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The map label for this gene is mprA [H]

Identifier: 108801553

GI number: 108801553

Start: 4865305

End: 4866024

Strand: Reverse

Name: mprA [H]

Synonym: Mmcs_4590

Alternate gene names: 108801553

Gene position: 4866024-4865305 (Counterclockwise)

Preceding gene: 108801556

Following gene: 108801552

Centisome position: 85.29

GC content: 66.67

Gene sequence:

>720_bases
ATGGCGATGGCTGCGTTGTCCGAAACCACCCCCGAGGCCCGGGTCCTCGTCGTCGACGACGAGGCCAACATCGTCGAGCT
GTTGTCGGTCAGTCTGAAGTTCCAGGGATTCGAGGTGCACACCGCTTCCGACGGTGCCTCTGCGCTCGACAAGGCGCGCG
ACGTCCGGCCCGACGCGGTGATCCTCGACGTGATGATGCCTGGGATGGACGGGTTCGGTCTGCTGCGCCGTCTGCGGGCC
GACGGTATCGACGCCCCGGCGTTGTTCCTGACCGCCCGCGATTCGCTGCAGGACAAGATCGCGGGGTTGACGCTCGGCGG
CGACGACTACGTCACCAAACCGTTCAGCCTCGAGGAGGTCGTCGCCCGGCTGCGGGTGATCCTGCGGCGCACCGGCCGCG
GCGCCGAGGAGCCGAAGACCTCGCGGCTGAGCTTCGCCGACATCGAACTCGACGAGGACACCCACGAGGTGTGGAAGGCC
GGCGAGCCGGTGTCGCTGTCTCCCACCGAGTTCACCCTGCTGCGGTACTTCATCATCAACGCGGGCACGGTGTTGTCCAA
GCCCAAGATCCTCGACCACGTGTGGCGCTACGACTTCGGTGGCGACGTCAACGTCGTCGAGTCCTATGTCTCGTACCTAC
GTCGCAAGATCGACACGGGGGAGAGGCGGCTGCTGCACACGCTGCGGGGTGTGGGGTACGTCCTGCGCGAGCCACGGTAG

Upstream 100 bases:

>100_bases
TCCATGCCGCCAGTGTATGGACAGTGCAAGCGTCGACTCACAGAGATCTCACAGCCAACCCGCAGCATTACTCCAAGGCC
GGTAGCGGACATTGAAGTAC

Downstream 100 bases:

>100_bases
TGCGCGGAGGTGTGCCGCTGCGGCTGGGGCTGGTGGCCGCGACGCTGGTGCTCGTGGCGTTCGGGCTGCTGGCCTCCGGC
ATCGCGGTGACGTCGATCAT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MAMAALSETTPEARVLVVDDEANIVELLSVSLKFQGFEVHTASDGASALDKARDVRPDAVILDVMMPGMDGFGLLRRLRA
DGIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRTGRGAEEPKTSRLSFADIELDEDTHEVWKA
GEPVSLSPTEFTLLRYFIINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDTGERRLLHTLRGVGYVLREPR

Sequences:

>Translated_239_residues
MAMAALSETTPEARVLVVDDEANIVELLSVSLKFQGFEVHTASDGASALDKARDVRPDAVILDVMMPGMDGFGLLRRLRA
DGIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRTGRGAEEPKTSRLSFADIELDEDTHEVWKA
GEPVSLSPTEFTLLRYFIINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDTGERRLLHTLRGVGYVLREPR
>Mature_238_residues
AMAALSETTPEARVLVVDDEANIVELLSVSLKFQGFEVHTASDGASALDKARDVRPDAVILDVMMPGMDGFGLLRRLRAD
GIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRTGRGAEEPKTSRLSFADIELDEDTHEVWKAG
EPVSLSPTEFTLLRYFIINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDTGERRLLHTLRGVGYVLREPR

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=35.8744394618834, Blast_Score=150, Evalue=6e-38,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=37.6106194690265, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=38.8392857142857, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=37.5, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=33.0316742081448, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=31.5789473684211, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788394, Length=236, Percent_Identity=33.0508474576271, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=35.7466063348416, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=33.6322869955157, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=35.6521739130435, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1788550, Length=162, Percent_Identity=32.7160493827161, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.140350877193, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=30.2222222222222, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=34.2592592592593, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790437, Length=132, Percent_Identity=32.5757575757576, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788191, Length=124, Percent_Identity=37.0967741935484, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI145693157, Length=116, Percent_Identity=34.4827586206897, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788713, Length=111, Percent_Identity=36.9369369369369, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26560; Mature: 26429

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMAALSETTPEARVLVVDDEANIVELLSVSLKFQGFEVHTASDGASALDKARDVRPDAV
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHEECCEEEEECCCCHHHHHHHHCCCCCEE
ILDVMMPGMDGFGLLRRLRADGIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEV
EEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHEEEECCCCCCCCCCCHHHH
VARLRVILRRTGRGAEEPKTSRLSFADIELDEDTHEVWKAGEPVSLSPTEFTLLRYFIIN
HHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHH
AGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDTGERRLLHTLRGVGYVLREPR
CCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AMAALSETTPEARVLVVDDEANIVELLSVSLKFQGFEVHTASDGASALDKARDVRPDAV
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHEECCEEEEECCCCHHHHHHHHCCCCCEE
ILDVMMPGMDGFGLLRRLRADGIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEV
EEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHEEEECCCCCCCCCCCHHHH
VARLRVILRRTGRGAEEPKTSRLSFADIELDEDTHEVWKAGEPVSLSPTEFTLLRYFIIN
HHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHH
AGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDTGERRLLHTLRGVGYVLREPR
CCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA