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The map label for this gene is frdB [H]

Identifier: 109946984

GI number: 109946984

Start: 321937

End: 322674

Strand: Reverse

Name: frdB [H]

Synonym: Hac_0376

Alternate gene names: 109946984

Gene position: 322674-321937 (Counterclockwise)

Preceding gene: 109946985

Following gene: 109946983

Centisome position: 20.77

GC content: 43.63

Gene sequence:

>738_bases
ATGGGTGATAATGAACGAACGATTATAGTTAGAGTGCTAAAGTTTGACCCTCAAAGCACGGTGAGTAAGCCGCATTTTAA
AGAGTATCAGTTGAAAGAAACGCCATCCATGACGCTCTTTATCGCTTTAAATCTCATTAGAGAGCATCAAGATCCGGATT
TGAGCTTTGACTTTGTGTGCCGTGCTGGGATTTGTGGCTCTTGTGCGATGATGGTTAATGGGAGACCACGACTAGCTTGT
AAAACCCTAACTTCTAGTTTTGAAAGTGGGGTGATTACGCTGATGCCCATGCCTAGTTTTACGCTCATTAAAGATTTGAG
CGTGAATACCGGCGATTGGTTTTTGGACATGACTAAAAGAGTGGAGAGCTGGGCGCATTCTAAAGAAGAAGTGGATATTA
CTAAACCGGAAAAAAGGATTGAGCCTGATGAAGCCCAAGAGGTTTTTGAATTAGACAGGTGTATTGAATGTGGGTGCTGT
ATCGCCTCTTGTGGGACCAAACTCATGCGCCCTAATTTCATTGGAGCTGCTGGCATGAATAGAGTCATGCGTTTTATGAT
TGACAGCCACGATGGAAGAAGCGATGATGATTTTTATGAATTAGTCGGCGATGATGATGGCGTTTTTGGGTGCATGAGCT
TGATCGCTTGCCATGACACTTGCCCTAAAGAATTACCCTTACAAAGCAGTATCGCTACTTTGCGCAACCGAATGTTGAAA
GTGGGTAAAAGCCGCTAA

Upstream 100 bases:

>100_bases
TTAGAAGATGAAGAGGTGAGAGCTAGGGGGGAACATTTGTATTCTTTCAATGTCCATGATTTATTAGACAAACACAACGC
CAATCTAAAAGGAGAACACC

Downstream 100 bases:

>100_bases
TTTCTTTTAGTGGGTTGTTTTTGAAAGTCTTTTTAGTTCTTTTAAGCGTCTTTTTTTTTAGTGGGTGTTTTGGGTTAGTC
TATGAGGCTCCCATTTCAAA

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MGDNERTIIVRVLKFDPQSTVSKPHFKEYQLKETPSMTLFIALNLIREHQDPDLSFDFVCRAGICGSCAMMVNGRPRLAC
KTLTSSFESGVITLMPMPSFTLIKDLSVNTGDWFLDMTKRVESWAHSKEEVDITKPEKRIEPDEAQEVFELDRCIECGCC
IASCGTKLMRPNFIGAAGMNRVMRFMIDSHDGRSDDDFYELVGDDDGVFGCMSLIACHDTCPKELPLQSSIATLRNRMLK
VGKSR

Sequences:

>Translated_245_residues
MGDNERTIIVRVLKFDPQSTVSKPHFKEYQLKETPSMTLFIALNLIREHQDPDLSFDFVCRAGICGSCAMMVNGRPRLAC
KTLTSSFESGVITLMPMPSFTLIKDLSVNTGDWFLDMTKRVESWAHSKEEVDITKPEKRIEPDEAQEVFELDRCIECGCC
IASCGTKLMRPNFIGAAGMNRVMRFMIDSHDGRSDDDFYELVGDDDGVFGCMSLIACHDTCPKELPLQSSIATLRNRMLK
VGKSR
>Mature_244_residues
GDNERTIIVRVLKFDPQSTVSKPHFKEYQLKETPSMTLFIALNLIREHQDPDLSFDFVCRAGICGSCAMMVNGRPRLACK
TLTSSFESGVITLMPMPSFTLIKDLSVNTGDWFLDMTKRVESWAHSKEEVDITKPEKRIEPDEAQEVFELDRCIECGCCI
ASCGTKLMRPNFIGAAGMNRVMRFMIDSHDGRSDDDFYELVGDDDGVFGCMSLIACHDTCPKELPLQSSIATLRNRMLKV
GKSR

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=229, Percent_Identity=30.1310043668122, Blast_Score=109, Evalue=2e-24,
Organism=Escherichia coli, GI1790596, Length=231, Percent_Identity=29.004329004329, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786943, Length=234, Percent_Identity=30.3418803418803, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17533915, Length=234, Percent_Identity=27.3504273504274, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322987, Length=236, Percent_Identity=29.2372881355932, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17137106, Length=233, Percent_Identity=30.0429184549356, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24643156, Length=225, Percent_Identity=29.3333333333333, Blast_Score=104, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27581; Mature: 27450

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
10.2 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
9.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDNERTIIVRVLKFDPQSTVSKPHFKEYQLKETPSMTLFIALNLIREHQDPDLSFDFVC
CCCCCEEEEEEEEECCCHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCHHHHH
RAGICGSCAMMVNGRPRLACKTLTSSFESGVITLMPMPSFTLIKDLSVNTGDWFLDMTKR
HCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCCCHHHHHHHHH
VESWAHSKEEVDITKPEKRIEPDEAQEVFELDRCIECGCCIASCGTKLMRPNFIGAAGMN
HHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHH
RVMRFMIDSHDGRSDDDFYELVGDDDGVFGCMSLIACHDTCPKELPLQSSIATLRNRMLK
HHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
VGKSR
HCCCC
>Mature Secondary Structure 
GDNERTIIVRVLKFDPQSTVSKPHFKEYQLKETPSMTLFIALNLIREHQDPDLSFDFVC
CCCCEEEEEEEEECCCHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCHHHHH
RAGICGSCAMMVNGRPRLACKTLTSSFESGVITLMPMPSFTLIKDLSVNTGDWFLDMTKR
HCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCCCHHHHHHHHH
VESWAHSKEEVDITKPEKRIEPDEAQEVFELDRCIECGCCIASCGTKLMRPNFIGAAGMN
HHHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHH
RVMRFMIDSHDGRSDDDFYELVGDDDGVFGCMSLIACHDTCPKELPLQSSIATLRNRMLK
HHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
VGKSR
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]