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The map label for this gene is fabG2 [H]

Identifier: 108801032

GI number: 108801032

Start: 4336377

End: 4337129

Strand: Reverse

Name: fabG2 [H]

Synonym: Mmcs_4068

Alternate gene names: 108801032

Gene position: 4337129-4336377 (Counterclockwise)

Preceding gene: 108801033

Following gene: 108801031

Centisome position: 76.02

GC content: 68.13

Gene sequence:

>753_bases
GTGGAAATCAAAGACGCCGCCGCCGTCGTCACCGGCGGAGCATCGGGTCTCGGCCTGGCCACCACGAAGCGGCTGCTCGA
CCGGGGCGCCTCGGTCGTGGTCATCGACCTCAAAGGTGAAGAGGCCGTCAAGGAACTGGGCGACCGCGCCAAGTTCGTGC
AGGCCAACGTCACCGATCCCGAGCAGGTCAGCGCAGCGCTGGACGCCGCGGAGGAGATGGGCCCGCTGCGCATCAACGTC
AACTGCGCCGGTATCGGCAACGCGATCAAGACGCTGAGCAAGAACGGCGCGTTCCCGCTCGACGAGTTCAACAAGGTCAT
CCAGGTCAACCTGGTCGGCACCTTCAACGTGCTGCGGCTGAGCGCCGAGCGGATCGCCAAGACCGAACCGATCAACGGTG
AGCGTGGCGTCATCATCAACACCGCCTCGGTGGCCGCGTTCGAGGGCCAGATCGGCCAGGCCGCGTACTCGGCGTCCAAG
GGCGGCGTCGTCGGCATGACCCTGCCCATCGCCCGCGACCTGTCGCGCGAGTTCATCCGCGTCTGCACCATCGCCCCCGG
TCTGTTCAAGACCCCGCTGCTGGGCTCGCTGCCCGAGGAGGCGCAGAAGTCGCTCGGCCAGCAGGTCCCGCATCCCGCGC
GGCTCGGCGATCCGGACGAGTACGGCGCGCTCGCCGTCCACATCGTCGAGAACCCGATGCTCAACGGCGAGACGATCCGC
CTGGACGGCGCGATCCGGATGGCGCCGAGGTAG

Upstream 100 bases:

>100_bases
GCGTGCCCGGCGCCGACACCGAAGCGGTCCTCAACGACTGGGTCTGATCTCAAGGTCTGATTCGAACGGTCGATCTCAAC
CAACAGAAAGGTATGTGCGA

Downstream 100 bases:

>100_bases
ACGCCATGACCCTGCACACCAAGTTCACCGAGACCTTCGGTGTCGAACACCCGATCGTCCAGGGTGGGATGCAGTGGGTC
GGACGCGCCGAACTCGTCGC

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MEIKDAAAVVTGGASGLGLATTKRLLDRGASVVVIDLKGEEAVKELGDRAKFVQANVTDPEQVSAALDAAEEMGPLRINV
NCAGIGNAIKTLSKNGAFPLDEFNKVIQVNLVGTFNVLRLSAERIAKTEPINGERGVIINTASVAAFEGQIGQAAYSASK
GGVVGMTLPIARDLSREFIRVCTIAPGLFKTPLLGSLPEEAQKSLGQQVPHPARLGDPDEYGALAVHIVENPMLNGETIR
LDGAIRMAPR

Sequences:

>Translated_250_residues
MEIKDAAAVVTGGASGLGLATTKRLLDRGASVVVIDLKGEEAVKELGDRAKFVQANVTDPEQVSAALDAAEEMGPLRINV
NCAGIGNAIKTLSKNGAFPLDEFNKVIQVNLVGTFNVLRLSAERIAKTEPINGERGVIINTASVAAFEGQIGQAAYSASK
GGVVGMTLPIARDLSREFIRVCTIAPGLFKTPLLGSLPEEAQKSLGQQVPHPARLGDPDEYGALAVHIVENPMLNGETIR
LDGAIRMAPR
>Mature_250_residues
MEIKDAAAVVTGGASGLGLATTKRLLDRGASVVVIDLKGEEAVKELGDRAKFVQANVTDPEQVSAALDAAEEMGPLRINV
NCAGIGNAIKTLSKNGAFPLDEFNKVIQVNLVGTFNVLRLSAERIAKTEPINGERGVIINTASVAAFEGQIGQAAYSASK
GGVVGMTLPIARDLSREFIRVCTIAPGLFKTPLLGSLPEEAQKSLGQQVPHPARLGDPDEYGALAVHIVENPMLNGETIR
LDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=59.2156862745098, Blast_Score=270, Evalue=6e-73,
Organism=Homo sapiens, GI83715985, Length=256, Percent_Identity=57.03125, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI15277342, Length=263, Percent_Identity=31.5589353612167, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI31542939, Length=261, Percent_Identity=28.3524904214559, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=28.8, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI224922801, Length=188, Percent_Identity=30.8510638297872, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI22507405, Length=241, Percent_Identity=29.8755186721992, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI10190704, Length=193, Percent_Identity=29.5336787564767, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4504505, Length=222, Percent_Identity=30.1801801801802, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI59889578, Length=214, Percent_Identity=28.5046728971963, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=30.5882352941176, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790717, Length=255, Percent_Identity=31.3725490196078, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=29.9610894941634, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=31.25, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=31.0204081632653, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI2367175, Length=200, Percent_Identity=31.5, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787905, Length=238, Percent_Identity=30.672268907563, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789057, Length=207, Percent_Identity=31.8840579710145, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789378, Length=238, Percent_Identity=27.7310924369748, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788459, Length=251, Percent_Identity=26.2948207171315, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=52.5896414342629, Blast_Score=233, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI25147288, Length=248, Percent_Identity=30.6451612903226, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=31.8725099601594, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=29.6442687747036, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=30.46875, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=263, Percent_Identity=24.3346007604563, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320089, Length=225, Percent_Identity=28.4444444444444, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=220, Percent_Identity=30.4545454545455, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=59.0551181102362, Blast_Score=285, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=30.952380952381, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24665243, Length=209, Percent_Identity=28.7081339712919, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355319, Length=245, Percent_Identity=27.3469387755102, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221331218, Length=209, Percent_Identity=28.7081339712919, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24665247, Length=210, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221331216, Length=210, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI28571526, Length=265, Percent_Identity=26.4150943396226, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26232; Mature: 26232

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKDAAAVVTGGASGLGLATTKRLLDRGASVVVIDLKGEEAVKELGDRAKFVQANVTDP
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHCCHHEEEECCCCCH
EQVSAALDAAEEMGPLRINVNCAGIGNAIKTLSKNGAFPLDEFNKVIQVNLVGTFNVLRL
HHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCCCCCHHHCCCEEEEEEEECHHHHHH
SAERIAKTEPINGERGVIINTASVAAFEGQIGQAAYSASKGGVVGMTLPIARDLSREFIR
HHHHHHCCCCCCCCCCEEEEECCEEEECCCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHH
VCTIAPGLFKTPLLGSLPEEAQKSLGQQVPHPARLGDPDEYGALAVHIVENPMLNGETIR
HHHCCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEE
LDGAIRMAPR
ECCEEEECCC
>Mature Secondary Structure
MEIKDAAAVVTGGASGLGLATTKRLLDRGASVVVIDLKGEEAVKELGDRAKFVQANVTDP
CCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHCCHHEEEECCCCCH
EQVSAALDAAEEMGPLRINVNCAGIGNAIKTLSKNGAFPLDEFNKVIQVNLVGTFNVLRL
HHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCCCCCHHHCCCEEEEEEEECHHHHHH
SAERIAKTEPINGERGVIINTASVAAFEGQIGQAAYSASKGGVVGMTLPIARDLSREFIR
HHHHHHCCCCCCCCCCEEEEECCEEEECCCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHH
VCTIAPGLFKTPLLGSLPEEAQKSLGQQVPHPARLGDPDEYGALAVHIVENPMLNGETIR
HHHCCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEE
LDGAIRMAPR
ECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]