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The map label for this gene is eryA [H]

Identifier: 108800434

GI number: 108800434

Start: 3687327

End: 3688658

Strand: Reverse

Name: eryA [H]

Synonym: Mmcs_3468

Alternate gene names: 108800434

Gene position: 3688658-3687327 (Counterclockwise)

Preceding gene: 108800435

Following gene: 108800433

Centisome position: 64.65

GC content: 70.05

Gene sequence:

>1332_bases
ATGACCGGCGCGAACCGACTCGCCGCCGAACCGGATCCGGTCGTCATCGTCGGAATGGCGGTGGAGGCGCCCGGCGGCAT
CGACACTCCAGAGGACTACTGGACGCTGCTGTCCGAACAGCGCGAGGCGCTGTGTCCGTTTCCCACCGACCGCGGCTGGT
CGCTTCGCGAACTGTTCACCGGGTCCAGGCGCGAGGGTTTCAAACCGATCCACGATCTCGGCGGATTCCTTACCAGCGCA
TCGACATTCGATCCCGAGTTCTTCGGCCTCTCGCCGCGCGAGGCCGTCGCGATGGACCCGCAGCAGCGGGTGGCGCTGCG
CCTGGCGTGGCGTGCGCTGGAGAACAGCGGCATCAACCCCGACGACCTGGCCGGCCACGACGTCGGCTGCTATCTCGGGG
CCTCGGCACTGGAGTACGGGCCCGAACTCAGCGAGTTCTCCCACCACAGCGGCCACCTGATCACCGGCACGTCGCTGGGT
GTCGTCTCCGGGCGGATCGCCTACACCCTCGATCTGGCCGGCCCCGCCGTCACCGTCGACACCTCCTGCTCCTCGGCGCT
GTCCGCCTTCCACCTCGCCGTGCAGGCGCTGCGATCCGGTGACTGCGACCTCGCGCTGACCGGCGGGGTGTGCGTGATGG
GGTCCCCCGGATACTTCGTCGAATTCTCCACACAGCACGCGCTCTCCGACGACGGCCACTGCCGGCCCTACAGTGCACAC
GCCAGCGGCACCGTCTGGGCCGAGGGCGCGGGACTGTTCGTGCTGCAACGCAAGTCAGGCGCGGTGCGCGACGGCCGTGA
CATCCTCGCCGAGGTCCGCGCCAGCAGCATCAACTCCGACGGCCGCACCGTCGGGCTGACCGCGCCCAGCGAACGTGCCC
AGAGCCGCCTGTTCGGCAAGGCGATCCGAGAGGCCGGGATCTCATCCGAGGACGTCGGCATGATCGAAGGTCACGGCACC
GGAACGCGGCTGGGTGACAAGACCGAACTGCGCTCGCTGGCGGCCACCTACGGTGACACCGCCCCCGCCCGTGGACCGCT
GCTCGGCTCGGTGAAGTCCAACATCGGGCACACCCAGTCGGCGGCGGGCGCCCTCGGGCTGGCCAAGGTGCTCGTTTCCG
CCGAGCGCGCCACCATCCCGCCCACCCTGCACGCCGACGAGCCCAGTCGCGAGATCGACTGGGACACCAGCGGCCTTCGG
TTGGCGAACAAGCTCACCCCCTGGCCGGCCCGCAACGGCGAACGCGTGGGCGCGGTCTCGGCGTTCGGTATGAGCGGCAC
CAACACCCACGTGGTCGTGGCCGTGCCGGACCGGCCCCGGGAAGCGAAGTGA

Upstream 100 bases:

>100_bases
CCTCCCACACCGCGGGCCGGTTCACATTGTCGACGTTCCAGGGCGGCCACTTCTACCTCGACGAGCATCTCGACGAGGTG
GCTGCGCTGGTGGGCGGCGG

Downstream 100 bases:

>100_bases
CGCGGCCGAACCGGTGGCCCGACGGGCGGATCCCGGTGCTGCTGAGCGCACATGCCGGCGATCTCGTCGCCGAGGATGCC
CGCGCCGTGCTCGGATACCT

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 6-deoxyerythronolide B synthase I; DEBS 1; ORF 1 [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MTGANRLAAEPDPVVIVGMAVEAPGGIDTPEDYWTLLSEQREALCPFPTDRGWSLRELFTGSRREGFKPIHDLGGFLTSA
STFDPEFFGLSPREAVAMDPQQRVALRLAWRALENSGINPDDLAGHDVGCYLGASALEYGPELSEFSHHSGHLITGTSLG
VVSGRIAYTLDLAGPAVTVDTSCSSALSAFHLAVQALRSGDCDLALTGGVCVMGSPGYFVEFSTQHALSDDGHCRPYSAH
ASGTVWAEGAGLFVLQRKSGAVRDGRDILAEVRASSINSDGRTVGLTAPSERAQSRLFGKAIREAGISSEDVGMIEGHGT
GTRLGDKTELRSLAATYGDTAPARGPLLGSVKSNIGHTQSAAGALGLAKVLVSAERATIPPTLHADEPSREIDWDTSGLR
LANKLTPWPARNGERVGAVSAFGMSGTNTHVVVAVPDRPREAK

Sequences:

>Translated_443_residues
MTGANRLAAEPDPVVIVGMAVEAPGGIDTPEDYWTLLSEQREALCPFPTDRGWSLRELFTGSRREGFKPIHDLGGFLTSA
STFDPEFFGLSPREAVAMDPQQRVALRLAWRALENSGINPDDLAGHDVGCYLGASALEYGPELSEFSHHSGHLITGTSLG
VVSGRIAYTLDLAGPAVTVDTSCSSALSAFHLAVQALRSGDCDLALTGGVCVMGSPGYFVEFSTQHALSDDGHCRPYSAH
ASGTVWAEGAGLFVLQRKSGAVRDGRDILAEVRASSINSDGRTVGLTAPSERAQSRLFGKAIREAGISSEDVGMIEGHGT
GTRLGDKTELRSLAATYGDTAPARGPLLGSVKSNIGHTQSAAGALGLAKVLVSAERATIPPTLHADEPSREIDWDTSGLR
LANKLTPWPARNGERVGAVSAFGMSGTNTHVVVAVPDRPREAK
>Mature_442_residues
TGANRLAAEPDPVVIVGMAVEAPGGIDTPEDYWTLLSEQREALCPFPTDRGWSLRELFTGSRREGFKPIHDLGGFLTSAS
TFDPEFFGLSPREAVAMDPQQRVALRLAWRALENSGINPDDLAGHDVGCYLGASALEYGPELSEFSHHSGHLITGTSLGV
VSGRIAYTLDLAGPAVTVDTSCSSALSAFHLAVQALRSGDCDLALTGGVCVMGSPGYFVEFSTQHALSDDGHCRPYSAHA
SGTVWAEGAGLFVLQRKSGAVRDGRDILAEVRASSINSDGRTVGLTAPSERAQSRLFGKAIREAGISSEDVGMIEGHGTG
TRLGDKTELRSLAATYGDTAPARGPLLGSVKSNIGHTQSAAGALGLAKVLVSAERATIPPTLHADEPSREIDWDTSGLRL
ANKLTPWPARNGERVGAVSAFGMSGTNTHVVVAVPDRPREAK

Specific function: Catalyzes The Condensation Reaction Of Fatty Acid Synthesis By The Addition To An Acyl Acceptor Of Two Carbons From Malonyl-Acp. Has A Preference For Short Chain Acid Substrates And May Function To Supply The Octanoic Substrates For Lipoic Acid Biosynthe

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI41872631, Length=428, Percent_Identity=33.8785046728972, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI8923559, Length=365, Percent_Identity=26.5753424657534, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1787337, Length=289, Percent_Identity=28.0276816608997, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788663, Length=291, Percent_Identity=25.7731958762887, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212642053, Length=375, Percent_Identity=37.0666666666667, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17550940, Length=357, Percent_Identity=34.1736694677871, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71983541, Length=276, Percent_Identity=25.7246376811594, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=25.8426966292135, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=22.4719101123595, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19920632, Length=364, Percent_Identity=34.0659340659341, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI221330659, Length=364, Percent_Identity=34.0659340659341, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24581345, Length=365, Percent_Identity=33.972602739726, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24644341, Length=282, Percent_Identity=28.3687943262411, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR013968
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF08659 KR; PF00550 PP-binding [H]

EC number: =2.3.1.94 [H]

Molecular weight: Translated: 46554; Mature: 46423

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGANRLAAEPDPVVIVGMAVEAPGGIDTPEDYWTLLSEQREALCPFPTDRGWSLRELFT
CCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHC
GSRREGFKPIHDLGGFLTSASTFDPEFFGLSPREAVAMDPQQRVALRLAWRALENSGINP
CCCCCCCCCHHHHHHHHHCCCCCCCHHCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCH
DDLAGHDVGCYLGASALEYGPELSEFSHHSGHLITGTSLGVVSGRIAYTLDLAGPAVTVD
HHCCCCCCHHHHCCHHHHCCCCHHHHCCCCCCEEECCCCCCCCCEEEEEEEECCCEEEEE
TSCSSALSAFHLAVQALRSGDCDLALTGGVCVMGSPGYFVEFSTQHALSDDGHCRPYSAH
CCHHHHHHHHHHHHHHHHCCCCCEEEECCEEEECCCCEEEEECCCCCCCCCCCCCCCCCC
ASGTVWAEGAGLFVLQRKSGAVRDGRDILAEVRASSINSDGRTVGLTAPSERAQSRLFGK
CCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHH
AIREAGISSEDVGMIEGHGTGTRLGDKTELRSLAATYGDTAPARGPLLGSVKSNIGHTQS
HHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCHH
AAGALGLAKVLVSAERATIPPTLHADEPSREIDWDTSGLRLANKLTPWPARNGERVGAVS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEHHCCCCCCCCCCCCEEEEE
AFGMSGTNTHVVVAVPDRPREAK
EECCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
TGANRLAAEPDPVVIVGMAVEAPGGIDTPEDYWTLLSEQREALCPFPTDRGWSLRELFT
CCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHC
GSRREGFKPIHDLGGFLTSASTFDPEFFGLSPREAVAMDPQQRVALRLAWRALENSGINP
CCCCCCCCCHHHHHHHHHCCCCCCCHHCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCH
DDLAGHDVGCYLGASALEYGPELSEFSHHSGHLITGTSLGVVSGRIAYTLDLAGPAVTVD
HHCCCCCCHHHHCCHHHHCCCCHHHHCCCCCCEEECCCCCCCCCEEEEEEEECCCEEEEE
TSCSSALSAFHLAVQALRSGDCDLALTGGVCVMGSPGYFVEFSTQHALSDDGHCRPYSAH
CCHHHHHHHHHHHHHHHHCCCCCEEEECCEEEECCCCEEEEECCCCCCCCCCCCCCCCCC
ASGTVWAEGAGLFVLQRKSGAVRDGRDILAEVRASSINSDGRTVGLTAPSERAQSRLFGK
CCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHH
AIREAGISSEDVGMIEGHGTGTRLGDKTELRSLAATYGDTAPARGPLLGSVKSNIGHTQS
HHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCHH
AAGALGLAKVLVSAERATIPPTLHADEPSREIDWDTSGLRLANKLTPWPARNGERVGAVS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEHHCCCCCCCCCCCCEEEEE
AFGMSGTNTHVVVAVPDRPREAK
EECCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2024119; 8386127 [H]