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The map label for this gene is yrkH [H]

Identifier: 108800978

GI number: 108800978

Start: 4280104

End: 4281465

Strand: Reverse

Name: yrkH [H]

Synonym: Mmcs_4014

Alternate gene names: 108800978

Gene position: 4281465-4280104 (Counterclockwise)

Preceding gene: 108800979

Following gene: 108800976

Centisome position: 75.04

GC content: 67.25

Gene sequence:

>1362_bases
ATGCACGTCTCCATCATCGAAACCTCCGGCCTCGGGGATCGCAGCTACCTGATCAGCGACCGCGACACCGCCGTCGTCGT
CGATCCGCAGCGCGACATCGACCGGGTACTCGCACTCGCCGACGAGCGCCAGGCGCGGATCACCCATGTGTTGGAGACCC
ACCTGCACAACGACTATGTGACCGGGGGCCTGGAGCTCTCCCGCACGGTCGGTGCCGAATACGTGGTGCCCGCGGGCGAC
GACGTCGGTTACCCCAGGCGCGCCGTCACCGAAGGTGACGTCATCAATGCCGGGCCGATCCGGTTGGAGGTCCTCCACAC
ACCGGGGCACACCCACCACCACGTGAGCTATGTGCTGAGCGACGACACCGGAACGGTCCACGGCGTCTTCACCGGAGGCT
CGATGTTGTTCGGCACCACCGGACGCACCGATCTCGTCGGGCCCGACGACACCGAGAAGCTCACGCACGCGCAATACCAC
TCGGTGCGCAAGATCGCCGACCGGCTGCCCGCCGACACGGTCGTCTACCCGACCCATGGATTCGGCAGTTTCTGCTCGGC
GACACCGGCTTCCGGCGACGCGTCGACCATCGGCGAACAGTGGCAGGCGAATCCGGCGCTCACCAAGGACGAACAGAGCT
TCGTCGACGAACTGCTCGCCGGACTGGAGGCGTACCCCGCCTACTACGCGCACATGGGCGTGATCAACCGCGAAGGCCCT
GCACCGGTGGACCTCACACCGCCCGCACCGGTCGATCCGGCCGAACTACGCCGCCGGATCGAGGCCGGTGAGTGGGTGGT
CGATCTGCGCAACCGCACCGCGTTCGCCGCAGGACATCTGCAGGGGACGCTGGGTTTCGAGCTGTCCGGATCGTTCGTCA
GCTACTTCGGCTGGCTCTACGAGTGGGGCGCCCCGGTGACGCTGATCGGGGAGTCGCAGGACCAGATCGCCGACGCCAAA
CGGGAACTGGTGCGCATCGGGGTGGACCGCCTGACCGGTTCGGCCACCGGCGACATCGACGAACTGCGCGACGGGGCCGA
GGTCGGCAGCTATGCGGTGTCCGACTTCGCCGGTCTGGCAGAGCATCTGGACGATGACACGGTGGCGGTACTCGACGTGC
GGCAGCACGGCGAATACGAGGAAGACCACGTCCGGGGCGCGGTCAACATCCCGCTGCACGAACTCCCGCAACGGCTGGAC
GAGGTTCCCGCGGGAACGATCTGGGTGCACTGCGCCTCGGGTTACCGGTCGTCCATCGCGGCGTCGTACCTCGACCGCGC
CGGCCACGATGTCGTGCTGATCGACGACGACTTCGGCAACGCCGGTCAGTTGCCGCTCAGTTCGCGTGCAGCGCCTCGTT
GA

Upstream 100 bases:

>100_bases
CACCCGATTGCAGCGGTGGTTCGCCTACCTCGTATTCGCCGTTGCCGCATACGTAATCGTCGACACCGTCTTCCTACAGT
GACGTAGAAAGGGAAATCAC

Downstream 100 bases:

>100_bases
GCGTGACACCGGTGCCGTCGCGCCGGACCACTTCGACGGCACCGGAGACGGAGTTACGGCGGAACAGCAGGTTGTTCGCA
CCGGAGAGGTCACGCGCCTT

Product: beta-lactamase-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MHVSIIETSGLGDRSYLISDRDTAVVVDPQRDIDRVLALADERQARITHVLETHLHNDYVTGGLELSRTVGAEYVVPAGD
DVGYPRRAVTEGDVINAGPIRLEVLHTPGHTHHHVSYVLSDDTGTVHGVFTGGSMLFGTTGRTDLVGPDDTEKLTHAQYH
SVRKIADRLPADTVVYPTHGFGSFCSATPASGDASTIGEQWQANPALTKDEQSFVDELLAGLEAYPAYYAHMGVINREGP
APVDLTPPAPVDPAELRRRIEAGEWVVDLRNRTAFAAGHLQGTLGFELSGSFVSYFGWLYEWGAPVTLIGESQDQIADAK
RELVRIGVDRLTGSATGDIDELRDGAEVGSYAVSDFAGLAEHLDDDTVAVLDVRQHGEYEEDHVRGAVNIPLHELPQRLD
EVPAGTIWVHCASGYRSSIAASYLDRAGHDVVLIDDDFGNAGQLPLSSRAAPR

Sequences:

>Translated_453_residues
MHVSIIETSGLGDRSYLISDRDTAVVVDPQRDIDRVLALADERQARITHVLETHLHNDYVTGGLELSRTVGAEYVVPAGD
DVGYPRRAVTEGDVINAGPIRLEVLHTPGHTHHHVSYVLSDDTGTVHGVFTGGSMLFGTTGRTDLVGPDDTEKLTHAQYH
SVRKIADRLPADTVVYPTHGFGSFCSATPASGDASTIGEQWQANPALTKDEQSFVDELLAGLEAYPAYYAHMGVINREGP
APVDLTPPAPVDPAELRRRIEAGEWVVDLRNRTAFAAGHLQGTLGFELSGSFVSYFGWLYEWGAPVTLIGESQDQIADAK
RELVRIGVDRLTGSATGDIDELRDGAEVGSYAVSDFAGLAEHLDDDTVAVLDVRQHGEYEEDHVRGAVNIPLHELPQRLD
EVPAGTIWVHCASGYRSSIAASYLDRAGHDVVLIDDDFGNAGQLPLSSRAAPR
>Mature_453_residues
MHVSIIETSGLGDRSYLISDRDTAVVVDPQRDIDRVLALADERQARITHVLETHLHNDYVTGGLELSRTVGAEYVVPAGD
DVGYPRRAVTEGDVINAGPIRLEVLHTPGHTHHHVSYVLSDDTGTVHGVFTGGSMLFGTTGRTDLVGPDDTEKLTHAQYH
SVRKIADRLPADTVVYPTHGFGSFCSATPASGDASTIGEQWQANPALTKDEQSFVDELLAGLEAYPAYYAHMGVINREGP
APVDLTPPAPVDPAELRRRIEAGEWVVDLRNRTAFAAGHLQGTLGFELSGSFVSYFGWLYEWGAPVTLIGESQDQIADAK
RELVRIGVDRLTGSATGDIDELRDGAEVGSYAVSDFAGLAEHLDDDTVAVLDVRQHGEYEEDHVRGAVNIPLHELPQRLD
EVPAGTIWVHCASGYRSSIAASYLDRAGHDVVLIDDDFGNAGQLPLSSRAAPR

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=243, Percent_Identity=30.4526748971193, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI1787158, Length=202, Percent_Identity=27.2277227722772, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538952, Length=216, Percent_Identity=29.1666666666667, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221330176, Length=208, Percent_Identity=31.25, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356335, Length=170, Percent_Identity=31.1764705882353, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24667703, Length=170, Percent_Identity=31.1764705882353, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24667711, Length=170, Percent_Identity=31.1764705882353, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR001763 [H]

Pfam domain/function: PF00753 Lactamase_B; PF00581 Rhodanese [H]

EC number: NA

Molecular weight: Translated: 48966; Mature: 48966

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVSIIETSGLGDRSYLISDRDTAVVVDPQRDIDRVLALADERQARITHVLETHLHNDYV
CEEEEEECCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
TGGLELSRTVGAEYVVPAGDDVGYPRRAVTEGDVINAGPIRLEVLHTPGHTHHHVSYVLS
ECCEEEHHHCCCCEEEECCCCCCCCCCCCCCCCEECCCCEEEEEEECCCCCCEEEEEEEE
DDTGTVHGVFTGGSMLFGTTGRTDLVGPDDTEKLTHAQYHSVRKIADRLPADTVVYPTHG
CCCCEEEEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
FGSFCSATPASGDASTIGEQWQANPALTKDEQSFVDELLAGLEAYPAYYAHMGVINREGP
CCCHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCC
APVDLTPPAPVDPAELRRRIEAGEWVVDLRNRTAFAAGHLQGTLGFELSGSFVSYFGWLY
CCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCEEEEECCCCEEECEEECCHHHHHHHHHH
EWGAPVTLIGESQDQIADAKRELVRIGVDRLTGSATGDIDELRDGAEVGSYAVSDFAGLA
HCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHH
EHLDDDTVAVLDVRQHGEYEEDHVRGAVNIPLHELPQRLDEVPAGTIWVHCASGYRSSIA
HHCCCCCEEEEEEHHCCCCCHHHCCEEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHH
ASYLDRAGHDVVLIDDDFGNAGQLPLSSRAAPR
HHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHVSIIETSGLGDRSYLISDRDTAVVVDPQRDIDRVLALADERQARITHVLETHLHNDYV
CEEEEEECCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
TGGLELSRTVGAEYVVPAGDDVGYPRRAVTEGDVINAGPIRLEVLHTPGHTHHHVSYVLS
ECCEEEHHHCCCCEEEECCCCCCCCCCCCCCCCEECCCCEEEEEEECCCCCCEEEEEEEE
DDTGTVHGVFTGGSMLFGTTGRTDLVGPDDTEKLTHAQYHSVRKIADRLPADTVVYPTHG
CCCCEEEEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
FGSFCSATPASGDASTIGEQWQANPALTKDEQSFVDELLAGLEAYPAYYAHMGVINREGP
CCCHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCC
APVDLTPPAPVDPAELRRRIEAGEWVVDLRNRTAFAAGHLQGTLGFELSGSFVSYFGWLY
CCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCEEEEECCCCEEECEEECCHHHHHHHHHH
EWGAPVTLIGESQDQIADAKRELVRIGVDRLTGSATGDIDELRDGAEVGSYAVSDFAGLA
HCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHH
EHLDDDTVAVLDVRQHGEYEEDHVRGAVNIPLHELPQRLDEVPAGTIWVHCASGYRSSIA
HHCCCCCEEEEEEHHCCCCCHHHCCEEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHH
ASYLDRAGHDVVLIDDDFGNAGQLPLSSRAAPR
HHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]