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The map label for this gene is murC [H]

Identifier: 109947307

GI number: 109947307

Start: 646955

End: 648304

Strand: Direct

Name: murC [H]

Synonym: Hac_0737

Alternate gene names: 109947307

Gene position: 646955-648304 (Clockwise)

Preceding gene: 109947306

Following gene: 109947308

Centisome position: 41.63

GC content: 36.67

Gene sequence:

>1350_bases
ATGCTTGAAATCCCAAAAGTTTTACTAAAAAATTTGCAAGATTGTAAGATCCATTTCATTGGCATAGGGGGGATTGGTAT
TTCAGGCTTAGCCAAATACCTTAAAGCTCAAGGGGCTAAAATCAGCGGATCTGATATTGCCATAAGCCCTAGCGTTAAGT
ATTTAAAAGCCTTAGGCGTAGAAGTTAATATCCCACATGACCCAAAGGCGATTAAAAATCAAGATGTGATCATCCATTCA
GCCATTATTAAAGAAGACAATATAGAAATACAAAGGGCTAAAGAATTAGAAATCCCTATTTTATCTCGTAAAGACGCCTT
GTATTCTATCCTTAAAGACAAGCGGGTTTTTAGCGTGTGCGGGGCTCATGGAAAAAGCAGTATTAGCGCGATGTTGAGCG
CGATTTGCCCCACTTTTGGGGCGATTATTGGGGCGCATTCTAAAGAGTTTGATTCCAATGTGCGAGAGAGCGCGAATGTT
AGCTTGGTTTTTGAAGCAGATGAAAGCGATTCAAGTTTTTTATTTTCTAACCCTTATTGCGCGATTGTGCCTAATACAGA
GCCAGAACATTTGGAGCATTATGACCACGATTTAGAGCGATTCTTCTTCGCTTATGAATATTTTTTAGACCATGCACAAA
AAAGAGTGATCTATAAAGAAGATCCTTTTTTAAAAAATTATTCTAAAGACGCCATTATCTTAGAAAAAAAAGACATTCAA
AATATCCAATACATTTTAAAAGAGGGCGAGCCTTACACTTCATTTGAATTGAAAGACTTGGGGACTTTTTTAGTGTGGGG
GTTAGGCGAACATAACGCCACGAATGCGAGTTTGGCGATTTTAAGCGCTTTAGATGAATTAAATTTAGAAGAAATTAGAA
ACAACCTTTTAAATTTCAAAGGCATTAAAAAACGCTTTGATATTTTGCAAAAAAACGCACTCATTCTTATTGATGATTAC
GCCCACCACCCCACCGAAATTAGTGCTACTTTAAAGAGCGCTAGGATTTATGCTAATTTATTAAACACGCAAGAAAAAAT
TATTGTGATCTGGCAAGCACACAAATATTCCCGCTTAATGGATAATTTAGAAGAGTTTAAAAAATGTTTTTCAGAGCATT
GCGACAGGCTGATCATTTTACCCATTTATAGTGCATGTGAAGTTAAAAGAGATATTGATTTGAAAGCCCATTTTAAGCAT
TATAACCCCACCTTTATAGATAGGGTGCGTAAAAAAGGGGATTTTTTAGAGCTGTTAGTCAATGATAAGGTAGTAGAAAC
GATTGAAAAAGGGTTTGTGATTGGCTTTGGAGCGGGGGATATTACCTACCAATTAAGGGGCGAAATGTAA

Upstream 100 bases:

>100_bases
CGTAACAACATCGGCACTGACTATGCGCGTTTAGCCCTTGTCTATGACACCCCTCTTTTAGAAAAACCTTTAGAAATCAT
AGAAACTTACCGAGAAAATC

Downstream 100 bases:

>100_bases
TGGGCGTAGCGATTGTTTTATTTTTAACGCTGATTTTATTGTTTTTAGTTTTAAGGGATTTTGGTCTAATGAGTCTTAAG
CAAAAAATATTAGCTTTTTT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MLEIPKVLLKNLQDCKIHFIGIGGIGISGLAKYLKAQGAKISGSDIAISPSVKYLKALGVEVNIPHDPKAIKNQDVIIHS
AIIKEDNIEIQRAKELEIPILSRKDALYSILKDKRVFSVCGAHGKSSISAMLSAICPTFGAIIGAHSKEFDSNVRESANV
SLVFEADESDSSFLFSNPYCAIVPNTEPEHLEHYDHDLERFFFAYEYFLDHAQKRVIYKEDPFLKNYSKDAIILEKKDIQ
NIQYILKEGEPYTSFELKDLGTFLVWGLGEHNATNASLAILSALDELNLEEIRNNLLNFKGIKKRFDILQKNALILIDDY
AHHPTEISATLKSARIYANLLNTQEKIIVIWQAHKYSRLMDNLEEFKKCFSEHCDRLIILPIYSACEVKRDIDLKAHFKH
YNPTFIDRVRKKGDFLELLVNDKVVETIEKGFVIGFGAGDITYQLRGEM

Sequences:

>Translated_449_residues
MLEIPKVLLKNLQDCKIHFIGIGGIGISGLAKYLKAQGAKISGSDIAISPSVKYLKALGVEVNIPHDPKAIKNQDVIIHS
AIIKEDNIEIQRAKELEIPILSRKDALYSILKDKRVFSVCGAHGKSSISAMLSAICPTFGAIIGAHSKEFDSNVRESANV
SLVFEADESDSSFLFSNPYCAIVPNTEPEHLEHYDHDLERFFFAYEYFLDHAQKRVIYKEDPFLKNYSKDAIILEKKDIQ
NIQYILKEGEPYTSFELKDLGTFLVWGLGEHNATNASLAILSALDELNLEEIRNNLLNFKGIKKRFDILQKNALILIDDY
AHHPTEISATLKSARIYANLLNTQEKIIVIWQAHKYSRLMDNLEEFKKCFSEHCDRLIILPIYSACEVKRDIDLKAHFKH
YNPTFIDRVRKKGDFLELLVNDKVVETIEKGFVIGFGAGDITYQLRGEM
>Mature_449_residues
MLEIPKVLLKNLQDCKIHFIGIGGIGISGLAKYLKAQGAKISGSDIAISPSVKYLKALGVEVNIPHDPKAIKNQDVIIHS
AIIKEDNIEIQRAKELEIPILSRKDALYSILKDKRVFSVCGAHGKSSISAMLSAICPTFGAIIGAHSKEFDSNVRESANV
SLVFEADESDSSFLFSNPYCAIVPNTEPEHLEHYDHDLERFFFAYEYFLDHAQKRVIYKEDPFLKNYSKDAIILEKKDIQ
NIQYILKEGEPYTSFELKDLGTFLVWGLGEHNATNASLAILSALDELNLEEIRNNLLNFKGIKKRFDILQKNALILIDDY
AHHPTEISATLKSARIYANLLNTQEKIIVIWQAHKYSRLMDNLEEFKKCFSEHCDRLIILPIYSACEVKRDIDLKAHFKH
YNPTFIDRVRKKGDFLELLVNDKVVETIEKGFVIGFGAGDITYQLRGEM

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=405, Percent_Identity=31.1111111111111, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1790680, Length=348, Percent_Identity=27.0114942528736, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 50937; Mature: 50937

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEIPKVLLKNLQDCKIHFIGIGGIGISGLAKYLKAQGAKISGSDIAISPSVKYLKALGV
CCCCHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEECCCCEEECCCHHHHHHCCC
EVNIPHDPKAIKNQDVIIHSAIIKEDNIEIQRAKELEIPILSRKDALYSILKDKRVFSVC
EEECCCCCCCCCCCCEEEEEEEEECCCCEEEECCCCCCCEECCHHHHHHHHHCCHHHHHH
GAHGKSSISAMLSAICPTFGAIIGAHSKEFDSNVRESANVSLVFEADESDSSFLFSNPYC
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEECCCEE
AIVPNTEPEHLEHYDHDLERFFFAYEYFLDHAQKRVIYKEDPFLKNYSKDAIILEKKDIQ
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCEEEEEHHHHH
NIQYILKEGEPYTSFELKDLGTFLVWGLGEHNATNASLAILSALDELNLEEIRNNLLNFK
HHHHHHHCCCCCCCEEHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCHH
GIKKRFDILQKNALILIDDYAHHPTEISATLKSARIYANLLNTQEKIIVIWQAHKYSRLM
HHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHH
DNLEEFKKCFSEHCDRLIILPIYSACEVKRDIDLKAHFKHYNPTFIDRVRKKGDFLELLV
HHHHHHHHHHHHHCCEEEEEECCHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCEEHHH
NDKVVETIEKGFVIGFGAGDITYQLRGEM
CCHHHHHHHCCCEEEECCCCEEEEEECCC
>Mature Secondary Structure
MLEIPKVLLKNLQDCKIHFIGIGGIGISGLAKYLKAQGAKISGSDIAISPSVKYLKALGV
CCCCHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEECCCCEEECCCHHHHHHCCC
EVNIPHDPKAIKNQDVIIHSAIIKEDNIEIQRAKELEIPILSRKDALYSILKDKRVFSVC
EEECCCCCCCCCCCCEEEEEEEEECCCCEEEECCCCCCCEECCHHHHHHHHHCCHHHHHH
GAHGKSSISAMLSAICPTFGAIIGAHSKEFDSNVRESANVSLVFEADESDSSFLFSNPYC
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEECCCEE
AIVPNTEPEHLEHYDHDLERFFFAYEYFLDHAQKRVIYKEDPFLKNYSKDAIILEKKDIQ
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCEEEEEHHHHH
NIQYILKEGEPYTSFELKDLGTFLVWGLGEHNATNASLAILSALDELNLEEIRNNLLNFK
HHHHHHHCCCCCCCEEHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCHH
GIKKRFDILQKNALILIDDYAHHPTEISATLKSARIYANLLNTQEKIIVIWQAHKYSRLM
HHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHH
DNLEEFKKCFSEHCDRLIILPIYSACEVKRDIDLKAHFKHYNPTFIDRVRKKGDFLELLV
HHHHHHHHHHHHHCCEEEEEECCHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCEEHHH
NDKVVETIEKGFVIGFGAGDITYQLRGEM
CCHHHHHHHCCCEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA