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The map label for this gene is vacA beta fragment 3 [H]

Identifier: 109947108

GI number: 109947108

Start: 442980

End: 443192

Strand: Reverse

Name: vacA beta fragment 3 [H]

Synonym: Hac_0513

Alternate gene names: 109947108

Gene position: 443192-442980 (Counterclockwise)

Preceding gene: 109947109

Following gene: 109947107

Centisome position: 28.52

GC content: 45.07

Gene sequence:

>213_bases
GTGCAAGAAGGGATTGCAAGCGCTGAAAACGCTGAAATTTCTCTTTATGATGGCACTACCCTTAATTTGCAAGGAGCGCG
CGCTGTGAATTTATTGGGTAAGGTGTGGATGGGCCGTTTGCAATATGCGGGAGCGTATTTAGCCCCTTCATGGAGCATGG
TGAAGCATCTTGGCATTTTAAATACCCACTACAATATTTCGCATTTGTTCTAG

Upstream 100 bases:

>100_bases
AACGCTAAAAATGTCATAATCGGTAATTTTTTAGAGATCCATAACCGCATGGGTTCTGGGGCTAGGAGAAAAGCCAGCTC
TGCGATTTTAACTTTACAAA

Downstream 100 bases:

>100_bases
CGCCCGATAAACACTTCAAAGGTGCAAGGGGATGTGAATTGGTGCCATCTCGTTGTGGGTGATCACAACGCCGCTCAAGC
AGGCATTGCTGCTAATGAAA

Product: vacuolating cytotoxin fragment 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 70; Mature: 70

Protein sequence:

>70_residues
MQEGIASAENAEISLYDGTTLNLQGARAVNLLGKVWMGRLQYAGAYLAPSWSMVKHLGILNTHYNISHLF

Sequences:

>Translated_70_residues
MQEGIASAENAEISLYDGTTLNLQGARAVNLLGKVWMGRLQYAGAYLAPSWSMVKHLGILNTHYNISHLF
>Mature_70_residues
MQEGIASAENAEISLYDGTTLNLQGARAVNLLGKVWMGRLQYAGAYLAPSWSMVKHLGILNTHYNISHLF

Specific function: Induces vacuolation of eukaryotic cells. Causes ulceration and gastric lesions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Vacuolating cytotoxin translocator:Cell outer membrane; Multi-pass membrane protein. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 autotransporter (TC 1.B.12) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005546
- InterPro:   IPR006315
- InterPro:   IPR003842 [H]

Pfam domain/function: PF02691 VacA [H]

EC number: NA

Molecular weight: Translated: 7707; Mature: 7707

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEGIASAENAEISLYDGTTLNLQGARAVNLLGKVWMGRLQYAGAYLAPSWSMVKHLGIL
CCCCCCCCCCCEEEEECCCEEEECCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCC
NTHYNISHLF
CCCCEEEECC
>Mature Secondary Structure
MQEGIASAENAEISLYDGTTLNLQGARAVNLLGKVWMGRLQYAGAYLAPSWSMVKHLGIL
CCCCCCCCCCCEEEEECCCEEEECCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCC
NTHYNISHLF
CCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8168917; 8163943 [H]