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The map label for this gene is ppe42 [H]

Identifier: 108801245

GI number: 108801245

Start: 4548035

End: 4549588

Strand: Reverse

Name: ppe42 [H]

Synonym: Mmcs_4281

Alternate gene names: 108801245

Gene position: 4549588-4548035 (Counterclockwise)

Preceding gene: 108801247

Following gene: 108801244

Centisome position: 79.74

GC content: 65.77

Gene sequence:

>1554_bases
ATGCGTGGTCCTGTCGGTTCGCTGCTAGCCGTGTTCACCGCAATAGCCGGTGTGGTGTTGTTGGCATTCTCAGGAATGCT
CACAGGAATTGTTCAGCTTCTGGCTACGACGGCATTGATCATGGGCGGCACAGACCACCCGTTGTCGACGCCGCCGGACA
CCATCTCCTTCGTCGACGGCTACATGGACGACGCGGTGGACAACTACATCGATCCCGGGCTGGACACGGGCCCATCTGTC
AACAAAGTCGCGGTCATCACGCCCGAGCAGTTCTTCCCCGCATTCGGGTCGATGACGTTCGACGACTCGGTGCAGGAGGG
CCGCGACAACCTCAACGAGTGCGTGGCTGGAACCCCGTCGTGCGAGTACAACGAGAGTGAGGCGCTCGGATCCGATGCGC
CCAAGCCAGACGACAGCTTCATCGTCTTCGGCTACTCGCAGAGCGCCGTCATCGCCTCGCTCGTGAAACGCGATCTCATG
CAGACCCCTCCCGCGGATGCCACCGGTGTCTCCTTCGTGCTCCTCTCCAATGCGATGCGCCCCAACGGCGGCATCCTCGC
GCGCGGGTTCGAGGGCATGACGATCCCGCTACTCGGCGTGACCTTCTACGGCCCGACGCCGACCGACTCGTGCGAGGCCG
ATGGACCCTGCTACCCGACTGTGGACGTCGCCCAGCAGTACGACTTCATGGGGGGCGACGCCCCTGTCGCGCCGCTCAAT
GTGGTGGCGATGGCGAATTCGTTGGCGGCCTACTACTACCTGCACGGTTCGGTTCCGGCCAAGTCACTCGACGATCCGAA
CGTCATCGATCAGGGCGAGTGGGGTGATACCCACTACTACCTGATTCCGGCTGAGCGGTTACCGCTGCTCATGCCGTTCG
AGCAGGCGGGTGTCCCCGCACCCATCCTGGCCGTTCTGGATGCGCCGCTGCGTGTCATCGTCGAGGCCGGTTACGACCGC
GAGAGCAGCCCTGGTGAGCACGTGCAGTTCAGGCTGCTACCCATCGGCGATCCTTTCCGCTTCCTGGTGAACCTCGCCAA
GTCGGTTCCCGTCGGCATCGACGACGGTCTGCAAGAGGCCGGACTCGGCCGGGCGCTCGGAACGGAAGACGTCTTCCGGC
CGTACGGCGTGGGCGGTGAAGACCTGCCCCAGCCGGGTGACTCCGCCACCGAGGACAACCTCCGTACTGCCGCCGTGCCG
ACAGAGACGACCGCATCGGAGCCGGCTGCCGAACCGCTGACCGATGGACCGGTGGTCAGCGGTCAACCGAGCGAACGGAA
AGGCGACGAGCCGAGCCAGCTGAGCAACGATTCTCCCGTCCCGCCGGCCCCCGAACAGGTCAAGGAACGCCGTCTCTCGC
CCTTGCTCCGTGGGCTGAGTGATCGCGAGGAGGCCGATGCGCCCAAGCTGCCGTCGATTCGTCCGCCGGGCGAGCGCCTG
GTGCGGCGTGTGGTCGAGAGTGTGACCGGCCAGCGAGCCGAGCGGCCCGACGACTCGGGCGACGATGCGTCCGGCGGCAC
TCCGGCGGCCGAAAGCGACCCGGACGCAGCCTGA

Upstream 100 bases:

>100_bases
GTGAGCTGCTGATAAGAGATTGCAGACGATTGTCTGTCGACGCGACAGCTATCGGAAATATCATCTCGGCAGATCTGGGG
ATATCGGAGGGGTTCTTTTC

Downstream 100 bases:

>100_bases
CCGACGCGGGGCGCACGTTGTGATATCAACGCGACGTGCGCCGCTTCGCGGTCATCATGGCCGCCGCCGTCTGTGTCTGC
TCCTGCGGTCAACCGTCGCC

Product: PE-PPE-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MRGPVGSLLAVFTAIAGVVLLAFSGMLTGIVQLLATTALIMGGTDHPLSTPPDTISFVDGYMDDAVDNYIDPGLDTGPSV
NKVAVITPEQFFPAFGSMTFDDSVQEGRDNLNECVAGTPSCEYNESEALGSDAPKPDDSFIVFGYSQSAVIASLVKRDLM
QTPPADATGVSFVLLSNAMRPNGGILARGFEGMTIPLLGVTFYGPTPTDSCEADGPCYPTVDVAQQYDFMGGDAPVAPLN
VVAMANSLAAYYYLHGSVPAKSLDDPNVIDQGEWGDTHYYLIPAERLPLLMPFEQAGVPAPILAVLDAPLRVIVEAGYDR
ESSPGEHVQFRLLPIGDPFRFLVNLAKSVPVGIDDGLQEAGLGRALGTEDVFRPYGVGGEDLPQPGDSATEDNLRTAAVP
TETTASEPAAEPLTDGPVVSGQPSERKGDEPSQLSNDSPVPPAPEQVKERRLSPLLRGLSDREEADAPKLPSIRPPGERL
VRRVVESVTGQRAERPDDSGDDASGGTPAAESDPDAA

Sequences:

>Translated_517_residues
MRGPVGSLLAVFTAIAGVVLLAFSGMLTGIVQLLATTALIMGGTDHPLSTPPDTISFVDGYMDDAVDNYIDPGLDTGPSV
NKVAVITPEQFFPAFGSMTFDDSVQEGRDNLNECVAGTPSCEYNESEALGSDAPKPDDSFIVFGYSQSAVIASLVKRDLM
QTPPADATGVSFVLLSNAMRPNGGILARGFEGMTIPLLGVTFYGPTPTDSCEADGPCYPTVDVAQQYDFMGGDAPVAPLN
VVAMANSLAAYYYLHGSVPAKSLDDPNVIDQGEWGDTHYYLIPAERLPLLMPFEQAGVPAPILAVLDAPLRVIVEAGYDR
ESSPGEHVQFRLLPIGDPFRFLVNLAKSVPVGIDDGLQEAGLGRALGTEDVFRPYGVGGEDLPQPGDSATEDNLRTAAVP
TETTASEPAAEPLTDGPVVSGQPSERKGDEPSQLSNDSPVPPAPEQVKERRLSPLLRGLSDREEADAPKLPSIRPPGERL
VRRVVESVTGQRAERPDDSGDDASGGTPAAESDPDAA
>Mature_517_residues
MRGPVGSLLAVFTAIAGVVLLAFSGMLTGIVQLLATTALIMGGTDHPLSTPPDTISFVDGYMDDAVDNYIDPGLDTGPSV
NKVAVITPEQFFPAFGSMTFDDSVQEGRDNLNECVAGTPSCEYNESEALGSDAPKPDDSFIVFGYSQSAVIASLVKRDLM
QTPPADATGVSFVLLSNAMRPNGGILARGFEGMTIPLLGVTFYGPTPTDSCEADGPCYPTVDVAQQYDFMGGDAPVAPLN
VVAMANSLAAYYYLHGSVPAKSLDDPNVIDQGEWGDTHYYLIPAERLPLLMPFEQAGVPAPILAVLDAPLRVIVEAGYDR
ESSPGEHVQFRLLPIGDPFRFLVNLAKSVPVGIDDGLQEAGLGRALGTEDVFRPYGVGGEDLPQPGDSATEDNLRTAAVP
TETTASEPAAEPLTDGPVVSGQPSERKGDEPSQLSNDSPVPPAPEQVKERRLSPLLRGLSDREEADAPKLPSIRPPGERL
VRRVVESVTGQRAERPDDSGDDASGGTPAAESDPDAA

Specific function: Elicits a high humoral and a low T cell response. Could be involved in directing the host toward development of a more humoral type of immune response [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PPE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002989
- InterPro:   IPR013228
- InterPro:   IPR000030 [H]

Pfam domain/function: PF08237 PE-PPE; PF01469 Pentapeptide_2; PF00823 PPE [H]

EC number: NA

Molecular weight: Translated: 54410; Mature: 54410

Theoretical pI: Translated: 3.94; Mature: 3.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGPVGSLLAVFTAIAGVVLLAFSGMLTGIVQLLATTALIMGGTDHPLSTPPDTISFVDG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
YMDDAVDNYIDPGLDTGPSVNKVAVITPEQFFPAFGSMTFDDSVQEGRDNLNECVAGTPS
HHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
CEYNESEALGSDAPKPDDSFIVFGYSQSAVIASLVKRDLMQTPPADATGVSFVLLSNAMR
CCCCCHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHEEHHCCCC
PNGGILARGFEGMTIPLLGVTFYGPTPTDSCEADGPCYPTVDVAQQYDFMGGDAPVAPLN
CCCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHH
VVAMANSLAAYYYLHGSVPAKSLDDPNVIDQGEWGDTHYYLIPAERLPLLMPFEQAGVPA
HHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHCCEECCHHHCCCCH
PILAVLDAPLRVIVEAGYDRESSPGEHVQFRLLPIGDPFRFLVNLAKSVPVGIDDGLQEA
HHHHHHHCCHHHHHHCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHH
GLGRALGTEDVFRPYGVGGEDLPQPGDSATEDNLRTAAVPTETTASEPAAEPLTDGPVVS
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCC
GQPSERKGDEPSQLSNDSPVPPAPEQVKERRLSPLLRGLSDREEADAPKLPSIRPPGERL
CCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHH
VRRVVESVTGQRAERPDDSGDDASGGTPAAESDPDAA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRGPVGSLLAVFTAIAGVVLLAFSGMLTGIVQLLATTALIMGGTDHPLSTPPDTISFVDG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
YMDDAVDNYIDPGLDTGPSVNKVAVITPEQFFPAFGSMTFDDSVQEGRDNLNECVAGTPS
HHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
CEYNESEALGSDAPKPDDSFIVFGYSQSAVIASLVKRDLMQTPPADATGVSFVLLSNAMR
CCCCCHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHEEHHCCCC
PNGGILARGFEGMTIPLLGVTFYGPTPTDSCEADGPCYPTVDVAQQYDFMGGDAPVAPLN
CCCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHH
VVAMANSLAAYYYLHGSVPAKSLDDPNVIDQGEWGDTHYYLIPAERLPLLMPFEQAGVPA
HHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHCCEECCHHHCCCCH
PILAVLDAPLRVIVEAGYDRESSPGEHVQFRLLPIGDPFRFLVNLAKSVPVGIDDGLQEA
HHHHHHHCCHHHHHHCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHH
GLGRALGTEDVFRPYGVGGEDLPQPGDSATEDNLRTAAVPTETTASEPAAEPLTDGPVVS
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCC
GQPSERKGDEPSQLSNDSPVPPAPEQVKERRLSPLLRGLSDREEADAPKLPSIRPPGERL
CCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHH
VRRVVESVTGQRAERPDDSGDDASGGTPAAESDPDAA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]