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The map label for this gene is mhpA

Identifier: 108800751

GI number: 108800751

Start: 4040409

End: 4042130

Strand: Reverse

Name: mhpA

Synonym: Mmcs_3786

Alternate gene names: 108800751

Gene position: 4042130-4040409 (Counterclockwise)

Preceding gene: 108800752

Following gene: 108800750

Centisome position: 70.85

GC content: 68.99

Gene sequence:

>1722_bases
ATGACCCCGGCCACCGCACGAGACGCCACCGAACGAGACGCCACCGACACCGACGTCGTCATCGTCGGCGCCGGCCCGGT
GGGCCTGACGCTGGCGAACATCCTCGGCCTCCAGGGCGTACGCACCATGATCGTCGAGGAGCGCGCCACGCTCATCGACT
ACCCGCGCGGAGTCGGGCTCGACGACGAGGCGCTGCGGACCTTCCAGGCGATCGGACTGGTGGACAAGGTCCTGCCGCAC
ACCGTGCCGAACCAGATCCTGCGATTCTTCGACGGCAACCGGCGACTGCTCGCGGAGATGGCGCCGCCGGACGCACGGTT
CGGCTGGCCCAAACGCAACGGTTTCGTGCAACCCATGGTGGATGCCGAACTGCACGCCGGATTGGCGCGATTCCCCCACG
TCGAGGTGCGCTGGGGGCACAGGATGGCCGAATGCGAGGAGACCGCGGACGGTGTGACGGTGCGACTGGACGGTGACCCC
ACACCGGTGCGGGCGCGCTATCTGGTCGGCTGCGACGGTGGGCGCAGTGCGACCCGGCGCCTGATGGGGGTGTCCTTCGA
CGGCACCACCTCCCCGACACGCTGGCTGGTCGTCGACATCGCCAACGATCCGCTCGGCCACCCCAACAGCGAGGTCGGCG
CCGATCCGGCCCGGCCGTACGCCTCGATCTCGATCGCGCACGGAATCCGCCGCTTCGAGTTCATGATCCACGCCGACGAG
ACCGACGAACAGGCCGAGGACCCCGCGTTCATCCACCGGATGCTGGGGCTGCTGGTGCCCCATCCCGAACGTGTCGAGGT
CATCCGGCACCGGGTCTACACCCACCACTCCCGGATCGCCGGCGCCTTCCGCAAGGGCCGGATGTTCCTGGCCGGTGACG
CCGCGCACCTGATGCCGGTGTGGCAGGGCCAGGGGTACAACAGCGGAATCCGCGACGCCGCGAACCTCGGCTGGAAACTC
GCCGCGGTGGTCGACGGGCGCGCCGGTGACGCCCTGCTCGACACCTACGACGTCGAGCGCCGCAAACACGCCAGGGCGAT
GATCGACCTGTCCACCATGGTCGGACGGGTCATCTCACCGACCAACCGGCGCGTCGCGGCGGTGCGCGACAAGCTGATTC
GCGGCGCATCGGTGGTACCCACCCTCAAGCGCTACGTGCTGGAGATGCGGTTCAAGCCGATGCCCCGTTACGAGCAGGGC
GCGGTCTTCCATCCGGAGGCGCCCTCGCCCACCTCGCCGGCGGGCACGCTGTTCATCCAACCGCGCGTCGACACCCGCGA
CGCGCAGAACGTGTTGCTCGACGAGGTGCTCGGCACCGGGTTCGCGGTGTTGTGCTGGAACAACAACCCGCGCGCACTCC
TGGGTGCCGACCTCTTCGACCGGTGGAAGGCGCTCGGTGCCAGATTCGTCGCGGCCCGCCCTCTGACACAGTTGCACTGG
ACCGGTCACGACGATCCCGACGTCACCGTGATCGGCGACCGCACCGGCGCGCTGAAGGGCTGGTTCGACGCCCACGCCGA
ATCGGTGCTGTTCCTGCGCCCCGACCGTTGTATCGCCGGCGCCTGCATCGCGCAGCGTGCCCCCGAAGTGAGCACCGCCC
TGTTCGGGGTGCTCCATCTGACCCAGGGAGGAGGCAATGGTCACCATGGCGCAGATCGCCCTGTGCTGCACGTCGCACAG
TCCGCTACTGAACCTTCCGGGACCGTCGCGGGAACTCCTTGA

Upstream 100 bases:

>100_bases
GCGCACGGTTCGAGGTGATGCCCGGCTGCGGGCACTGGCCGCAGTACGAAGACCCCAAGACCTTCAACCGGTTACACGTC
GACTTCCTGCTGGGACGCTG

Downstream 100 bases:

>100_bases
CGACATCGGGTCGGCGTTGGCCGTCGCCCGTGATTTCGTCACCGAATTCGACCCGGACCTGGTGGTCACCTTCTCGCCGG
ACCACTACAACGGGTTCTTC

Product: 3-(3-hydroxyphenyl)propionate hydroxylase

Products: NA

Alternate protein names: 3-HCI hydroxylase; 3-HPP hydroxylase

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MTPATARDATERDATDTDVVIVGAGPVGLTLANILGLQGVRTMIVEERATLIDYPRGVGLDDEALRTFQAIGLVDKVLPH
TVPNQILRFFDGNRRLLAEMAPPDARFGWPKRNGFVQPMVDAELHAGLARFPHVEVRWGHRMAECEETADGVTVRLDGDP
TPVRARYLVGCDGGRSATRRLMGVSFDGTTSPTRWLVVDIANDPLGHPNSEVGADPARPYASISIAHGIRRFEFMIHADE
TDEQAEDPAFIHRMLGLLVPHPERVEVIRHRVYTHHSRIAGAFRKGRMFLAGDAAHLMPVWQGQGYNSGIRDAANLGWKL
AAVVDGRAGDALLDTYDVERRKHARAMIDLSTMVGRVISPTNRRVAAVRDKLIRGASVVPTLKRYVLEMRFKPMPRYEQG
AVFHPEAPSPTSPAGTLFIQPRVDTRDAQNVLLDEVLGTGFAVLCWNNNPRALLGADLFDRWKALGARFVAARPLTQLHW
TGHDDPDVTVIGDRTGALKGWFDAHAESVLFLRPDRCIAGACIAQRAPEVSTALFGVLHLTQGGGNGHHGADRPVLHVAQ
SATEPSGTVAGTP

Sequences:

>Translated_573_residues
MTPATARDATERDATDTDVVIVGAGPVGLTLANILGLQGVRTMIVEERATLIDYPRGVGLDDEALRTFQAIGLVDKVLPH
TVPNQILRFFDGNRRLLAEMAPPDARFGWPKRNGFVQPMVDAELHAGLARFPHVEVRWGHRMAECEETADGVTVRLDGDP
TPVRARYLVGCDGGRSATRRLMGVSFDGTTSPTRWLVVDIANDPLGHPNSEVGADPARPYASISIAHGIRRFEFMIHADE
TDEQAEDPAFIHRMLGLLVPHPERVEVIRHRVYTHHSRIAGAFRKGRMFLAGDAAHLMPVWQGQGYNSGIRDAANLGWKL
AAVVDGRAGDALLDTYDVERRKHARAMIDLSTMVGRVISPTNRRVAAVRDKLIRGASVVPTLKRYVLEMRFKPMPRYEQG
AVFHPEAPSPTSPAGTLFIQPRVDTRDAQNVLLDEVLGTGFAVLCWNNNPRALLGADLFDRWKALGARFVAARPLTQLHW
TGHDDPDVTVIGDRTGALKGWFDAHAESVLFLRPDRCIAGACIAQRAPEVSTALFGVLHLTQGGGNGHHGADRPVLHVAQ
SATEPSGTVAGTP
>Mature_572_residues
TPATARDATERDATDTDVVIVGAGPVGLTLANILGLQGVRTMIVEERATLIDYPRGVGLDDEALRTFQAIGLVDKVLPHT
VPNQILRFFDGNRRLLAEMAPPDARFGWPKRNGFVQPMVDAELHAGLARFPHVEVRWGHRMAECEETADGVTVRLDGDPT
PVRARYLVGCDGGRSATRRLMGVSFDGTTSPTRWLVVDIANDPLGHPNSEVGADPARPYASISIAHGIRRFEFMIHADET
DEQAEDPAFIHRMLGLLVPHPERVEVIRHRVYTHHSRIAGAFRKGRMFLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLA
AVVDGRAGDALLDTYDVERRKHARAMIDLSTMVGRVISPTNRRVAAVRDKLIRGASVVPTLKRYVLEMRFKPMPRYEQGA
VFHPEAPSPTSPAGTLFIQPRVDTRDAQNVLLDEVLGTGFAVLCWNNNPRALLGADLFDRWKALGARFVAARPLTQLHWT
GHDDPDVTVIGDRTGALKGWFDAHAESVLFLRPDRCIAGACIAQRAPEVSTALFGVLHLTQGGGNGHHGADRPVLHVAQS
ATEPSGTVAGTP

Specific function: Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3- hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI)

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pheA/tfdB FAD monooxygenase family

Homologues:

Organism=Escherichia coli, GI1786543, Length=530, Percent_Identity=47.5471698113208, Blast_Score=508, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MHPA_MYCSK (A1UJP4)

Other databases:

- EMBL:   CP000518
- RefSeq:   YP_939842.1
- ProteinModelPortal:   A1UJP4
- SMR:   A1UJP4
- STRING:   A1UJP4
- EnsemblBacteria:   EBMYCT00000057094
- GeneID:   4611794
- GenomeReviews:   CP000518_GR
- KEGG:   mkm:Mkms_3859
- eggNOG:   COG0654
- GeneTree:   EBGT00050000016090
- HOGENOM:   HBG565573
- OMA:   TTSSTRW
- ProtClustDB:   PRK06183
- BioCyc:   MSP189918:MKMS_3859-MONOMER
- HAMAP:   MF_01652
- InterPro:   IPR002938
- InterPro:   IPR003042
- PRINTS:   PR00420

Pfam domain/function: PF01494 FAD_binding_3

EC number: 1.14.13.-

Molecular weight: Translated: 62571; Mature: 62440

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPATARDATERDATDTDVVIVGAGPVGLTLANILGLQGVRTMIVEERATLIDYPRGVGL
CCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DDEALRTFQAIGLVDKVLPHTVPNQILRFFDGNRRLLAEMAPPDARFGWPKRNGFVQPMV
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
DAELHAGLARFPHVEVRWGHRMAECEETADGVTVRLDGDPTPVRARYLVGCDGGRSATRR
CHHHHHHHHHCCEEEEECCCHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCHHHHHH
LMGVSFDGTTSPTRWLVVDIANDPLGHPNSEVGADPARPYASISIAHGIRRFEFMIHADE
HEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHHHHEEEEEEEECCC
TDEQAEDPAFIHRMLGLLVPHPERVEVIRHRVYTHHSRIAGAFRKGRMFLAGDAAHLMPV
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHEEEE
WQGQGYNSGIRDAANLGWKLAAVVDGRAGDALLDTYDVERRKHARAMIDLSTMVGRVISP
ECCCCCCCCCCHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TNRRVAAVRDKLIRGASVVPTLKRYVLEMRFKPMPRYEQGAVFHPEAPSPTSPAGTLFIQ
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCEEEEE
PRVDTRDAQNVLLDEVLGTGFAVLCWNNNPRALLGADLFDRWKALGARFVAARPLTQLHW
CCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEECHHHHHHHHHHHHHHHHCCCCCEEEE
TGHDDPDVTVIGDRTGALKGWFDAHAESVLFLRPDRCIAGACIAQRAPEVSTALFGVLHL
CCCCCCCEEEEECCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHE
TQGGGNGHHGADRPVLHVAQSATEPSGTVAGTP
ECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TPATARDATERDATDTDVVIVGAGPVGLTLANILGLQGVRTMIVEERATLIDYPRGVGL
CCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DDEALRTFQAIGLVDKVLPHTVPNQILRFFDGNRRLLAEMAPPDARFGWPKRNGFVQPMV
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
DAELHAGLARFPHVEVRWGHRMAECEETADGVTVRLDGDPTPVRARYLVGCDGGRSATRR
CHHHHHHHHHCCEEEEECCCHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCHHHHHH
LMGVSFDGTTSPTRWLVVDIANDPLGHPNSEVGADPARPYASISIAHGIRRFEFMIHADE
HEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHHHHEEEEEEEECCC
TDEQAEDPAFIHRMLGLLVPHPERVEVIRHRVYTHHSRIAGAFRKGRMFLAGDAAHLMPV
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHEEEE
WQGQGYNSGIRDAANLGWKLAAVVDGRAGDALLDTYDVERRKHARAMIDLSTMVGRVISP
ECCCCCCCCCCHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TNRRVAAVRDKLIRGASVVPTLKRYVLEMRFKPMPRYEQGAVFHPEAPSPTSPAGTLFIQ
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCEEEEE
PRVDTRDAQNVLLDEVLGTGFAVLCWNNNPRALLGADLFDRWKALGARFVAARPLTQLHW
CCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEECHHHHHHHHHHHHHHHHCCCCCEEEE
TGHDDPDVTVIGDRTGALKGWFDAHAESVLFLRPDRCIAGACIAQRAPEVSTALFGVLHL
CCCCCCCEEEEECCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHE
TQGGGNGHHGADRPVLHVAQSATEPSGTVAGTP
ECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA