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The map label for this gene is fadK [H]

Identifier: 108800623

GI number: 108800623

Start: 3914514

End: 3916085

Strand: Reverse

Name: fadK [H]

Synonym: Mmcs_3657

Alternate gene names: 108800623

Gene position: 3916085-3914514 (Counterclockwise)

Preceding gene: 108800628

Following gene: 108800622

Centisome position: 68.64

GC content: 69.02

Gene sequence:

>1572_bases
ATGCGCGAAATCCCGGTTGAGCTGATCAAACGGTACGAGCAGGAGGGGTGGTGGACACCCGAAACGCTCGGCGAACTCCT
GGCGCGACACCTGGCGACGGGGCCGGACACCGGTTTCTGCGTGTACTCCGACGTGCGGCCCTACCGCGGCACCTTCGGCG
ACGTGGAACTACAGGCCCGCCGGTTGGCCGCCGGCCTGCGCCGGCGCGGGGTCGGGCCGGGCGACGTCGTCGCATTCCAG
CTGCCCAACTGGGCGGAGGCGGCCATGGCGTTCTGGGCCTCGGCGTTCCTCGGGGCCGTGGTCGTGCCGATCGTGCACTT
CTACGGCCGCAAGGAACTCGCCCACATCATGGCGACGGCGCGCCCCAAGGTCTTCATCACCGTCGCCGAGTTCGGCCGCA
TGACGTTCCAGCCCGATCTGTGCGCGGACGTGCCGATCGTCGGACTGGTCGGCGAGGCCGGCTTCGACGAACTGTTCGAC
GACGAGTCGATGACCGATACGGTCCATACGGATCCGGCCGGCCCGGCGTTGATCGCCTTCACGTCGGGCACCACTCGAGA
TCCCAAGGGCGTCATCCACAGTCACCAGACCCTCGGCTTCGAGACCCGCCAGCTGCTCGAGAACTATCCCCCCGACCGCG
GCCGCCAGTTGACGGCAACACCGGTCGGACACTTCATCGGGATGGTCGGCGCCTTTCTCATCCCGGTGCTCGAGAACGCC
CCCATCGACCTGTGTGACGTCTGGGACCCCGGCAAGGTGCTGGGCCTGATCGAGACCGAGGGGTTGTCCGTCGGCGGGGG
ACCGCCGTACTTCGTCACCAGCCTGCTCGACCATCCCGACTGCACGCCGGAGCACATCGCGCGCTTCTCGACGGTGGGGC
TCGGCGGCTCGACGGTCCCGGCCGCGGTGACGCGCCGACTGGCCGACCTCGGACTGTTCGTGTTCCGGTCCTACGGCAGC
ACCGAACACCCGTCGATCACCGGGTCACGGCCCACCGCGCCGGAGGATAAACGCCTCTACACCGACGGCGATCCCCGCCC
CGGCGTCGAGATCAGACTCACCGACGACGGCGAGATCCTCTCGCGGGGCCCCGACCTCTGTCTCGGCTACACCGACGATG
CCCTGACCGCCCAGGCCTTCGACGACGACGGGTGGTACCACACCGGTGACGTCGGCGTCCTCGACGCGGACGGGTACCTG
ACCATCACCGACCGCAAGGCCGACGTGATCATCCGCGGCGGCGAGAACATCAGCGCGCTCGAGGTCGAAGAGGTGTTGCT
GAGCATGCCGGCCGTCGCCGAGGCGGTGGTGGTGGCGGCGCCCGACGCGCGGCTCGGCGAACACGCCGCCGCCGTGCTGC
GGCTGCGGAACGGCCATCCGATGCCCACCCTCGACGACGTCCGCGCGCACTTCGAGCACGCCGGGGTCGCCCGGCAGAAG
TGGCCCGAGGAGCTGCATCAGGTCGACGAGGACTTCCCCCGCACCGCGAGCGGCAAAGTCCAGAAGGTGCTCGTCCGCGA
GCAGATCCGTCAATGCAGCCCGACACGGGACATTGCAGCCTTCTCGAAATGA

Upstream 100 bases:

>100_bases
CGGTATTGGCATTCTCGGCTGCGGAGAATAGCATCACCGAGAGGGCGCCGGCGCGAGCAACTGCGGCGGCGCACCGCTTG
CCGCCGACAGTTTGGGGACC

Downstream 100 bases:

>100_bases
GAATACGATTCTCCCGATAAGCAAAGGAGTTTTCCATGGGTCAACTGTCACACCGGGTCGACATCCCGTTCCCGTTGTTC
GATGCGGACAACCACCTCTA

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acyl-CoA synthetase [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MREIPVELIKRYEQEGWWTPETLGELLARHLATGPDTGFCVYSDVRPYRGTFGDVELQARRLAAGLRRRGVGPGDVVAFQ
LPNWAEAAMAFWASAFLGAVVVPIVHFYGRKELAHIMATARPKVFITVAEFGRMTFQPDLCADVPIVGLVGEAGFDELFD
DESMTDTVHTDPAGPALIAFTSGTTRDPKGVIHSHQTLGFETRQLLENYPPDRGRQLTATPVGHFIGMVGAFLIPVLENA
PIDLCDVWDPGKVLGLIETEGLSVGGGPPYFVTSLLDHPDCTPEHIARFSTVGLGGSTVPAAVTRRLADLGLFVFRSYGS
TEHPSITGSRPTAPEDKRLYTDGDPRPGVEIRLTDDGEILSRGPDLCLGYTDDALTAQAFDDDGWYHTGDVGVLDADGYL
TITDRKADVIIRGGENISALEVEEVLLSMPAVAEAVVVAAPDARLGEHAAAVLRLRNGHPMPTLDDVRAHFEHAGVARQK
WPEELHQVDEDFPRTASGKVQKVLVREQIRQCSPTRDIAAFSK

Sequences:

>Translated_523_residues
MREIPVELIKRYEQEGWWTPETLGELLARHLATGPDTGFCVYSDVRPYRGTFGDVELQARRLAAGLRRRGVGPGDVVAFQ
LPNWAEAAMAFWASAFLGAVVVPIVHFYGRKELAHIMATARPKVFITVAEFGRMTFQPDLCADVPIVGLVGEAGFDELFD
DESMTDTVHTDPAGPALIAFTSGTTRDPKGVIHSHQTLGFETRQLLENYPPDRGRQLTATPVGHFIGMVGAFLIPVLENA
PIDLCDVWDPGKVLGLIETEGLSVGGGPPYFVTSLLDHPDCTPEHIARFSTVGLGGSTVPAAVTRRLADLGLFVFRSYGS
TEHPSITGSRPTAPEDKRLYTDGDPRPGVEIRLTDDGEILSRGPDLCLGYTDDALTAQAFDDDGWYHTGDVGVLDADGYL
TITDRKADVIIRGGENISALEVEEVLLSMPAVAEAVVVAAPDARLGEHAAAVLRLRNGHPMPTLDDVRAHFEHAGVARQK
WPEELHQVDEDFPRTASGKVQKVLVREQIRQCSPTRDIAAFSK
>Mature_523_residues
MREIPVELIKRYEQEGWWTPETLGELLARHLATGPDTGFCVYSDVRPYRGTFGDVELQARRLAAGLRRRGVGPGDVVAFQ
LPNWAEAAMAFWASAFLGAVVVPIVHFYGRKELAHIMATARPKVFITVAEFGRMTFQPDLCADVPIVGLVGEAGFDELFD
DESMTDTVHTDPAGPALIAFTSGTTRDPKGVIHSHQTLGFETRQLLENYPPDRGRQLTATPVGHFIGMVGAFLIPVLENA
PIDLCDVWDPGKVLGLIETEGLSVGGGPPYFVTSLLDHPDCTPEHIARFSTVGLGGSTVPAAVTRRLADLGLFVFRSYGS
TEHPSITGSRPTAPEDKRLYTDGDPRPGVEIRLTDDGEILSRGPDLCLGYTDDALTAQAFDDDGWYHTGDVGVLDADGYL
TITDRKADVIIRGGENISALEVEEVLLSMPAVAEAVVVAAPDARLGEHAAAVLRLRNGHPMPTLDDVRAHFEHAGVARQK
WPEELHQVDEDFPRTASGKVQKVLVREQIRQCSPTRDIAAFSK

Specific function: Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It has a low activity on medium or long chain fatty acids and is ma

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Membrane; Peripheral membrane protein. Note=Partially membrane-associated [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=518, Percent_Identity=28.1853281853282, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI187761345, Length=516, Percent_Identity=25.968992248062, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI187761343, Length=516, Percent_Identity=25.968992248062, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI42544132, Length=494, Percent_Identity=23.6842105263158, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI38505220, Length=504, Percent_Identity=24.6031746031746, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI58082049, Length=484, Percent_Identity=25, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI122937307, Length=494, Percent_Identity=25.1012145748988, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI157311624, Length=485, Percent_Identity=24.9484536082474, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI157311622, Length=485, Percent_Identity=24.9484536082474, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI27477105, Length=154, Percent_Identity=33.7662337662338, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI115511026, Length=508, Percent_Identity=22.4409448818898, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI40807491, Length=157, Percent_Identity=35.031847133758, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI57165410, Length=143, Percent_Identity=34.965034965035, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI57165412, Length=143, Percent_Identity=34.965034965035, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI145693145, Length=525, Percent_Identity=32.7619047619048, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1786810, Length=549, Percent_Identity=28.0510018214936, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI221142682, Length=481, Percent_Identity=26.4033264033264, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788107, Length=512, Percent_Identity=25, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788595, Length=277, Percent_Identity=27.4368231046931, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786801, Length=454, Percent_Identity=27.3127753303965, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790505, Length=561, Percent_Identity=24.0641711229947, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17558820, Length=475, Percent_Identity=27.7894736842105, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17560308, Length=552, Percent_Identity=26.8115942028986, Blast_Score=149, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71994694, Length=546, Percent_Identity=26.5567765567766, Blast_Score=148, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI71994690, Length=546, Percent_Identity=26.5567765567766, Blast_Score=148, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI71994703, Length=546, Percent_Identity=26.5567765567766, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI32563687, Length=476, Percent_Identity=26.4705882352941, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17559526, Length=529, Percent_Identity=24.1965973534972, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71996755, Length=471, Percent_Identity=23.5668789808917, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17557194, Length=520, Percent_Identity=24.0384615384615, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17531443, Length=349, Percent_Identity=25.214899713467, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17538037, Length=542, Percent_Identity=22.6937269372694, Blast_Score=89, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319699, Length=486, Percent_Identity=24.6913580246914, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319264, Length=573, Percent_Identity=22.8621291448517, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24581924, Length=510, Percent_Identity=26.8627450980392, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI21356947, Length=517, Percent_Identity=25.1450676982592, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18859661, Length=507, Percent_Identity=25.6410256410256, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI21355181, Length=481, Percent_Identity=24.1164241164241, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24653035, Length=516, Percent_Identity=23.062015503876, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI161076582, Length=523, Percent_Identity=22.9445506692161, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24648255, Length=505, Percent_Identity=24.1584158415842, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24648253, Length=490, Percent_Identity=24.6938775510204, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24648260, Length=512, Percent_Identity=23.4375, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648257, Length=356, Percent_Identity=25.561797752809, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21358303, Length=479, Percent_Identity=24.6346555323591, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20130357, Length=273, Percent_Identity=25.6410256410256, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356441, Length=482, Percent_Identity=22.1991701244813, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17933690, Length=201, Percent_Identity=27.363184079602, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 56903; Mature: 56903

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREIPVELIKRYEQEGWWTPETLGELLARHLATGPDTGFCVYSDVRPYRGTFGDVELQAR
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHH
RLAAGLRRRGVGPGDVVAFQLPNWAEAAMAFWASAFLGAVVVPIVHFYGRKELAHIMATA
HHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHC
RPKVFITVAEFGRMTFQPDLCADVPIVGLVGEAGFDELFDDESMTDTVHTDPAGPALIAF
CCEEEEEEHHCCCEECCCCCCCCCCEEEEECCCCCHHHCCCCCCCCCCCCCCCCCEEEEE
TSGTTRDPKGVIHSHQTLGFETRQLLENYPPDRGRQLTATPVGHFIGMVGAFLIPVLENA
CCCCCCCCCHHHHCCHHCCHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCC
PIDLCDVWDPGKVLGLIETEGLSVGGGPPYFVTSLLDHPDCTPEHIARFSTVGLGGSTVP
CCCEEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHH
AAVTRRLADLGLFVFRSYGSTEHPSITGSRPTAPEDKRLYTDGDPRPGVEIRLTDDGEIL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCHHH
SRGPDLCLGYTDDALTAQAFDDDGWYHTGDVGVLDADGYLTITDRKADVIIRGGENISAL
HCCCCEEEECCCCCCEEEEECCCCCEEECCEEEEECCCEEEEECCCCEEEEECCCCCCHH
EVEEVLLSMPAVAEAVVVAAPDARLGEHAAAVLRLRNGHPMPTLDDVRAHFEHAGVARQK
HHHHHHHHCCHHHHEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHH
WPEELHQVDEDFPRTASGKVQKVLVREQIRQCSPTRDIAAFSK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure
MREIPVELIKRYEQEGWWTPETLGELLARHLATGPDTGFCVYSDVRPYRGTFGDVELQAR
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHH
RLAAGLRRRGVGPGDVVAFQLPNWAEAAMAFWASAFLGAVVVPIVHFYGRKELAHIMATA
HHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHC
RPKVFITVAEFGRMTFQPDLCADVPIVGLVGEAGFDELFDDESMTDTVHTDPAGPALIAF
CCEEEEEEHHCCCEECCCCCCCCCCEEEEECCCCCHHHCCCCCCCCCCCCCCCCCEEEEE
TSGTTRDPKGVIHSHQTLGFETRQLLENYPPDRGRQLTATPVGHFIGMVGAFLIPVLENA
CCCCCCCCCHHHHCCHHCCHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCC
PIDLCDVWDPGKVLGLIETEGLSVGGGPPYFVTSLLDHPDCTPEHIARFSTVGLGGSTVP
CCCEEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHH
AAVTRRLADLGLFVFRSYGSTEHPSITGSRPTAPEDKRLYTDGDPRPGVEIRLTDDGEIL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCHHH
SRGPDLCLGYTDDALTAQAFDDDGWYHTGDVGVLDADGYLTITDRKADVIIRGGENISAL
HCCCCEEEECCCCCCEEEEECCCCCEEECCEEEEECCCEEEEECCCCEEEEECCCCCCHH
EVEEVLLSMPAVAEAVVVAAPDARLGEHAAAVLRLRNGHPMPTLDDVRAHFEHAGVARQK
HHHHHHHHCCHHHHEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHH
WPEELHQVDEDFPRTASGKVQKVLVREQIRQCSPTRDIAAFSK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 7984428; 12535077 [H]