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The map label for this gene is ndk

Identifier: 109946991

GI number: 109946991

Start: 329649

End: 330062

Strand: Direct

Name: ndk

Synonym: Hac_0383

Alternate gene names: 109946991

Gene position: 329649-330062 (Clockwise)

Preceding gene: 109946990

Following gene: 109946992

Centisome position: 21.21

GC content: 41.06

Gene sequence:

>414_bases
TTGAAACAAAGAACGCTGTCTATTATTAAACCGGATGCACTTAAGAAGAAAGTGGTAGGGAAGATTATTGATCGTTTTGA
GAGCAACGGCTTGGAAGTCATTGCTATGAAACGCTTGCATTTAAGCGTTAAAGACGCTGAAAACTTTTATGCGATCCATA
GAGAAAGACCTTTTTTTAAAGACTTGATAGAATTTATGGTCAGTGGTCCGGTGGTGGTTATGGTTTTAGAAGGTAAGGAC
GCTGTGGCTAAGAATAGAGATCTTATGGGAGCGACTGATCCAAAGCTCGCCCAAAAAGGCACTATAAGAGCGGATTTTGC
TGAAAGCATTGACGCTAATGCGGTGCATGGGAGCGATAGCTTGGAAAACGCACACAATGAAATCGCTTTCTTTTTTGCCA
CTAGAGAGTTTTAA

Upstream 100 bases:

>100_bases
GGCTGAAGAGATTAAAGCGTTCTTTAAGCATTAAAAAAATATTTTAAGGGTCATATTTTAAAAAATTTTTGTATAATCAA
CAATTCACAAGGAGTTTAAA

Downstream 100 bases:

>100_bases
GATTAAGAGCGTTTAAGAATAAGCATGCAATTTGAAATGCGTAAAATCGCTTTTAATGTGCCTAGAGCGTTTTCTTTAGA
GCATGAGGGAGTGGTTTTAG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MKQRTLSIIKPDALKKKVVGKIIDRFESNGLEVIAMKRLHLSVKDAENFYAIHRERPFFKDLIEFMVSGPVVVMVLEGKD
AVAKNRDLMGATDPKLAQKGTIRADFAESIDANAVHGSDSLENAHNEIAFFFATREF

Sequences:

>Translated_137_residues
MKQRTLSIIKPDALKKKVVGKIIDRFESNGLEVIAMKRLHLSVKDAENFYAIHRERPFFKDLIEFMVSGPVVVMVLEGKD
AVAKNRDLMGATDPKLAQKGTIRADFAESIDANAVHGSDSLENAHNEIAFFFATREF
>Mature_137_residues
MKQRTLSIIKPDALKKKVVGKIIDRFESNGLEVIAMKRLHLSVKDAENFYAIHRERPFFKDLIEFMVSGPVVVMVLEGKD
AVAKNRDLMGATDPKLAQKGTIRADFAESIDANAVHGSDSLENAHNEIAFFFATREF

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=44.4444444444444, Blast_Score=129, Evalue=8e-31,
Organism=Homo sapiens, GI66392203, Length=135, Percent_Identity=42.2222222222222, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI66392227, Length=135, Percent_Identity=42.2222222222222, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI66392205, Length=135, Percent_Identity=42.2222222222222, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4505409, Length=135, Percent_Identity=42.2222222222222, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI66392192, Length=135, Percent_Identity=42.2222222222222, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=41.1764705882353, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=40.7407407407407, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=40.7407407407407, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI7019465, Length=141, Percent_Identity=36.8794326241135, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI37574614, Length=141, Percent_Identity=36.8794326241135, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI5031951, Length=134, Percent_Identity=36.5671641791045, Blast_Score=86, Evalue=9e-18,
Organism=Homo sapiens, GI30023828, Length=140, Percent_Identity=32.8571428571429, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=32.089552238806, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=34.3065693430657, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1788866, Length=134, Percent_Identity=54.4776119402985, Blast_Score=160, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17506807, Length=134, Percent_Identity=44.0298507462687, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=40, Blast_Score=117, Evalue=6e-28,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=44.1176470588235, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI18860097, Length=131, Percent_Identity=32.0610687022901, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24645457, Length=139, Percent_Identity=31.6546762589928, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_HELAH (Q17YQ6)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664219.1
- ProteinModelPortal:   Q17YQ6
- SMR:   Q17YQ6
- STRING:   Q17YQ6
- GeneID:   4177438
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0383
- NMPDR:   fig|382638.8.peg.372
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q17YQ6
- ProtClustDB:   PRK00668
- BioCyc:   HACI382638:HAC_0383-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15378; Mature: 15378

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 116-116 BINDING 10-10 BINDING 58-58 BINDING 86-86 BINDING 92-92 BINDING 103-103 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQRTLSIIKPDALKKKVVGKIIDRFESNGLEVIAMKRLHLSVKDAENFYAIHRERPFFK
CCCCCCEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEEHEEEEECCCCEEEECCCCCHHH
DLIEFMVSGPVVVMVLEGKDAVAKNRDLMGATDPKLAQKGTIRADFAESIDANAVHGSDS
HHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHCCCCCCCCCCCH
LENAHNEIAFFFATREF
HHHHCCCEEEEEEECCC
>Mature Secondary Structure
MKQRTLSIIKPDALKKKVVGKIIDRFESNGLEVIAMKRLHLSVKDAENFYAIHRERPFFK
CCCCCCEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEEHEEEEECCCCEEEECCCCCHHH
DLIEFMVSGPVVVMVLEGKDAVAKNRDLMGATDPKLAQKGTIRADFAESIDANAVHGSDS
HHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHCCCCCCCCCCCH
LENAHNEIAFFFATREF
HHHHCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA