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The map label for this gene is clpP [H]

Identifier: 109947464

GI number: 109947464

Start: 802087

End: 802674

Strand: Reverse

Name: clpP [H]

Synonym: Hac_0916

Alternate gene names: 109947464

Gene position: 802674-802087 (Counterclockwise)

Preceding gene: 109947465

Following gene: 109947463

Centisome position: 51.65

GC content: 41.67

Gene sequence:

>588_bases
GTGGGATACATTCCTTATGTGATAGAAAATACTGATCGAGGGGAGCGCAGTTATGATATTTACTCGCGCCTTTTAAAGGA
TCGCATTGTTTTATTGAGCGGTGAAATCAATGACAGCGTGGCGTCTTCTATTGTGGCTCAACTCTTGTTTTTGGAAGCTG
AGGATCCAGAAAAAGATATTGGCTTGTATATCAATTCTCCCGGTGGGGTGATAACAAGTGGTCTTAGTATTTATGATACG
ATGAATTTTATCCGCCCTGATGTTTCCACGATTTGCATCGGTCAAGCGGCTTCTATGGGGGCGTTTTTATTGAGCTGTGG
GGCTAAGGGCAAGCGCTTTTCATTACCTCATTCAAGGATTATGATCCACCAGCCTTTAGGGGGGGCTCAAGGGCAAGCGA
GTGATATTGAAATCATTTCTAACGAAATTATCAGGCTTAAGGGTTTGATGAATTCTATTTTGGCTCAAAATTCAAAGCAA
AGCTTAGAACGGATCGCTAAAGACACGGATAGGGATTTTTACATGAGCGCTTTAGAAGCTAAAGAGTATGGCTTGATTGA
TAAGGTGTTGGAGAAAAATGTAAAGTGA

Upstream 100 bases:

>100_bases
TTGGATAAAAACCTATCTAAAGAACAGCAAGAAATTTTGGAAAAAATGAGGCCTAACGCTCAAAAAACTCAAGTGAGTTG
AATAATAAAAAGGAGAAATG

Downstream 100 bases:

>100_bases
TTGCATGGCGTTATTAGAGATTATCCATTACCCTTCTAAAATCTTAAGAACGATTTCTAAAGAGGTCGTTTCTTTTGATG
CAAAATTCCATCAGCAATTA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MGYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDIGLYINSPGGVITSGLSIYDT
MNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRIMIHQPLGGAQGQASDIEIISNEIIRLKGLMNSILAQNSKQ
SLERIAKDTDRDFYMSALEAKEYGLIDKVLEKNVK

Sequences:

>Translated_195_residues
MGYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDIGLYINSPGGVITSGLSIYDT
MNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRIMIHQPLGGAQGQASDIEIISNEIIRLKGLMNSILAQNSKQ
SLERIAKDTDRDFYMSALEAKEYGLIDKVLEKNVK
>Mature_194_residues
GYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDIGLYINSPGGVITSGLSIYDTM
NFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRIMIHQPLGGAQGQASDIEIISNEIIRLKGLMNSILAQNSKQS
LERIAKDTDRDFYMSALEAKEYGLIDKVLEKNVK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=187, Percent_Identity=59.3582887700535, Blast_Score=234, Evalue=3e-62,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=68.4210526315789, Blast_Score=284, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=54.7368421052632, Blast_Score=213, Evalue=5e-56,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=55.8510638297872, Blast_Score=231, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21480; Mature: 21349

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDI
CCCCCEEEECCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
GLYINSPGGVITSGLSIYDTMNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRI
CEEECCCCCCCCCCHHHHHHHHHHCCCHHHEECCCHHHHHHHHHHCCCCCCEECCCCCEE
MIHQPLGGAQGQASDIEIISNEIIRLKGLMNSILAQNSKQSLERIAKDTDRDFYMSALEA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHH
KEYGLIDKVLEKNVK
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
GYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDI
CCCCEEEECCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
GLYINSPGGVITSGLSIYDTMNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRI
CEEECCCCCCCCCCHHHHHHHHHHCCCHHHEECCCHHHHHHHHHHCCCCCCEECCCCCEE
MIHQPLGGAQGQASDIEIISNEIIRLKGLMNSILAQNSKQSLERIAKDTDRDFYMSALEA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHH
KEYGLIDKVLEKNVK
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]