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The map label for this gene is hsaD [H]

Identifier: 108800752

GI number: 108800752

Start: 4042130

End: 4042993

Strand: Reverse

Name: hsaD [H]

Synonym: Mmcs_3787

Alternate gene names: 108800752

Gene position: 4042993-4042130 (Counterclockwise)

Preceding gene: 108800755

Following gene: 108800751

Centisome position: 70.86

GC content: 68.17

Gene sequence:

>864_bases
GTGGCCGAGTACGAAAGCGTCTGGAGCGACCTGCAGGGCGTCGCGTTCTCGCAGGGTTATCTCGACGCCGGCGGGGTGCG
CACGCGCTACCTGCACGCCGGCGAGACCAGCAAGCCGGCGCTGGTGTTCCTGCACGGTTCCGGCGGCCACGCCGAGGCCT
ATGTCCGCAACCTCGAGGCGCACGCCGAGCACTTCTCGACGTGGTCGATCGACATGCTGGGGCACGGGTACACCGACAAA
CCCGGCCATCCTCTCGAGGTCCGTCACTACGTCGACCATCTGCGCGCGTTCCTCGATGCCATCGGCGCCGAGAAGGCCCA
CATCAGTGGCGAATCGCTCGGCGGGTGGGTGGCGGCCCGGCTGGCCGCCGACCACGGGGACCGGGTGATGCGGTTGGTGC
TCAACACCGCCGGTGGTTCGCAGGCCGATCCCGAGGTGATGAAGCGCATCGTTACGCTGTCCATGGCGGCCGCCGAGGAT
CCCAGCTGGGAGACGGTCCAGGCCCGCATCAAGTGGCTGATGGCCGACAAGAGCAAGGCGTACGACGACATCGTCGCCAG
CCGCCAACGCGTCTACCGCCAACCGGGATTCGTGACGGCAATGCGCGACATCATGGCGCTGCAGGATCCGGAGATCCGCG
CCCGCAACCTGCTCGGCCCCGAGCAGTACGGCGCGATCACCGCGCCGACGCTGGTCGTGTGGACCAGTGACGATCCGACC
GCCGACGTGGAGGAGGGCCGGCGGATCGCGTCGATGATCCCCGGCGCACGGTTCGAGGTGATGCCCGGCTGCGGGCACTG
GCCGCAGTACGAAGACCCCAAGACCTTCAACCGGTTACACGTCGACTTCCTGCTGGGACGCTGA

Upstream 100 bases:

>100_bases
GATGCTCTTAACATAGTGCACATTAGTGAGCGATATTAGCACGCATTGCTACCGCTGAGCGAGAATGGCATTTCCGCACC
GGAAGGGAGACCGAGCCCCC

Downstream 100 bases:

>100_bases
TGACCCCGGCCACCGCACGAGACGCCACCGAACGAGACGCCACCGACACCGACGTCGTCATCGTCGGCGCCGGCCCGGTG
GGCCTGACGCTGGCGAACAT

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; Meta-cleavage product hydrolase; MCP hydrolase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MAEYESVWSDLQGVAFSQGYLDAGGVRTRYLHAGETSKPALVFLHGSGGHAEAYVRNLEAHAEHFSTWSIDMLGHGYTDK
PGHPLEVRHYVDHLRAFLDAIGAEKAHISGESLGGWVAARLAADHGDRVMRLVLNTAGGSQADPEVMKRIVTLSMAAAED
PSWETVQARIKWLMADKSKAYDDIVASRQRVYRQPGFVTAMRDIMALQDPEIRARNLLGPEQYGAITAPTLVVWTSDDPT
ADVEEGRRIASMIPGARFEVMPGCGHWPQYEDPKTFNRLHVDFLLGR

Sequences:

>Translated_287_residues
MAEYESVWSDLQGVAFSQGYLDAGGVRTRYLHAGETSKPALVFLHGSGGHAEAYVRNLEAHAEHFSTWSIDMLGHGYTDK
PGHPLEVRHYVDHLRAFLDAIGAEKAHISGESLGGWVAARLAADHGDRVMRLVLNTAGGSQADPEVMKRIVTLSMAAAED
PSWETVQARIKWLMADKSKAYDDIVASRQRVYRQPGFVTAMRDIMALQDPEIRARNLLGPEQYGAITAPTLVVWTSDDPT
ADVEEGRRIASMIPGARFEVMPGCGHWPQYEDPKTFNRLHVDFLLGR
>Mature_286_residues
AEYESVWSDLQGVAFSQGYLDAGGVRTRYLHAGETSKPALVFLHGSGGHAEAYVRNLEAHAEHFSTWSIDMLGHGYTDKP
GHPLEVRHYVDHLRAFLDAIGAEKAHISGESLGGWVAARLAADHGDRVMRLVLNTAGGSQADPEVMKRIVTLSMAAAEDP
SWETVQARIKWLMADKSKAYDDIVASRQRVYRQPGFVTAMRDIMALQDPEIRARNLLGPEQYGAITAPTLVVWTSDDPTA
DVEEGRRIASMIPGARFEVMPGCGHWPQYEDPKTFNRLHVDFLLGR

Specific function: Catalyzes the hydrolysis of a carbon-carbon bond in 4,5- 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19- hexanorandrostan-5-oic acid (DOHNAA) and 2-hydroxy-hexa-2,4- dienoic acid (HHD). Al

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. HsaD family [H]

Homologues:

Organism=Escherichia coli, GI87081721, Length=277, Percent_Identity=26.7148014440433, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.7.1.8 [H]

Molecular weight: Translated: 31766; Mature: 31635

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEYESVWSDLQGVAFSQGYLDAGGVRTRYLHAGETSKPALVFLHGSGGHAEAYVRNLEA
CCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHH
HAEHFSTWSIDMLGHGYTDKPGHPLEVRHYVDHLRAFLDAIGAEKAHISGESLGGWVAAR
HHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LAADHGDRVMRLVLNTAGGSQADPEVMKRIVTLSMAAAEDPSWETVQARIKWLMADKSKA
HHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHH
YDDIVASRQRVYRQPGFVTAMRDIMALQDPEIRARNLLGPEQYGAITAPTLVVWTSDDPT
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHCCCHHHCCCEECCEEEEECCCCCC
ADVEEGRRIASMIPGARFEVMPGCGHWPQYEDPKTFNRLHVDFLLGR
CCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHEEEEEEECC
>Mature Secondary Structure 
AEYESVWSDLQGVAFSQGYLDAGGVRTRYLHAGETSKPALVFLHGSGGHAEAYVRNLEA
CCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHH
HAEHFSTWSIDMLGHGYTDKPGHPLEVRHYVDHLRAFLDAIGAEKAHISGESLGGWVAAR
HHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LAADHGDRVMRLVLNTAGGSQADPEVMKRIVTLSMAAAEDPSWETVQARIKWLMADKSKA
HHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHH
YDDIVASRQRVYRQPGFVTAMRDIMALQDPEIRARNLLGPEQYGAITAPTLVVWTSDDPT
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHCCCHHHCCCEECCEEEEECCCCCC
ADVEEGRRIASMIPGARFEVMPGCGHWPQYEDPKTFNRLHVDFLLGR
CCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA