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The map label for this gene is lldP [H]

Identifier: 109946933

GI number: 109946933

Start: 273222

End: 274868

Strand: Direct

Name: lldP [H]

Synonym: Hac_0321

Alternate gene names: 109946933

Gene position: 273222-274868 (Clockwise)

Preceding gene: 109946927

Following gene: 109946937

Centisome position: 17.58

GC content: 42.81

Gene sequence:

>1647_bases
ATGGAATTTCATCAAATCTATGACCCATTAGGCAATATTTGGATGAGTGCTCTAGTTGCACTCTCGCCTATTGCACTCTT
TTTTGTCTCTCTTATTGTCTTTAAGCTTAAGGGGTATAGTGCTGGGTTTTTGAGTTTGGCACTTTCAGTGTTGATCGCGC
TATTTGTGTATAAAATGCCTACTGAAATGGTGAGCACGAGTTTTATTTATGGCTTTCTCTATGGCTTATGGCCGATCGCT
TGGATCGTGATCGCTGCGATTTTTCTTTACAACCTTTCAGTGAAATCCGGGTATTTTGAGATTTTAAAAGAAAGCATCTT
AAGTTTGACCCCAGATCATCGCATTTTAGTGATTTTGATTGGCTTTTGTTTTGGCTCGTTTTTAGAAGGAGCGATTGGTT
TTGGAGGTCCAGTAGCAATCACAGCAGCGATTTTAGTAGGTCTTGGGCTAAACCCTTTATACGCTGCTGGGTTATGCTTA
ATCGCTAATACCGCCCCTGTGGCTTTTGGTGCGGTGGGTATCCCTATTACCGCTATGGCTAGTGTGGTGGGTGTCCCTGA
ATTAGAGATTTCTCAAATGGTGGGCAGGGTGTTGCCCATTTTTTCTATTGGCATTCCTTTTTTCATCGTGTTTTTAATGG
ATGGTTTTAAGGGCGTTAGAGAAACCTTTCCGGCGGTGGCGGTTACTGGGTTTAGCTTTGCTATCGTGCAATTTTTAAGC
TCTAATTATTTGGGACCACAACTCCCAGATATTATTTCAGCTTTAGTGTCATTGATTGCTACCACTTTATTTTTAAAGTT
TTGGCAACCTAAAAATATTTTCACTAGCAATGGCAAAGAGCCTACGATTAGCACAGAAAAACACCATATTTGCAAGGTGA
TCGTGGCGTGGATGCCTTTTGTGTTGCTCACTATCACGATTATTATATGGACGCAACCTTGGTTTAAAGCGCTCTTTAAA
GAAGGTGGGGCTTTGGCGTTTTCTAGCTTTGCGTTTGAATTCAGTTCTATCAGTCAAAAGATTTTCAAAACCGCTCCCAT
CGTCGCTGAAGCGAAAAGTTTTCCTGTCGTGTTTAAATTACCTTTAATCTTAACGACAGGCACTTCCATCTTTTTAGCCG
CCATTTTGAGCGTGTTTATTTTGCGCGTGAAAATCAGCGATGCAATAGGGGTGTTTGGGACCACTTTAAAAGAAATGCGT
TTGCCGATTTTAACCATTGGCGTGGTCTTGGCGTTTGCGTATGTGGCTAATTATAGTGGCATGAGCGCTACTTTAGCGTT
GGCGTTAGCCGATACTGGGCATGTTTTCACTTTCTTTTCGCCTGTTGTAGGCTGGCTTGGAGTGTTTTTAACCGGAAGCG
ATACGAGCTCCAACCTTTTATTTGGCTCTTTGCAAATGCTCATCGCCACACAGCTTGGCTTGCCTGAAGTGCTTTTCTTG
GCGGCAAACACTTCAGGAGGCGTTGTGGGTAAAATGATAAGCCCTCAAAGTATCGCTATCGCTTGTGCGGCGGTGGGGTT
AGTGGGTAAAGAGAGCGAATTGTTCAAATTCACGGTTAAATATTCCCTTGTTTTTGTAGTAATCATGGGAGTTGTGTTCA
GCGCGATTGCGTATTTGATCCCTGAAGTGGTGCCTGCGATAAAGTAG

Upstream 100 bases:

>100_bases
TACAAATCTGCTCAACCCCACTTAATATTAAACGCTACTCAAAATTAGTTTTTCTTTTAAGTAAGATATAAAAATACTTT
TAATCATTCAAGGAAAATGC

Downstream 100 bases:

>100_bases
GCTCGCTTTGTATTTGGCAAGAATTAAACCCCCTTTGAGTGGGGAATGTTGAAAAATAAAGCGGATCTAAATTGAGCCAT
TCTTTAGAATGCTGGTTGGA

Product: hypothetical protein

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MEFHQIYDPLGNIWMSALVALSPIALFFVSLIVFKLKGYSAGFLSLALSVLIALFVYKMPTEMVSTSFIYGFLYGLWPIA
WIVIAAIFLYNLSVKSGYFEILKESILSLTPDHRILVILIGFCFGSFLEGAIGFGGPVAITAAILVGLGLNPLYAAGLCL
IANTAPVAFGAVGIPITAMASVVGVPELEISQMVGRVLPIFSIGIPFFIVFLMDGFKGVRETFPAVAVTGFSFAIVQFLS
SNYLGPQLPDIISALVSLIATTLFLKFWQPKNIFTSNGKEPTISTEKHHICKVIVAWMPFVLLTITIIIWTQPWFKALFK
EGGALAFSSFAFEFSSISQKIFKTAPIVAEAKSFPVVFKLPLILTTGTSIFLAAILSVFILRVKISDAIGVFGTTLKEMR
LPILTIGVVLAFAYVANYSGMSATLALALADTGHVFTFFSPVVGWLGVFLTGSDTSSNLLFGSLQMLIATQLGLPEVLFL
AANTSGGVVGKMISPQSIAIACAAVGLVGKESELFKFTVKYSLVFVVIMGVVFSAIAYLIPEVVPAIK

Sequences:

>Translated_548_residues
MEFHQIYDPLGNIWMSALVALSPIALFFVSLIVFKLKGYSAGFLSLALSVLIALFVYKMPTEMVSTSFIYGFLYGLWPIA
WIVIAAIFLYNLSVKSGYFEILKESILSLTPDHRILVILIGFCFGSFLEGAIGFGGPVAITAAILVGLGLNPLYAAGLCL
IANTAPVAFGAVGIPITAMASVVGVPELEISQMVGRVLPIFSIGIPFFIVFLMDGFKGVRETFPAVAVTGFSFAIVQFLS
SNYLGPQLPDIISALVSLIATTLFLKFWQPKNIFTSNGKEPTISTEKHHICKVIVAWMPFVLLTITIIIWTQPWFKALFK
EGGALAFSSFAFEFSSISQKIFKTAPIVAEAKSFPVVFKLPLILTTGTSIFLAAILSVFILRVKISDAIGVFGTTLKEMR
LPILTIGVVLAFAYVANYSGMSATLALALADTGHVFTFFSPVVGWLGVFLTGSDTSSNLLFGSLQMLIATQLGLPEVLFL
AANTSGGVVGKMISPQSIAIACAAVGLVGKESELFKFTVKYSLVFVVIMGVVFSAIAYLIPEVVPAIK
>Mature_548_residues
MEFHQIYDPLGNIWMSALVALSPIALFFVSLIVFKLKGYSAGFLSLALSVLIALFVYKMPTEMVSTSFIYGFLYGLWPIA
WIVIAAIFLYNLSVKSGYFEILKESILSLTPDHRILVILIGFCFGSFLEGAIGFGGPVAITAAILVGLGLNPLYAAGLCL
IANTAPVAFGAVGIPITAMASVVGVPELEISQMVGRVLPIFSIGIPFFIVFLMDGFKGVRETFPAVAVTGFSFAIVQFLS
SNYLGPQLPDIISALVSLIATTLFLKFWQPKNIFTSNGKEPTISTEKHHICKVIVAWMPFVLLTITIIIWTQPWFKALFK
EGGALAFSSFAFEFSSISQKIFKTAPIVAEAKSFPVVFKLPLILTTGTSIFLAAILSVFILRVKISDAIGVFGTTLKEMR
LPILTIGVVLAFAYVANYSGMSATLALALADTGHVFTFFSPVVGWLGVFLTGSDTSSNLLFGSLQMLIATQLGLPEVLFL
AANTSGGVVGKMISPQSIAIACAAVGLVGKESELFKFTVKYSLVFVVIMGVVFSAIAYLIPEVVPAIK

Specific function: Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=548, Percent_Identity=56.7518248175182, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI1789347, Length=552, Percent_Identity=55.2536231884058, Blast_Score=570, Evalue=1e-164,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 58868; Mature: 58868

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCC
>Mature Secondary Structure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HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]