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The map label for this gene is norM [H]

Identifier: 109947234

GI number: 109947234

Start: 576898

End: 578187

Strand: Reverse

Name: norM [H]

Synonym: Hac_0657

Alternate gene names: 109947234

Gene position: 578187-576898 (Counterclockwise)

Preceding gene: 109947235

Following gene: 109947231

Centisome position: 37.21

GC content: 37.98

Gene sequence:

>1290_bases
TTGGCCCTGCCCTCTGGGGTCAATGCCGTTTTAGATGTGTTGGTGGTCGCGCTTTCAGTCTTTTTCGTGGGCAAAATTTC
ACACCATCATATTGTGGCTTTAGGGGTGGGCTTGCAGTTTTTGATGCTTTTTTATGGGATCAATACGATTTTATACACCG
GCACTAACGCCATTCTTTCTAGGCTTGTGGGTGCTAGGGATTTCACTCAAATCAATAACGCTTTTTCTAGTATTTTCATT
GGGGCGTTTGTGATTTGTCTAGGCGCACTGTTTGTTTCTTATTTTTTGATCGATCCTTTTTTAGCGTGGATGCAATTACA
AGATCCTTCACGCCAATTGACGCAAGATTATTTAAAAGTTTTAATCATAGCGTTACCAAGTATTTTTTTAAAAAATGTTT
TAGTTTCAGCGCTCGCTAGTTTTTCAGACACCCTAACCCCTTTTATCGTTAAAATTGTCATGGTCATAGCATGCATTTTT
TTAAATCAAGCCTTGATTTTTGGGGATTTTGGCTTTAAAGAAATGGGGATTGTGGGATCGGCTTTAGCGAATGTGATTGT
CTCTTATTTGGAATTAGTTGTGCTTGGGTTTTGGATACAAATCAAAAAAATCCCTTTAAAATTCAAAATAACCTTTGATA
TTTCTTTTTTAAAAACCATGTTTAGAGTGGGTTGGCCAGCTGGGTTTGAACGCTTATTAACCTTATTTTCTTTAATGCTT
TTGTCTAAATTTGTAGCGAGCTATGGGGATAAGGTGCTAGCGGGCATGCAAATAGGCATTAGAGTGGAAACCTTTTCATT
CATGCCAGGATTTGGGTTTATGATAGCTGCGATGGTTTTAATAGGGCAAAATTTAGGGGCGAACAAGCCAAAAATTGCTA
CGGAATACGCACATTTGATTTTAAAAATCTCTATGAGTTTAATGGGGGTTTTAGGGATTGTTTTAATCTTGTTTGCCAAA
GAATTTGCGAGCCTTTTTTCTCAAGATGAAGAAGTTTTGGAAGTAGCACGCTCTTATTTAGTCGCTGTGGGCCTCTCTCA
AGCCCCCTTAATTGGGTATTTTGTGCTAGATGGAGTTTTTAGGGGGGCTGGTATTTCTAAAGTTTCGTTATGCATTAACA
CCTTAAGTTTATGGGGGTTAAGGATCGTGCCTATTTACCTGCTTTTAATCTATCATTTTAAGGTGGAATTTATTTTTGCG
GTGATCACGCTAGAGACTTTTTTCCGCTCGCTCATTTATTATAAAGTTTTTTCTAAAGGCATTTGGAAAAGGTGTGGGAA
AAAGGCTTAA

Upstream 100 bases:

>100_bases
GCGTGCCGACTTTTTTAGTCTATAACCTCCCTTTGATCGCCTTTGGGGTTGCTGGAGCGTTACTATTAGGCTAATCTATC
AAATTAAGAAAATTTTTTCT

Downstream 100 bases:

>100_bases
AAACGCTTATTGCTTGAGCGTAGCTGTGGTTTTGAAACGACTTTCTCGCACCACTTGCACACCCACTTCGCCTACATATT
GAGCACTCTCTTCTATCTTT

Product: hypothetical protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MALPSGVNAVLDVLVVALSVFFVGKISHHHIVALGVGLQFLMLFYGINTILYTGTNAILSRLVGARDFTQINNAFSSIFI
GAFVICLGALFVSYFLIDPFLAWMQLQDPSRQLTQDYLKVLIIALPSIFLKNVLVSALASFSDTLTPFIVKIVMVIACIF
LNQALIFGDFGFKEMGIVGSALANVIVSYLELVVLGFWIQIKKIPLKFKITFDISFLKTMFRVGWPAGFERLLTLFSLML
LSKFVASYGDKVLAGMQIGIRVETFSFMPGFGFMIAAMVLIGQNLGANKPKIATEYAHLILKISMSLMGVLGIVLILFAK
EFASLFSQDEEVLEVARSYLVAVGLSQAPLIGYFVLDGVFRGAGISKVSLCINTLSLWGLRIVPIYLLLIYHFKVEFIFA
VITLETFFRSLIYYKVFSKGIWKRCGKKA

Sequences:

>Translated_429_residues
MALPSGVNAVLDVLVVALSVFFVGKISHHHIVALGVGLQFLMLFYGINTILYTGTNAILSRLVGARDFTQINNAFSSIFI
GAFVICLGALFVSYFLIDPFLAWMQLQDPSRQLTQDYLKVLIIALPSIFLKNVLVSALASFSDTLTPFIVKIVMVIACIF
LNQALIFGDFGFKEMGIVGSALANVIVSYLELVVLGFWIQIKKIPLKFKITFDISFLKTMFRVGWPAGFERLLTLFSLML
LSKFVASYGDKVLAGMQIGIRVETFSFMPGFGFMIAAMVLIGQNLGANKPKIATEYAHLILKISMSLMGVLGIVLILFAK
EFASLFSQDEEVLEVARSYLVAVGLSQAPLIGYFVLDGVFRGAGISKVSLCINTLSLWGLRIVPIYLLLIYHFKVEFIFA
VITLETFFRSLIYYKVFSKGIWKRCGKKA
>Mature_428_residues
ALPSGVNAVLDVLVVALSVFFVGKISHHHIVALGVGLQFLMLFYGINTILYTGTNAILSRLVGARDFTQINNAFSSIFIG
AFVICLGALFVSYFLIDPFLAWMQLQDPSRQLTQDYLKVLIIALPSIFLKNVLVSALASFSDTLTPFIVKIVMVIACIFL
NQALIFGDFGFKEMGIVGSALANVIVSYLELVVLGFWIQIKKIPLKFKITFDISFLKTMFRVGWPAGFERLLTLFSLMLL
SKFVASYGDKVLAGMQIGIRVETFSFMPGFGFMIAAMVLIGQNLGANKPKIATEYAHLILKISMSLMGVLGIVLILFAKE
FASLFSQDEEVLEVARSYLVAVGLSQAPLIGYFVLDGVFRGAGISKVSLCINTLSLWGLRIVPIYLLLIYHFKVEFIFAV
ITLETFFRSLIYYKVFSKGIWKRCGKKA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=457, Percent_Identity=23.8512035010941, Blast_Score=85, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47539; Mature: 47408

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCC
>Mature Secondary Structure 
ALPSGVNAVLDVLVVALSVFFVGKISHHHIVALGVGLQFLMLFYGINTILYTGTNAILS
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
RLVGARDFTQINNAFSSIFIGAFVICLGALFVSYFLIDPFLAWMQLQDPSRQLTQDYLKV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LIIALPSIFLKNVLVSALASFSDTLTPFIVKIVMVIACIFLNQALIFGDFGFKEMGIVGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ALANVIVSYLELVVLGFWIQIKKIPLKFKITFDISFLKTMFRVGWPAGFERLLTLFSLML
HHHHHHHHHHHHHHHHHHHHHEECCEEEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHH
LSKFVASYGDKVLAGMQIGIRVETFSFMPGFGFMIAAMVLIGQNLGANKPKIATEYAHLI
HHHHHHHHCCHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LKISMSLMGVLGIVLILFAKEFASLFSQDEEVLEVARSYLVAVGLSQAPLIGYFVLDGVF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
RGAGISKVSLCINTLSLWGLRIVPIYLLLIYHFKVEFIFAVITLETFFRSLIYYKVFSKG
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWKRCGKKA
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]