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The map label for this gene is gltS [H]

Identifier: 109946710

GI number: 109946710

Start: 76679

End: 77905

Strand: Direct

Name: gltS [H]

Synonym: Hac_0078

Alternate gene names: 109946710

Gene position: 76679-77905 (Clockwise)

Preceding gene: 109946708

Following gene: 109946711

Centisome position: 4.93

GC content: 42.05

Gene sequence:

>1227_bases
TTGCAAGAAATTAAATTAGACATTTATGCCACTTTGGTGTGCATGGTTTTAGTGTTGCTTTTGGGGCGTTATGTGATTTC
TAAAGTCAAGTTTTTACGAGATTATGATATTCCAGAACCTGTTGTGGGTGGGGTTTTGATCGCTTTTTTTATCATGCTAG
CCCACCATTTTTATAATTTTGATTTGCGTTTTGATTCTTCTTTAAAAGATCCTTTGATGCTGACTTTCTTTATCACTATT
GGTTTGAGTGCGGATTTCAAATCTTTACAAAAAGGCGGGAAAATGCTCGCGGTTTTTTTGTTGGTTGTGTCTGGGTTTGT
GGTGTGTCAAAATGTGGTAGGGGTTTCTGTCGCCGGTCTTTTAGGGGTCAATCCTTTAATGGGGCTTTTAGGCGGATCTA
TCGCTTTAGTGGGAGGGCATGGCACTAGTGCGGCATGGGCTAATTTTTTCACCCAACCGCCTTATGATTTTAATTCTAGC
CTAGAAGTGGGCATGGTGTGTGCGACTTTTGGCTTGGTGAGTGGGGGGATTATTGGGGGGCCTGTCGCTAAATATTTGAT
TTCAAGATACAAACTAGAGCCTAAAGACACTAAAGAAAAAGACGCTTTAGAGGGTATTGTGGCTAAAGGTTTTGAAACCC
CTAAAGAGCAACGCTTAATCACCGCATCTAGTTTTGTAGAAACTTTAGCTCTAATTGCGATCGCTTTATTGGTGGGGACT
TTTTTATCGCATTTGATGCCTAAAAGTTTCACCTTGCCCACTTTTGTGTGGTGCTTGTTTATAGGGGTTCTTTTAAGGAA
TGCCTTGTCGTTTTTTAAAATCCATAGCGTGTTTGATAGGGAAGTTTCAGTCATTGGGAATGTGAGCTTGAGCTTGTTTT
TGGCTTACGCTTTAATGAGCGTGAATTTGTTAGAATTATTAAAACTCGCTGTGCCATTGGCGATTATTTTGAGCGTTCAA
GTGGTGTTTATGATCCTTTATGCGGTGTTTGTGACCTTTAGGATTTGTGGGAAGGATTATGATGCGGCGGTGTTGTGTGC
GGGGCATTGCGGTTTTGGGCTTGGAGCGACACCAACAGCTATGGTGAATATGCAAACCATCACCAACCACTATGGGGCGT
CGCATGTGGCGTTTATCGTGGTGCCTTTAGTGGGAGCGTTTTTCATTGACATCATCAACGCTTTGGCGATCAAAGGCTTT
TTGTCCTTACCCTTTTTCCCATCATGA

Upstream 100 bases:

>100_bases
AATACTGTATGCAAGGAACACCTACTTTCTAGCTAATCTCGTTCTTTTAAGTGTCTATTATATTATAATAAGATGAATTG
ATTAACCAAAGGAGACAAGC

Downstream 100 bases:

>100_bases
GACTTTATGAGAGTTTATTAGAAATTTGTTTGAATAAGGCGTGGGAATACCAGACCCTAGCCTTAGAAAACCCAAGTGTG
GCTTGCATGGTGTTAGATAA

Product: sodium/glutamate symport carrier protein

Products: Na (I) [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate permease [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MQEIKLDIYATLVCMVLVLLLGRYVISKVKFLRDYDIPEPVVGGVLIAFFIMLAHHFYNFDLRFDSSLKDPLMLTFFITI
GLSADFKSLQKGGKMLAVFLLVVSGFVVCQNVVGVSVAGLLGVNPLMGLLGGSIALVGGHGTSAAWANFFTQPPYDFNSS
LEVGMVCATFGLVSGGIIGGPVAKYLISRYKLEPKDTKEKDALEGIVAKGFETPKEQRLITASSFVETLALIAIALLVGT
FLSHLMPKSFTLPTFVWCLFIGVLLRNALSFFKIHSVFDREVSVIGNVSLSLFLAYALMSVNLLELLKLAVPLAIILSVQ
VVFMILYAVFVTFRICGKDYDAAVLCAGHCGFGLGATPTAMVNMQTITNHYGASHVAFIVVPLVGAFFIDIINALAIKGF
LSLPFFPS

Sequences:

>Translated_408_residues
MQEIKLDIYATLVCMVLVLLLGRYVISKVKFLRDYDIPEPVVGGVLIAFFIMLAHHFYNFDLRFDSSLKDPLMLTFFITI
GLSADFKSLQKGGKMLAVFLLVVSGFVVCQNVVGVSVAGLLGVNPLMGLLGGSIALVGGHGTSAAWANFFTQPPYDFNSS
LEVGMVCATFGLVSGGIIGGPVAKYLISRYKLEPKDTKEKDALEGIVAKGFETPKEQRLITASSFVETLALIAIALLVGT
FLSHLMPKSFTLPTFVWCLFIGVLLRNALSFFKIHSVFDREVSVIGNVSLSLFLAYALMSVNLLELLKLAVPLAIILSVQ
VVFMILYAVFVTFRICGKDYDAAVLCAGHCGFGLGATPTAMVNMQTITNHYGASHVAFIVVPLVGAFFIDIINALAIKGF
LSLPFFPS
>Mature_408_residues
MQEIKLDIYATLVCMVLVLLLGRYVISKVKFLRDYDIPEPVVGGVLIAFFIMLAHHFYNFDLRFDSSLKDPLMLTFFITI
GLSADFKSLQKGGKMLAVFLLVVSGFVVCQNVVGVSVAGLLGVNPLMGLLGGSIALVGGHGTSAAWANFFTQPPYDFNSS
LEVGMVCATFGLVSGGIIGGPVAKYLISRYKLEPKDTKEKDALEGIVAKGFETPKEQRLITASSFVETLALIAIALLVGT
FLSHLMPKSFTLPTFVWCLFIGVLLRNALSFFKIHSVFDREVSVIGNVSLSLFLAYALMSVNLLELLKLAVPLAIILSVQ
VVFMILYAVFVTFRICGKDYDAAVLCAGHCGFGLGATPTAMVNMQTITNHYGASHVAFIVVPLVGAFFIDIINALAIKGF
LSLPFFPS

Specific function: Catalyzes the sodium-dependent uptake of extracellular glutamate [H]

COG id: COG0786

COG function: function code E; Na+/glutamate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gltS symporter family [H]

Homologues:

Organism=Escherichia coli, GI1790085, Length=386, Percent_Identity=54.9222797927461, Blast_Score=380, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004445 [H]

Pfam domain/function: PF03616 Glt_symporter [H]

EC number: NA

Molecular weight: Translated: 44156; Mature: 44156

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure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HEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + L-glutamate [Periplasm] = Na (I) [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2254324; 2017136; 7686882; 9278503; 1544582 [H]