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The map label for this gene is bhbA [H]

Identifier: 108800790

GI number: 108800790

Start: 4071339

End: 4073018

Strand: Reverse

Name: bhbA [H]

Synonym: Mmcs_3826

Alternate gene names: 108800790

Gene position: 4073018-4071339 (Counterclockwise)

Preceding gene: 108800797

Following gene: 108800789

Centisome position: 71.39

GC content: 66.79

Gene sequence:

>1680_bases
GTGTGGGGTCAACCGCCGGCGGGTGCCGAACAGGTGCCGCTGTCTCGCCCTTCCCGATTGCGGTATTGGCATTCTCATTT
TTTGCAAGTACGTTATCCACTGATGAGCGACCTCGTGCAGACCTCCTCGGGCCTCCCGCTCGAGCCCGTCTACGGGCCGG
GCGATCGGAGCGGCGAACCACCCGCGCCCGGCACCTATCCCTTCACGCGCGGAAACTTCGCGTCGGGATACCGCGGCAAG
TTGTGGACCTTCCGGCAGTATTCCGGTTTCGGCACCGCGGAGGAGTCGAACCGCCGTTACCGGTACCTGCTCGATCAGGG
CGGCACCGGCCTCTCGGTGGCGCTGGACCTGCCCACCCAGTGCGGATACGACTCCGACGATCCCGAGTTCGGCGAGGAGG
TCGGCCGAGTCGGTGTCGCCGTCGACACCCTGGCCGACGCGGAGATCCTGTTCGACGGGATCCCGCTCGACAAGATCAGC
ACGAGCTTCACCATCAACGGCACCGCCGCGATCCTGCTGGCGTTCTACGTCGCCGCCGCGGAGAAGTCCGGCGTGCCGCG
CGAGAAGCTCACCGGCACCATCCAGAACGACATCCTCAAGGAGTACGCCTCCCGCGGCACCTGGATCTGGCCGCCGGAGC
CCTCGCTGCGGCTGATCGCCGACACCATCGAGTTCTGCGCCGCGGAGGTGCCGCGGTTCAACGCCATCTCGGTGGCGGGG
GCGCACTTCCGCGACGCGGGCGCGAACGCCGTGCAGGAGATGGCGTTCACGCTCGCCGACGGCGTCACCTACTGCGACAC
GGTGGTCGAACGCGGCCGGATGTCGATCGACAAGTTCGCACCGCAGATCTCGTTCTTCTTCTACACCCACGGCGACTTCT
TCGAGGAGATCGCCAAATACCGCGCCGGACGGCGGCGTTGGGCGACGATCGTGCGGGAACGCTACGGGTCGACCAGCGAC
AAGGCGTCGATGTTCCGGTTCGGCTGTGTCTCCGGCGGCGCGTCGCTATACGCGCCGCAGGCGCAGAACAACGTCGTGCG
GATCGCATACGAGGCGATGGCTTCGGTGCTCGGCGGCGTGCAGTCGATGTTCACCGCCGCATGGGACGAGCCGTTCGCCC
TGCCCAGCGAGGAGTCCGCCACCCTCGCCCTGCGCACCCAGCAGATCCTGGCCTACGAGACGGGCGTGACCAGGGTGGCC
GATCCGCTCGGCGGCTCCTACTTCGTCGAGGCGCTGACCGATGCCACCGAGGCCAAGATCATCGAGATCATGCACGACCT
CGAGGCGCACGGCGGTATGGTCCGCGCGATCGAGGACGGCTACCTGCAGGGGCTGATCGCCGACGAGGCCTACAAGCTCC
ACCAGGAGGTCGAGTCCGGAGAGCGGCCCGTCGTCGGGGTGAACAAGTTCGTCACCGACGAACCGCCACCGGACATCGAC
ACCTACGAACTCGATGCCGAAGGCCGCGATCTGCAACTCAAGCGGCTGTCGAAGGTCAAGGCGGACCGTGACGCCGATGC
GGTGGCGGCCGCGTTGGCGGCACTGTCCCGGGCGGCCGAGGGTGACGACAACCTGATGCACAAACTGATCGACTGCGCGA
AGGCGTACTGCACCGTCGGCGAGATGGTCTCGGCGCTCAAAGCGGTGTGGGGCGAATTCCAGCAGCCTGTCGTCTTTTAG

Upstream 100 bases:

>100_bases
GACTCACCTCGATGGTATTGCCATTCTCATTTTCTGCAAGTGACGTATCCAGCGATTGTGTCGCATGCGCCGGTGCAGGT
GGGCGCTGGGGTGTCGACGG

Downstream 100 bases:

>100_bases
AAGGGGGGTGTTCTAGATGCCGACTCGTGTTCTCGTCGCCAAACCCGGCCTGGACGGCCATGACCGAGGCGCCAAGATCG
TCGCGCGCACCCTGCGCGAC

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MWGQPPAGAEQVPLSRPSRLRYWHSHFLQVRYPLMSDLVQTSSGLPLEPVYGPGDRSGEPPAPGTYPFTRGNFASGYRGK
LWTFRQYSGFGTAEESNRRYRYLLDQGGTGLSVALDLPTQCGYDSDDPEFGEEVGRVGVAVDTLADAEILFDGIPLDKIS
TSFTINGTAAILLAFYVAAAEKSGVPREKLTGTIQNDILKEYASRGTWIWPPEPSLRLIADTIEFCAAEVPRFNAISVAG
AHFRDAGANAVQEMAFTLADGVTYCDTVVERGRMSIDKFAPQISFFFYTHGDFFEEIAKYRAGRRRWATIVRERYGSTSD
KASMFRFGCVSGGASLYAPQAQNNVVRIAYEAMASVLGGVQSMFTAAWDEPFALPSEESATLALRTQQILAYETGVTRVA
DPLGGSYFVEALTDATEAKIIEIMHDLEAHGGMVRAIEDGYLQGLIADEAYKLHQEVESGERPVVGVNKFVTDEPPPDID
TYELDAEGRDLQLKRLSKVKADRDADAVAAALAALSRAAEGDDNLMHKLIDCAKAYCTVGEMVSALKAVWGEFQQPVVF

Sequences:

>Translated_559_residues
MWGQPPAGAEQVPLSRPSRLRYWHSHFLQVRYPLMSDLVQTSSGLPLEPVYGPGDRSGEPPAPGTYPFTRGNFASGYRGK
LWTFRQYSGFGTAEESNRRYRYLLDQGGTGLSVALDLPTQCGYDSDDPEFGEEVGRVGVAVDTLADAEILFDGIPLDKIS
TSFTINGTAAILLAFYVAAAEKSGVPREKLTGTIQNDILKEYASRGTWIWPPEPSLRLIADTIEFCAAEVPRFNAISVAG
AHFRDAGANAVQEMAFTLADGVTYCDTVVERGRMSIDKFAPQISFFFYTHGDFFEEIAKYRAGRRRWATIVRERYGSTSD
KASMFRFGCVSGGASLYAPQAQNNVVRIAYEAMASVLGGVQSMFTAAWDEPFALPSEESATLALRTQQILAYETGVTRVA
DPLGGSYFVEALTDATEAKIIEIMHDLEAHGGMVRAIEDGYLQGLIADEAYKLHQEVESGERPVVGVNKFVTDEPPPDID
TYELDAEGRDLQLKRLSKVKADRDADAVAAALAALSRAAEGDDNLMHKLIDCAKAYCTVGEMVSALKAVWGEFQQPVVF
>Mature_559_residues
MWGQPPAGAEQVPLSRPSRLRYWHSHFLQVRYPLMSDLVQTSSGLPLEPVYGPGDRSGEPPAPGTYPFTRGNFASGYRGK
LWTFRQYSGFGTAEESNRRYRYLLDQGGTGLSVALDLPTQCGYDSDDPEFGEEVGRVGVAVDTLADAEILFDGIPLDKIS
TSFTINGTAAILLAFYVAAAEKSGVPREKLTGTIQNDILKEYASRGTWIWPPEPSLRLIADTIEFCAAEVPRFNAISVAG
AHFRDAGANAVQEMAFTLADGVTYCDTVVERGRMSIDKFAPQISFFFYTHGDFFEEIAKYRAGRRRWATIVRERYGSTSD
KASMFRFGCVSGGASLYAPQAQNNVVRIAYEAMASVLGGVQSMFTAAWDEPFALPSEESATLALRTQQILAYETGVTRVA
DPLGGSYFVEALTDATEAKIIEIMHDLEAHGGMVRAIEDGYLQGLIADEAYKLHQEVESGERPVVGVNKFVTDEPPPDID
TYELDAEGRDLQLKRLSKVKADRDADAVAAALAALSRAAEGDDNLMHKLIDCAKAYCTVGEMVSALKAVWGEFQQPVVF

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=522, Percent_Identity=44.0613026819923, Blast_Score=449, Evalue=1e-126,
Organism=Escherichia coli, GI1789284, Length=521, Percent_Identity=43.5700575815739, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI25144500, Length=517, Percent_Identity=44.4874274661509, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 61178; Mature: 61178

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWGQPPAGAEQVPLSRPSRLRYWHSHFLQVRYPLMSDLVQTSSGLPLEPVYGPGDRSGEP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PAPGTYPFTRGNFASGYRGKLWTFRQYSGFGTAEESNRRYRYLLDQGGTGLSVALDLPTQ
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCC
CGYDSDDPEFGEEVGRVGVAVDTLADAEILFDGIPLDKISTSFTINGTAAILLAFYVAAA
CCCCCCCHHHHHHHHHHCHHHHHHCCHHHHCCCCCHHHCCCEEEECHHHHHHHHHHHHHH
EKSGVPREKLTGTIQNDILKEYASRGTWIWPPEPSLRLIADTIEFCAAEVPRFNAISVAG
HHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECC
AHFRDAGANAVQEMAFTLADGVTYCDTVVERGRMSIDKFAPQISFFFYTHGDFFEEIAKY
CHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHCCCEEEEEEECCHHHHHHHHH
RAGRRRWATIVRERYGSTSDKASMFRFGCVSGGASLYAPQAQNNVVRIAYEAMASVLGGV
HHCHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCCEECCCCCCCEEEHHHHHHHHHHHHH
QSMFTAAWDEPFALPSEESATLALRTQQILAYETGVTRVADPLGGSYFVEALTDATEAKI
HHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHH
IEIMHDLEAHGGMVRAIEDGYLQGLIADEAYKLHQEVESGERPVVGVNKFVTDEPPPDID
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHCCCCCCCCCC
TYELDAEGRDLQLKRLSKVKADRDADAVAAALAALSRAAEGDDNLMHKLIDCAKAYCTVG
CEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EMVSALKAVWGEFQQPVVF
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MWGQPPAGAEQVPLSRPSRLRYWHSHFLQVRYPLMSDLVQTSSGLPLEPVYGPGDRSGEP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PAPGTYPFTRGNFASGYRGKLWTFRQYSGFGTAEESNRRYRYLLDQGGTGLSVALDLPTQ
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCC
CGYDSDDPEFGEEVGRVGVAVDTLADAEILFDGIPLDKISTSFTINGTAAILLAFYVAAA
CCCCCCCHHHHHHHHHHCHHHHHHCCHHHHCCCCCHHHCCCEEEECHHHHHHHHHHHHHH
EKSGVPREKLTGTIQNDILKEYASRGTWIWPPEPSLRLIADTIEFCAAEVPRFNAISVAG
HHCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECC
AHFRDAGANAVQEMAFTLADGVTYCDTVVERGRMSIDKFAPQISFFFYTHGDFFEEIAKY
CHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHCCCEEEEEEECCHHHHHHHHH
RAGRRRWATIVRERYGSTSDKASMFRFGCVSGGASLYAPQAQNNVVRIAYEAMASVLGGV
HHCHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCCEECCCCCCCEEEHHHHHHHHHHHHH
QSMFTAAWDEPFALPSEESATLALRTQQILAYETGVTRVADPLGGSYFVEALTDATEAKI
HHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHH
IEIMHDLEAHGGMVRAIEDGYLQGLIADEAYKLHQEVESGERPVVGVNKFVTDEPPPDID
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHCCCCCCCCCC
TYELDAEGRDLQLKRLSKVKADRDADAVAAALAALSRAAEGDDNLMHKLIDCAKAYCTVG
CEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EMVSALKAVWGEFQQPVVF
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]