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The map label for this gene is fumC [H]

Identifier: 109946754

GI number: 109946754

Start: 119764

End: 121155

Strand: Direct

Name: fumC [H]

Synonym: Hac_0131

Alternate gene names: 109946754

Gene position: 119764-121155 (Clockwise)

Preceding gene: 109946753

Following gene: 109946755

Centisome position: 7.71

GC content: 41.95

Gene sequence:

>1392_bases
ATGCAATTTAGAATCGAACATGACACGATGGGCGAAATTCAAGTAGATGACAGCAAATACTGGGGGGCTCAAACGCAACG
CAGCTTTGAAAACTTTAAAATCGGCACTGAAAGAATGCCTAAAGAGCTGATTGGCGCGTTTGCAAAGCTTAAAAGAAGTT
TAGCGGTAGTCAATCACAAGTTAGGAAAATTGAGTCTAGAAAAATCGCAAGCCATTATCAAGGCGTGCGATTGCATTTTA
AAAGGTGAGTTGTGCGGCGAATTCCCTTTAGTGATATGGCAAACAGGGAGTGGGACTCAAACGAACATGAATCTCAATGA
AGTCATTGCCAATAAGGCTACCGAAATTTTAGGGGGTAATTTTAGAGAGAAAAAACTCATCCACCCTAACGATGATGTGA
ATATGTCCCAAAGCTCTAACGACACTTTCCCTACCGCAATGCATATTGTGAGCGTGCTAGAAATCACGCATAAACTGCTC
CCTAGTTTGGAGAATTTGTTAAAAACCTTTAAAGAAAAAAGCCAACAATTTAAAGAGATTGTCAAAATTGGGCGCACGCA
TTTACAAGACGCCACGCCTTTAACTTTGGGGCAAGAATTTAGCGGTTATGCGAGCATGCTAGAGCATTCTAAACAACAAA
TTTTAGAGAGTTTGGAGCATTTAAGAGAGCTAGCCATAGGTGGGACTGCCGTAGGTACCGGACTAAACGCTCATAAAGAA
TTGAGCGAAAAAGTGGCTGAAGAATTGAGCCAATTTAGTGGGGTGAAATTTATCTCTGCACCTAATAAATTCCACGCTCT
CACTAGCCATGACGCTATCGCTTATGCACATGGGGCTCTTAAAGCTTTGGCGGCGAATTTGATGAAAATCGCTAACGATA
TTAGATGGCTTGCGAGTGGGCCGCGCTGTGGTTTGGGCGAGCTGAATATCCCTGAAAACGAGCCAGGTAGCTCTATTATG
CCCGGTAAAGTCAATCCCACGCAATGCGAAGCGATGACAATGGTAGCCGTGCAGGTGATGGGGAATGATACCGCTATTGG
TGTTGCAGCCAGTCAGGGTAATTTTGAATTGAATGTTTTTAAGCCGGTGATTATTTATAATTTCTTGCAAAGTTTAAGGC
TGCTAAGCGATAGCATGGAAAGTTTTAATATCCATTGCGCGAGTGGCATTGAACCTAATAGAGAAAAAATTGATTATTAC
TTGCATCATTCTTTAATGCTAGTAACCGCTCTCAACCCGCATGTAGGCTATGAAAACGCCGCTAAAATCGCTAAAAACGC
CCACAAAAAAGGCATTTCTTTAAAAGAAAGTGCAGTGGAATTGAAGCTATTGAGCGCTGAAGATTTTGACAAATTCGTAG
TGCCTGAAAAAATGATTGGACCTAAGGTTTGA

Upstream 100 bases:

>100_bases
GTGTTTTAAAGAAGTTGAAAAAAATGGCGTTTTTAAGTAGAAGGTATAGGAGTTTATGCTATTTTTTTAAGGTTTTAAAA
TCAAATTTCAAAGGATTAGC

Downstream 100 bases:

>100_bases
AAACCTTGGGTGGGGGAGTTAGATTTTAGCAAGATTAAGGTTTTTGCATGGCAGATGAAGAAAAAATTAAAACAGAAAGA
GAGTCTTACTTTTTAAAATC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MQFRIEHDTMGEIQVDDSKYWGAQTQRSFENFKIGTERMPKELIGAFAKLKRSLAVVNHKLGKLSLEKSQAIIKACDCIL
KGELCGEFPLVIWQTGSGTQTNMNLNEVIANKATEILGGNFREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITHKLL
PSLENLLKTFKEKSQQFKEIVKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGALKALAANLMKIANDIRWLASGPRCGLGELNIPENEPGSSIM
PGKVNPTQCEAMTMVAVQVMGNDTAIGVAASQGNFELNVFKPVIIYNFLQSLRLLSDSMESFNIHCASGIEPNREKIDYY
LHHSLMLVTALNPHVGYENAAKIAKNAHKKGISLKESAVELKLLSAEDFDKFVVPEKMIGPKV

Sequences:

>Translated_463_residues
MQFRIEHDTMGEIQVDDSKYWGAQTQRSFENFKIGTERMPKELIGAFAKLKRSLAVVNHKLGKLSLEKSQAIIKACDCIL
KGELCGEFPLVIWQTGSGTQTNMNLNEVIANKATEILGGNFREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITHKLL
PSLENLLKTFKEKSQQFKEIVKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGALKALAANLMKIANDIRWLASGPRCGLGELNIPENEPGSSIM
PGKVNPTQCEAMTMVAVQVMGNDTAIGVAASQGNFELNVFKPVIIYNFLQSLRLLSDSMESFNIHCASGIEPNREKIDYY
LHHSLMLVTALNPHVGYENAAKIAKNAHKKGISLKESAVELKLLSAEDFDKFVVPEKMIGPKV
>Mature_463_residues
MQFRIEHDTMGEIQVDDSKYWGAQTQRSFENFKIGTERMPKELIGAFAKLKRSLAVVNHKLGKLSLEKSQAIIKACDCIL
KGELCGEFPLVIWQTGSGTQTNMNLNEVIANKATEILGGNFREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITHKLL
PSLENLLKTFKEKSQQFKEIVKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGALKALAANLMKIANDIRWLASGPRCGLGELNIPENEPGSSIM
PGKVNPTQCEAMTMVAVQVMGNDTAIGVAASQGNFELNVFKPVIIYNFLQSLRLLSDSMESFNIHCASGIEPNREKIDYY
LHHSLMLVTALNPHVGYENAAKIAKNAHKKGISLKESAVELKLLSAEDFDKFVVPEKMIGPKV

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=59.0909090909091, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=55.5555555555556, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=63.019693654267, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI87082375, Length=462, Percent_Identity=37.6623376623377, Blast_Score=320, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=58.963282937365, Blast_Score=562, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=60.6707317073171, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=60.6060606060606, Blast_Score=561, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=56.8965517241379, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=56.8965517241379, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=55.8189655172414, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=54.6236559139785, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=48.8120950323974, Blast_Score=458, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 51018; Mature: 51018

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFRIEHDTMGEIQVDDSKYWGAQTQRSFENFKIGTERMPKELIGAFAKLKRSLAVVNHK
CCEEECCCCCCCEEECCCCCCCCHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHH
LGKLSLEKSQAIIKACDCILKGELCGEFPLVIWQTGSGTQTNMNLNEVIANKATEILGGN
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
FREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITHKLLPSLENLLKTFKEKSQQFKEI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHH
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGALKALAANLMKIANDIRWLASG
HHHHHHHHHHHHCCCEEEECCCHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGLGELNIPENEPGSSIMPGKVNPTQCEAMTMVAVQVMGNDTAIGVAASQGNFELNVF
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEEH
KPVIIYNFLQSLRLLSDSMESFNIHCASGIEPNREKIDYYLHHSLMLVTALNPHVGYENA
HHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHEEEECCCCCCCHHH
AKIAKNAHKKGISLKESAVELKLLSAEDFDKFVVPEKMIGPKV
HHHHHHHHHCCCCHHHHHHEEEEECCCCCCHHCCCHHHCCCCC
>Mature Secondary Structure
MQFRIEHDTMGEIQVDDSKYWGAQTQRSFENFKIGTERMPKELIGAFAKLKRSLAVVNHK
CCEEECCCCCCCEEECCCCCCCCHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHH
LGKLSLEKSQAIIKACDCILKGELCGEFPLVIWQTGSGTQTNMNLNEVIANKATEILGGN
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
FREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITHKLLPSLENLLKTFKEKSQQFKEI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHH
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGALKALAANLMKIANDIRWLASG
HHHHHHHHHHHHCCCEEEECCCHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGLGELNIPENEPGSSIMPGKVNPTQCEAMTMVAVQVMGNDTAIGVAASQGNFELNVF
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEEH
KPVIIYNFLQSLRLLSDSMESFNIHCASGIEPNREKIDYYLHHSLMLVTALNPHVGYENA
HHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHEEEECCCCCCCHHH
AKIAKNAHKKGISLKESAVELKLLSAEDFDKFVVPEKMIGPKV
HHHHHHHHHCCCCHHHHHHEEEEECCCCCCHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]