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The map label for this gene is gltA [H]

Identifier: 109946674

GI number: 109946674

Start: 39328

End: 40608

Strand: Reverse

Name: gltA [H]

Synonym: Hac_0040

Alternate gene names: 109946674

Gene position: 40608-39328 (Counterclockwise)

Preceding gene: 109946677

Following gene: 109946673

Centisome position: 2.61

GC content: 42.54

Gene sequence:

>1281_bases
ATGTCTGTTACTTTAATCAATAATGAAAATAATGAACGCTACGAATTTGAGATAATTGAATGCACCCGTGGACCTAAAGC
GGTGGATTTTTCCAAGCTTTTTGAAACGACTGGGTTTTTTTCTTACGACCCAGGGTATTCTTCCACTGCCGGTTGCCAAT
CCACCATAAGCTATATCAATGGTAAACAAGGCGAATTGTATTACAGAGGGCATAAAATAGAAGATCTAGTCGCCAAATAC
CAATATGTAGATGTGTGCAAATTGCTCCTTACAGGGGAATTGCCTAAAAATCAAGAGGAAAGCCTAGAGTTTGAACTAGA
ATTACGTCACAGAAGTTTTGTGCATGAAAGCTTACTCAACATGTTTTCAGCCTTCCCCACTAACGCCCACCCTATGGCAA
AACTCTCTAGCGGTGTGTCTATTTTATCCACTCTTTATTCCACGCACCAAAACATGCACACTGAAGAAGATTACCAAACG
ATGGCAAGAAGGATCATCGCCAAAATCCCCACTCTTGCGGCTATTTGCTATCGTAATGAAGTGGGAGCACCTATTATTTA
TCCGGATATTGCACGCTCTTATGTGGAAAATATCCTTTTTATGTTGAGAGGTTATCCTTATAGCCGCTTAAAACACACCA
CCAAAGGCGAAGTCGAAATCACGCCCCTAGAAATAGAAGCCTTTGACAAGATTCTAACTTTACACGCCGATCACAGCCAA
AACGCCTCTTCTACCACCGTAAGGAATGTCGCTAGCACCGGCGTGCACCCTTATGCTGCAATTAGTGCGGGGATTAGCGC
TTTATGGGGGCATTTGCATGGCGGAGCGAATGAAAAAGTCCTTTTGCAATTAGAAGAAATCGGCGATGTGAAAAATGTGG
ATAAATACATCGCACGAGTGAAAGATAAAAACGACAGCTTCAAACTCATGGGCTTTGGGCATAGGGTGTATAAGAGTTAC
GATCCGCGTGCCAAAATCCTAAAAGGCTTGAAAGATGAATTGCATAAAAAAGGCGTTAAAATGGACGAAAGGTTAAGCGA
AATCGCCGCTAAAGTGGAAGAAATCGCCCTAAAAGACGAGTATTTCATTGAAAGGAATCTCTACCCTAATGTGGATTTTT
ACTCCGGCACAATCTTAAGGGCTTTAAAAATTCCGGTGCGTTTTTTCACGCCGGTTTTTGTCATCGGCAGAACCGTGGGT
TGGTGTGCACAACTTTTAGAGCATGTCAAAAACCCTCAAGCCAAAATCACGCGCCCAAGACAGGTTTATGTGGGGAAATA
A

Upstream 100 bases:

>100_bases
AGCGTTTAGAAATAACTTGAAAAAACGAAATGTTTTTAAAAAAATATTTAATTTTTTGGCTTATAATTTATCATTCATTC
TGAAACTTTAAGGAAGTCAA

Downstream 100 bases:

>100_bases
CCACTACCACAAAAAAGGGGGGGGTTAACCCCCACAATTTAACAATCCACCAATAAAAAACTCAATTTGATAAACAAAAG
TCAAAAACCGCTTTTATTTG

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSVTLINNENNERYEFEIIECTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSTISYINGKQGELYYRGHKIEDLVAKY
QYVDVCKLLLTGELPKNQEESLEFELELRHRSFVHESLLNMFSAFPTNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQT
MARRIIAKIPTLAAICYRNEVGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTKGEVEITPLEIEAFDKILTLHADHSQ
NASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARVKDKNDSFKLMGFGHRVYKSY
DPRAKILKGLKDELHKKGVKMDERLSEIAAKVEEIALKDEYFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVG
WCAQLLEHVKNPQAKITRPRQVYVGK

Sequences:

>Translated_426_residues
MSVTLINNENNERYEFEIIECTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSTISYINGKQGELYYRGHKIEDLVAKY
QYVDVCKLLLTGELPKNQEESLEFELELRHRSFVHESLLNMFSAFPTNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQT
MARRIIAKIPTLAAICYRNEVGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTKGEVEITPLEIEAFDKILTLHADHSQ
NASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARVKDKNDSFKLMGFGHRVYKSY
DPRAKILKGLKDELHKKGVKMDERLSEIAAKVEEIALKDEYFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVG
WCAQLLEHVKNPQAKITRPRQVYVGK
>Mature_425_residues
SVTLINNENNERYEFEIIECTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSTISYINGKQGELYYRGHKIEDLVAKYQ
YVDVCKLLLTGELPKNQEESLEFELELRHRSFVHESLLNMFSAFPTNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQTM
ARRIIAKIPTLAAICYRNEVGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTKGEVEITPLEIEAFDKILTLHADHSQN
ASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARVKDKNDSFKLMGFGHRVYKSYD
PRAKILKGLKDELHKKGVKMDERLSEIAAKVEEIALKDEYFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVGW
CAQLLEHVKNPQAKITRPRQVYVGK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=337, Percent_Identity=29.080118694362, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1786939, Length=412, Percent_Identity=43.9320388349515, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1786527, Length=366, Percent_Identity=28.9617486338798, Blast_Score=141, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17555174, Length=389, Percent_Identity=26.9922879177378, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319850, Length=354, Percent_Identity=27.1186440677966, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6324328, Length=352, Percent_Identity=27.8409090909091, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6325257, Length=345, Percent_Identity=27.536231884058, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21356863, Length=443, Percent_Identity=27.9909706546275, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24640124, Length=343, Percent_Identity=27.6967930029155, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24640126, Length=343, Percent_Identity=27.6967930029155, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48393; Mature: 48262

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTLINNENNERYEFEIIECTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSTISYIN
CEEEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHHCCCCEECCCCCCCCHHHHHHHHHC
GKQGELYYRGHKIEDLVAKYQYVDVCKLLLTGELPKNQEESLEFELELRHRSFVHESLLN
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
MFSAFPTNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQTMARRIIAKIPTLAAICYRNE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTKGEVEITPLEIEAFDKILTLHADHSQ
CCCCEECHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEEHHHHHHHHEEECCCCC
NASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARV
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCHHHHHHHHHHH
KDKNDSFKLMGFGHRVYKSYDPRAKILKGLKDELHKKGVKMDERLSEIAAKVEEIALKDE
CCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCH
YFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVGWCAQLLEHVKNPQAKITRPR
HHEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHCCCCC
QVYVGK
EEECCC
>Mature Secondary Structure 
SVTLINNENNERYEFEIIECTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSTISYIN
EEEEEECCCCCEEEEEEEEECCCCCCCCHHHHHHHCCCCEECCCCCCCCHHHHHHHHHC
GKQGELYYRGHKIEDLVAKYQYVDVCKLLLTGELPKNQEESLEFELELRHRSFVHESLLN
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
MFSAFPTNAHPMAKLSSGVSILSTLYSTHQNMHTEEDYQTMARRIIAKIPTLAAICYRNE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
VGAPIIYPDIARSYVENILFMLRGYPYSRLKHTTKGEVEITPLEIEAFDKILTLHADHSQ
CCCCEECHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEEHHHHHHHHEEECCCCC
NASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKVLLQLEEIGDVKNVDKYIARV
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCHHHHHHHHHHH
KDKNDSFKLMGFGHRVYKSYDPRAKILKGLKDELHKKGVKMDERLSEIAAKVEEIALKDE
CCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCH
YFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVGWCAQLLEHVKNPQAKITRPR
HHEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHCCCCC
QVYVGK
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]