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The map label for this gene is glmU

Identifier: 109947416

GI number: 109947416

Start: 753517

End: 754818

Strand: Reverse

Name: glmU

Synonym: Hac_0863

Alternate gene names: 109947416

Gene position: 754818-753517 (Counterclockwise)

Preceding gene: 109947418

Following gene: 109947415

Centisome position: 48.57

GC content: 39.78

Gene sequence:

>1302_bases
ATGCTTTCTGTGATCATACTAGCCGCTGGTAAAGGCACTCGCATGCACTCTAGCCTGCCTAAGACTTTACACACTCTTTG
TGGGGAGCCTATGTTATTTTATATTTTAGAAACGGCTTTTTCAATCAGTAACGATGTGCATCTTATCTTACACCACCAAC
AAGAACGCATTAAAGAAGCGGTGTTGGAGCGTTTTAAGGGAGTGGTTTTTCACACTCAAATCGTGGAAAAATATTCAGGA
ACGGGTGGGGCTATCATGCAAGAAGACAAAACGCCTATTCTTACCAAACATGAGCGGATTTTAATCTTGAATGCAGACAT
GCCCTTAATCACTAAAGACGCTCTCACCCCCTTATTAAAAAGCCACAATAACGCCATAGGTTTACTGCATTTGGCTGATC
CTAAAGGTTATGGGCGTGTTATTTTAGAAAACCATCAAGTCAGAAAGATTGTAGAAGAAAAGGACGCTAATGATGAAGAA
AAAGCCATTAAAAGCGTGAATGCTGGCGTGTATTTGTTTGAAAGAAAGTTTTTAGAAAAATATTTACCCAAACTCCATAA
CCAAAACGCCCAAAAAGAATACTACCTCACGGATTTAACCGCTTTTGGTATCAATGAAAATGAAAAAATTGATGCCATTT
TCTTAGAAGAAGAGTTTTTTTTAGGGGTGAATTGCCAAACAGAAAGGGCGAAGGCTGAAGAAATCATGCTAGAAAGGTTA
CGCAAAAACGCTATGGATTTAGGGGTAGTGATGCAATTACCCAAGAGTATTTACTTAGAAAAAGGCGTGAGTTTTAAGGG
GGAGTGTGTTTTAGAGCAAGGGGTACGTTTGAGTGGGACTTGTTTGATAGAAAATGCACACATTAAAGCTTATAGCGTTA
TAGAAGAGAGCCAAATTGTTAATAGCAGTGTGGGACCATTTGCCCATGCACGCCCTAAAAGCACGATTTGTGATAGCCAT
GTGGGGAATTTTGTAGAGACGAAAAACGCTAAACTTCAAGGCACTAAAGCAGGGCATTTGAGCTATTTAGGGGATTGTGA
GATAGGAAAAAACACAAATGTAGGGGCTGGCGTGATCACTTGCAATTACGATGGCAAAAAGAAACACCAAACGATCATTG
GTGAAAATGTCTTTATAGGGAGCGATAGTCAGCTAGTCGCCCCTGTAACTATTGGCTCTAATGTTTTAATTGGCAGTGGC
ACAACCATCACCAAAGACATTCCTAGCGGTTTTTTAAGCCTTTCACGCACCCCTCAAACTAACATTGAAAATGGGTATTT
TAAGTTTTTTAAGAAGTCATAA

Upstream 100 bases:

>100_bases
CGCAAAATTCTAGCCTTAAATCTTTGATGAAAAACAAGTTAAATTATAAGATAAGGCATGTTAAAATTCCCTAAAATAAC
CCCTAAATTGAAGGATTTTA

Downstream 100 bases:

>100_bases
AACAAGAAATCTTAAGGCGTAGTTTTTTTTAAGCACTTTGTTATTATAATTCCGAATTTAAAAAACAAACGATTTAATTC
AAATTTAAGGATAAGTTTTG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLSVIILAAGKGTRMHSSLPKTLHTLCGEPMLFYILETAFSISNDVHLILHHQQERIKEAVLERFKGVVFHTQIVEKYSG
TGGAIMQEDKTPILTKHERILILNADMPLITKDALTPLLKSHNNAIGLLHLADPKGYGRVILENHQVRKIVEEKDANDEE
KAIKSVNAGVYLFERKFLEKYLPKLHNQNAQKEYYLTDLTAFGINENEKIDAIFLEEEFFLGVNCQTERAKAEEIMLERL
RKNAMDLGVVMQLPKSIYLEKGVSFKGECVLEQGVRLSGTCLIENAHIKAYSVIEESQIVNSSVGPFAHARPKSTICDSH
VGNFVETKNAKLQGTKAGHLSYLGDCEIGKNTNVGAGVITCNYDGKKKHQTIIGENVFIGSDSQLVAPVTIGSNVLIGSG
TTITKDIPSGFLSLSRTPQTNIENGYFKFFKKS

Sequences:

>Translated_433_residues
MLSVIILAAGKGTRMHSSLPKTLHTLCGEPMLFYILETAFSISNDVHLILHHQQERIKEAVLERFKGVVFHTQIVEKYSG
TGGAIMQEDKTPILTKHERILILNADMPLITKDALTPLLKSHNNAIGLLHLADPKGYGRVILENHQVRKIVEEKDANDEE
KAIKSVNAGVYLFERKFLEKYLPKLHNQNAQKEYYLTDLTAFGINENEKIDAIFLEEEFFLGVNCQTERAKAEEIMLERL
RKNAMDLGVVMQLPKSIYLEKGVSFKGECVLEQGVRLSGTCLIENAHIKAYSVIEESQIVNSSVGPFAHARPKSTICDSH
VGNFVETKNAKLQGTKAGHLSYLGDCEIGKNTNVGAGVITCNYDGKKKHQTIIGENVFIGSDSQLVAPVTIGSNVLIGSG
TTITKDIPSGFLSLSRTPQTNIENGYFKFFKKS
>Mature_433_residues
MLSVIILAAGKGTRMHSSLPKTLHTLCGEPMLFYILETAFSISNDVHLILHHQQERIKEAVLERFKGVVFHTQIVEKYSG
TGGAIMQEDKTPILTKHERILILNADMPLITKDALTPLLKSHNNAIGLLHLADPKGYGRVILENHQVRKIVEEKDANDEE
KAIKSVNAGVYLFERKFLEKYLPKLHNQNAQKEYYLTDLTAFGINENEKIDAIFLEEEFFLGVNCQTERAKAEEIMLERL
RKNAMDLGVVMQLPKSIYLEKGVSFKGECVLEQGVRLSGTCLIENAHIKAYSVIEESQIVNSSVGPFAHARPKSTICDSH
VGNFVETKNAKLQGTKAGHLSYLGDCEIGKNTNVGAGVITCNYDGKKKHQTIIGENVFIGSDSQLVAPVTIGSNVLIGSG
TTITKDIPSGFLSLSRTPQTNIENGYFKFFKKS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=457, Percent_Identity=39.1684901531729, Blast_Score=312, Evalue=3e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_HELAH (Q17XI1)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664644.1
- ProteinModelPortal:   Q17XI1
- SMR:   Q17XI1
- STRING:   Q17XI1
- GeneID:   4177768
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0863
- NMPDR:   fig|382638.8.peg.839
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   Q17XI1
- ProtClustDB:   PRK14359
- BioCyc:   HACI382638:HAC_0863-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48042; Mature: 48042

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 339-339 BINDING 138-138 BINDING 152-152 BINDING 167-167 BINDING 363-363 BINDING 381-381 BINDING 399-399 BINDING 416-416

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVIILAAGKGTRMHSSLPKTLHTLCGEPMLFYILETAFSISNDVHLILHHQQERIKEA
CEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHH
VLERFKGVVFHTQIVEKYSGTGGAIMQEDKTPILTKHERILILNADMPLITKDALTPLLK
HHHHHCCEEHHHHHHHHHCCCCCCEEECCCCCCEECCCEEEEEECCCCEEEHHHHHHHHH
SHNNAIGLLHLADPKGYGRVILENHQVRKIVEEKDANDEEKAIKSVNAGVYLFERKFLEK
CCCCEEEEEEEECCCCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHCCCEEEHHHHHHHH
YLPKLHNQNAQKEYYLTDLTAFGINENEKIDAIFLEEEFFLGVNCQTERAKAEEIMLERL
HHHHHCCCCCCCEEEEEEEEEECCCCCCCEEEEEEECEEEEECCCCCHHHHHHHHHHHHH
RKNAMDLGVVMQLPKSIYLEKGVSFKGECVLEQGVRLSGTCLIENAHIKAYSVIEESQIV
HHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHCCCCEEEEEEEECCCEEEEEHHHHHHHH
NSSVGPFAHARPKSTICDSHVGNFVETKNAKLQGTKAGHLSYLGDCEIGKNTNVGAGVIT
CCCCCCCCCCCCCCCHHHHHCCCCEECCCCEEECCCCCCCEEEECCCCCCCCCCCCEEEE
CNYDGKKKHQTIIGENVFIGSDSQLVAPVTIGSNVLIGSGTTITKDIPSGFLSLSRTPQT
ECCCCCCCCCEEECCEEEECCCCCEEEEEEECCEEEEECCCEEECCCCCHHHCCCCCCCC
NIENGYFKFFKKS
CCCCCEEEEEECC
>Mature Secondary Structure
MLSVIILAAGKGTRMHSSLPKTLHTLCGEPMLFYILETAFSISNDVHLILHHQQERIKEA
CEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHH
VLERFKGVVFHTQIVEKYSGTGGAIMQEDKTPILTKHERILILNADMPLITKDALTPLLK
HHHHHCCEEHHHHHHHHHCCCCCCEEECCCCCCEECCCEEEEEECCCCEEEHHHHHHHHH
SHNNAIGLLHLADPKGYGRVILENHQVRKIVEEKDANDEEKAIKSVNAGVYLFERKFLEK
CCCCEEEEEEEECCCCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHCCCEEEHHHHHHHH
YLPKLHNQNAQKEYYLTDLTAFGINENEKIDAIFLEEEFFLGVNCQTERAKAEEIMLERL
HHHHHCCCCCCCEEEEEEEEEECCCCCCCEEEEEEECEEEEECCCCCHHHHHHHHHHHHH
RKNAMDLGVVMQLPKSIYLEKGVSFKGECVLEQGVRLSGTCLIENAHIKAYSVIEESQIV
HHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHCCCCEEEEEEEECCCEEEEEHHHHHHHH
NSSVGPFAHARPKSTICDSHVGNFVETKNAKLQGTKAGHLSYLGDCEIGKNTNVGAGVIT
CCCCCCCCCCCCCCCHHHHHCCCCEECCCCEEECCCCCCCEEEECCCCCCCCCCCCEEEE
CNYDGKKKHQTIIGENVFIGSDSQLVAPVTIGSNVLIGSGTTITKDIPSGFLSLSRTPQT
ECCCCCCCCCEEECCEEEECCCCCEEEEEEECCEEEEECCCEEECCCCCHHHCCCCCCCC
NIENGYFKFFKKS
CCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA