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The map label for this gene is purL [H]

Identifier: 108801509

GI number: 108801509

Start: 4818495

End: 4820801

Strand: Reverse

Name: purL [H]

Synonym: Mmcs_4546

Alternate gene names: 108801509

Gene position: 4820801-4818495 (Counterclockwise)

Preceding gene: 108801510

Following gene: 108801508

Centisome position: 84.49

GC content: 68.75

Gene sequence:

>2307_bases
GTGACGCAGGAGCTTGCCCCCACGCTGGACACCGTCGAGCGTGCCGCAGCCACCCCCGACCAGCCTCAACCGTTCCGCGA
ACTGGGCCTCAAGGACGACGAGTACCAGCGCATACGCGAGATCCTCGGGCGCAGACCCACCGACGCCGAACTGGCGATGT
ACTCGGTGATGTGGAGCGAGCACTGCTCGTACAAGTCCTCGAAGGTGCACCTGCGGTACTTCGGCGAGACCACCACCGAA
AAGATGCGCTCGACGATGCTCGCCGGTATCGGCGAGAACGCGGGTGTCGTCGACATCGGCGACGGCTGGGCGGTGACCTT
CAAGGTCGAATCCCACAACCATCCCTCCTACGTCGAGCCGTACCAGGGCGCGGCCACCGGCGTCGGCGGCATCGTCCGCG
ACATCATGGCGATGGGCGCGCGCCCGGTGGCCGTGATGGACCAGCTCCGCTTTGGCGCCGCCGACGCCCCCGACACCAAG
CGCGTGCTCGACGGCGTGGTGCGCGGGGTCGGTGGATACGGGAACTCGCTCGGCCTGCCCAACATCGGCGGCGAGACCGT
CTTCGACCCCTCCTACGCGGGTAACCCGCTGGTCAACGCTCTCTGCGTCGGCGCGATGCGCAAGGAGGACCTGCACCTGG
CATTCGCCTCGGGTGCGGGCAACAAGATCATCCTGTTCGGTGCGCGCACCGGGCTCGACGGCATCGGCGGGGTGTCGGTG
CTGGCCTCGGACACCTTCTCCGGCGACGAGTCGGGGGCGGGCCGCAAGAAGCTCCCCTCGGTGCAGGTCGGGGACCCCTT
CATGGAGAAGGTGCTCATCGAATGCTGCCTCGAGCTGTACGCCGCGGACCTCGTGGTCGGCATCCAGGACCTGGGCGGCG
CCGGATTGTCCTGTGCCACATCTGAACTCGCGTCAGCCGGGGACGGTGGGATGCGTGTGGAACTCGATCAGGTCCCGCTG
CGTGCGGCGAACATGACTCCCGCCGAGATCCTGTCCAGCGAGTCGCAGGAACGCATGTGCGCGGTCGTCACACCGGACAA
CGTCGAGGCCTTCCTGGCGGTCTGCCGCAAATGGGAGGTGCTCGCCACCGTGATCGGCGAGGTCACCGACGGGGACCGTC
TGGTGATCACCTGGCACGGCGACACCGTCGTCGACGTGCCGCCGCGCACCGTCGCCCACGAGGGTCCGGTGTACCAGCGC
CCGGTCACCCGCCCTGACACCCAGGACGCGCTCAACGCCGACACGTCGGCCGATCTGCCGCGACCCGCCACCGGCGACGA
ACTGCGCGCCACCCTGCTCGCCATGATCGGCAGCCCGCACCTGTGCAGCCGCGGGTACATCACCGAACAGTACGACCGCT
ATGTGCGCGGCAACACGGTGCTGGCCGAACACGCCGACGGCGGCGTGCTGCGCATCGACGAGGCCACCGGCCGCGGCATC
GCGGTCTCGACCGACGCCTCCGGCCGCTACACCGCACTCGATCCCTACACCGGTGCGCAACTGGCCCTCGCCGAGGCCTA
CCGCAACGTCGCGGTCACCGGCGCCACACCGGTCGCCGTGACGAACTGCCTCAACTTCGGCTCCCCTGAGGATCCGGGTG
TCATGTGGCAGTTCAGCCAGGCGGTGCGCGGTTTGGCCGATGGTTGTGCGGCCCTTGGCATCCCGGTCACCGGTGGCAAC
GTGAGCTTCTACAACCAGACCGGGTCGACCGCGATCCTGCCCACCCCGGTCGTGGGGGTGCTGGGCGTGCTCGACGACGT
CAAGCGGCGTATCCCGACCGGTCTTGGCACCGAACCCGGCGAGACGCTGATGCTGCTCGGCGACACCCGCGACGAGTTCG
ACGGGTCGATCTGGGCGCAGGTCACCGCCGGTCACCTCGGCGGGTTGCCCCCCAAAGTCGACCTCGAACGGGAGAAGCTG
CTCGCCGATGTGCTCACGGCCGCCTCGCGTGACGGATTGATCTCCGCCGCACACGATCTCAGTGAGGGCGGGCTGATCCA
AGCCGTCGTGGAGGCCGCGCTGGCCGGTGAAACGGGTTGCCGGGTCCTCATTCCCGAGAACTTCGAGAACGGCACAGGTC
CGTTCACGTTCCTCTTCAGCGAATCGGCCGGCCGGGTACTCGTCGCGGTGCCCCGCACCGAGGAGAGCCGCTTCCGCGCG
ATGTGCGAAGCCCGCGGCCTGCCCATCACCCGCATCGGTGTGGTCGATCCCGGCAGCGATGCGGTCGAAGTGCAGGGCCA
CTTCACGGTGCCACTGGCGGAACTGCGGACCACCTCCGAGGGCGTGTTGCCCGGACTGTTCGGGTGA

Upstream 100 bases:

>100_bases
GCACGGTGTGGCCGCCCCCGCCGCCGCTCACGCCTACGCCGCGCGCCACCCGGCGTCCCGCGACGCGGAGCACAGCGGCC
CGGGGAAATAGACTGTCTGC

Downstream 100 bases:

>100_bases
GAGCACAGACCGATCAGATCTCCGGTGACACCGTCACCGACACTCCCGAACGCCCGCGGCGCCACCCCTTGCTCATCCGG
GTGTGGGGCCTCATCCGCCT

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 768; Mature: 767

Protein sequence:

>768_residues
MTQELAPTLDTVERAAATPDQPQPFRELGLKDDEYQRIREILGRRPTDAELAMYSVMWSEHCSYKSSKVHLRYFGETTTE
KMRSTMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADAPDTK
RVLDGVVRGVGGYGNSLGLPNIGGETVFDPSYAGNPLVNALCVGAMRKEDLHLAFASGAGNKIILFGARTGLDGIGGVSV
LASDTFSGDESGAGRKKLPSVQVGDPFMEKVLIECCLELYAADLVVGIQDLGGAGLSCATSELASAGDGGMRVELDQVPL
RAANMTPAEILSSESQERMCAVVTPDNVEAFLAVCRKWEVLATVIGEVTDGDRLVITWHGDTVVDVPPRTVAHEGPVYQR
PVTRPDTQDALNADTSADLPRPATGDELRATLLAMIGSPHLCSRGYITEQYDRYVRGNTVLAEHADGGVLRIDEATGRGI
AVSTDASGRYTALDPYTGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFSQAVRGLADGCAALGIPVTGGN
VSFYNQTGSTAILPTPVVGVLGVLDDVKRRIPTGLGTEPGETLMLLGDTRDEFDGSIWAQVTAGHLGGLPPKVDLEREKL
LADVLTAASRDGLISAAHDLSEGGLIQAVVEAALAGETGCRVLIPENFENGTGPFTFLFSESAGRVLVAVPRTEESRFRA
MCEARGLPITRIGVVDPGSDAVEVQGHFTVPLAELRTTSEGVLPGLFG

Sequences:

>Translated_768_residues
MTQELAPTLDTVERAAATPDQPQPFRELGLKDDEYQRIREILGRRPTDAELAMYSVMWSEHCSYKSSKVHLRYFGETTTE
KMRSTMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADAPDTK
RVLDGVVRGVGGYGNSLGLPNIGGETVFDPSYAGNPLVNALCVGAMRKEDLHLAFASGAGNKIILFGARTGLDGIGGVSV
LASDTFSGDESGAGRKKLPSVQVGDPFMEKVLIECCLELYAADLVVGIQDLGGAGLSCATSELASAGDGGMRVELDQVPL
RAANMTPAEILSSESQERMCAVVTPDNVEAFLAVCRKWEVLATVIGEVTDGDRLVITWHGDTVVDVPPRTVAHEGPVYQR
PVTRPDTQDALNADTSADLPRPATGDELRATLLAMIGSPHLCSRGYITEQYDRYVRGNTVLAEHADGGVLRIDEATGRGI
AVSTDASGRYTALDPYTGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFSQAVRGLADGCAALGIPVTGGN
VSFYNQTGSTAILPTPVVGVLGVLDDVKRRIPTGLGTEPGETLMLLGDTRDEFDGSIWAQVTAGHLGGLPPKVDLEREKL
LADVLTAASRDGLISAAHDLSEGGLIQAVVEAALAGETGCRVLIPENFENGTGPFTFLFSESAGRVLVAVPRTEESRFRA
MCEARGLPITRIGVVDPGSDAVEVQGHFTVPLAELRTTSEGVLPGLFG
>Mature_767_residues
TQELAPTLDTVERAAATPDQPQPFRELGLKDDEYQRIREILGRRPTDAELAMYSVMWSEHCSYKSSKVHLRYFGETTTEK
MRSTMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADAPDTKR
VLDGVVRGVGGYGNSLGLPNIGGETVFDPSYAGNPLVNALCVGAMRKEDLHLAFASGAGNKIILFGARTGLDGIGGVSVL
ASDTFSGDESGAGRKKLPSVQVGDPFMEKVLIECCLELYAADLVVGIQDLGGAGLSCATSELASAGDGGMRVELDQVPLR
AANMTPAEILSSESQERMCAVVTPDNVEAFLAVCRKWEVLATVIGEVTDGDRLVITWHGDTVVDVPPRTVAHEGPVYQRP
VTRPDTQDALNADTSADLPRPATGDELRATLLAMIGSPHLCSRGYITEQYDRYVRGNTVLAEHADGGVLRIDEATGRGIA
VSTDASGRYTALDPYTGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFSQAVRGLADGCAALGIPVTGGNV
SFYNQTGSTAILPTPVVGVLGVLDDVKRRIPTGLGTEPGETLMLLGDTRDEFDGSIWAQVTAGHLGGLPPKVDLEREKLL
ADVLTAASRDGLISAAHDLSEGGLIQAVVEAALAGETGCRVLIPENFENGTGPFTFLFSESAGRVLVAVPRTEESRFRAM
CEARGLPITRIGVVDPGSDAVEVQGHFTVPLAELRTTSEGVLPGLFG

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=682, Percent_Identity=24.3401759530792, Blast_Score=101, Evalue=3e-21,
Organism=Escherichia coli, GI48994899, Length=774, Percent_Identity=28.0361757105943, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6321498, Length=828, Percent_Identity=24.7584541062802, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24582111, Length=716, Percent_Identity=24.7206703910615, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24582109, Length=716, Percent_Identity=24.7206703910615, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17137292, Length=716, Percent_Identity=24.7206703910615, Blast_Score=124, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 80968; Mature: 80837

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQELAPTLDTVERAAATPDQPQPFRELGLKDDEYQRIREILGRRPTDAELAMYSVMWSE
CCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
HCSYKSSKVHLRYFGETTTEKMRSTMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEP
HCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEEEECCCCCCCCCC
YQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADAPDTKRVLDGVVRGVGGYGNSLGLP
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
NIGGETVFDPSYAGNPLVNALCVGAMRKEDLHLAFASGAGNKIILFGARTGLDGIGGVSV
CCCCCCEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCEEE
LASDTFSGDESGAGRKKLPSVQVGDPFMEKVLIECCLELYAADLVVGIQDLGGAGLSCAT
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
SELASAGDGGMRVELDQVPLRAANMTPAEILSSESQERMCAVVTPDNVEAFLAVCRKWEV
HHHHHCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHH
LATVIGEVTDGDRLVITWHGDTVVDVPPRTVAHEGPVYQRPVTRPDTQDALNADTSADLP
HHHHHHCCCCCCEEEEEECCCEEEECCCCHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCC
RPATGDELRATLLAMIGSPHLCSRGYITEQYDRYVRGNTVLAEHADGGVLRIDEATGRGI
CCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCEEEEECCCCCEE
AVSTDASGRYTALDPYTGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFSQ
EEEECCCCCEEEECCCCCHHHHHHHHHHCEEEECCCHHHHHHHHCCCCCCCCCCEEEHHH
AVRGLADGCAALGIPVTGGNVSFYNQTGSTAILPTPVVGVLGVLDDVKRRIPTGLGTEPG
HHHHHHCCHHHCCEEEECCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCC
ETLMLLGDTRDEFDGSIWAQVTAGHLGGLPPKVDLEREKLLADVLTAASRDGLISAAHDL
CEEEEEECCCHHHCCCEEEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHC
SEGGLIQAVVEAALAGETGCRVLIPENFENGTGPFTFLFSESAGRVLVAVPRTEESRFRA
CCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHH
MCEARGLPITRIGVVDPGSDAVEVQGHFTVPLAELRTTSEGVLPGLFG
HHHHCCCCEEEEEEECCCCCEEEEECEEECCHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TQELAPTLDTVERAAATPDQPQPFRELGLKDDEYQRIREILGRRPTDAELAMYSVMWSE
CCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
HCSYKSSKVHLRYFGETTTEKMRSTMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEP
HCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEEEECCCCCCCCCC
YQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADAPDTKRVLDGVVRGVGGYGNSLGLP
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
NIGGETVFDPSYAGNPLVNALCVGAMRKEDLHLAFASGAGNKIILFGARTGLDGIGGVSV
CCCCCCEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCEEE
LASDTFSGDESGAGRKKLPSVQVGDPFMEKVLIECCLELYAADLVVGIQDLGGAGLSCAT
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
SELASAGDGGMRVELDQVPLRAANMTPAEILSSESQERMCAVVTPDNVEAFLAVCRKWEV
HHHHHCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHH
LATVIGEVTDGDRLVITWHGDTVVDVPPRTVAHEGPVYQRPVTRPDTQDALNADTSADLP
HHHHHHCCCCCCEEEEEECCCEEEECCCCHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCC
RPATGDELRATLLAMIGSPHLCSRGYITEQYDRYVRGNTVLAEHADGGVLRIDEATGRGI
CCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCEEEEECCCCCEE
AVSTDASGRYTALDPYTGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFSQ
EEEECCCCCEEEECCCCCHHHHHHHHHHCEEEECCCHHHHHHHHCCCCCCCCCCEEEHHH
AVRGLADGCAALGIPVTGGNVSFYNQTGSTAILPTPVVGVLGVLDDVKRRIPTGLGTEPG
HHHHHHCCHHHCCEEEECCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCC
ETLMLLGDTRDEFDGSIWAQVTAGHLGGLPPKVDLEREKLLADVLTAASRDGLISAAHDL
CEEEEEECCCHHHCCCEEEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHC
SEGGLIQAVVEAALAGETGCRVLIPENFENGTGPFTFLFSESAGRVLVAVPRTEESRFRA
CCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHH
MCEARGLPITRIGVVDPGSDAVEVQGHFTVPLAELRTTSEGVLPGLFG
HHHHCCCCEEEEEEECCCCCEEEEECEEECCHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA