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The map label for this gene is panC

Identifier: 109946876

GI number: 109946876

Start: 213501

End: 214331

Strand: Direct

Name: panC

Synonym: Hac_0259

Alternate gene names: 109946876

Gene position: 213501-214331 (Clockwise)

Preceding gene: 109946875

Following gene: 109946880

Centisome position: 13.74

GC content: 38.51

Gene sequence:

>831_bases
ATGCAAGTTTTAGAAACGATTTCTGATTTAAGAGAATATCGTAAAAATGTAAAAGAAAGCGTTGGTTTTGTGCCGACTAT
GGGAGCCTTACACAAAGGGCATCAAAGCTTGATAGAAAGGAGTTTGAAAGAAAATTTTCACACGATTACGAGCGTTTTTG
TCAATCCCACGCAATTTGGAGCTAATGAAGATTTTAGTGCTTATCCGCGTCCTTTAGAAAAGGATTTGGCTTTATGCGAA
AAATTAGGCGTTGATGTGGTGTTTGTGCCTAAAATTAGCGAGATGTATCCTTACAAATCAGAGCAACGCTTAAAACTTTA
TGCCCCTAAATTTTTATCCCATTCTTTAGAAGGAGCGATGCGTAAGGGGCATTTTGATGGCGTCGCTCAAGTCGTGTTAA
GGTTGTTTCATCTTGTCAATCCCACTAGAGCGTATTTTGGTAAAAAGGACGCCCAACAGCTTTTAATCATTCAGCATTTA
GTCAAAGATTTGCTTTTAGACATTGAAATAGTGCCATGCGAAATTGTGCGCGATAGCGATCATTTAGCTTTAAGCTCTAG
GAATGTGTATTTGAATGCAGTAGAAAGAAAACAAGCCCTAGCGATCCCAAAAGCTTTAGAAAATATCCAGCAAGCCATAG
ACATGGGTGAAAAAGCGTGCGAAATGCTCAAAAAAATAGGGCTTGAAATTTTAAAAAATTTAGAAGTGGATTATTTGGAG
TTTTGTAACCACAAACTAGAGCCTTTAAAGATCATAGAGCCAACTAACACGCTCATTTTAGTGGCGGCTCGTGCGGGCAA
AACAAGGCTTTTAGACAATTTATGGGTGTAG

Upstream 100 bases:

>100_bases
CTAAACAAAATTTAAGCGATTTTATCGTGGTGGGCCGCCCCATTTACCAAGCTAAAGAGCCTAGAGAAGTGGCTTTAGAG
CTTTTAAAGGATTGTTGAGA

Downstream 100 bases:

>100_bases
TTAAAATTTTGTTTTTGGGGTTAAAATAGCTTATTATCCCCACCAATAGCTAACAAAACGCATGGCGTTTATTTTGAGAT
GATACCATTAAACACAGCCA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MQVLETISDLREYRKNVKESVGFVPTMGALHKGHQSLIERSLKENFHTITSVFVNPTQFGANEDFSAYPRPLEKDLALCE
KLGVDVVFVPKISEMYPYKSEQRLKLYAPKFLSHSLEGAMRKGHFDGVAQVVLRLFHLVNPTRAYFGKKDAQQLLIIQHL
VKDLLLDIEIVPCEIVRDSDHLALSSRNVYLNAVERKQALAIPKALENIQQAIDMGEKACEMLKKIGLEILKNLEVDYLE
FCNHKLEPLKIIEPTNTLILVAARAGKTRLLDNLWV

Sequences:

>Translated_276_residues
MQVLETISDLREYRKNVKESVGFVPTMGALHKGHQSLIERSLKENFHTITSVFVNPTQFGANEDFSAYPRPLEKDLALCE
KLGVDVVFVPKISEMYPYKSEQRLKLYAPKFLSHSLEGAMRKGHFDGVAQVVLRLFHLVNPTRAYFGKKDAQQLLIIQHL
VKDLLLDIEIVPCEIVRDSDHLALSSRNVYLNAVERKQALAIPKALENIQQAIDMGEKACEMLKKIGLEILKNLEVDYLE
FCNHKLEPLKIIEPTNTLILVAARAGKTRLLDNLWV
>Mature_276_residues
MQVLETISDLREYRKNVKESVGFVPTMGALHKGHQSLIERSLKENFHTITSVFVNPTQFGANEDFSAYPRPLEKDLALCE
KLGVDVVFVPKISEMYPYKSEQRLKLYAPKFLSHSLEGAMRKGHFDGVAQVVLRLFHLVNPTRAYFGKKDAQQLLIIQHL
VKDLLLDIEIVPCEIVRDSDHLALSSRNVYLNAVERKQALAIPKALENIQQAIDMGEKACEMLKKIGLEILKNLEVDYLE
FCNHKLEPLKIIEPTNTLILVAARAGKTRLLDNLWV

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=285, Percent_Identity=40.7017543859649, Blast_Score=183, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322046, Length=224, Percent_Identity=41.0714285714286, Blast_Score=170, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_HELAH (Q17Z21)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664104.1
- ProteinModelPortal:   Q17Z21
- SMR:   Q17Z21
- STRING:   Q17Z21
- GeneID:   4177337
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0259
- NMPDR:   fig|382638.8.peg.250
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   Q17Z21
- ProtClustDB:   PRK00380
- BioCyc:   HACI382638:HAC_0259-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31417; Mature: 31417

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: NA

Important sites: ACT_SITE 34-34 BINDING 58-58 BINDING 58-58 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVLETISDLREYRKNVKESVGFVPTMGALHKGHQSLIERSLKENFHTITSVFVNPTQFG
CCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCC
ANEDFSAYPRPLEKDLALCEKLGVDVVFVPKISEMYPYKSEQRLKLYAPKFLSHSLEGAM
CCCCCCCCCCCHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
RKGHFDGVAQVVLRLFHLVNPTRAYFGKKDAQQLLIIQHLVKDLLLDIEIVPCEIVRDSD
HCCCHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEECHHEEECCC
HLALSSRNVYLNAVERKQALAIPKALENIQQAIDMGEKACEMLKKIGLEILKNLEVDYLE
CEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHH
FCNHKLEPLKIIEPTNTLILVAARAGKTRLLDNLWV
HCCCCCCCEEEECCCCEEEEEEECCCCHHHHHHCCC
>Mature Secondary Structure
MQVLETISDLREYRKNVKESVGFVPTMGALHKGHQSLIERSLKENFHTITSVFVNPTQFG
CCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCC
ANEDFSAYPRPLEKDLALCEKLGVDVVFVPKISEMYPYKSEQRLKLYAPKFLSHSLEGAM
CCCCCCCCCCCHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
RKGHFDGVAQVVLRLFHLVNPTRAYFGKKDAQQLLIIQHLVKDLLLDIEIVPCEIVRDSD
HCCCHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEECHHEEECCC
HLALSSRNVYLNAVERKQALAIPKALENIQQAIDMGEKACEMLKKIGLEILKNLEVDYLE
CEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHH
FCNHKLEPLKIIEPTNTLILVAARAGKTRLLDNLWV
HCCCCCCCEEEECCCCEEEEEEECCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA