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The map label for this gene is algA [H]

Identifier: 109946688

GI number: 109946688

Start: 52044

End: 53471

Strand: Direct

Name: algA [H]

Synonym: Hac_0055

Alternate gene names: 109946688

Gene position: 52044-53471 (Clockwise)

Preceding gene: 109946687

Following gene: 109946689

Centisome position: 3.35

GC content: 38.52

Gene sequence:

>1428_bases
ATGACAAGAAAGCCCATGAAAATCAAACATATCTTACTGAGTGGGGGGAGTGGCAAACGCCTATGGCCTTTGAGCCGTAG
CCTATACCCTAAGCAATTTTTAAAGCTTTTTGATCATAAAAGCCTGTTTGAGTTGAGTTTTAAAAGAAACACTCCCTTAG
TAGATGAAACGTTGATCGTGTGCAATGAAAAGCATTATTTTTTAGCCCTAGAAGAAATAGAGGGCGAAATCCAAAATAAA
AGCGTGGGTTTTTTATTGGAGAGTTTGAGTAAAAATACTGCTAATGCCATTAGTTTGAGTGCTTTAATGAGCGATAAAGA
AGATTTGCTCATCGTTACGCCAAGCGATCATTTGATTAAAGACATTCAAGCGTATGAAAATGCGATGCAAAAAGCGATTG
ATTTAGCCAAAAAAGGCTTTTTAGTTACTTTTGGCGTGAGCATTGAAAAGCCTAACACGGAGTTTGGGTATATTGAAAGT
CCTAACGCTTTAGATGTCAAACGATTCATTGAAAAGCCAAGGTTAGAAAAAGCGATAGAGTTCCAACAAAATGGAGGGTT
TTATTTCAATAGTGGCATGTTTGTTTTTCAAGCGGGCGTTTTTTTAGAGGAATTGAAAAAACATGCCCCTAATGTTTTAA
AGGGGTGTGAAAGGGCGTTTGAATCGCTAGAAAACACGCATTTTTTTGGCAAAAAGATTGCACGCTTGAGTGTGGAGAGC
ATGCAAGATCTAGAGGATGTGAGCGTTGATATAGCCTTAATGCAACAAAGCCATAAAATCAAAATGGTAGAATTGAACGC
TAAGTGGAGCGATTTAGGGAATTTTAACGCTCTTTTTGAAGAAACAGCTAACGGATCTAAAGAAAATGTCAGCTTGAATC
AAACGCCCGTTTTTGCTAAAGAAAGCGAGAATAATTTAATCTTTTCTCATAAAGTCAGCGCTCTTTTAGGGGTTGGGAAT
TTAGCGATCATTGACACTAAAGACGCTCTTTTAGTCGCCCATAAAGACAAGGCTAAGGATTTAAAAGCTTTAGTGGGCGA
GATAGAAACACACAACCAGGAATTATTGCAAACGCACACTAAAGTGTATCGCCCTTGGGGGAGTTATGAAGTCTTGCATG
AGAGCGGTTGCTATAAGGTTAAGATTTTAGAAGTCAAACCAAACGCTAGGCTTTCTTTACAAAAGCATTTCCATAGGAGC
GAACATTGGGTGGTGATTAGTGGGATGGCGAGCGTGGAATTAGATTATCAATTGTTTGAATTGCAAGCCAATGAATCCAC
TTATATCCCTAAAAACACCTTGCACCGCTTGGCTAATTATGGCAAAATCCCTTTAATTATCATAGAAGTCCAAGTGGGCG
AGTATGTCGGTGAAGACGATATTGTAAGGGTTGATGATGATTTTAACAGACAAAATCCGAGTAAATAA

Upstream 100 bases:

>100_bases
TTCTTCCCTATACCCAGAGACAATGAAGTCATCGCTGAGTTTTTGAAGTGATAAATGCTGTGTTAAAAACGCTATAATAA
CCCTAAAAGCAAAAGAGAGC

Downstream 100 bases:

>100_bases
AGGACAATAATGAAAGAAAAAATCGCTTTAATCACTGGGGTTACCGGTCAAGATGGGAGCTATCTGACTGAATACTTGCT
GAATTTAGGCTATGAAGTGC

Product: mannose-6-phosphate isomerase / mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MTRKPMKIKHILLSGGSGKRLWPLSRSLYPKQFLKLFDHKSLFELSFKRNTPLVDETLIVCNEKHYFLALEEIEGEIQNK
SVGFLLESLSKNTANAISLSALMSDKEDLLIVTPSDHLIKDIQAYENAMQKAIDLAKKGFLVTFGVSIEKPNTEFGYIES
PNALDVKRFIEKPRLEKAIEFQQNGGFYFNSGMFVFQAGVFLEELKKHAPNVLKGCERAFESLENTHFFGKKIARLSVES
MQDLEDVSVDIALMQQSHKIKMVELNAKWSDLGNFNALFEETANGSKENVSLNQTPVFAKESENNLIFSHKVSALLGVGN
LAIIDTKDALLVAHKDKAKDLKALVGEIETHNQELLQTHTKVYRPWGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRS
EHWVVISGMASVELDYQLFELQANESTYIPKNTLHRLANYGKIPLIIIEVQVGEYVGEDDIVRVDDDFNRQNPSK

Sequences:

>Translated_475_residues
MTRKPMKIKHILLSGGSGKRLWPLSRSLYPKQFLKLFDHKSLFELSFKRNTPLVDETLIVCNEKHYFLALEEIEGEIQNK
SVGFLLESLSKNTANAISLSALMSDKEDLLIVTPSDHLIKDIQAYENAMQKAIDLAKKGFLVTFGVSIEKPNTEFGYIES
PNALDVKRFIEKPRLEKAIEFQQNGGFYFNSGMFVFQAGVFLEELKKHAPNVLKGCERAFESLENTHFFGKKIARLSVES
MQDLEDVSVDIALMQQSHKIKMVELNAKWSDLGNFNALFEETANGSKENVSLNQTPVFAKESENNLIFSHKVSALLGVGN
LAIIDTKDALLVAHKDKAKDLKALVGEIETHNQELLQTHTKVYRPWGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRS
EHWVVISGMASVELDYQLFELQANESTYIPKNTLHRLANYGKIPLIIIEVQVGEYVGEDDIVRVDDDFNRQNPSK
>Mature_474_residues
TRKPMKIKHILLSGGSGKRLWPLSRSLYPKQFLKLFDHKSLFELSFKRNTPLVDETLIVCNEKHYFLALEEIEGEIQNKS
VGFLLESLSKNTANAISLSALMSDKEDLLIVTPSDHLIKDIQAYENAMQKAIDLAKKGFLVTFGVSIEKPNTEFGYIESP
NALDVKRFIEKPRLEKAIEFQQNGGFYFNSGMFVFQAGVFLEELKKHAPNVLKGCERAFESLENTHFFGKKIARLSVESM
QDLEDVSVDIALMQQSHKIKMVELNAKWSDLGNFNALFEETANGSKENVSLNQTPVFAKESENNLIFSHKVSALLGVGNL
AIIDTKDALLVAHKDKAKDLKALVGEIETHNQELLQTHTKVYRPWGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRSE
HWVVISGMASVELDYQLFELQANESTYIPKNTLHRLANYGKIPLIIIEVQVGEYVGEDDIVRVDDDFNRQNPSK

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=480, Percent_Identity=37.5, Blast_Score=329, Evalue=3e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 53915; Mature: 53784

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRKPMKIKHILLSGGSGKRLWPLSRSLYPKQFLKLFDHKSLFELSFKRNTPLVDETLIV
CCCCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEE
CNEKHYFLALEEIEGEIQNKSVGFLLESLSKNTANAISLSALMSDKEDLLIVTPSDHLIK
ECCCEEEEEEEHHCCCCCCCHHHHHHHHHCCCCCHHEEHHHHHCCCCCEEEECCCHHHHH
DIQAYENAMQKAIDLAKKGFLVTFGVSIEKPNTEFGYIESPNALDVKRFIEKPRLEKAIE
HHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCEECCCCCHHHHHHHCCCCHHHHHH
FQQNGGFYFNSGMFVFQAGVFLEELKKHAPNVLKGCERAFESLENTHFFGKKIARLSVES
HHCCCCEEEECCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
MQDLEDVSVDIALMQQSHKIKMVELNAKWSDLGNFNALFEETANGSKENVSLNQTPVFAK
HHHHHHHCEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCEECCCCCEEEE
ESENNLIFSHKVSALLGVGNLAIIDTKDALLVAHKDKAKDLKALVGEIETHNQELLQTHT
CCCCCEEEEEHHHHHHCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHH
KVYRPWGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRSEHWVVISGMASVELDYQLFE
HHHCCCCCEEEEECCCCEEEEEEEECCCCCCHHHHHHCCCCCEEEEECCEEEEEEEEEEE
LQANESTYIPKNTLHRLANYGKIPLIIIEVQVGEYVGEDDIVRVDDDFNRQNPSK
EECCCCCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
TRKPMKIKHILLSGGSGKRLWPLSRSLYPKQFLKLFDHKSLFELSFKRNTPLVDETLIV
CCCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEE
CNEKHYFLALEEIEGEIQNKSVGFLLESLSKNTANAISLSALMSDKEDLLIVTPSDHLIK
ECCCEEEEEEEHHCCCCCCCHHHHHHHHHCCCCCHHEEHHHHHCCCCCEEEECCCHHHHH
DIQAYENAMQKAIDLAKKGFLVTFGVSIEKPNTEFGYIESPNALDVKRFIEKPRLEKAIE
HHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCEECCCCCHHHHHHHCCCCHHHHHH
FQQNGGFYFNSGMFVFQAGVFLEELKKHAPNVLKGCERAFESLENTHFFGKKIARLSVES
HHCCCCEEEECCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
MQDLEDVSVDIALMQQSHKIKMVELNAKWSDLGNFNALFEETANGSKENVSLNQTPVFAK
HHHHHHHCEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCEECCCCCEEEE
ESENNLIFSHKVSALLGVGNLAIIDTKDALLVAHKDKAKDLKALVGEIETHNQELLQTHT
CCCCCEEEEEHHHHHHCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHH
KVYRPWGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRSEHWVVISGMASVELDYQLFE
HHHCCCCCEEEEECCCCEEEEEEEECCCCCCHHHHHHCCCCCEEEEECCEEEEEEEEEEE
LQANESTYIPKNTLHRLANYGKIPLIIIEVQVGEYVGEDDIVRVDDDFNRQNPSK
EECCCCCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]