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The map label for this gene is hcpD [H]

Identifier: 109947303

GI number: 109947303

Start: 642347

End: 643390

Strand: Reverse

Name: hcpD [H]

Synonym: Hac_0733

Alternate gene names: 109947303

Gene position: 643390-642347 (Counterclockwise)

Preceding gene: 109947304

Following gene: 109947302

Centisome position: 41.4

GC content: 42.82

Gene sequence:

>1044_bases
ATGCTCAAAAAAAGTTTGTTATTGCTTGTTTTTTTAGTCTTACGGATTGGTGGTGCTGAAGAAAACAATCAAGCCCCTGG
ATTAAACCCCGCTAACGCTAAAGGCATGCCAAACCCTAACACGCAAATCAACCCTAAAGAAGACAACTCCAATTTATTGG
ACAAATTGGGTTCGCCTGAAAACGCTGAAACCAAGCTTTCTGCTGGTATTGATTTGGCTAAAAAGGGCGATTATGAAGGG
GCTTTTAAGCTCTTTTCTCAATCATGCGATAACGGCAATGCGGCTGGGTGTTTTGCAGTGGGGGCGATGTATGCTAATGG
AGTGGGTGTTCAAACCAACAGATTGAAAGCCGCCCGCTATTATGAAATGGGTTGCAGTGGAGGCGATGCGACCGCTTGCG
CGAATCTGGCTCAAATGTATGAAAACAAGAAAAACGCTGATGCAAACGATAAAGAAAACGCTCTGCAATTGTATGCGGTG
GCTTGTCAAGGGGGGGATATGATTGCATGCAATAATTTGGGGTGGATGTTTGCAAATGGGAGTGGGGTCCCAAAAGATTA
TTACAAAGCGATGGGTTATTATAAATTTTCATGCGAAAATGGGAATGACATGGGGTGCTATAATCTGGGCTTGATGTCTA
ATGTGAATAATATTTATGGTATTGATAAAGCCCAACTTAGTCAAGTGGATTTGAATTATTTGGCTTGCAATGCGGGGGAT
ATGATGGGGTGCGCGAATTTAGGCTGGATTTATGCGAATGGGGATTTAGGGGCTCCGTTGAATAACCACTATGCAGCGAA
ATATTTCCAAATGGCATGCGATGGGGGGATTTTGGGGAGCTGTAATAATTTAGGCGTGCTGTATCAAAAGGGTTTGGGCG
TGCCTCAAGATGATCAAAGGGCGTTAGATTTATTCTCTTACGCGTGCGATAATGGTTTTGAATCAAGCTGTCGTAATTAT
GGGAACTTCAAAGAGTATTTATTGCGCATGAATCCTAATTATGGGCGTTTGTTCATGCCGCATAATTCTTATGATACACC
ATAG

Upstream 100 bases:

>100_bases
GCGTACATTTTCGCTCAAATAGCCAAAATGGCAAGTTGATTGCTTTTAGGAGCGTGAAAAAAATTGAGTTGAATCAAAAC
TTGCACTAAGGATTAAAAGA

Downstream 100 bases:

>100_bases
AAATTAAAAAATGCTTTTAGCATTTTTAAGATAAATATTAAATAGCTTGACGCCGGTCAAGTGATAATCTCTTAAATCCA
CCCACAAATTGCGGTTTTTT

Product: hypothetical protein

Products: NA

Alternate protein names: Cysteine-rich protein D; Penicillin-binding protein 4; PBP 4 [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MLKKSLLLLVFLVLRIGGAEENNQAPGLNPANAKGMPNPNTQINPKEDNSNLLDKLGSPENAETKLSAGIDLAKKGDYEG
AFKLFSQSCDNGNAAGCFAVGAMYANGVGVQTNRLKAARYYEMGCSGGDATACANLAQMYENKKNADANDKENALQLYAV
ACQGGDMIACNNLGWMFANGSGVPKDYYKAMGYYKFSCENGNDMGCYNLGLMSNVNNIYGIDKAQLSQVDLNYLACNAGD
MMGCANLGWIYANGDLGAPLNNHYAAKYFQMACDGGILGSCNNLGVLYQKGLGVPQDDQRALDLFSYACDNGFESSCRNY
GNFKEYLLRMNPNYGRLFMPHNSYDTP

Sequences:

>Translated_347_residues
MLKKSLLLLVFLVLRIGGAEENNQAPGLNPANAKGMPNPNTQINPKEDNSNLLDKLGSPENAETKLSAGIDLAKKGDYEG
AFKLFSQSCDNGNAAGCFAVGAMYANGVGVQTNRLKAARYYEMGCSGGDATACANLAQMYENKKNADANDKENALQLYAV
ACQGGDMIACNNLGWMFANGSGVPKDYYKAMGYYKFSCENGNDMGCYNLGLMSNVNNIYGIDKAQLSQVDLNYLACNAGD
MMGCANLGWIYANGDLGAPLNNHYAAKYFQMACDGGILGSCNNLGVLYQKGLGVPQDDQRALDLFSYACDNGFESSCRNY
GNFKEYLLRMNPNYGRLFMPHNSYDTP
>Mature_347_residues
MLKKSLLLLVFLVLRIGGAEENNQAPGLNPANAKGMPNPNTQINPKEDNSNLLDKLGSPENAETKLSAGIDLAKKGDYEG
AFKLFSQSCDNGNAAGCFAVGAMYANGVGVQTNRLKAARYYEMGCSGGDATACANLAQMYENKKNADANDKENALQLYAV
ACQGGDMIACNNLGWMFANGSGVPKDYYKAMGYYKFSCENGNDMGCYNLGLMSNVNNIYGIDKAQLSQVDLNYLACNAGD
MMGCANLGWIYANGDLGAPLNNHYAAKYFQMACDGGILGSCNNLGVLYQKGLGVPQDDQRALDLFSYACDNGFESSCRNY
GNFKEYLLRMNPNYGRLFMPHNSYDTP

Specific function: May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives. Binds to penicillin [H]

COG id: COG0790

COG function: function code R; FOG: TPR repeat, SEL1 subfamily

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI19923669, Length=291, Percent_Identity=26.8041237113402, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI151301150, Length=252, Percent_Identity=27.3809523809524, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI87081769, Length=234, Percent_Identity=24.3589743589744, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21355295, Length=273, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006597
- InterPro:   IPR011990 [H]

Pfam domain/function: PF08238 Sel1 [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 37484; Mature: 37484

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
8.4 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
8.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKSLLLLVFLVLRIGGAEENNQAPGLNPANAKGMPNPNTQINPKEDNSNLLDKLGSPE
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCC
NAETKLSAGIDLAKKGDYEGAFKLFSQSCDNGNAAGCFAVGAMYANGVGVQTNRLKAARY
CCCHHHHCCCCHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHH
YEMGCSGGDATACANLAQMYENKKNADANDKENALQLYAVACQGGDMIACNNLGWMFANG
EECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCEEEECCCCEEEECC
SGVPKDYYKAMGYYKFSCENGNDMGCYNLGLMSNVNNIYGIDKAQLSQVDLNYLACNAGD
CCCCHHHHHHCCEEEEEECCCCCCCEEECHHHHCCCHHCCCCHHHHHHCCCEEEEECCCC
MMGCANLGWIYANGDLGAPLNNHYAAKYFQMACDGGILGSCNNLGVLYQKGLGVPQDDQR
CCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCHHHCCCCCCCCCHHH
ALDLFSYACDNGFESSCRNYGNFKEYLLRMNPNYGRLFMPHNSYDTP
HHHHHHHHHCCCHHHHHHCCCCHHHHHEEECCCCCEEEECCCCCCCC
>Mature Secondary Structure
MLKKSLLLLVFLVLRIGGAEENNQAPGLNPANAKGMPNPNTQINPKEDNSNLLDKLGSPE
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCC
NAETKLSAGIDLAKKGDYEGAFKLFSQSCDNGNAAGCFAVGAMYANGVGVQTNRLKAARY
CCCHHHHCCCCHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHH
YEMGCSGGDATACANLAQMYENKKNADANDKENALQLYAVACQGGDMIACNNLGWMFANG
EECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCEEEECCCCEEEECC
SGVPKDYYKAMGYYKFSCENGNDMGCYNLGLMSNVNNIYGIDKAQLSQVDLNYLACNAGD
CCCCHHHHHHCCEEEEEECCCCCCCEEECHHHHCCCHHCCCCHHHHHHCCCEEEEECCCC
MMGCANLGWIYANGDLGAPLNNHYAAKYFQMACDGGILGSCNNLGVLYQKGLGVPQDDQR
CCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCHHHCCCCCCCCCHHH
ALDLFSYACDNGFESSCRNYGNFKEYLLRMNPNYGRLFMPHNSYDTP
HHHHHHHHHCCCHHHHHHCCCCHHHHHEEECCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185; 10438788 [H]