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The map label for this gene is phoR [H]

Identifier: 108801552

GI number: 108801552

Start: 4863884

End: 4865305

Strand: Reverse

Name: phoR [H]

Synonym: Mmcs_4589

Alternate gene names: 108801552

Gene position: 4865305-4863884 (Counterclockwise)

Preceding gene: 108801553

Following gene: 108801541

Centisome position: 85.27

GC content: 71.31

Gene sequence:

>1422_bases
GTGCGCGGAGGTGTGCCGCTGCGGCTGGGGCTGGTGGCCGCGACGCTGGTGCTCGTGGCGTTCGGGCTGCTGGCCTCCGG
CATCGCGGTGACGTCGATCATGCGGCACAGCCTGGAGAGCCGCGTTGATCAGACACTGCTCGACGCCTCGCGCAGTTGGG
CACAGGCGCCCCGGCAGCTGCCAGTGGCGCCGCTGGCGGGTCCCAACCCGGCCCGCCCACCGTCGGACTTCTACGTCCGC
GGCACCGGACCCGACGGGCGGATGTGGACGGCCGTGAACGACCGCGAGGCCGAACCGGTGTTGCCGTCGTCCAACGACGT
GGGACCGGTCCCCGTCACCGTGCGGTCGGTGAACCACTCCGACGTCGAGTGGCGCGCGATGACGGTTCGCGGCCCCGGTG
GGGCGCTCACCACGGTGGCGATCGACCTGTCCGAAGTGCAGTCGACGGTTCGCGCGCTGGTGTGGTCGCAGATCGGTATC
GGTGCGGCCGTGCTGCTGGTGCTCGGAGTCGCGGGTTATGCCGTGGTGCAACGCAGCCTGCGCCCGTTGACCGAGGTCGA
GGAGACCGCCGCGGCGATCGCGGCCGGTCAGCTCGACCGCCGGGTGCCGCAGCGGGATCCGCGCACGGAGGTGGGCCGAC
TGTCGTTGGCCCTCAACGGAATGCTGGCACAGATCCAGCGGGCGGTGGCGTCGTCGGAGTCCTCGGCGGACGCTGCGCGC
ACCTCGGAGGAGCGGATGCGCCGGTTCATCACCGATGCCAGCCACGAGTTGCGCACCCCGTTGACGACGATCCGCGGGTT
CGCCGAGCTGTACCGCCAGGGCGCCGCGCGTGACGTCGAGATGTTGATGAACCGCATCGAGAGCGAATCGCGCCGGATGG
GCCTGCTCGTCGAGGACCTGCTGCTGCTGGCCCGCCTCGACGCGCAGCGGCCGTTGGAGCGGCACCGCGTCGACCTGCTG
GCGCTGGCCACCGACGCCGTCCATGACGCGCAGTCGATCGCACCCGAGCGGACGATCACCCTGCAGGTGCTCGACGGGCC
CGGCACACCGGAGGTGGTCGGCGACGAAGCGCGACTGCGGCAGGTGCTGGGCAATCTCGTCGCCAATGCGCTCCAGCACA
CCCCGAAGCATGCCGGCATCACGGTGCGGGTGGGCACCGACGAGACCAACGCCGTCCTGGAGGTGTGTGACGAGGGGCCG
GGTATGACCGAAGAGGACGCGCGCAGGGTGTTCGAGCGCTTCTACCGCACCGACTCGTCGCGGGCCCGCGAGAGCGGAGG
GACCGGACTCGGGCTGTCGATCGTGGATTCGCTGGTCCTGGCCCACGGCGGGACGGTGCGCGTGACGACGGCGCCGGGGC
AGGGCTGCCGGTTCACCGTGCACCTACCGCGGTTCAGCGACGTTCCCGTCGAAACGGCTTGA

Upstream 100 bases:

>100_bases
AGTCCTATGTCTCGTACCTACGTCGCAAGATCGACACGGGGGAGAGGCGGCTGCTGCACACGCTGCGGGGTGTGGGGTAC
GTCCTGCGCGAGCCACGGTA

Downstream 100 bases:

>100_bases
TGCTCAACCGAGTTCGGCGAGTGCGGCCTTGATCTTGGACTGGGCCTCGTCGAGCGATTCCGGCGACGGGTTGTTGTCGA
CGTTCGCGAATCCGAAGTCG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MRGGVPLRLGLVAATLVLVAFGLLASGIAVTSIMRHSLESRVDQTLLDASRSWAQAPRQLPVAPLAGPNPARPPSDFYVR
GTGPDGRMWTAVNDREAEPVLPSSNDVGPVPVTVRSVNHSDVEWRAMTVRGPGGALTTVAIDLSEVQSTVRALVWSQIGI
GAAVLLVLGVAGYAVVQRSLRPLTEVEETAAAIAAGQLDRRVPQRDPRTEVGRLSLALNGMLAQIQRAVASSESSADAAR
TSEERMRRFITDASHELRTPLTTIRGFAELYRQGAARDVEMLMNRIESESRRMGLLVEDLLLLARLDAQRPLERHRVDLL
ALATDAVHDAQSIAPERTITLQVLDGPGTPEVVGDEARLRQVLGNLVANALQHTPKHAGITVRVGTDETNAVLEVCDEGP
GMTEEDARRVFERFYRTDSSRARESGGTGLGLSIVDSLVLAHGGTVRVTTAPGQGCRFTVHLPRFSDVPVETA

Sequences:

>Translated_473_residues
MRGGVPLRLGLVAATLVLVAFGLLASGIAVTSIMRHSLESRVDQTLLDASRSWAQAPRQLPVAPLAGPNPARPPSDFYVR
GTGPDGRMWTAVNDREAEPVLPSSNDVGPVPVTVRSVNHSDVEWRAMTVRGPGGALTTVAIDLSEVQSTVRALVWSQIGI
GAAVLLVLGVAGYAVVQRSLRPLTEVEETAAAIAAGQLDRRVPQRDPRTEVGRLSLALNGMLAQIQRAVASSESSADAAR
TSEERMRRFITDASHELRTPLTTIRGFAELYRQGAARDVEMLMNRIESESRRMGLLVEDLLLLARLDAQRPLERHRVDLL
ALATDAVHDAQSIAPERTITLQVLDGPGTPEVVGDEARLRQVLGNLVANALQHTPKHAGITVRVGTDETNAVLEVCDEGP
GMTEEDARRVFERFYRTDSSRARESGGTGLGLSIVDSLVLAHGGTVRVTTAPGQGCRFTVHLPRFSDVPVETA
>Mature_473_residues
MRGGVPLRLGLVAATLVLVAFGLLASGIAVTSIMRHSLESRVDQTLLDASRSWAQAPRQLPVAPLAGPNPARPPSDFYVR
GTGPDGRMWTAVNDREAEPVLPSSNDVGPVPVTVRSVNHSDVEWRAMTVRGPGGALTTVAIDLSEVQSTVRALVWSQIGI
GAAVLLVLGVAGYAVVQRSLRPLTEVEETAAAIAAGQLDRRVPQRDPRTEVGRLSLALNGMLAQIQRAVASSESSADAAR
TSEERMRRFITDASHELRTPLTTIRGFAELYRQGAARDVEMLMNRIESESRRMGLLVEDLLLLARLDAQRPLERHRVDLL
ALATDAVHDAQSIAPERTITLQVLDGPGTPEVVGDEARLRQVLGNLVANALQHTPKHAGITVRVGTDETNAVLEVCDEGP
GMTEEDARRVFERFYRTDSSRARESGGTGLGLSIVDSLVLAHGGTVRVTTAPGQGCRFTVHLPRFSDVPVETA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=293, Percent_Identity=31.3993174061433, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=36.322869955157, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786783, Length=365, Percent_Identity=30.1369863013699, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788393, Length=294, Percent_Identity=30.6122448979592, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787894, Length=317, Percent_Identity=29.9684542586751, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1790861, Length=342, Percent_Identity=28.6549707602339, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1789149, Length=382, Percent_Identity=26.7015706806283, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=31.6037735849057, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=31.4159292035398, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI48994928, Length=246, Percent_Identity=28.4552845528455, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=27.3109243697479, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788279, Length=235, Percent_Identity=29.3617021276596, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790551, Length=304, Percent_Identity=28.6184210526316, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788549, Length=213, Percent_Identity=28.169014084507, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789808, Length=313, Percent_Identity=28.7539936102236, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081816, Length=355, Percent_Identity=27.0422535211268, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=251, Percent_Identity=28.2868525896414, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789403, Length=354, Percent_Identity=28.8135593220339, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=225, Percent_Identity=26.2222222222222, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790300, Length=241, Percent_Identity=30.2904564315353, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50815; Mature: 50815

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGGVPLRLGLVAATLVLVAFGLLASGIAVTSIMRHSLESRVDQTLLDASRSWAQAPRQL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVAPLAGPNPARPPSDFYVRGTGPDGRMWTAVNDREAEPVLPSSNDVGPVPVTVRSVNHS
CCCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCC
DVEWRAMTVRGPGGALTTVAIDLSEVQSTVRALVWSQIGIGAAVLLVLGVAGYAVVQRSL
CCEEEEEEEECCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPLTEVEETAAAIAAGQLDRRVPQRDPRTEVGRLSLALNGMLAQIQRAVASSESSADAAR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
TSEERMRRFITDASHELRTPLTTIRGFAELYRQGAARDVEMLMNRIESESRRMGLLVEDL
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLLARLDAQRPLERHRVDLLALATDAVHDAQSIAPERTITLQVLDGPGTPEVVGDEARLR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHH
QVLGNLVANALQHTPKHAGITVRVGTDETNAVLEVCDEGPGMTEEDARRVFERFYRTDSS
HHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCH
RARESGGTGLGLSIVDSLVLAHGGTVRVTTAPGQGCRFTVHLPRFSDVPVETA
HHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRGGVPLRLGLVAATLVLVAFGLLASGIAVTSIMRHSLESRVDQTLLDASRSWAQAPRQL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVAPLAGPNPARPPSDFYVRGTGPDGRMWTAVNDREAEPVLPSSNDVGPVPVTVRSVNHS
CCCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCC
DVEWRAMTVRGPGGALTTVAIDLSEVQSTVRALVWSQIGIGAAVLLVLGVAGYAVVQRSL
CCEEEEEEEECCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPLTEVEETAAAIAAGQLDRRVPQRDPRTEVGRLSLALNGMLAQIQRAVASSESSADAAR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
TSEERMRRFITDASHELRTPLTTIRGFAELYRQGAARDVEMLMNRIESESRRMGLLVEDL
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLLARLDAQRPLERHRVDLLALATDAVHDAQSIAPERTITLQVLDGPGTPEVVGDEARLR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHH
QVLGNLVANALQHTPKHAGITVRVGTDETNAVLEVCDEGPGMTEEDARRVFERFYRTDSS
HHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCH
RARESGGTGLGLSIVDSLVLAHGGTVRVTTAPGQGCRFTVHLPRFSDVPVETA
HHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]