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The map label for this gene is ppiC [C]

Identifier: 109946965

GI number: 109946965

Start: 301924

End: 302820

Strand: Direct

Name: ppiC [C]

Synonym: Hac_0356

Alternate gene names: 109946965

Gene position: 301924-302820 (Clockwise)

Preceding gene: 109946953

Following gene: 109946966

Centisome position: 19.43

GC content: 37.68

Gene sequence:

>897_bases
ATGAAAAAAGGTATTTTAAGTTTAGCGTTAATGGGTATGTTGAGTGCATCGTTTTTGGGGGCTAAGCCTGCTCACAACAC
GGCTAATAACAGCAAAAAAACGACTGATGCTTCAGCAGGCGTGTTAGCAACAGTGGATGGCAAGCCCATCACTAAAAGCG
ATTTTGATGCGATCAAGCAACGAAACCCTAATTTTGATTTTGACAAGCTTAAAGAAGAAGAAAAAAAGGCTTTGGTTGAG
CAAGCCATTCGCACTGTGCTTGTGGAAAATGAAGCTAAAACCGAAAAATTGGATAGCACTCCAGAATTTAAGGCGATGAT
TGATGCGGTTAAAAAACAGGCTTTAGTGGAATTTTGGGCTAAAAAACAAGCCGAACAAGTGAAAAAAGTTAAAATTCCAG
AAAAAGAAATGCAAGATTTTTATAACGCCAATAAAGAGCAAATTTTTGTGAAACAAGAAGCGCACGCCAGACATATTTTA
GTGAAAAGCGAAGATGAGGCTAAAAGGATTATTTCTGAAATTGACAAACAGCCAAAGACTAAAAGAGAAGCTAAATTCAT
TGAGTTGGCTAATCGTGATACGATCGATCCTAACAGCAAAAACGCGCAAAATGGTGGCGATTTAGGGAAATTCCAAAAAA
ACCAAATGGCTCCGGATTTTTCTAAAGCCGCTTTTGCCTTAACTCCTGGGAATTACACTAAAACCCCTATTAAAACGGAG
TTTGGTTATCATATTATCTATTTGATCTCCAAAGATAACCCTGTAACTTACACTTACGAGCAAGCTAAACCCACTATTAA
AGGCATGTTGCAAGAAAAGCTTTTCCAAGAGCGCATGAATCAAAAAATTGAGCAACTAAGGAAGCAGGCTAAGATTGTTA
TCAACGATAAATTATGA

Upstream 100 bases:

>100_bases
TATAAAACACTAGAATAGTTAAAAGAGTATAGAATTTTGCTTTAAACTTGCTATAATGTAGTTTTAATGATGACATTTTA
GTAAGGTGGAGAACACACAG

Downstream 100 bases:

>100_bases
GGTGTTGTCATGCTGGTTAGAGGTAATGAAATCTTATTGAAAGCCCATAAGGAAGGTTATGGGGTAGGGGCGTTTAACTT
TGTGAATTTTGAAATGCTAA

Product: peptidyl-prolyl cis-trans isomerase

Products: peptidylproline (omega=0) [C]

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MKKGILSLALMGMLSASFLGAKPAHNTANNSKKTTDASAGVLATVDGKPITKSDFDAIKQRNPNFDFDKLKEEEKKALVE
QAIRTVLVENEAKTEKLDSTPEFKAMIDAVKKQALVEFWAKKQAEQVKKVKIPEKEMQDFYNANKEQIFVKQEAHARHIL
VKSEDEAKRIISEIDKQPKTKREAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGNYTKTPIKTE
FGYHIIYLISKDNPVTYTYEQAKPTIKGMLQEKLFQERMNQKIEQLRKQAKIVINDKL

Sequences:

>Translated_298_residues
MKKGILSLALMGMLSASFLGAKPAHNTANNSKKTTDASAGVLATVDGKPITKSDFDAIKQRNPNFDFDKLKEEEKKALVE
QAIRTVLVENEAKTEKLDSTPEFKAMIDAVKKQALVEFWAKKQAEQVKKVKIPEKEMQDFYNANKEQIFVKQEAHARHIL
VKSEDEAKRIISEIDKQPKTKREAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGNYTKTPIKTE
FGYHIIYLISKDNPVTYTYEQAKPTIKGMLQEKLFQERMNQKIEQLRKQAKIVINDKL
>Mature_298_residues
MKKGILSLALMGMLSASFLGAKPAHNTANNSKKTTDASAGVLATVDGKPITKSDFDAIKQRNPNFDFDKLKEEEKKALVE
QAIRTVLVENEAKTEKLDSTPEFKAMIDAVKKQALVEFWAKKQAEQVKKVKIPEKEMQDFYNANKEQIFVKQEAHARHIL
VKSEDEAKRIISEIDKQPKTKREAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGNYTKTPIKTE
FGYHIIYLISKDNPVTYTYEQAKPTIKGMLQEKLFQERMNQKIEQLRKQAKIVINDKL

Specific function: Ppiases Accelerate The Folding Of Proteins. It Prefers Amino Acid Residues With Hydrophobic Side Chains Like Leucine And Phenylalanine In The P1 Position Of The Peptides Substrates. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 33778; Mature: 33778

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGILSLALMGMLSASFLGAKPAHNTANNSKKTTDASAGVLATVDGKPITKSDFDAIKQ
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHH
RNPNFDFDKLKEEEKKALVEQAIRTVLVENEAKTEKLDSTPEFKAMIDAVKKQALVEFWA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
KKQAEQVKKVKIPEKEMQDFYNANKEQIFVKQEAHARHILVKSEDEAKRIISEIDKQPKT
HHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHCCCCH
KREAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGNYTKTPIKTE
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHCCEEEECCCCCCCCCCEEC
FGYHIIYLISKDNPVTYTYEQAKPTIKGMLQEKLFQERMNQKIEQLRKQAKIVINDKL
CCEEEEEEEECCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCC
>Mature Secondary Structure
MKKGILSLALMGMLSASFLGAKPAHNTANNSKKTTDASAGVLATVDGKPITKSDFDAIKQ
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHH
RNPNFDFDKLKEEEKKALVEQAIRTVLVENEAKTEKLDSTPEFKAMIDAVKKQALVEFWA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
KKQAEQVKKVKIPEKEMQDFYNANKEQIFVKQEAHARHILVKSEDEAKRIISEIDKQPKT
HHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHCCCCH
KREAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGNYTKTPIKTE
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHCCEEEECCCCCCCCCCEEC
FGYHIIYLISKDNPVTYTYEQAKPTIKGMLQEKLFQERMNQKIEQLRKQAKIVINDKL
CCEEEEEEEECCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]