Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 109947340

GI number: 109947340

Start: 674734

End: 675972

Strand: Reverse

Name: fabF [H]

Synonym: Hac_0779

Alternate gene names: 109947340

Gene position: 675972-674734 (Counterclockwise)

Preceding gene: 109947341

Following gene: 109947339

Centisome position: 43.5

GC content: 43.66

Gene sequence:

>1239_bases
GTGCGTCGGATTGTAGTAACTGGAATGGGGATGATCAATTCGCTAGGTTTAAATAAAGAAGATTCTTTTTTGGCGATCGC
TAAGGGGGAATGCGGTATCAAAAACATAGAAAGTTTTGATGCGAGTGCGTTTCCTGTGCGTATTGCTGGAGAAATCACTG
ACTTTGACCCTACAGAGGTGATGAATCCCAAAGATGTTAAAAAGGCAGGTCGTTTCATTCAATTAGCCTTGAAAGCTGCA
AGAGAGGCGATGAAAGATAGTGGGATTTTAGACGCTCAAAATAGATGCCCTGAAGAATTGGCTAATCGCATGGGCGTAAG
CTCTGGCTCTGGAATTGGCGGATTGGGGAATATTGAAGCGAATTCCATTTTTTGTTTTGAAAAAGGTCCTAGAAAAGTCA
ATCCCTTTTTTATCACTTCTGCGTTAGTGAATATGATCGGAGGTTTCACTTCTATTGAGTTTGGCGTTAAAGGGCCTAAT
CTCTCTGTCGTAACGGCTTGTGCAGCTGGCACTCATGCGATTATTGAAGCGGTTAAAACCATTTTACTTGGTGGGGCTGA
TAAAATGCTAGTCGTGGGAGCAGAATCCACCATTTGTCCTGTAGGCATTGGTGGGTTTGCAAGCATTAAAGCCCTTTCTA
CAAGAAATGATGAGCCTAAAAAAGCTTCAAGACCTTTTGATAAAGATCGCAATGGTTTTGTGATGGGGGAAGGTGCTGGG
GCTTTAGTGCTTGAAGAATATGAAAGCGCAAAAAAAAGGGGGGCGAAAATTTATGCAGAATTTGCCGGATATGGTGAGAG
TGGCGATGCTAACCATATCACAGCCCCAGCCCCTGAGGGCGAAGGGGCTTTTAGAGCCATGAAAATGGCTTTAGAAATGG
CGAAAGTGGAGATAGGCTATGTGAATGCCCATGGGACTAGCACGCATTATAACGATTGGTATGAAAGCATCGCTCTCAAA
AATGTGTTTGGCTCTAAAGAAAAAGTTCCTCCTGTTAGCTCCACTAAAGGGCAGATTGGGCATTGTTTAGGGGCTGCGGG
TGCTTTAGAAGCCGTTATTTCCATTATGGCGATGAATCAAGGGATCTTACCTCCCACCATCAATCAAGAAACGCCTGACC
CAGAATGCGATCTAGATTATATCCCTAATACGGCTAGAGAAAAGCAAGTGAATGCGGTGATGAGCAACTCATTTGGTTTT
GGTGGCACTAATGGTGTTGTGATTTTCAAAAAAGTCTAG

Upstream 100 bases:

>100_bases
TTTTGACTTGGAGCGTTTGTCTCCAAGTTTTACTTAAAAATTTAGTTTTAGCTAAAATCTAGTTTTATTGAATTAAAGTT
TTTGAAATGAGGAGCTATTG

Downstream 100 bases:

>100_bases
TTTTACAAAGTCTAGGATTTTGAATGGCCATTTATTTAGATTTTGAAAATCATATTAAAGAGATTCAAAATGAAATTGAA
TTAGCCCTCATTAGAGGCGA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKNIESFDASAFPVRIAGEITDFDPTEVMNPKDVKKAGRFIQLALKAA
REAMKDSGILDAQNRCPEELANRMGVSSGSGIGGLGNIEANSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGVKGPN
LSVVTACAAGTHAIIEAVKTILLGGADKMLVVGAESTICPVGIGGFASIKALSTRNDEPKKASRPFDKDRNGFVMGEGAG
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEIGYVNAHGTSTHYNDWYESIALK
NVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQGILPPTINQETPDPECDLDYIPNTAREKQVNAVMSNSFGF
GGTNGVVIFKKV

Sequences:

>Translated_412_residues
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKNIESFDASAFPVRIAGEITDFDPTEVMNPKDVKKAGRFIQLALKAA
REAMKDSGILDAQNRCPEELANRMGVSSGSGIGGLGNIEANSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGVKGPN
LSVVTACAAGTHAIIEAVKTILLGGADKMLVVGAESTICPVGIGGFASIKALSTRNDEPKKASRPFDKDRNGFVMGEGAG
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEIGYVNAHGTSTHYNDWYESIALK
NVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQGILPPTINQETPDPECDLDYIPNTAREKQVNAVMSNSFGF
GGTNGVVIFKKV
>Mature_412_residues
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKNIESFDASAFPVRIAGEITDFDPTEVMNPKDVKKAGRFIQLALKAA
REAMKDSGILDAQNRCPEELANRMGVSSGSGIGGLGNIEANSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGVKGPN
LSVVTACAAGTHAIIEAVKTILLGGADKMLVVGAESTICPVGIGGFASIKALSTRNDEPKKASRPFDKDRNGFVMGEGAG
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEIGYVNAHGTSTHYNDWYESIALK
NVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQGILPPTINQETPDPECDLDYIPNTAREKQVNAVMSNSFGF
GGTNGVVIFKKV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=42.8571428571429, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=50, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI41872631, Length=388, Percent_Identity=23.9690721649485, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1787337, Length=415, Percent_Identity=49.6385542168675, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1788663, Length=420, Percent_Identity=36.4285714285714, Blast_Score=241, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=421, Percent_Identity=36.3420427553444, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=43.0232558139535, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI212642053, Length=428, Percent_Identity=27.1028037383178, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=412, Percent_Identity=26.4563106796117, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=35.6502242152466, Blast_Score=241, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24644341, Length=414, Percent_Identity=41.7874396135266, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI19920632, Length=398, Percent_Identity=27.1356783919598, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI221330659, Length=398, Percent_Identity=27.1356783919598, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24581345, Length=395, Percent_Identity=27.3417721518987, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43501; Mature: 43501

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKNIESFDASAFPVRIAGEITDFDPTEV
CCEEEEECCCHHHHCCCCCCCCEEEEECCCCCCCCHHHCCCCCCCEEEECCCCCCCCHHC
MNPKDVKKAGRFIQLALKAAREAMKDSGILDAQNRCPEELANRMGVSSGSGIGGLGNIEA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHCCCCCCCCCCCCCCCCC
NSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGVKGPNLSVVTACAAGTHAIIEAVKT
CEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCHHHHHHHHHH
ILLGGADKMLVVGAESTICPVGIGGFASIKALSTRNDEPKKASRPFDKDRNGFVMGEGAG
HHHCCCCCEEEEECCCCCCEECCCCHHHEEEECCCCCCCHHHCCCCCCCCCCEEEECCCC
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEIGY
EEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHEEEEE
VNAHGTSTHYNDWYESIALKNVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQ
EECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GILPPTINQETPDPECDLDYIPNTAREKQVNAVMSNSFGFGGTNGVVIFKKV
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKNIESFDASAFPVRIAGEITDFDPTEV
CCEEEEECCCHHHHCCCCCCCCEEEEECCCCCCCCHHHCCCCCCCEEEECCCCCCCCHHC
MNPKDVKKAGRFIQLALKAAREAMKDSGILDAQNRCPEELANRMGVSSGSGIGGLGNIEA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHCCCCCCCCCCCCCCCCC
NSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGVKGPNLSVVTACAAGTHAIIEAVKT
CEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCHHHHHHHHHH
ILLGGADKMLVVGAESTICPVGIGGFASIKALSTRNDEPKKASRPFDKDRNGFVMGEGAG
HHHCCCCCEEEEECCCCCCEECCCCHHHEEEECCCCCCCHHHCCCCCCCCCCEEEECCCC
ALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEIGY
EEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHEEEEE
VNAHGTSTHYNDWYESIALKNVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQ
EECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GILPPTINQETPDPECDLDYIPNTAREKQVNAVMSNSFGFGGTNGVVIFKKV
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]