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The map label for this gene is sucD [H]

Identifier: 108801290

GI number: 108801290

Start: 4599922

End: 4600824

Strand: Reverse

Name: sucD [H]

Synonym: Mmcs_4326

Alternate gene names: 108801290

Gene position: 4600824-4599922 (Counterclockwise)

Preceding gene: 108801291

Following gene: 108801289

Centisome position: 80.64

GC content: 66.11

Gene sequence:

>903_bases
ATGTCGATCTTTCTGAACAAGGACTCCAAGGTCATCGTCCAGGGCATCACCGGCGGTGAGGGCACCAAGCACACCGCGCT
GATGCTCAAGGCCGGCACCCAGCTGGTCGGCGGGGTCAACGCCCGTAAGGCGGGGACCACCGTCAGCCATGTCGACAAGG
ACGGCAAGGACGTCGAACTGCCGGTGTTCGGCAGCGTTGGCGATGCGATGAAGGAGACCGGCGCCGACGTGTCGGTGGTC
TTCGTGCCGCCGAAGTTCGCCAAGGACGCGATCATCGAGGCCATCGACGCCGAGATCCCGCTGCTCGTGGTGATCACCGA
GGGCATCCCGGTGCAGGACACCGCCTACGCGTGGGCCTACAACGTCGAGAAGGGACAGAAGACCCGCATCATCGGCCCCA
ACTGCCCCGGCATCATCACCCCCGGTGAGGCGCTGGCCGGCATCACGCCCGCCAACATCACCGGCTCCGGCCCGGTCGGC
CTGGTCTCGAAGTCCGGCACGTTGACCTACCAGATGATGTACGAGCTGCGTGACTTCGGCTTCTCGACCGCGATCGGCAT
CGGCGGCGACCCGGTCATCGGCACCACGCACATCGACGCGATCGAGGCGTTCGAGAAGGATCCCGACACAAAGGTCATCG
TGATGATCGGTGAGATCGGCGGCGACGCCGAGGAGCGGGCGGCTGACTACATCAAGGACAACGTCTCCAAGCCGGTCGTC
GGCTATGTCGCGGGCTTCACGGCTCCGGAGGGCAAGACGATGGGCCACGCCGGTGCCATCGTGTCCGGTTCGTCGGGCAC
CGCGGCGGCCAAGAAGGAAGCGCTCGAGGCGGCAGGCGTGAAGGTCGGCAAGACCCCGTCGGAGACCGCGCAGCTCGCCC
GGGAGATCCTGCAGAACCAGTAG

Upstream 100 bases:

>100_bases
ATCCTCGCCGACGCCAACCACCCGCTGGTGGTGCTGGCGCAGACCATGGACGAGGGCGCCGACAAGGCCGCCGAGTTGGC
GAACAAGTAAGGGACCTGCA

Downstream 100 bases:

>100_bases
CGACTTTTCGCCGAGACTGCGGTCAGATCACGAATCCTCCGGGATTCCCGATCTGGCCGCAGTCTCGTTGTACGGGTGGG
CCGGTTCGCCAAACCGGAAC

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQLVGGVNARKAGTTVSHVDKDGKDVELPVFGSVGDAMKETGADVSVV
FVPPKFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNVEKGQKTRIIGPNCPGIITPGEALAGITPANITGSGPVG
LVSKSGTLTYQMMYELRDFGFSTAIGIGGDPVIGTTHIDAIEAFEKDPDTKVIVMIGEIGGDAEERAADYIKDNVSKPVV
GYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAAGVKVGKTPSETAQLAREILQNQ

Sequences:

>Translated_300_residues
MSIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQLVGGVNARKAGTTVSHVDKDGKDVELPVFGSVGDAMKETGADVSVV
FVPPKFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNVEKGQKTRIIGPNCPGIITPGEALAGITPANITGSGPVG
LVSKSGTLTYQMMYELRDFGFSTAIGIGGDPVIGTTHIDAIEAFEKDPDTKVIVMIGEIGGDAEERAADYIKDNVSKPVV
GYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAAGVKVGKTPSETAQLAREILQNQ
>Mature_299_residues
SIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQLVGGVNARKAGTTVSHVDKDGKDVELPVFGSVGDAMKETGADVSVVF
VPPKFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNVEKGQKTRIIGPNCPGIITPGEALAGITPANITGSGPVGL
VSKSGTLTYQMMYELRDFGFSTAIGIGGDPVIGTTHIDAIEAFEKDPDTKVIVMIGEIGGDAEERAADYIKDNVSKPVVG
YVAGFTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAAGVKVGKTPSETAQLAREILQNQ

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=292, Percent_Identity=48.2876712328767, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI38569423, Length=260, Percent_Identity=31.5384615384615, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI38569421, Length=260, Percent_Identity=31.5384615384615, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1786949, Length=300, Percent_Identity=52.6666666666667, Blast_Score=292, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17550194, Length=293, Percent_Identity=50.8532423208191, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17553126, Length=293, Percent_Identity=49.4880546075085, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17557344, Length=259, Percent_Identity=28.957528957529, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17551266, Length=259, Percent_Identity=28.1853281853282, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324716, Length=300, Percent_Identity=47, Blast_Score=232, Evalue=5e-62,
Organism=Drosophila melanogaster, GI21356559, Length=305, Percent_Identity=45.9016393442623, Blast_Score=248, Evalue=3e-66,
Organism=Drosophila melanogaster, GI28574296, Length=303, Percent_Identity=47.1947194719472, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI281363477, Length=244, Percent_Identity=31.5573770491803, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281363475, Length=244, Percent_Identity=31.5573770491803, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI281363473, Length=244, Percent_Identity=31.5573770491803, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30911; Mature: 30779

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQLVGGVNARKAGTTVSHVDKDGKDVEL
CEEEEECCCEEEEEEECCCCCCCEEEEEEECCCHHHCCCCCCCCCCCHHHCCCCCCEEEE
PVFGSVGDAMKETGADVSVVFVPPKFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAY
EECCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEE
NVEKGQKTRIIGPNCPGIITPGEALAGITPANITGSGPVGLVSKSGTLTYQMMYELRDFG
ECCCCCEEEEECCCCCCEECCCHHHCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHCC
FSTAIGIGGDPVIGTTHIDAIEAFEKDPDTKVIVMIGEIGGDAEERAADYIKDNVSKPVV
CEEEECCCCCCEEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEE
GYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAAGVKVGKTPSETAQLAREILQNQ
EEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIFLNKDSKVIVQGITGGEGTKHTALMLKAGTQLVGGVNARKAGTTVSHVDKDGKDVEL
EEEEECCCEEEEEEECCCCCCCEEEEEEECCCHHHCCCCCCCCCCCHHHCCCCCCEEEE
PVFGSVGDAMKETGADVSVVFVPPKFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAY
EECCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEE
NVEKGQKTRIIGPNCPGIITPGEALAGITPANITGSGPVGLVSKSGTLTYQMMYELRDFG
ECCCCCEEEEECCCCCCEECCCHHHCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHCC
FSTAIGIGGDPVIGTTHIDAIEAFEKDPDTKVIVMIGEIGGDAEERAADYIKDNVSKPVV
CEEEECCCCCCEEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEE
GYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAAGVKVGKTPSETAQLAREILQNQ
EEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]