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The map label for this gene is caiA [H]

Identifier: 108801639

GI number: 108801639

Start: 4956979

End: 4957989

Strand: Reverse

Name: caiA [H]

Synonym: Mmcs_4676

Alternate gene names: 108801639

Gene position: 4957989-4956979 (Counterclockwise)

Preceding gene: 108801640

Following gene: 108801638

Centisome position: 86.9

GC content: 68.84

Gene sequence:

>1011_bases
GTGGATTTCAGTCCAGACGAGGGGCAGCAGGCTGTCGCCGATGTGGTGACGGCGGTGCTCGAGCGTGACAACACTTGGGA
CGCCCTGGTTTCCGGCGGCGTCACCGCGCTCGGGGTGCCGGAACGCCTCGGCGGGGACGGCGTCGGCTTGGCCGAGCTCG
CCACCGCGCTGACCGAGATCGGCAGGCGCGGTACCATCAGCCCGGCGCTCGCCACGGTCGGACTCGGGCTCGTCCCGCTG
CTCGACCTGGCTTCCGACGAACAGCAGGACCGCTACCTCGCAGGCGTGGCCAAGGGCGCGATCCTGACCGCCGCGCTCAA
CGAGCCGGGTGTGGCGCTGCCGGATCGGCCGGCGACCACGCTGGTCGGCGACCGCCTCAACGGCACCAAGGTCGGAGTTC
CGTATGCCGGTAGGGCTGAATACATCCTGGTGAGCACCGACAACGGTGTCGTGGTGGTGTCGGCGTCCGCCGACGGCGTG
CAGGTCACCGAGACGCCGACCTCCAACGGCGGGGACGAGGCTGCGGTCACGTTCTCCGACGTCGCGGTCGACGACGCCGA
TGTGCTGGGGTCCGGTTCGGAGGCGGTCCGTCGTGTCAATGCGCTGGCGCTGGCCGCCACTGGGGCGTTCGCCGCCGGGC
TGGTGGCGGGTGCCCTGCGGCTGACCGCGGACTACGTCGCCAACCGGCATCAGTTCGGGCGTCCGCTGTCGACGTTCCAG
ACCGTCGCCGCGCAGCTTGCCGAGGTGTACATCGCCTCTCGCACATTGGATCTCGCTGCGAATTCGGTGGTCTGGCGGCT
AGCTGAAGGGCTTGACGCCGCTGACGACCTCGAGGTGCTCGGGTACTGGCTGACCTCGCAGGCGCCGCCGGTCATGCAGA
CCTGCCATCACCTGCACGGCGGTATGGGTATGGACATCACCTACCCGATGGACCGCTACTACTCGACGATCAAGGACCTG
TCCCGGTTACTGGGTGGCCCGTCGCATCGTCTGGACCTGGTGGGAGTTTGA

Upstream 100 bases:

>100_bases
CAAGCACTGGCAGGTCGACTACACCGGCGCCGGCGGGCCGGCAATCGAACAGAAGTGCCCCGTCGCTCATTAGGATTTCC
CGGGATCAAGGAGGATTCGG

Downstream 100 bases:

>100_bases
TGTTCATCGATCTGACGCCTGAGCAGCGGCGGCTGCAAGCTGAACTGCGGGAGTACTTCTCGACGCTCATCTCGCCCGGA
GAGCGCGATGCCATGGAGAC

Product: acyl-CoA dehydrogenase-like protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: Crotonobetainyl-CoA reductase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MDFSPDEGQQAVADVVTAVLERDNTWDALVSGGVTALGVPERLGGDGVGLAELATALTEIGRRGTISPALATVGLGLVPL
LDLASDEQQDRYLAGVAKGAILTAALNEPGVALPDRPATTLVGDRLNGTKVGVPYAGRAEYILVSTDNGVVVVSASADGV
QVTETPTSNGGDEAAVTFSDVAVDDADVLGSGSEAVRRVNALALAATGAFAAGLVAGALRLTADYVANRHQFGRPLSTFQ
TVAAQLAEVYIASRTLDLAANSVVWRLAEGLDAADDLEVLGYWLTSQAPPVMQTCHHLHGGMGMDITYPMDRYYSTIKDL
SRLLGGPSHRLDLVGV

Sequences:

>Translated_336_residues
MDFSPDEGQQAVADVVTAVLERDNTWDALVSGGVTALGVPERLGGDGVGLAELATALTEIGRRGTISPALATVGLGLVPL
LDLASDEQQDRYLAGVAKGAILTAALNEPGVALPDRPATTLVGDRLNGTKVGVPYAGRAEYILVSTDNGVVVVSASADGV
QVTETPTSNGGDEAAVTFSDVAVDDADVLGSGSEAVRRVNALALAATGAFAAGLVAGALRLTADYVANRHQFGRPLSTFQ
TVAAQLAEVYIASRTLDLAANSVVWRLAEGLDAADDLEVLGYWLTSQAPPVMQTCHHLHGGMGMDITYPMDRYYSTIKDL
SRLLGGPSHRLDLVGV
>Mature_336_residues
MDFSPDEGQQAVADVVTAVLERDNTWDALVSGGVTALGVPERLGGDGVGLAELATALTEIGRRGTISPALATVGLGLVPL
LDLASDEQQDRYLAGVAKGAILTAALNEPGVALPDRPATTLVGDRLNGTKVGVPYAGRAEYILVSTDNGVVVVSASADGV
QVTETPTSNGGDEAAVTFSDVAVDDADVLGSGSEAVRRVNALALAATGAFAAGLVAGALRLTADYVANRHQFGRPLSTFQ
TVAAQLAEVYIASRTLDLAANSVVWRLAEGLDAADDLEVLGYWLTSQAPPVMQTCHHLHGGMGMDITYPMDRYYSTIKDL
SRLLGGPSHRLDLVGV

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=309, Percent_Identity=25.5663430420712, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786223, Length=365, Percent_Identity=23.2876712328767, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17508101, Length=332, Percent_Identity=23.4939759036145, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17506239, Length=348, Percent_Identity=23.2758620689655, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21356377, Length=324, Percent_Identity=25.6172839506173, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 34707; Mature: 34707

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSPDEGQQAVADVVTAVLERDNTWDALVSGGVTALGVPERLGGDGVGLAELATALTEI
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCEEEECCHHHCCCCCCCHHHHHHHHHHH
GRRGTISPALATVGLGLVPLLDLASDEQQDRYLAGVAKGAILTAALNEPGVALPDRPATT
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHH
LVGDRLNGTKVGVPYAGRAEYILVSTDNGVVVVSASADGVQVTETPTSNGGDEAAVTFSD
HCCCCCCCCEECCCCCCCCCEEEEECCCCEEEEEECCCCEEEEECCCCCCCCCEEEEEEC
VAVDDADVLGSGSEAVRRVNALALAATGAFAAGLVAGALRLTADYVANRHQFGRPLSTFQ
CEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
TVAAQLAEVYIASRTLDLAANSVVWRLAEGLDAADDLEVLGYWLTSQAPPVMQTCHHLHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHC
GMGMDITYPMDRYYSTIKDLSRLLGGPSHRLDLVGV
CCCCEEECCHHHHHHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MDFSPDEGQQAVADVVTAVLERDNTWDALVSGGVTALGVPERLGGDGVGLAELATALTEI
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCEEEECCHHHCCCCCCCHHHHHHHHHHH
GRRGTISPALATVGLGLVPLLDLASDEQQDRYLAGVAKGAILTAALNEPGVALPDRPATT
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHH
LVGDRLNGTKVGVPYAGRAEYILVSTDNGVVVVSASADGVQVTETPTSNGGDEAAVTFSD
HCCCCCCCCEECCCCCCCCCEEEEECCCCEEEEEECCCCEEEEECCCCCCCCCEEEEEEC
VAVDDADVLGSGSEAVRRVNALALAATGAFAAGLVAGALRLTADYVANRHQFGRPLSTFQ
CEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
TVAAQLAEVYIASRTLDLAANSVVWRLAEGLDAADDLEVLGYWLTSQAPPVMQTCHHLHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHC
GMGMDITYPMDRYYSTIKDLSRLLGGPSHRLDLVGV
CCCCEEECCHHHHHHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA