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The map label for this gene is vdh [H]

Identifier: 108801910

GI number: 108801910

Start: 5238023

End: 5239246

Strand: Reverse

Name: vdh [H]

Synonym: Mmcs_4947

Alternate gene names: 108801910

Gene position: 5239246-5238023 (Counterclockwise)

Preceding gene: 108801911

Following gene: 108801909

Centisome position: 91.83

GC content: 71.81

Gene sequence:

>1224_bases
ATGACCGCGACCGCGGACCCCCGGGCGCTGCTCGGCCGGCTGCTCGACCCGGCCAACCGGGCCGACCCCTACCCGCTGTA
CGCGGACTTCCGGGCGGCCGGACCGTTGGCGTTGCCCGAAGCCAACCTGGTGGTGTTCTCCGCCTTCGCCGACTGCGACG
AGGTGCTGCGGCACCCCGCATCGGCCAGCGACCGGCTGAAGTCGACGGTCGCGCAACGGGAGATCGCCGCCGGCGCCGTC
GCGCGCCCGTTCGGGACCCCCGGGTTCCTGTTCCTCGATCCGCCGGACCACACCCGGTTGCGCCGGCTGGTCAGCTCGGC
GTTCGTGCCCAGGGTGGTCAAGGCGCTCGAACCCGAGATCGTGTCGCTGGTCGACTCGCTGCTGGATGCGGTGGCGGCCA
GGGGCGAGTTCGACGTCATCGCCGATCTGGCCCATCCGCTGCCGGTGGCGGTGATCTGCCGTCTGCTCGGGGTGCCGCTG
GAAGACGAACCCCAGTTCAGCCGTGCGTCGGCGTTGCTCGCCCAGTCGCTCGACCCGTTCGTCACCGTCACCGGTCAGGC
CGCGCAGGGGGCCGAGGACCGGCTGGAGGCGGGGCTGTGGCTGCGGGGTTACCTGCGCGAGCTGATCGCCAAGCGCCGCG
TCGAACCGCGCGACGACCTGATCTCCGGACTGATCGCCGCCGAGGAGGCCGGTGACCAGCTCACCGAGGACGAGATCGTC
GCCACCTGCAACCTGCTGCTGGTGGCCGGACACGAGACGACGGTCAACCTGATCGCCAACGCGATACTGGCGATGCTGCG
ACACCCCGCGGCATGGGATGCGCTGGCGGCGGAGCCGCAGCGGGTGTCCGCGGTCGCGGAGGAGACGCTGCGGTTCGACC
CGCCGGTCCAGCTGGTCGGCCGCATCGCCGCCGAGGAGATGACGGTCAACGGGGTCACGGTGCCCAAGGGCGACAGCATG
CTGCTTCTGCTGGCCGCCGCGCACCGCGATCCGGACGCCTTCGACCGGGCCGACACGTTCGACCCGGACCGTTCCAACCT
CCGGCACCTCGGGTTCGGCAAGGGGCCGCACTTCTGCCTCGGGGCGCCGCTGGCCCGGTTGGAGGCCGCCGTCGCCCTGT
CGGCGGTGACCTCCCGGTTCCCCGACGCCCGGTTGGCGGCCGAACCGGTCTACAAGCCGAACCTCACGCTGCGCGGTATG
GGAACGCTTTCCGTCGCCATTTAG

Upstream 100 bases:

>100_bases
CTCGTCGACCAGATCCGGGCCTCGATCGTCGCGGGCAACTTCGACGAACTCCGCGAGCACGTGCTCGGGCGGTACTACGC
CGCGCGTGGACAATGAGTGG

Downstream 100 bases:

>100_bases
CACCTTTGGTGTGGAAACCGTTGTCGAAGCCGGGCATGGCCCCGGAATCCGTATTAGGGTGCCGGTCATGCGAATCCTGT
TGGTGGGTGCCGGCGGTGTC

Product: cytochrome P450

Products: NA

Alternate protein names: Cytochrome P450 [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTATADPRALLGRLLDPANRADPYPLYADFRAAGPLALPEANLVVFSAFADCDEVLRHPASASDRLKSTVAQREIAAGAV
ARPFGTPGFLFLDPPDHTRLRRLVSSAFVPRVVKALEPEIVSLVDSLLDAVAARGEFDVIADLAHPLPVAVICRLLGVPL
EDEPQFSRASALLAQSLDPFVTVTGQAAQGAEDRLEAGLWLRGYLRELIAKRRVEPRDDLISGLIAAEEAGDQLTEDEIV
ATCNLLLVAGHETTVNLIANAILAMLRHPAAWDALAAEPQRVSAVAEETLRFDPPVQLVGRIAAEEMTVNGVTVPKGDSM
LLLLAAAHRDPDAFDRADTFDPDRSNLRHLGFGKGPHFCLGAPLARLEAAVALSAVTSRFPDARLAAEPVYKPNLTLRGM
GTLSVAI

Sequences:

>Translated_407_residues
MTATADPRALLGRLLDPANRADPYPLYADFRAAGPLALPEANLVVFSAFADCDEVLRHPASASDRLKSTVAQREIAAGAV
ARPFGTPGFLFLDPPDHTRLRRLVSSAFVPRVVKALEPEIVSLVDSLLDAVAARGEFDVIADLAHPLPVAVICRLLGVPL
EDEPQFSRASALLAQSLDPFVTVTGQAAQGAEDRLEAGLWLRGYLRELIAKRRVEPRDDLISGLIAAEEAGDQLTEDEIV
ATCNLLLVAGHETTVNLIANAILAMLRHPAAWDALAAEPQRVSAVAEETLRFDPPVQLVGRIAAEEMTVNGVTVPKGDSM
LLLLAAAHRDPDAFDRADTFDPDRSNLRHLGFGKGPHFCLGAPLARLEAAVALSAVTSRFPDARLAAEPVYKPNLTLRGM
GTLSVAI
>Mature_406_residues
TATADPRALLGRLLDPANRADPYPLYADFRAAGPLALPEANLVVFSAFADCDEVLRHPASASDRLKSTVAQREIAAGAVA
RPFGTPGFLFLDPPDHTRLRRLVSSAFVPRVVKALEPEIVSLVDSLLDAVAARGEFDVIADLAHPLPVAVICRLLGVPLE
DEPQFSRASALLAQSLDPFVTVTGQAAQGAEDRLEAGLWLRGYLRELIAKRRVEPRDDLISGLIAAEEAGDQLTEDEIVA
TCNLLLVAGHETTVNLIANAILAMLRHPAAWDALAAEPQRVSAVAEETLRFDPPVQLVGRIAAEEMTVNGVTVPKGDSML
LLLAAAHRDPDAFDRADTFDPDRSNLRHLGFGKGPHFCLGAPLARLEAAVALSAVTSRFPDARLAAEPVYKPNLTLRGMG
TLSVAI

Specific function: Hydroxylates vitamin D(3) into 25-hydroxyvitamin D(3) and 1-alpha,25-dihydroxyvitamin D(3), its physiologically active forms. It first hydroxylates the C-25 position of vitamin D(3) to form 25-hydroxyvitamin D(3), then subsequently hydroxylates the C- 1-a

COG id: COG2124

COG function: function code Q; Cytochrome P450

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family [H]

Homologues:

Organism=Homo sapiens, GI119220562, Length=279, Percent_Identity=25.089605734767, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI13435391, Length=279, Percent_Identity=24.7311827956989, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI193083180, Length=215, Percent_Identity=25.5813953488372, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI193083178, Length=215, Percent_Identity=25.5813953488372, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI16933533, Length=378, Percent_Identity=23.015873015873, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310125128, Length=209, Percent_Identity=29.6650717703349, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI14550409, Length=209, Percent_Identity=29.6650717703349, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI310125130, Length=209, Percent_Identity=29.6650717703349, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI190570174, Length=209, Percent_Identity=29.6650717703349, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI13435386, Length=376, Percent_Identity=22.6063829787234, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI150036266, Length=215, Percent_Identity=24.6511627906977, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI12383060, Length=379, Percent_Identity=22.9551451187335, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI261278370, Length=175, Percent_Identity=30.2857142857143, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI261278372, Length=198, Percent_Identity=29.7979797979798, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI195972896, Length=175, Percent_Identity=30.2857142857143, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI195972898, Length=175, Percent_Identity=30.2857142857143, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI6005737, Length=279, Percent_Identity=23.2974910394265, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI158138530, Length=218, Percent_Identity=26.605504587156, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI4503231, Length=178, Percent_Identity=25.2808988764045, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI16933535, Length=335, Percent_Identity=23.2835820895522, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4503211, Length=191, Percent_Identity=28.2722513089005, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI158937242, Length=212, Percent_Identity=27.3584905660377, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI62952506, Length=212, Percent_Identity=26.8867924528302, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI16933530, Length=348, Percent_Identity=22.7011494252874, Blast_Score=66, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17540354, Length=197, Percent_Identity=25.3807106598985, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982956, Length=197, Percent_Identity=25.8883248730964, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17552522, Length=197, Percent_Identity=24.8730964467005, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI115532670, Length=197, Percent_Identity=25.3807106598985, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71982977, Length=197, Percent_Identity=24.8730964467005, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193206712, Length=195, Percent_Identity=25.6410256410256, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71990269, Length=195, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17933518, Length=225, Percent_Identity=25.7777777777778, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24642101, Length=203, Percent_Identity=31.0344827586207, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355669, Length=232, Percent_Identity=25.4310344827586, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24656064, Length=217, Percent_Identity=26.2672811059908, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24582534, Length=191, Percent_Identity=25.6544502617801, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221330299, Length=327, Percent_Identity=23.8532110091743, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19921824, Length=356, Percent_Identity=25, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357631, Length=363, Percent_Identity=23.9669421487603, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17864130, Length=212, Percent_Identity=24.0566037735849, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24660171, Length=203, Percent_Identity=25.1231527093596, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI18079270, Length=217, Percent_Identity=23.0414746543779, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972 [H]

Pfam domain/function: PF00067 p450 [H]

EC number: =1.14.13.15 [H]

Molecular weight: Translated: 43528; Mature: 43397

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATADPRALLGRLLDPANRADPYPLYADFRAAGPLALPEANLVVFSAFADCDEVLRHPA
CCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCC
SASDRLKSTVAQREIAAGAVARPFGTPGFLFLDPPDHTRLRRLVSSAFVPRVVKALEPEI
CHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHH
VSLVDSLLDAVAARGEFDVIADLAHPLPVAVICRLLGVPLEDEPQFSRASALLAQSLDPF
HHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCE
VTVTGQAAQGAEDRLEAGLWLRGYLRELIAKRRVEPRDDLISGLIAAEEAGDQLTEDEIV
EEEECCCCCCHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHH
ATCNLLLVAGHETTVNLIANAILAMLRHPAAWDALAAEPQRVSAVAEETLRFDPPVQLVG
HEEEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCCHHHHH
RIAAEEMTVNGVTVPKGDSMLLLLAAAHRDPDAFDRADTFDPDRSNLRHLGFGKGPHFCL
HHHHHHEEECCEECCCCCCEEEEEEECCCCCHHHCCCCCCCCCHHCCCCCCCCCCCCCCC
GAPLARLEAAVALSAVTSRFPDARLAAEPVYKPNLTLRGMGTLSVAI
CCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCEEEEECCCEEEEC
>Mature Secondary Structure 
TATADPRALLGRLLDPANRADPYPLYADFRAAGPLALPEANLVVFSAFADCDEVLRHPA
CCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCC
SASDRLKSTVAQREIAAGAVARPFGTPGFLFLDPPDHTRLRRLVSSAFVPRVVKALEPEI
CHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHH
VSLVDSLLDAVAARGEFDVIADLAHPLPVAVICRLLGVPLEDEPQFSRASALLAQSLDPF
HHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCE
VTVTGQAAQGAEDRLEAGLWLRGYLRELIAKRRVEPRDDLISGLIAAEEAGDQLTEDEIV
EEEECCCCCCHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHH
ATCNLLLVAGHETTVNLIANAILAMLRHPAAWDALAAEPQRVSAVAEETLRFDPPVQLVG
HEEEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHCCCCCHHHHH
RIAAEEMTVNGVTVPKGDSMLLLLAAAHRDPDAFDRADTFDPDRSNLRHLGFGKGPHFCL
HHHHHHEEECCEECCCCCCEEEEEEECCCCCHHHCCCCCCCCCHHCCCCCCCCCCCCCCC
GAPLARLEAAVALSAVTSRFPDARLAAEPVYKPNLTLRGMGTLSVAI
CCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCEEEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA