Definition Mycobacterium sp. MCS chromosome, complete genome.
Accession NC_008146
Length 5,705,448

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The map label for this gene is ucpA [C]

Identifier: 108801367

GI number: 108801367

Start: 4682960

End: 4683880

Strand: Reverse

Name: ucpA [C]

Synonym: Mmcs_4404

Alternate gene names: 108801367

Gene position: 4683880-4682960 (Counterclockwise)

Preceding gene: 108801368

Following gene: 108801366

Centisome position: 82.09

GC content: 69.49

Gene sequence:

>921_bases
GTGACCGACTTGAGGTACGACGGCCGCGTCGCCGTCGTCACCGGCGGTGGCCGCGGACTCGGCCGGGCGTACGCGCTGCT
GCTCGCCTCCCGCGGGGCGAAGGTCGTCGTCAACGATCTGGGCGGCGACCTCACCGGGGACGGTGTCGATGCGGGACCGG
CCCACGAGGTCGTCCGCGAGATCGTCGCCGCCGGAGGCGAGGCGGTTGCCAGCACCGACTCCGTCGCGACGCCCGAGGGC
GGCAGGGCGATCGTCGACACGGCGATGGACACCTACGGCCGGCTGGACATCCTGATCCACAACGCGGGCAACGTCCGGCG
CGCATCGCTGAGTGAGATCAGCGACGAGGACTTCGATGCGGTGGTCGACGTCCATCTGCGCGGCGCGTTCCACGTTGTGC
GGCCGGCCTTTCCGGTGATGTGTGACGCCGGCTACGGCCGCATCGTGCTGACGTCGTCCATCGGTGGTCTCTACGGCAAT
CACGACGTGGTGAACTACGCGGTCGCCAAGGCGGGGGTGATCGGCTTGTCCAACGTCGCCGCCATCGAAGGGGCCGAGTA
CGGGGTGCGTAGCAACGTCATCGTGCCGGCGGCCGTCACCCGGATGGCCGAGGGTATCGACACGTCGGCCTATCCGCCGA
TGGATCCGGAACTGGTGGCGCCGACCGTCGGCTGGTTGTCACACGAAACCTGTTCGGTGACAGGCGAGATGTTCATCGCG
CTGGCCGGCAGGGTGGCCACCGCCGTCCTCGTCGAGACGCCGGGTGTGTACCGGTCGTCGTGGACGGTCGAGGACGTCGC
CGCCGACCTCGACGCCATCCGCGACCGTTCACACCCCGTGGTGTTCCCGGTGGTGCCCGACGGCCACAACGCCCACATCC
GCTACAGCTTCGCGATGGCCGCCCAGAAGGCGGGGACCTGA

Upstream 100 bases:

>100_bases
GTGCATTCCTCGGCGACTTCTACTCGCCCGGCTTCTACGCGTTCGACGAGCTGATTGCGGCGTGGCGGGACAGTGGCGAC
CTCGAGGGCCTGGAACTTTC

Downstream 100 bases:

>100_bases
TGAGCGGCCCGCTGGAGGGGGTGCGCGTGGTCGACCTCACCGCGATGGTGATGGGTCCGTACTGCACCCAGATCATGGCG
GACATGGGCGCCGACGTGGT

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTDLRYDGRVAVVTGGGRGLGRAYALLLASRGAKVVVNDLGGDLTGDGVDAGPAHEVVREIVAAGGEAVASTDSVATPEG
GRAIVDTAMDTYGRLDILIHNAGNVRRASLSEISDEDFDAVVDVHLRGAFHVVRPAFPVMCDAGYGRIVLTSSIGGLYGN
HDVVNYAVAKAGVIGLSNVAAIEGAEYGVRSNVIVPAAVTRMAEGIDTSAYPPMDPELVAPTVGWLSHETCSVTGEMFIA
LAGRVATAVLVETPGVYRSSWTVEDVAADLDAIRDRSHPVVFPVVPDGHNAHIRYSFAMAAQKAGT

Sequences:

>Translated_306_residues
MTDLRYDGRVAVVTGGGRGLGRAYALLLASRGAKVVVNDLGGDLTGDGVDAGPAHEVVREIVAAGGEAVASTDSVATPEG
GRAIVDTAMDTYGRLDILIHNAGNVRRASLSEISDEDFDAVVDVHLRGAFHVVRPAFPVMCDAGYGRIVLTSSIGGLYGN
HDVVNYAVAKAGVIGLSNVAAIEGAEYGVRSNVIVPAAVTRMAEGIDTSAYPPMDPELVAPTVGWLSHETCSVTGEMFIA
LAGRVATAVLVETPGVYRSSWTVEDVAADLDAIRDRSHPVVFPVVPDGHNAHIRYSFAMAAQKAGT
>Mature_305_residues
TDLRYDGRVAVVTGGGRGLGRAYALLLASRGAKVVVNDLGGDLTGDGVDAGPAHEVVREIVAAGGEAVASTDSVATPEGG
RAIVDTAMDTYGRLDILIHNAGNVRRASLSEISDEDFDAVVDVHLRGAFHVVRPAFPVMCDAGYGRIVLTSSIGGLYGNH
DVVNYAVAKAGVIGLSNVAAIEGAEYGVRSNVIVPAAVTRMAEGIDTSAYPPMDPELVAPTVGWLSHETCSVTGEMFIAL
AGRVATAVLVETPGVYRSSWTVEDVAADLDAIRDRSHPVVFPVVPDGHNAHIRYSFAMAAQKAGT

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=278, Percent_Identity=44.9640287769784, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI15277342, Length=263, Percent_Identity=31.5589353612167, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI40807363, Length=218, Percent_Identity=27.5229357798165, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=27.6, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI209862901, Length=245, Percent_Identity=30.6122448979592, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI19923983, Length=245, Percent_Identity=30.6122448979592, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40254992, Length=191, Percent_Identity=30.3664921465969, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI25282469, Length=238, Percent_Identity=25.2100840336134, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI126723191, Length=191, Percent_Identity=28.2722513089005, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87082100, Length=217, Percent_Identity=31.7972350230415, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787335, Length=193, Percent_Identity=32.6424870466321, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789208, Length=197, Percent_Identity=29.4416243654822, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87082160, Length=197, Percent_Identity=26.9035532994924, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=27.8225806451613, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789057, Length=184, Percent_Identity=34.2391304347826, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=28.1632653061224, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=31.3492063492063, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790717, Length=197, Percent_Identity=25.8883248730964, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=273, Percent_Identity=44.3223443223443, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI193204405, Length=242, Percent_Identity=30.9917355371901, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=209, Percent_Identity=34.4497607655502, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=203, Percent_Identity=32.512315270936, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562908, Length=221, Percent_Identity=31.2217194570136, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=256, Percent_Identity=31.25, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193203117, Length=261, Percent_Identity=28.735632183908, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=203, Percent_Identity=33.4975369458128, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17564282, Length=218, Percent_Identity=29.3577981651376, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI193203115, Length=263, Percent_Identity=29.277566539924, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17567345, Length=236, Percent_Identity=31.3559322033898, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17531453, Length=204, Percent_Identity=30.8823529411765, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=273, Percent_Identity=27.8388278388278, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=189, Percent_Identity=30.6878306878307, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17538486, Length=204, Percent_Identity=31.8627450980392, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=27.027027027027, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=27.7992277992278, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=212, Percent_Identity=29.2452830188679, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=204, Percent_Identity=27.4509803921569, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17555706, Length=222, Percent_Identity=29.7297297297297, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=224, Percent_Identity=25.8928571428571, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=204, Percent_Identity=28.921568627451, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=209, Percent_Identity=26.7942583732057, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=209, Percent_Identity=30.622009569378, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=275, Percent_Identity=26.1818181818182, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=204, Percent_Identity=27.9411764705882, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=210, Percent_Identity=27.1428571428571, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=174, Percent_Identity=29.3103448275862, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=246, Percent_Identity=45.5284552845528, Blast_Score=205, Evalue=9e-54,
Organism=Drosophila melanogaster, GI18859837, Length=253, Percent_Identity=51.3833992094862, Blast_Score=237, Evalue=6e-63,
Organism=Drosophila melanogaster, GI21357041, Length=213, Percent_Identity=30.9859154929577, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24639444, Length=193, Percent_Identity=34.1968911917098, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571526, Length=230, Percent_Identity=30.4347826086957, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644339, Length=219, Percent_Identity=26.9406392694064, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355319, Length=257, Percent_Identity=28.0155642023346, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17737361, Length=199, Percent_Identity=30.1507537688442, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI23397609, Length=199, Percent_Identity=27.6381909547739, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281364892, Length=169, Percent_Identity=28.4023668639053, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21357673, Length=242, Percent_Identity=26.0330578512397, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640492, Length=187, Percent_Identity=25.1336898395722, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 31780; Mature: 31649

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MTDLRYDGRVAVVTGGGRGLGRAYALLLASRGAKVVVNDLGGDLTGDGVDAGPAHEVVRE
CCCCEECCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
IVAAGGEAVASTDSVATPEGGRAIVDTAMDTYGRLDILIHNAGNVRRASLSEISDEDFDA
HHHCCCCEEECCCCCCCCCCCCEEEHHHHHCCCCEEEEEECCCCCEECHHHHCCCCCCCE
VVDVHLRGAFHVVRPAFPVMCDAGYGRIVLTSSIGGLYGNHDVVNYAVAKAGVIGLSNVA
EEEEEECCEEEECCCCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHCEEECCCEE
AIEGAEYGVRSNVIVPAAVTRMAEGIDTSAYPPMDPELVAPTVGWLSHETCSVTGEMFIA
EECCCCCCCCCCEECHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHH
LAGRVATAVLVETPGVYRSSWTVEDVAADLDAIRDRSHPVVFPVVPDGHNAHIRYSFAMA
HHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEEEH
AQKAGT
HHCCCC
>Mature Secondary Structure 
TDLRYDGRVAVVTGGGRGLGRAYALLLASRGAKVVVNDLGGDLTGDGVDAGPAHEVVRE
CCCEECCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
IVAAGGEAVASTDSVATPEGGRAIVDTAMDTYGRLDILIHNAGNVRRASLSEISDEDFDA
HHHCCCCEEECCCCCCCCCCCCEEEHHHHHCCCCEEEEEECCCCCEECHHHHCCCCCCCE
VVDVHLRGAFHVVRPAFPVMCDAGYGRIVLTSSIGGLYGNHDVVNYAVAKAGVIGLSNVA
EEEEEECCEEEECCCCCCEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHCEEECCCEE
AIEGAEYGVRSNVIVPAAVTRMAEGIDTSAYPPMDPELVAPTVGWLSHETCSVTGEMFIA
EECCCCCCCCCCEECHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHH
LAGRVATAVLVETPGVYRSSWTVEDVAADLDAIRDRSHPVVFPVVPDGHNAHIRYSFAMA
HHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEEEH
AQKAGT
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]