Click here to switch to the map view.

The map label for this gene is mbtB [H]

Identifier: 108800435

GI number: 108800435

Start: 3688655

End: 3689392

Strand: Reverse

Name: mbtB [H]

Synonym: Mmcs_3469

Alternate gene names: 108800435

Gene position: 3689392-3688655 (Counterclockwise)

Preceding gene: 108800436

Following gene: 108800434

Centisome position: 64.66

GC content: 72.09

Gene sequence:

>738_bases
ATGACGGCCCGGCAACTCGAGTTCGCGCCCTGGGTCAAACACTTCCCGGCGTCCGGTGGTGCGACGGCGGTCGTGTTCCC
GCACGCCGGCGGCGCCGCCGCGGCATACCGCGCGCTGGCGAAGTCGTTGTCCGGCAACGGAATCGACACCCACGTCGTGC
AGTATCCGCAGCGGGCCGACCGCTTGCGGCATCCCGCGGCGGACAGCATCGGTGCGCTCGCGGCCCAGTTGTTCGAGGCC
GGGCCGTGGGACCGCCTCGGCCCGCTCGACCTGTTCGGCCACTGCATGGGCGCGGTGGTGGCGTTCGAGTTCGCCCGGGT
CGCCGAACGCAACGGTGTCACGGTGCGCACGCTGTGGGCGTCGGCGGGCCAGGCCCCGTCGACCGTCGCCGAGGCCGCGC
CGCTGCCGAGCACCGACCGTGACGTCCTGGCCGACATGGTCGACCTCGGCGGCACCGACCCCCGGCTGCTAGAGGACGAG
GACTTCGTCGAACTCCTCGTGACGGCGGTGCGGGCCGACTACCGCGCGCTGAGCGGATACGCCTGCGGGCGTGACGTGCA
GATCCGCGCCGACATCCACGCATTGCGCGGTGACCGCGACCACCGGATCAGCCGGGAGTGGTCGCAGCGCTGGGCCTCCC
ACACCGCGGGCCGGTTCACATTGTCGACGTTCCAGGGCGGCCACTTCTACCTCGACGAGCATCTCGACGAGGTGGCTGCG
CTGGTGGGCGGCGGATGA

Upstream 100 bases:

>100_bases
ACCGCCTCGAAGGCGTCGCCGAGCTCTACCTCGAAGTCGCGGACATGAACTCCGCCGATGTGGCGTCGGCCCTGCACTCG
ACGTCCGCGCAGGCGTCGCG

Downstream 100 bases:

>100_bases
CCGGCGCGAACCGACTCGCCGCCGAACCGGATCCGGTCGTCATCGTCGGAATGGCGGTGGAGGCGCCCGGCGGCATCGAC
ACTCCAGAGGACTACTGGAC

Product: thioesterase

Products: NA

Alternate protein names: Mycobactin synthetase protein B [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MTARQLEFAPWVKHFPASGGATAVVFPHAGGAAAAYRALAKSLSGNGIDTHVVQYPQRADRLRHPAADSIGALAAQLFEA
GPWDRLGPLDLFGHCMGAVVAFEFARVAERNGVTVRTLWASAGQAPSTVAEAAPLPSTDRDVLADMVDLGGTDPRLLEDE
DFVELLVTAVRADYRALSGYACGRDVQIRADIHALRGDRDHRISREWSQRWASHTAGRFTLSTFQGGHFYLDEHLDEVAA
LVGGG

Sequences:

>Translated_245_residues
MTARQLEFAPWVKHFPASGGATAVVFPHAGGAAAAYRALAKSLSGNGIDTHVVQYPQRADRLRHPAADSIGALAAQLFEA
GPWDRLGPLDLFGHCMGAVVAFEFARVAERNGVTVRTLWASAGQAPSTVAEAAPLPSTDRDVLADMVDLGGTDPRLLEDE
DFVELLVTAVRADYRALSGYACGRDVQIRADIHALRGDRDHRISREWSQRWASHTAGRFTLSTFQGGHFYLDEHLDEVAA
LVGGG
>Mature_244_residues
TARQLEFAPWVKHFPASGGATAVVFPHAGGAAAAYRALAKSLSGNGIDTHVVQYPQRADRLRHPAADSIGALAAQLFEAG
PWDRLGPLDLFGHCMGAVVAFEFARVAERNGVTVRTLWASAGQAPSTVAEAAPLPSTDRDVLADMVDLGGTDPRLLEDED
FVELLVTAVRADYRALSGYACGRDVQIRADIHALRGDRDHRISREWSQRWASHTAGRFTLSTFQGGHFYLDEHLDEVAAL
VGGG

Specific function: Involved in the initial steps of the mycobactin biosynthetic pathway. Putatively couples activated salicylic acid with serine or threonine and cyclizes this precursor to the hydroxyphenyloxazoline ring system present in this class of siderophores [H]

COG id: COG3208

COG function: function code Q; Predicted thioesterase involved in non-ribosomal peptide biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 acyl carrier domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR013624
- InterPro:   IPR006163
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF08415 NRPS; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: NA

Molecular weight: Translated: 26343; Mature: 26212

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARQLEFAPWVKHFPASGGATAVVFPHAGGAAAAYRALAKSLSGNGIDTHVVQYPQRAD
CCCCCCCCCHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHCCHHHH
RLRHPAADSIGALAAQLFEAGPWDRLGPLDLFGHCMGAVVAFEFARVAERNGVTVRTLWA
HHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
SAGQAPSTVAEAAPLPSTDRDVLADMVDLGGTDPRLLEDEDFVELLVTAVRADYRALSGY
CCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
ACGRDVQIRADIHALRGDRDHRISREWSQRWASHTAGRFTLSTFQGGHFYLDEHLDEVAA
CCCCCCEEEEHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHH
LVGGG
HHCCC
>Mature Secondary Structure 
TARQLEFAPWVKHFPASGGATAVVFPHAGGAAAAYRALAKSLSGNGIDTHVVQYPQRAD
CCCCCCCCHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHCCHHHH
RLRHPAADSIGALAAQLFEAGPWDRLGPLDLFGHCMGAVVAFEFARVAERNGVTVRTLWA
HHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
SAGQAPSTVAEAAPLPSTDRDVLADMVDLGGTDPRLLEDEDFVELLVTAVRADYRALSGY
CCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
ACGRDVQIRADIHALRGDRDHRISREWSQRWASHTAGRFTLSTFQGGHFYLDEHLDEVAA
CCCCCCEEEEHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHH
LVGGG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]