING:   Q17WI2
- GeneID:   4177162
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_1242
- NMPDR:   fig|382638.8.peg.1206
- eggNOG:   COG0817
- HOGENOM:   HBG437552
- OMA:   RTGWGVI
- PhylomeDB:   Q17WI2
- ProtClustDB:   PRK00039
- BioCyc:   HACI382638:HAC_1242-MONOMER
- HAMAP:   MF_00034
- InterPro:   IPR012337
- InterPro:   IPR020563
- InterPro:   IPR002176
- PRINTS:   PR00696
- TIGRFAMs:   TIGR00228

Pfam domain/function: PF02075 RuvC; SSF53098 RNaseH_fold

EC number: =3.1.22.4

Molecular weight: Translated: 17501; Mature: 17501

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS01321 RUVC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHILGIDPGSRKCGYAIISYASNKLSLITAGFINITTTHLQEQILDLIEALDCLLDRYEV
CEEECCCCCCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HEVAIEDIFFGYNPKSVIKLAQFRGALSLKILERVGNFSEYTPLQVKKALTGNGKAAKEQ
HHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHH
VAFMVKRLLHITSEIKPLDISDAIAVAIMHAQRLKLY
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHILGIDPGSRKCGYAIISYASNKLSLITAGFINITTTHLQEQILDLIEALDCLLDRYEV
CEEECCCCCCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HEVAIEDIFFGYNPKSVIKLAQFRGALSLKILERVGNFSEYTPLQVKKALTGNGKAAKEQ
HHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHH
VAFMVKRLLHITSEIKPLDISDAIAVAIMHAQRLKLY
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA