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The map label for this gene is clcB [H]

Identifier: 108811904

GI number: 108811904

Start: 1962471

End: 1963763

Strand: Reverse

Name: clcB [H]

Synonym: YPN_1742

Alternate gene names: 108811904

Gene position: 1963763-1962471 (Counterclockwise)

Preceding gene: 108811905

Following gene: 108811900

Centisome position: 43.31

GC content: 52.05

Gene sequence:

>1293_bases
ATGTTGTCTTGCATGAAACGGCCAATCCATCTCTATTACTACCGTGCGATGCTGCGTCGATTAGTGATCTCCATCATGCT
CGGCATGGTATCCGCGCTCATCGTTTGGCTGTTTCATCAGGCGATGCTGGGGCTGGAGTGGCTGCTCTTCTCACGAACAG
ATGGTAGCCTGGTTGCTGCTGCGGCCTCTATTACTGGGTGGCGGCGGGCATTAACTCCTGCTTTGGGGGGATTGGCGGCA
GGTTTGCTGTTATGGGCATACCAACGTTATCAACACCGTAAACCCAGTGCGCCCACTGATTATATGGAAGCCATTGAAAT
CGGTGATGGCCGATTAGATGTTTCCGCCAGCCTAGTGAAGTCCCTCGCCTCTTTGTTAGTCGTATCCAGCGGCAGTGCCA
TTGGTCGTGAAGGCGCTATGGTATTGTTGGCCGCCCTGTTCGCTTCGGTTTTCGCTCAACGCTATGCAAAACCTAAAGAG
TGGAAGTTGTGGGTCGCCTGTGGGGCCGCTGCGGGAATGGCAAGTGCTTACCATGCTCCGTTGGCTGGCAGCCTGTTTAT
TGCAGAAATTCTATTTGGAACACTGATGTTGGCTTCACTCGGCCCGGTAGTGATCGCCGCGGTCAGTGCGTTATTGACGA
TCAACTTGCTACAAGGTGGTCAGGAAACCCTTTATCAAGTGCAGACACTCCCTTCTCCTTGGCCGGTACAATATTTCCTG
ATGGCGCTTCTAGGATTAATGGCGGGCTTCAGCGGCCCTTTATTTTTAAAAGCGATGGCGGCTAGCAGTCATGCTTTCCG
CTCCCTGAATTTATTGCCACCTCTGCAATTGGCGCTGGGGGGGATAATTGTTGGTTTACTATCATTGATATTTCCAGAGG
TCTGGGGCAATGGCTACAGCGTAGTGCAATCACTCCTCACCACGCCGCCGGGGGTGTTACTGATAGGCGGCATATTGATC
TGTAAGTTATTGGCCGTGCTTGCCAGTAGTGGGTCCGGCGCTCCGGGAGGGGTATTTACACCTACATTGTTTGTCGGTGC
CGCACTCGGCATGTTATGTGGGCAGATATTTTCTTTGTGGCCCGTGCTGGGCGACAATATTGGGTTATTAATGGCACTGA
CCGGCATGGCAACATTATTGGCAGCAACGACCCATGCGCCCATTATGGCCGCTTTAATGGTTTGTGAAATGACCGGCGAG
TACACCTTATTGCCAGGGCTATTATTATCTTGTGTTATCGCGACAACAATAGCCCGCTGGTTGCGCCCAATATCGGTATA
TCGGTCTCACTAA

Upstream 100 bases:

>100_bases
CTGTTGGCTGCGCTTCAACTTTTGCTGACTTACCTACGCTAATGCAACTGAGCCATTATTTCCACAACCAATCCCCCGAG
GATAAGTTTTATAAAATTTG

Downstream 100 bases:

>100_bases
ATGATGGGCCGAGTAACGAAAGCAGCCAACATACATTCAGCTTGAAACATACATTCAGCTTGAAACACACATTCCAGCTT
GAAACACACATTCAGCTTGA

Product: putative voltage-gated ClC-type chloride channel ClcB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MLSCMKRPIHLYYYRAMLRRLVISIMLGMVSALIVWLFHQAMLGLEWLLFSRTDGSLVAAAASITGWRRALTPALGGLAA
GLLLWAYQRYQHRKPSAPTDYMEAIEIGDGRLDVSASLVKSLASLLVVSSGSAIGREGAMVLLAALFASVFAQRYAKPKE
WKLWVACGAAAGMASAYHAPLAGSLFIAEILFGTLMLASLGPVVIAAVSALLTINLLQGGQETLYQVQTLPSPWPVQYFL
MALLGLMAGFSGPLFLKAMAASSHAFRSLNLLPPLQLALGGIIVGLLSLIFPEVWGNGYSVVQSLLTTPPGVLLIGGILI
CKLLAVLASSGSGAPGGVFTPTLFVGAALGMLCGQIFSLWPVLGDNIGLLMALTGMATLLAATTHAPIMAALMVCEMTGE
YTLLPGLLLSCVIATTIARWLRPISVYRSH

Sequences:

>Translated_430_residues
MLSCMKRPIHLYYYRAMLRRLVISIMLGMVSALIVWLFHQAMLGLEWLLFSRTDGSLVAAAASITGWRRALTPALGGLAA
GLLLWAYQRYQHRKPSAPTDYMEAIEIGDGRLDVSASLVKSLASLLVVSSGSAIGREGAMVLLAALFASVFAQRYAKPKE
WKLWVACGAAAGMASAYHAPLAGSLFIAEILFGTLMLASLGPVVIAAVSALLTINLLQGGQETLYQVQTLPSPWPVQYFL
MALLGLMAGFSGPLFLKAMAASSHAFRSLNLLPPLQLALGGIIVGLLSLIFPEVWGNGYSVVQSLLTTPPGVLLIGGILI
CKLLAVLASSGSGAPGGVFTPTLFVGAALGMLCGQIFSLWPVLGDNIGLLMALTGMATLLAATTHAPIMAALMVCEMTGE
YTLLPGLLLSCVIATTIARWLRPISVYRSH
>Mature_430_residues
MLSCMKRPIHLYYYRAMLRRLVISIMLGMVSALIVWLFHQAMLGLEWLLFSRTDGSLVAAAASITGWRRALTPALGGLAA
GLLLWAYQRYQHRKPSAPTDYMEAIEIGDGRLDVSASLVKSLASLLVVSSGSAIGREGAMVLLAALFASVFAQRYAKPKE
WKLWVACGAAAGMASAYHAPLAGSLFIAEILFGTLMLASLGPVVIAAVSALLTINLLQGGQETLYQVQTLPSPWPVQYFL
MALLGLMAGFSGPLFLKAMAASSHAFRSLNLLPPLQLALGGIIVGLLSLIFPEVWGNGYSVVQSLLTTPPGVLLIGGILI
CKLLAVLASSGSGAPGGVFTPTLFVGAALGMLCGQIFSLWPVLGDNIGLLMALTGMATLLAATTHAPIMAALMVCEMTGE
YTLLPGLLLSCVIATTIARWLRPISVYRSH

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=414, Percent_Identity=63.5265700483092, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1786350, Length=252, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 45517; Mature: 45517

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCC
>Mature Secondary Structure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HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA