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The map label for this gene is ribA

Identifier: 109947468

GI number: 109947468

Start: 805967

End: 806545

Strand: Reverse

Name: ribA

Synonym: Hac_0920

Alternate gene names: 109947468

Gene position: 806545-805967 (Counterclockwise)

Preceding gene: 109947469

Following gene: 109947467

Centisome position: 51.9

GC content: 39.55

Gene sequence:

>579_bases
TTGAAGCGATTAGAAGTTTCTAACCAAGCCAAATTACCCACTCAATTTGGGGAGTTTTATATCCAGTGTTTTAGAGAAAA
AAACTCTAATGGCTCTAAAGATCATTTGGTGATTTTCACCCTTGATTTTCCAGAAAATCCTTTAGTGCGTTTGCATTCAG
AATGCTTAACCGGCGACGCTCTAGGCTCTCAAAAATGCGATTGTGGGGTGGCGTTGCAAATGGCGTTAGAAAGGATTTCT
AAAGAAGGGGGGCTAGTGATTTATTTGCGCCAAGAAGGGCGTGGGATAGGGCTGTTTAATAAAGTCAATGCCTACGCTTT
ACAAGATAAGGGCTATGATACTATTCAAGCCAATGAAATGATAGGGTTTAAAGACGATGAAAGGGATTATGGTATTGCAG
GTGAGATTTTAGAATACTACCGCATTAAAAAAATGCGCTTGCTCACAAATAACCCTAAAAAAATCGCCGCTTTAGAAAAA
TACGCTGAGGTTACAAGAGAGAGCTTGATCGTGTGCGCTAATGAGCATAATCAAGGGTATTTAGAAGTCAAAAAGCTCAA
AATGGGGCATTTGCTATAA

Upstream 100 bases:

>100_bases
CTCTTGGTTTTTAGAATATTTTATTAATAAAAATTACAAAGAGTTTTGATAGAATACCTTTTTTAAAAGATGTGTTTTTA
AACTAATTTTAGGAGTATTC

Downstream 100 bases:

>100_bases
AAACCTTTTAAAGAGTTTTAAAGGCAATCCAAACGGCTAAAAAAGATCAATAATCTTTTGGCATGGCTTGTAAGCTTGAA
AATGTTAGGGTAAAATAACT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MKRLEVSNQAKLPTQFGEFYIQCFREKNSNGSKDHLVIFTLDFPENPLVRLHSECLTGDALGSQKCDCGVALQMALERIS
KEGGLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANEMIGFKDDERDYGIAGEILEYYRIKKMRLLTNNPKKIAALEK
YAEVTRESLIVCANEHNQGYLEVKKLKMGHLL

Sequences:

>Translated_192_residues
MKRLEVSNQAKLPTQFGEFYIQCFREKNSNGSKDHLVIFTLDFPENPLVRLHSECLTGDALGSQKCDCGVALQMALERIS
KEGGLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANEMIGFKDDERDYGIAGEILEYYRIKKMRLLTNNPKKIAALEK
YAEVTRESLIVCANEHNQGYLEVKKLKMGHLL
>Mature_192_residues
MKRLEVSNQAKLPTQFGEFYIQCFREKNSNGSKDHLVIFTLDFPENPLVRLHSECLTGDALGSQKCDCGVALQMALERIS
KEGGLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANEMIGFKDDERDYGIAGEILEYYRIKKMRLLTNNPKKIAALEK
YAEVTRESLIVCANEHNQGYLEVKKLKMGHLL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=189, Percent_Identity=48.6772486772487, Blast_Score=171, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319438, Length=177, Percent_Identity=40.6779661016949, Blast_Score=111, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_HELAH (Q17XC9)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664696.1
- ProteinModelPortal:   Q17XC9
- SMR:   Q17XC9
- STRING:   Q17XC9
- GeneID:   4177085
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0920
- NMPDR:   fig|382638.8.peg.894
- eggNOG:   COG0807
- HOGENOM:   HBG735778
- OMA:   MVIYLRQ
- PhylomeDB:   Q17XC9
- ProtClustDB:   PRK00393
- BioCyc:   HACI382638:HAC_0920-MONOMER
- HAMAP:   MF_00179
- InterPro:   IPR000926
- TIGRFAMs:   TIGR00505

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 21840; Mature: 21840

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: ACT_SITE 126-126 ACT_SITE 128-128 BINDING 114-114 BINDING 149-149 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLEVSNQAKLPTQFGEFYIQCFREKNSNGSKDHLVIFTLDFPENPLVRLHSECLTGDA
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCC
LGSQKCDCGVALQMALERISKEGGLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANEM
CCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEECEEECCCEEEECCCCCCEEECCCE
IGFKDDERDYGIAGEILEYYRIKKMRLLTNNPKKIAALEKYAEVTRESLIVCANEHNQGY
ECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHEEEEEECCCCCCE
LEVKKLKMGHLL
EEEEEECCCCCC
>Mature Secondary Structure
MKRLEVSNQAKLPTQFGEFYIQCFREKNSNGSKDHLVIFTLDFPENPLVRLHSECLTGDA
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCC
LGSQKCDCGVALQMALERISKEGGLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANEM
CCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEECEEECCCEEEECCCCCCEEECCCE
IGFKDDERDYGIAGEILEYYRIKKMRLLTNNPKKIAALEKYAEVTRESLIVCANEHNQGY
ECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHEEEEEECCCCCCE
LEVKKLKMGHLL
EEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA