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The map label for this gene is cysM [H]

Identifier: 108800812

GI number: 108800812

Start: 4093073

End: 4094044

Strand: Reverse

Name: cysM [H]

Synonym: Mmcs_3848

Alternate gene names: 108800812

Gene position: 4094044-4093073 (Counterclockwise)

Preceding gene: 108800813

Following gene: 108800811

Centisome position: 71.76

GC content: 67.49

Gene sequence:

>972_bases
TTGGCGCGTTACGACTCGGTGCTCGAGGCCCTCGGCAACACCCCGCTGGTGGGGTGCCCGCACCTGTCGCCGAGATGGGA
TGACGACGAGAACGGACCGCATGTGCGGCTGTGGGCCAAACTCGAGGACCGCAACCCGACCGGTTCGATCAAGGACCGGC
CCGCGCTGCGGATGATCGAACAGGCCGAGCGCGACGGGCTGCTGCAGCCCGGTTCGACGATCCTGGAACCCACCAGCGGC
AACACCGGGATCTCGCTGGCGATGGCAGCGCTGCTCAAGGGCTACCAGATGATCTGCGTGATGCCGGAGAACACCTCGAT
CGAGCGCAGGCAGCTGCTCGAACTCTACGGGGCCCGCATCATCTTCTCGCCGGCCGAAGGCGGCTCCAACACCGCCGTCG
CGCACGCCAAGGAACTGGCGGCGGCAAACCCGGACTGGGTGATGCTCTACCAGTACGGCAACCCCGCGAACGCCGATGCG
CACTATTACGGCACGGGACCCGAACTGCTCGCCGACCTGCCCGAGATCACCCACTTCGTCGCGGGTCTGGGCACCACGGG
GACGCTGATGGGCACCGGCCGGTTCCTGCGCGAGAAGGTGCCGGGTGTGCAGATCGTGGCCGCCGAGCCGCGCTACGGCG
AAGGCGTGTACGCGCTGCGCAACATCGACGAGGGCTTCATCCCCGAGCTGTACGACCCCGACGTGCTGACCACCCGGTTC
TCCGTGGGGTCGTTCGACGCGATCAAGCGGACCCGCGAACTGGTCACCAAAGAGGGGATCTTCGCGGGTGTCTCGACCGG
GGCGATCCTGCACGCCGCGCTGGGGATGGCCGCCAAGGCGATCAAGGCGGGCGAACGCGCCGACATCGCGTTCACCGTGT
GTGACGCCGGCTGGAAGTATCTGTCGACCGGTGCGTACACCGGTAGCCTCGTCGACGCAGAGGACGCGTTGGAAGGGCAG
CTATGGGCGTGA

Upstream 100 bases:

>100_bases
ACGTCAACGACGAGGATGTGCGCTTCTCGGGTGGACTCGACACCCCGATCTCCGACGGGGACTCGGTGACGATCCTGCCC
GCCGTGGCAGGTGGGTGACC

Downstream 100 bases:

>100_bases
CGGGGCCGACGGGGTCTCCCGCGTACCCGGCGCCGTCCAGCAAGCGGCCCGCCTGGATCGTCGGCGGCGCCACGATCGTC
AGCTTCGTCGTCCTGCTCTA

Product: cysteine synthase

Products: NA

Alternate protein names: OPS sulfhydrylase; CysO-thiocarboxylate-dependent cysteine synthase; Cysteine synthase B; CSase B; O-phosphoserine-specific cysteine synthase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MARYDSVLEALGNTPLVGCPHLSPRWDDDENGPHVRLWAKLEDRNPTGSIKDRPALRMIEQAERDGLLQPGSTILEPTSG
NTGISLAMAALLKGYQMICVMPENTSIERRQLLELYGARIIFSPAEGGSNTAVAHAKELAAANPDWVMLYQYGNPANADA
HYYGTGPELLADLPEITHFVAGLGTTGTLMGTGRFLREKVPGVQIVAAEPRYGEGVYALRNIDEGFIPELYDPDVLTTRF
SVGSFDAIKRTRELVTKEGIFAGVSTGAILHAALGMAAKAIKAGERADIAFTVCDAGWKYLSTGAYTGSLVDAEDALEGQ
LWA

Sequences:

>Translated_323_residues
MARYDSVLEALGNTPLVGCPHLSPRWDDDENGPHVRLWAKLEDRNPTGSIKDRPALRMIEQAERDGLLQPGSTILEPTSG
NTGISLAMAALLKGYQMICVMPENTSIERRQLLELYGARIIFSPAEGGSNTAVAHAKELAAANPDWVMLYQYGNPANADA
HYYGTGPELLADLPEITHFVAGLGTTGTLMGTGRFLREKVPGVQIVAAEPRYGEGVYALRNIDEGFIPELYDPDVLTTRF
SVGSFDAIKRTRELVTKEGIFAGVSTGAILHAALGMAAKAIKAGERADIAFTVCDAGWKYLSTGAYTGSLVDAEDALEGQ
LWA
>Mature_322_residues
ARYDSVLEALGNTPLVGCPHLSPRWDDDENGPHVRLWAKLEDRNPTGSIKDRPALRMIEQAERDGLLQPGSTILEPTSGN
TGISLAMAALLKGYQMICVMPENTSIERRQLLELYGARIIFSPAEGGSNTAVAHAKELAAANPDWVMLYQYGNPANADAH
YYGTGPELLADLPEITHFVAGLGTTGTLMGTGRFLREKVPGVQIVAAEPRYGEGVYALRNIDEGFIPELYDPDVLTTRFS
VGSFDAIKRTRELVTKEGIFAGVSTGAILHAALGMAAKAIKAGERADIAFTVCDAGWKYLSTGAYTGSLVDAEDALEGQL
WA

Specific function: Catalyzes the formation of a covalent CysO-cysteine adduct via a sulfur transfer, using the thiocarboxylated sulfur carrier protein CysO-COSH as sulfur donor and O-phospho-L-serine (OPS) as sulfur acceptor. Can also use sodium sulfide as sulfur donor in v

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=335, Percent_Identity=34.9253731343284, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI295821200, Length=335, Percent_Identity=34.9253731343284, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI4557415, Length=335, Percent_Identity=34.9253731343284, Blast_Score=175, Evalue=5e-44,
Organism=Escherichia coli, GI2367138, Length=299, Percent_Identity=41.8060200668896, Blast_Score=216, Evalue=1e-57,
Organism=Escherichia coli, GI1788754, Length=321, Percent_Identity=36.1370716510903, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=38.4364820846906, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17562970, Length=312, Percent_Identity=36.2179487179487, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI32566674, Length=303, Percent_Identity=36.6336633663366, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI115535073, Length=324, Percent_Identity=35.4938271604938, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17561720, Length=309, Percent_Identity=36.5695792880259, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI25147552, Length=316, Percent_Identity=33.5443037974684, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17534315, Length=317, Percent_Identity=34.0694006309148, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32566672, Length=219, Percent_Identity=33.7899543378995, Blast_Score=111, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6321594, Length=340, Percent_Identity=33.5294117647059, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321449, Length=355, Percent_Identity=32.6760563380282, Blast_Score=106, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24643623, Length=299, Percent_Identity=38.7959866220736, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20129101, Length=299, Percent_Identity=38.7959866220736, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.65 [H]

Molecular weight: Translated: 34769; Mature: 34638

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARYDSVLEALGNTPLVGCPHLSPRWDDDENGPHVRLWAKLEDRNPTGSIKDRPALRMIE
CCHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHH
QAERDGLLQPGSTILEPTSGNTGISLAMAALLKGYQMICVMPENTSIERRQLLELYGARI
HHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCEE
IFSPAEGGSNTAVAHAKELAAANPDWVMLYQYGNPANADAHYYGTGPELLADLPEITHFV
EEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHH
AGLGTTGTLMGTGRFLREKVPGVQIVAAEPRYGEGVYALRNIDEGFIPELYDPDVLTTRF
HCCCCCCEEECCCHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEE
SVGSFDAIKRTRELVTKEGIFAGVSTGAILHAALGMAAKAIKAGERADIAFTVCDAGWKY
CCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCE
LSTGAYTGSLVDAEDALEGQLWA
EECCCCCCCEECHHHHCCCCCCC
>Mature Secondary Structure 
ARYDSVLEALGNTPLVGCPHLSPRWDDDENGPHVRLWAKLEDRNPTGSIKDRPALRMIE
CHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHH
QAERDGLLQPGSTILEPTSGNTGISLAMAALLKGYQMICVMPENTSIERRQLLELYGARI
HHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCEE
IFSPAEGGSNTAVAHAKELAAANPDWVMLYQYGNPANADAHYYGTGPELLADLPEITHFV
EEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHH
AGLGTTGTLMGTGRFLREKVPGVQIVAAEPRYGEGVYALRNIDEGFIPELYDPDVLTTRF
HCCCCCCEEECCCHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEE
SVGSFDAIKRTRELVTKEGIFAGVSTGAILHAALGMAAKAIKAGERADIAFTVCDAGWKY
CCCCHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCE
LSTGAYTGSLVDAEDALEGQLWA
EECCCCCCCEECHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]